Primary Site >> Colorectal Cancer
Gene >> CDC25C
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Ref: Cell cycle molecular targets in novel anticancer drug discovery. PMID: 10788588 Ref: Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation. PMID: 10837000 |
Ref: Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma. PMID: 11304565 Ref: Analysis of the CHK2 gene in lymphoid malignancies. PMID: 11699418 |
Ref: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. PMID: 14614451 |
Ref: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. PMID: 15073169 Ref: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells. PMID: 15169628 Ref: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. PMID: 15326376 |
Ref: JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. PMID: 16179969 Ref: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. PMID: 16317137 |
Ref: Antitumor activity and downregulation of pro-angiogenic molecules in human prostate cancer cells by a novel thiazolidione compound. PMID: 16302260 Ref: Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. PMID: 16380080 Ref: Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis. PMID: 16649252 Ref: Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells. PMID: 16715141 Ref: Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes. PMID: 16737765 Ref: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. PMID: 17079455 Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 |
Ref: Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly. PMID: 17237290 Ref: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. PMID: 17273739 Ref: Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation. PMID: 17329004 Ref: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. PMID: 18075315 |
Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe. PMID: 18427544 Ref: Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines. PMID: 18508032 Ref: Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents. PMID: 18635965 |
Ref: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. PMID: 19038304 Ref: 1-Methylxanthine enhances the radiosensitivity of tumor cells. PMID: 19280470 Ref: Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis. PMID: 19502782 Ref: Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21. PMID: 19738433 |
Ref: c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. PMID: 19833164 Ref: Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. PMID: 19937855 Ref: Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth. PMID: 20051375 Ref: Diallylpolysulfides induce growth arrest and apoptosis. PMID: 20126995 Ref: Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression. PMID: 20564491 Ref: Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells. PMID: 20647931 Ref: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PMID: 20957031 |
Ref: Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. PMID: 21283624 Ref: A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis. PMID: 21321609 Ref: Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. PMID: 21598039 |
Ref: Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells. PMID: 22264758 Ref: Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. PMID: 22269172 Ref: Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells. PMID: 22474493 Ref: Nitric oxide-donating aspirin induces G2/M phase cell cycle arrest in human cancer cells by regulating phase transition proteins. PMID: 22552812 Ref: Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats. PMID: 22916810 Ref: Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. PMID: 23064444 |
Ref: HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways. PMID: 23600770 Ref: Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. PMID: 25337553 |
Ref: Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. PMID: 23604974 Ref: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-kappaB in HCT116 human colon cancer cells. PMID: 24190633 Ref: A functional role for Smad7 in sustaining colon cancer cell growth and survival. PMID: 24556688 Ref: Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. PMID: 24626522 Ref: Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer. PMID: 24858077 Ref: Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine. PMID: 24959718 Ref: Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo. PMID: 24968890 Ref: Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer. PMID: 24971465 Ref: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. PMID: 25301449 |
Ref: Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks. PMID: 26476078 |
Ref: Koelreuteria Formosana Extract Induces Growth Inhibition and Cell Death in Human Colon Carcinoma Cells via G2/M Arrest and LC3-II Activation-Dependent Autophagy. PMID: 27880045 Ref: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. PMID: 28178649 Ref: MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells. PMID: 28731136 Ref: Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells. PMID: 28849218 Ref: RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis. PMID: 29137316 |
Ref: Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. PMID: 29519997 Ref: Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells. PMID: 29794421 Ref: LncRNA BX357664 inhibits cell proliferation and invasion and promotes cell apoptosis in human colorectal cancer cells. PMID: 29844809 Ref: Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells. PMID: 30085332 Ref: Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. PMID: 30097580 |