Primary Site >> Stomach Cancer
Gene >> CDH1
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Ref: Hereditary Diffuse Gastric Cancer PMID: 20301318 |
Ref: E-cadherin and urokinase-type plasminogen activator tissue status in gastric carcinoma. PMID: 8625219 |
Ref: Mutations of the human E-cadherin (CDH1) gene. PMID: 9744472 |
Ref: Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. PMID: 10072428 Ref: Identification of eleven novel tumor-associated E-cadherin mutations. Mutations in brief no. 215. Online. PMID: 10094558 Ref: Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. PMID: 10433926 Ref: Familial gastric cancer: overview and guidelines for management. PMID: 10593993 |
Ref: The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. PMID: 10896919 Ref: Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. PMID: 10973239 |
Ref: E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. PMID: 11313896 Ref: Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. PMID: 11419427 Ref: A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination. PMID: 11434599 Ref: Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? PMID: 11443625 Ref: DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas. PMID: 11496321 Ref: A germline E-cadherin mutation in a family with gastric and colon cancer. PMID: 11562785 Ref: Prophylactic total gastrectomy for familial gastric cancer. PMID: 11602891 Ref: Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis. PMID: 11665847 Ref: Association of E-cadherin germ-line alterations with prostate cancer. PMID: 11705864 Ref: Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. PMID: 11729114 |
Ref: Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. PMID: 11896626 Ref: Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer. PMID: 11948460 Ref: Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. PMID: 11968083 Ref: Novel germline CDH1 mutations in hereditary diffuse gastric cancer families. PMID: 11968084 Ref: Molecular biology of gastric cancer. PMID: 11979414 Ref: Prophylactic gastrectomy for CDH1 mutation carriers. PMID: 11998610 Ref: E-cadherin mutations and hereditary gastric cancer: prevention by resection? PMID: 12145417 Ref: CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer. PMID: 12209998 Ref: Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. PMID: 12444556 |
Ref: Identification and characterization of human SNAIL3 (SNAI3) gene in silico. PMID: 12579345 Ref: Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. PMID: 12588804 Ref: Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer. PMID: 12604719 Ref: Preventive gastrectomy in patients with gastric cancer risk due to genetic alterations of the E-cadherin gene defect. PMID: 12690477 Ref: Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. PMID: 12763209 Ref: Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer: an analysis in the District of Urbino, Region Marche, Central Italy. PMID: 12908778 Ref: [Hereditary gastric cancer. Genetics and clinical management]. PMID: 12940100 Ref: DNA methylation of multiple genes in gastric carcinoma: association with histological type and CpG island methylator phenotype. PMID: 14556664 Ref: The G/A nucleotide change at cDNA position 2494 in the E-cadherin gene (CDH1): analysis in Italian patients. PMID: 14610318 Ref: The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice. PMID: 14630673 Ref: Familial gastric cancer. PMID: 14762482 |
Ref: Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour. PMID: 14661064 Ref: Combined analysis of E-cadherin gene (CDH1) promoter hypermethylation and E-cadherin protein expression in patients with gastric cancer: implications for treatment with demethylating drugs. PMID: 14998854 Ref: Genes and gastric cancer. PMID: 15011894 Ref: Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. PMID: 15083323 Ref: Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. PMID: 15102685 Ref: Germline mutational analysis of CDH1 and pathologic features in familial cancer syndrome with diffuse gastric cancer/breast cancer proband in a Chinese family. PMID: 15135482 Ref: Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. PMID: 15173255 Ref: Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. PMID: 15235021 Ref: E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. PMID: 15288293 Ref: Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age. PMID: 15307140 Ref: [Germline E-cadherin gene mutation screening in familial gastric cancer kindreds]. PMID: 15363252 Ref: A TP53-truncating germline mutation (E287X) in a family with characteristics of both hereditary diffuse gastric cancer and Li-Fraumeni syndrome. PMID: 15368100 Ref: CDH1 germline mutation in hereditary gastric carcinoma. PMID: 15457549 Ref: [18F]Fluoro-2-deoxy-D-glucose positron emission tomography detects gastric carcinoma in an early stage in an asymptomatic E-cadherin mutation carrier. PMID: 15475432 |
