Primary Site >> Pancreatic Cancer
Gene >> CD44
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Ref: A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. PMID: 1707342 Ref: CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. PMID: 1717145 |
Ref: The MHC class-II and CD44 molecules are involved in the induction of tumour necrosis factor (TNF) gene expression by human monocytes stimulated with tumour cells. PMID: 7508890 Ref: The significance of CD44 in human pancreatic cancer: I. High expression of CD44 in human pancreatic adenocarcinoma. PMID: 7531334 Ref: The significance of CD44 in human pancreatic cancer: II. The role of CD44 in human pancreatic adenocarcinoma invasion. PMID: 7531335 |
Ref: CD44 is the major peanut lectin-binding glycoprotein of human epidermal keratinocytes and plays a role in intercellular adhesion. PMID: 7544799 Ref: Characterization of human pancreatic adenocarcinoma cell line with high metastatic potential in SCID mice. PMID: 7545654 Ref: Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas. PMID: 7585621 |
Ref: Trans-acting factors regulate the expression of CD44 splice variants. PMID: 8670907 Ref: Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells. PMID: 8674073 Ref: Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. PMID: 8773262 Ref: Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors. PMID: 8893333 Ref: Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera. PMID: 8900434 Ref: Differential expression of the hyaluronan receptors CD44 and RHAMM in human pancreatic cancer cells. PMID: 9816340 |
Ref: Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas. PMID: 9066654 Ref: Low serum levels of soluble CD44 variant 6 are significantly associated with poor prognosis in patients with pancreatic carcinoma. PMID: 9351541 Ref: Biochemical diagnosis of neuroendocrine GEP tumor. PMID: 9825477 Ref: Adhesion of human gastric and pancreatic cancer cells to peritoneal mesothelial cells is mediated by CD44 and beta(1) integrin. PMID: 21533362 |
Ref: Involvement of adhesion molecules in metastasis of SW1990, human pancreatic cancer cells. PMID: 9486777 Ref: CD44 splice variants as prognostic markers in colorectal cancer. PMID: 9489913 Ref: The splice-pattern of CD44 is altered in chronic pancreatitis exhibiting dysplastic changes. PMID: 9737888 Ref: [The prognostic factors of pancreatic cancer--adhesion molecule CD44]. PMID: 9838904 Ref: Expression of CD44 variants and its association with survival in pancreatic cancer. PMID: 9849582 |
Ref: High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential. PMID: 10329398 Ref: CD44, bFGF and hyaluronan in human pancreatic cancer cell lines. PMID: 10415869 Ref: Cytokines modulate MIA PaCa 2 and CAPAN-1 adhesion to extracellular matrix proteins. PMID: 10547196 Ref: CD44 isoforms expression in intraductal and invasive pancreatic cancer and its correlation to p53 gene mutations. PMID: 10624116 |
Ref: Different expression of CD44, ICAM-1, and HSP60 on primary tumor and metastases of a human pancreatic carcinoma growing in scid mice. PMID: 10810361 |
Ref: CD44 in normal human pancreas and pancreatic carcinoma cell lines. PMID: 11135324 Ref: Diagnostic application of CD44 variant expression in pancreatic juice for detection of pancreatic neoplasm. PMID: 11501843 |
Ref: CD44v10: an antimetastatic membrane glycoprotein for pancreatic cancer. PMID: 12841682 |
Ref: Molecular prognostic markers in pancreatic cancer: a systematic review. PMID: 16146690 Ref: Invasive human pancreatic carcinoma cells adhere to endothelial tri-cellular corners and increase endothelial permeability. PMID: 16271070 |
Ref: Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. PMID: 16407205 Ref: The expression of adhesion molecules and the influence of inflammatory cytokines on the adhesion of human pancreatic carcinoma cells to mesothelial monolayers. PMID: 16670622 Ref: Characterization of the CXCR4 signaling in pancreatic cancer cells. PMID: 18175225 |
Ref: Identification of pancreatic cancer stem cells. PMID: 17283135 Ref: Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties. PMID: 17446842 Ref: Development and characterization of gemcitabine-resistant pancreatic tumor cells. PMID: 17909916 |
Ref: Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report. PMID: 18437074 Ref: Pancreatic cancer stem cells. PMID: 18539958 Ref: Human pancreatic cancer stem cells: implications for how we treat pancreatic cancer. PMID: 18607507 Ref: Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma. PMID: 18609717 Ref: Cancer initiating cells or cancer stem cells in the gastrointestinal tract and liver. PMID: 18651561 Ref: Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells. PMID: 18757435 |
Ref: Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. PMID: 18829980 Ref: A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. PMID: 19174553 Ref: Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. PMID: 19424602 Ref: Identification of human pancreatic cancer stem cells. PMID: 19582426 Ref: CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells. PMID: 19598259 Ref: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PMID: 19714243 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 |
Ref: Evidence linking CD44-positive cells and gemcitabine resistance in pancreatic cancer cells: need for further substantiation. PMID: 19877122 Ref: Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. PMID: 20043076 Ref: CD44, a therapeutic target for metastasising tumours. PMID: 20303742 Ref: Side population in the pancreatic cancer cell lines SW1990 and CFPAC-1 is enriched with cancer stem-like cells. PMID: 20372854 Ref: Isolation of stem cells from human pancreatic cancer xenografts. PMID: 20972397 Ref: [Establish a gemcitabine-resistant pancreatic cancer cell line SW1990/GZ and research the relationship between SW1990/GZ and pancreatic cancer stem cell]. PMID: 21054984 Ref: Genomic analysis of invasion-metastasis-related factors in pancreatic cancer cells. PMID: 23136617 |
