Primary Site >> Colorectal Cancer
Gene >> CDC42
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Ref: Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells. PMID: 10585277 |
Ref: Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. PMID: 11668177 Ref: Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. PMID: 11790459 Ref: The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894 Ref: Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. PMID: 11844789 Ref: Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. PMID: 11894124 Ref: Molecular cloning and characterization of WRCH2 on human chromosome 15q15. PMID: 11956592 Ref: Complex formation of IQGAP1 with E-cadherin/catenin during cohort migration of carcinoma cells. Its possible association with localized release from cell-cell adhesion. PMID: 12189501 |
Ref: Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. PMID: 14609961 |
Ref: LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane. PMID: 15057873 Ref: Pak-1 expression increases with progression of colorectal carcinomas to metastasis. PMID: 15161701 Ref: ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers. PMID: 15225876 Ref: [Proteome study of colorectal cancer genesis and hepatic metastasis]. PMID: 15329256 |
Ref: The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. PMID: 15657050 Ref: Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. PMID: 15788770 Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 |
Ref: PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. PMID: 16540666 |
Ref: Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein. PMID: 17126424 Ref: Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. PMID: 17145773 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. PMID: 17599059 Ref: Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. PMID: 17704816 |
Ref: Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins. PMID: 17936584 Ref: Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. PMID: 18575765 Ref: Rac regulates the interaction of fascin with protein kinase C in cell migration. PMID: 18716283 Ref: Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. PMID: 18767036 |
Ref: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. PMID: 19151759 Ref: P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. PMID: 19415746 Ref: Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. PMID: 19525225 Ref: CXCR4 regulates the early extravasation of metastatic tumor cells in vivo. PMID: 19568410 |
Ref: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. PMID: 20017136 Ref: A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism. PMID: 20043078 Ref: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. PMID: 20530489 Ref: p21-activated kinase 5 inhibits camptothecin-induced apoptosis in colorectal carcinoma cells. PMID: 20567954 |
Ref: miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. PMID: 20473940 Ref: miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. PMID: 21186079 Ref: Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PMID: 21311754 Ref: Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity. PMID: 21377450 Ref: The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. PMID: 21849478 Ref: [The effect of small GTPase Cdc42 on the multidrug resistance of oxaliplatin-resistant colon cancer cell lines]. PMID: 21866627 Ref: BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. PMID: 21943101 |
Ref: Clinical significance of Rho GDP dissociation inhibitor 2 in colorectal carcinoma. PMID: 21698524 Ref: Structural basis for the recognition of Asef by adenomatous polyposis coli. PMID: 21788986 Ref: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. PMID: 22252525 Ref: Rho GTPase signaling in the development of colorectal cancer. PMID: 22467564 Ref: A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability. PMID: 22883572 Ref: Murine colon proteome and characterization of the protein pathways. PMID: 22929016 Ref: Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. PMID: 23010077 Ref: Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PMID: 23144867 |
Ref: Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARgamma-targeted therapy. PMID: 22543585 Ref: A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression. PMID: 23059759 Ref: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. PMID: 23230270 Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 Ref: miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42. PMID: 23337504 Ref: Proteogenomic analysis of human colon carcinoma cell lines LIM1215, LIM1899, and LIM2405. PMID: 23458625 Ref: Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells. PMID: 23884297 Ref: The Cdc42/Rac nucleotide exchange factor protein beta1Pix (Pak-interacting exchange factor) modulates beta-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of beta1PIX with beta-catenin. PMID: 24129564 Ref: Network cluster analysis of protein-protein interaction network identified biomarker for early onset colorectal cancer. PMID: 24197691 Ref: The miR-1-NOTCH3-Asef pathway is important for colorectal tumor cell migration. PMID: 24244701 Ref: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. PMID: 24279335 Ref: PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system. PMID: 24348097 |
Ref: Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. PMID: 23644655 Ref: Piezoelectric ceramic (PZT) modulates axonal guidance growth of rat cortical neurons via RhoA, Rac1, and Cdc42 pathways. PMID: 24203571 Ref: Effect of StarD13 on colorectal cancer proliferation, motility and invasion. PMID: 24253896 Ref: MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42. PMID: 24817781 Ref: CDC42 inhibition suppresses progression of incipient intestinal tumors. PMID: 25113996 Ref: miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. PMID: 25379703 |
Ref: Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. PMID: 25892554 Ref: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. PMID: 25990418 Ref: Endomembrane control of cell polarity: Relevance to cancer. PMID: 26156751 Ref: Down-regualtion of miR-106b induces epithelial-mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer. PMID: 26617763 |
Ref: Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using fluorescence resonance energy transfer. PMID: 26787017 Ref: [Effect of shRNA-mediated CDC42 knockdown on morphology of colorectal cancer cells in vitro]. PMID: 27113179 Ref: Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype. PMID: 27119498 Ref: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma. PMID: 27323857 Ref: Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling. PMID: 27367023 Ref: Low Gene Dosage of Cdc42 Is Not Associated with Protein Dysfunction in Patients with Colorectal Cancer. PMID: 27540769 Ref: MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. PMID: 27566402 Ref: MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42. PMID: 27769041 Ref: srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer. PMID: 27923383 |
Ref: Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. PMID: 27862857 Ref: Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer. PMID: 28460460 Ref: Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. PMID: 28759015 |
Ref: Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion. PMID: 29072916 Ref: Cortactin recruits FMNL2 to promote actin polymerization and endosome motility in invadopodia formation. PMID: 29374558 Ref: Carboxylated graphene oxide promoted axonal guidance growth by activating Netrin-1/deleted in colorectal cancer signaling in rat primary cultured cortical neurons. PMID: 29377591 |