Primary Site >> Liver Cancer
Gene >> CDC25A
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Ref: Mad-overexpression down regulates the malignant growth and p53 mediated apoptosis in human hepatocellular carcinoma BEL-7404 cells. PMID: 10321688 Ref: Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. PMID: 10611320 |
Ref: Involvement of Cdc25A phosphatase in Hep3B hepatoma cell growth inhibition induced by novel K vitamin analogs. PMID: 11585757 |
Ref: Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. PMID: 12738732 |
Ref: Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway. PMID: 15534860 Ref: The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. PMID: 15707569 |
Ref: PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo. PMID: 16818510 Ref: Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK. PMID: 16930563 |
Ref: CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells. PMID: 18204780 Ref: 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis. PMID: 18246350 Ref: Aberrant Polo-like kinase 1-Cdc25A pathway in metastatic hepatocellular carcinoma. PMID: 18980975 Ref: Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies. PMID: 19075569 |
Ref: Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis. PMID: 20853273 |
Ref: Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells. PMID: 22583615 Ref: Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular carcinoma cells. PMID: 22705122 Ref: 13,28-Epoxy triterpenoid saponins from Ardisia japonica selectively inhibit proliferation of liver cancer cells without affecting normal liver cells. PMID: 22940450 Ref: Prevention of liver carcinogenesis by amarogentin through modulation of G1/S cell cycle check point and induction of apoptosis. PMID: 22948180 |
Ref: The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PMID: 23544130 Ref: Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. PMID: 24113455 |
Ref: CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. PMID: 24793486 Ref: Schedule-dependent effects of kappa-selenocarrageenan in combination with epirubicin on hepatocellular carcinoma. PMID: 24870773 Ref: Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate. PMID: 24922544 Ref: Telekin suppresses human hepatocellular carcinoma cells in vitro by inducing G2/M phase arrest via the p38 MAPK signaling pathway. PMID: 25176399 Ref: Silencing of NUF2 inhibits tumor growth and induces apoptosis in human hepatocellular carcinomas. PMID: 25374179 Ref: SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. PMID: 25527123 |
Ref: MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma. PMID: 25909324 Ref: Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells. PMID: 26451628 |
Ref: Identification of key genes in hepatocellular carcinoma and validation of the candidate gene, cdc25a, using gene set enrichment analysis, meta-analysis and cross-species comparison. PMID: 26647881 Ref: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. PMID: 26714930 Ref: MiR-675 Promotes the Growth of Hepatocellular Carcinoma Cells Through the Cdc25A Pathway. PMID: 27644634 Ref: The herbal medicine Cyperus amuricus inhibits proliferation of human hepatocellular carcinoma Hep3B cells by inducing apoptosis and arrest at the G0/G1 cell cycle phase. PMID: 27667556 |
Ref: Crude extract and solvent fractions of Calystegia soldanella induce G1 and S phase arrest of the cell cycle in HepG2 cells. PMID: 28101580 Ref: NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A. PMID: 28333141 Ref: XWL-1-48 exerts antitumor activity via targeting topoisomerase II and enhancing degradation of Mdm2 in human hepatocellular carcinoma. PMID: 28855652 |
Ref: Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway. PMID: 29484412 |