Ref: E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population. PMID: 15609397 Ref: A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer. PMID: 15617552 Ref: E-cadherin expression in sporadic gastric cancer from Mexico: exon 8 and 9 deletions are infrequent events associated with poor survival. PMID: 15712179 Ref: Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family. PMID: 15735979 Ref: CDH1 associated gastric cancer: a report of a family and review of the literature. PMID: 15780560 Ref: Gastric cancer: new genetic developments. PMID: 15895459 Ref: Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. PMID: 16053512 Ref: Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management. PMID: 16061854 Ref: Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs. PMID: 16142376 Ref: [Promoter methylation profile in gastric cancer]. PMID: 16163424 Ref: [Association of -160(C-->A) polymorphism in CDH1 gene with gastric cancer risk in Fujian Chinese population]. PMID: 16215948 Ref: Epithelial-mesenchymal transition in gastric cancer (Review). PMID: 16273224 Ref: Aberrant E-cadherin staining patterns in invasive mammary carcinoma. PMID: 16287501 |
Ref: Accumulation of DNA methylation is associated with tumor stage in gastric cancer. PMID: 16475210 Ref: Genetics, pathology, and clinics of familial gastric cancer. PMID: 16501831 Ref: CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion. PMID: 16531765 Ref: Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. PMID: 16555931 Ref: E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. PMID: 16600987 Ref: Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas. PMID: 16610016 Ref: CDH1/E-cadherin germline mutations in early-onset gastric cancer. PMID: 16801346 Ref: Disordered beta-catenin expression and E-cadherin/CDH1 promoter methylation in gastric carcinoma. PMID: 16830381 Ref: A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. PMID: 16870389 Ref: [Hereditary diffuse gastric cancer]. PMID: 17075480 Ref: [Preventive resection of hereditary diffuse gastric cancer]. PMID: 17131699 |
Ref: Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family. PMID: 17126523 Ref: Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. PMID: 17221870 Ref: Early onset gastric cancer: on the road to unraveling gastric carcinogenesis. PMID: 17311530 Ref: Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. PMID: 17363565 Ref: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. PMID: 17376510 Ref: Preemptive total gastrectomy for hereditary gastric cancer. PMID: 17458604 Ref: CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. PMID: 17522512 Ref: Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. PMID: 17545690 Ref: Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population. PMID: 17549573 Ref: Prophylactic laparoscopic-assisted total gastrectomy for hereditary diffuse gastric cancer. PMID: 17651578 Ref: Germline E-cadherin mutations in familial lobular breast cancer. PMID: 17660459 Ref: Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population. PMID: 17690113 Ref: Association between CDH1 haplotypes and gastric cancer risk in a Japanese population. PMID: 17852867 Ref: Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PMID: 17895985 Ref: [Hereditary diffuse gastric cancer (HDGC): presentation of a family with a new mutation of the CDH1 gene]. PMID: 17955726 Ref: Identification of an intronic single nucleotide polymorphism leading to allele dropout during validation of a CDH1 sequencing assay: implications for designing polymerase chain reaction-based assays. PMID: 18007144 Ref: A short guide to hereditary diffuse gastric cancer. PMID: 19725995 |
Ref: Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. PMID: 17513507 Ref: Endogastric capsule for E-cadherin gene (CDH1) promoter hypermethylation assessment in DNA from gastric juice of diffuse gastric cancer patients. PMID: 17986624 Ref: Hereditary diffuse gastric cancer: association with lobular breast cancer. PMID: 18046629 Ref: No mucosal escape of signet-ring cell carcinoma for ten years in a patient with familial aggregation of gastric cancer. PMID: 18161866 Ref: CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. PMID: 18205664 Ref: Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications. PMID: 18391748 Ref: [Familial aggregation of gastric cancer]. PMID: 18408421 Ref: The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. PMID: 18427545 Ref: Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy. PMID: 18442100 Ref: A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population. PMID: 18482459 Ref: Meta-analysis: tumour invasion-related genetic polymorphisms and gastric cancer susceptibility. PMID: 18544073 Ref: Promoter methylation of cancer-related genes in gastric carcinoma. PMID: 18566573 Ref: Increased frequency of CpG island methylator phenotype and CDH1 methylation in a gastric cancer high-risk region of china. PMID: 18607505 Ref: [Gene methylation patterns in digestive tumors]. PMID: 18769787 Ref: Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. PMID: 18788075 Ref: Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgery. PMID: 18798546 Ref: LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis. PMID: 18842996 Ref: Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. PMID: 19295016 |
Ref: AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts. PMID: 18683894 Ref: CDH1 C-160A promoter polymorphism and gastric cancer risk. PMID: 19077564 Ref: Germline CDH1 deletions in hereditary diffuse gastric cancer families. PMID: 19168852 Ref: E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. PMID: 19223545 Ref: Novel human pathological mutations. Gene symbol: CDH1. Disease: gastric cancer. PMID: 19309801 Ref: Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma. PMID: 19360301 Ref: Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. PMID: 19375306 Ref: Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. PMID: 19408054 Ref: Hereditary gastric cancer. PMID: 19414142 Ref: Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. PMID: 19424592 Ref: Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa. PMID: 19432886 Ref: Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients. PMID: 19671196 Ref: Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa. PMID: 19724898 Ref: [Associations of E-cadherin gene (CDH1) and hereditary gastric cancer in China]. PMID: 19781162 Ref: [Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. PMID: 19858019 |
Ref: Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa. PMID: 19184424 Ref: Germline mutation of the E-cadherin gene in three sibling cases with advanced gastric cancer: clinical consequences for the other family members. PMID: 19474748 Ref: Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. PMID: 19965908 Ref: Association between IL-17A, -17F and MIF polymorphisms predispose to CpG island hyper-methylation in gastric cancer. PMID: 20127054 Ref: CpG island promoter methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer. PMID: 20150642 Ref: Association between cyclin D1 polymorphism with CpG island promoter methylation status of tumor suppressor genes in gastric cancer. PMID: 20397048 Ref: Hereditary diffuse gastric cancer. PMID: 20517687 Ref: Methylation status of CDH1 gene in samples of gastric mucous from Brazilian patients with chronic gastritis infected by Helicobacter pylori. PMID: 20520968 Ref: Periodic acid-schiff is superior to hematoxylin and eosin for screening prophylactic gastrectomies from CDH1 mutation carriers. PMID: 20534996 Ref: Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. PMID: 20591882 Ref: Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk. PMID: 20632448 Ref: CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer. PMID: 20651371 Ref: Promoter polymorphisms and methylation of E-cadherin (CDH1) and KIT in gastric cancer patients from northern Brazil. PMID: 20651373 Ref: [Hereditary gastric cancer]. PMID: 20824432 Ref: De novo expression of CD44 variants in sporadic and hereditary gastric cancer. PMID: 20856229 Ref: The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. PMID: 21203466 Ref: Prophylactic laparoscopic gastrectomy for hereditary diffuse gastric cancer: a case series in a single family. PMID: 21333186 Ref: Association between common genetic variants in pre-microRNAs and the clinicopathological characteristics and survival of gastric cancer patients. PMID: 22993637 |
Ref: MSI phenotype and MMR alterations in familial and sporadic gastric cancer. PMID: 20533283 Ref: Prophylactic total gastrectomy for individuals with germline CDH1 mutation. PMID: 20719348 Ref: Trastuzumab and beyond: sequencing cancer genomes and predicting molecular networks. PMID: 20975737 Ref: Familial gastric cancer: update for practice management. PMID: 21184285 Ref: The E-cadherin (CDH1) -160C>A polymorphism associated with gastric cancer among Asians but not Europeans. PMID: 21214416 Ref: Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer. PMID: 21271559 Ref: Role of DNA methylation in the development of diffuse-type gastric cancer. PMID: 21273772 Ref: Hypermethylation of tumor-related genes in Tunisian patients with gastric carcinoma: clinical and biological significance. PMID: 21308683 Ref: [Familial gastric cancer: diagnosis, treatment and periodic surveillance]. PMID: 21329544 Ref: Hereditary diffuse gastric cancer: multidisciplinary case report with review of the literature. PMID: 21331337 Ref: A meta-analysis of CDH1 C-160A genetic polymorphism and gastric cancer risk. PMID: 21612411 Ref: Preventive and therapeutic implications of positive CDH1 testing in diffuse gastric cancer. PMID: 21761101 Ref: Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population. PMID: 21777349 Ref: Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). PMID: 21831520 Ref: How do you live without a stomach?: a multiple case study examination of total gastrectomy for palliation or prophylaxis. PMID: 21838951 Ref: Molecular pathology of gastric carcinoma. PMID: 22104201 Ref: Novel mechanism of a CDH1 splicing mutation in a Korean patient with signet ring cell carcinoma. PMID: 22118538 Ref: Global DNA methylation and tumor suppressor gene promoter methylation and gastric cancer risk in an Omani Arab population. PMID: 22126203 Ref: Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). PMID: 22152101 |
Ref: CDH1 promoter polymorphism and stomach cancer susceptibility. PMID: 21625863 Ref: De novo CDH1 mutation in a family presenting with early-onset diffuse gastric cancer. PMID: 21696387 Ref: Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. PMID: 21865403 Ref: Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report. PMID: 21992816 Ref: CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. PMID: 22020549 Ref: Integrated analysis of whole genome exon array and array-comparative genomic hybridization in gastric and colorectal cancer cells. PMID: 22034905 Ref: Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature. PMID: 22225527 Ref: Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. PMID: 22228973 Ref: Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines. PMID: 22290393 Ref: Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. PMID: 22388873 Ref: Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer. PMID: 22450781 Ref: CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer. PMID: 22514028 Ref: CDH1 gene polymorphisms, plasma CDH1 levels and risk of gastric cancer in a Chinese population. PMID: 22535324 Ref: CDH1 -160C>A gene polymorphism is an ethnicity-dependent risk factor for gastric cancer. PMID: 22575615 Ref: Gastric cancer carcinogenesis and tumor progression. PMID: 22595727 Ref: Familial gastric cancer and germline mutations of E-cadherin. PMID: 22595728 Ref: Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis. PMID: 22752307 Ref: Genetic testing by cancer site: stomach. PMID: 22846738 Ref: [Methylation status of CDH1 gene in preoperative abdominal lavage of patients with gastric cancer and its clinical significance]. PMID: 22851076 Ref: [Hereditary diffuse gastric cancer]. PMID: 22920204 Ref: Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile. PMID: 22929309 Ref: [Genetic and epigenetic alterations in gastric carcinogenesis]. PMID: 23198549 Ref: Prevention is better than cure. PMID: 24960683 |
Ref: A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy. PMID: 22543498 Ref: A RAND/UCLA appropriateness study of the management of familial gastric cancer. PMID: 22941158 Ref: Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. PMID: 23196062 Ref: An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. PMID: 23208944 Ref: Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients. PMID: 23264079 Ref: Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. PMID: 23341533 Ref: [E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. PMID: 23353171 Ref: [Familial gastric cancer - an update of Japanese cases]. PMID: 23411952 Ref: Novel CDH1 germline mutations identified in Chinese gastric cancer patients. PMID: 23431106 Ref: Mutation screen and RNA analysis disclose the changed splicing of the E-cadherin transcription in gastric cancer. PMID: 23435907 Ref: E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer. PMID: 23481202 Ref: Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population. PMID: 23504555 Ref: Molecular and survival differences between familial and sporadic gastric cancers. PMID: 23555086 Ref: CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study. PMID: 23709761 Ref: Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature. PMID: 23849133 Ref: Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. PMID: 23943784 Ref: Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. PMID: 23957294 Ref: Gastric cancer: epidemiologic aspects. PMID: 24011243 Ref: Frequent promoter methylation of CDH1 in non-neoplastic mucosa of sporadic diffuse gastric cancer. PMID: 24023308 Ref: Gastric cancer-molecular and clinical dimensions. PMID: 24061039 Ref: Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer. PMID: 24204729 Ref: [Molecular genetics study of hereditary predisposition to diffuse gastric cancer in Russian patients]. PMID: 24260884 Ref: Association among lifestyle, clinical examination, polymorphisms in CDH1 gene and Traditional Chinese Medicine syndrome differentiation of gastric cancer. PMID: 24660577 Ref: [Allelic imbalance of loci 17p13.1 (TP53), 1p36.1 (RUNX3), 16p22 (CDH1) and microsatellite instability in gastric cancer]. PMID: 25509356 |
Ref: Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. PMID: 23812922 Ref: Prophylactic gastrectomy in a 16-year-old. PMID: 24240619 Ref: Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. PMID: 24293408 Ref: DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. PMID: 24293545 Ref: Prophylactic total gastrectomy in hereditary diffuse gastric cancer: identification of two novel CDH1 gene mutations-a clinical observational study. PMID: 24389957 Ref: Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA. PMID: 24424122 Ref: The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study. PMID: 24424140 Ref: Prospective cohort study assessing outcomes of patients from families fulfilling criteria for hereditary diffuse gastric cancer undergoing endoscopic surveillance. PMID: 24472763 Ref: Complementary molecular approaches reveal heterogeneous CDH1 germline defects in Italian patients with hereditary diffuse gastric cancer (HDGC) syndrome. PMID: 24493355 Ref: CDH1 polymorphisms and haplotypes in sporadic diffuse and intestinal gastric cancer: a case-control study based on direct sequencing analysis. PMID: 24684952 Ref: Genomic profile analysis of diffuse-type gastric cancers. PMID: 24690483 Ref: Cancers of the upper gastro-intestinal tract: a review of somatic mutation distributions. PMID: 24724606 Ref: Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. PMID: 24728500 Ref: The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. PMID: 24742175 Ref: Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. PMID: 24784840 Ref: Gastric cancer patients less than 50 years of age exhibit significant downregulation of E-cadherin and CDX2 compared to older reference populations. PMID: 24797991 Ref: Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. PMID: 24816253 Ref: p16 Methylation is associated with chemosensitivity to fluorouracil in patients with advanced gastric cancer. PMID: 24816738 Ref: Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate. PMID: 24838934 Ref: Roles of E-cadherin (CDH1) genetic variations in cancer risk: a meta-analysis. PMID: 24870781 Ref: CD44(+) CD324(-) expression and prognosis in gastric cancer patients. PMID: 24910454 Ref: Different methylation profiles between intestinal and diffuse sporadic gastric carcinogenesis. PMID: 24953529 Ref: Sequence-based detection of mutations in cadherin 1 to determine the prevalence of germline mutations in patients with invasive lobular carcinoma of the breast. PMID: 25067988 Ref: Hereditary diffuse gastric cancer associated with E-cadherin germline mutation: a case report. PMID: 25089230 Ref: Genetic screening analysis of patients with hereditary diffuse gastric cancer from northern and northeastern Brazil. PMID: 25180051 Ref: Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. PMID: 25315765 Ref: E-cadherin germline mutation carriers: clinical management and genetic implications. PMID: 25332147 Ref: Association of genetic variants in and promoter hypermethylation of CDH1 with gastric cancer: a meta-analysis. PMID: 25340495 Ref: Germline mutations in MAP3K6 are associated with familial gastric cancer. PMID: 25340522 Ref: The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation. PMID: 25771876 |
Ref: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. PMID: 24510342 Ref: Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin. PMID: 25307412 Ref: Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer. PMID: 25576241 Ref: Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis. PMID: 25599647 Ref: [E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. PMID: 25613626 Ref: Familial gastric cancer: genetic susceptibility, pathology, and implications for management. PMID: 25638682 Ref: Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells. PMID: 25777964 Ref: From molecular classification to targeted therapeutics: the changing face of systemic therapy in metastatic gastroesophageal cancer. PMID: 25784931 Ref: [Current status of the study on hereditary diffuse gastric cancer]. PMID: 25809335 Ref: The Lauren classification highlights the role of epithelial-to-mesenchymal transition in gastric carcinogenesis: an immunohistochemistry study of the STAT3 and adhesion molecules expression. PMID: 25822437 Ref: Lobular breast cancer: incidence and genetic and non-genetic risk factors. PMID: 25848941 Ref: Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer. PMID: 25874772 Ref: Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies. PMID: 25882375 Ref: The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review. PMID: 25926721 Ref: Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. PMID: 25979631 Ref: A Long Non-coding RNA Activated by Transforming Growth Factor-beta is an Independent Prognostic Marker of Gastric Cancer. PMID: 25986864 Ref: Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study. PMID: 26032781 Ref: Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. PMID: 26033320 Ref: Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1. PMID: 26072394 Ref: LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer. PMID: 26136075 Ref: Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond. PMID: 26182300 Ref: E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. PMID: 26246502 Ref: miR-544a induces epithelial-mesenchymal transition through the activation of WNT signaling pathway in gastric cancer. PMID: 26264654 Ref: DNA Methylation Predicts Progression of Human Gastric Lesions. PMID: 26269563 Ref: Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. PMID: 26334097 Ref: Hereditary Gastric Cancer Syndromes. PMID: 26363540 Ref: Gene mutations in gastric cancer: a review of recent next-generation sequencing studies. PMID: 26364057 Ref: Prophylactic Laparoscopic Total Gastrectomy with Jejunal Pouch Reconstruction in Patients Carrying a CDH1 Germline Mutation. PMID: 26443527 Ref: Prevalence of deleterious ATM germline mutations in gastric cancer patients. PMID: 26506520 Ref: Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer. PMID: 26674321 Ref: Correlation between SNPs in CDH1 and gastric cancer in Chinese population. PMID: 28352678 |
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