Ref: Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells. PMID: 20426768 Ref: Hedgehog signaling and therapeutics in pancreatic cancer. PMID: 21186299 Ref: Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PMID: 21304978 Ref: Phenotypic heterogeneity of breast cancer stem cells. PMID: 21317983 Ref: Anti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer. PMID: 21408027 Ref: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. PMID: 21463919 Ref: Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells. PMID: 21503965 Ref: Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. PMID: 21622730 Ref: Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines. PMID: 21630164 Ref: Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine. PMID: 21673909 Ref: ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PMID: 21695188 Ref: Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. PMID: 21780159 Ref: Expression of CD44, CD24 and ESA in pancreatic adenocarcinoma cell lines varies with local microenvironment. PMID: 21813394 Ref: c-Met is a marker of pancreatic cancer stem cells and therapeutic target. PMID: 21864475 Ref: Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells. PMID: 21868510 Ref: Significance of CD133 as a cancer stem cell markers focusing on the tumorigenicity of pancreatic cancer cell lines. PMID: 22111082 Ref: [Altered expressions of embryonic stem-related genes in pancreatic cancer stem cell]. PMID: 22340650 |
Ref: Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells. PMID: 22086681 Ref: Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. PMID: 22108826 Ref: Biological and clinical relevance of stem cells in pancreatic adenocarcinoma. PMID: 22320910 Ref: Epithelial mesenchymal transition correlates with CD24+CD44+ and CD133+ cells in pancreatic cancer. PMID: 22322379 Ref: Identification of glycoprotein markers for pancreatic cancer CD24+CD44+ stem-like cells using nano-LC-MS/MS and tissue microarray. PMID: 22335271 Ref: Aberrations and therapeutics involving the developmental pathway Hedgehog in pancreatic cancer. PMID: 22391312 Ref: Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. PMID: 22457533 Ref: Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/beta-Catenin Pathways. PMID: 22570653 Ref: Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells. PMID: 22626610 Ref: Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study. PMID: 22629410 Ref: Nestin and other putative cancer stem cell markers in pancreatic cancer. PMID: 22718289 Ref: Transforming growth factor beta-induced epithelial-mesenchymal transition increases cancer stem-like cells in the PANC-1 cell line. PMID: 22740886 Ref: TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells. PMID: 22767216 Ref: Neoadjuvant chemotherapy with gemcitabine for pancreatic cancer increases in situ expression of the apoptosis marker M30 and stem cell marker CD44. PMID: 22783415 Ref: Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition. PMID: 22787433 Ref: The role of head and neck squamous cell carcinoma cancer stem cells in tumorigenesis, metastasis, and treatment failure. PMID: 22876238 Ref: Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. PMID: 22895640 Ref: Spatio-temporal patterns of pancreatic cancer cells expressing CD44 isoforms on supported membranes displaying hyaluronic acid oligomers arrays. PMID: 22916191 Ref: Pancreatic carcinoma cell lines reflect frequency and variability of cancer stem cell markers in clinical tissue. PMID: 22948659 Ref: Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells. PMID: 22963768 Ref: Pancreatic cancer cells surviving gemcitabine treatment express markers of stem cell differentiation and epithelial-mesenchymal transition. PMID: 23026911 Ref: Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by gamma-secretase inhibitor IX. PMID: 23094026 |
Ref: Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype. PMID: 22806240 Ref: CD133(+)/CD44(+)/Oct4(+)/Nestin(+) stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic cancer. PMID: 23036582 Ref: miRNA profiling in pancreatic cancer and restoration of chemosensitivity. PMID: 23073476 Ref: Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity. PMID: 23384419 Ref: In vitro enrichment of tumor-initiating cells from human established cell lines. PMID: 23404675 Ref: A tissue-engineered subcutaneous pancreatic cancer model for antitumor drug evaluation. PMID: 23658483 Ref: B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells. PMID: 23660627 Ref: Histological and prognostic importance of CD44(+) /CD24(+) /EpCAM(+) expression in clinical pancreatic cancer. PMID: 23679813 Ref: Cancer stem cell in the progression and therapy of pancreatic cancer. PMID: 23747847 Ref: A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. PMID: 23857777 Ref: Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer. PMID: 23864708 Ref: WNT5A/JNK signaling regulates pancreatic cancer cells migration by Phosphorylating Paxillin. PMID: 23890137 Ref: SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells. PMID: 23917223 Ref: Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli. PMID: 23990729 Ref: Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling. PMID: 24466367 |
Ref: uPAR-controlled oncolytic adenoviruses eliminate cancer stem cells in human pancreatic tumors. PMID: 24141108 Ref: MUC4-induced nuclear translocation of beta-catenin: a novel mechanism for growth, metastasis and angiogenesis in pancreatic cancer. PMID: 24374017 Ref: Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice. PMID: 24397969 Ref: Pancreatic cancer: pancreatic tumour formation and recurrence after radiotherapy are blocked by targeting CD44. PMID: 24445614 Ref: Antitumor efficacy of alpha-solanine against pancreatic cancer in vitro and in vivo. PMID: 24505326 Ref: Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined. PMID: 24505341 Ref: MiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cell. PMID: 24521357 Ref: Notch pathway activation is associated with pancreatic cancer treatment failure. PMID: 24555978 Ref: The low chamber pancreatic cancer cells had stem-like characteristics in modified transwell system: is it a novel method to identify and enrich cancer stem-like cells? PMID: 24689055 Ref: CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients. PMID: 24708709 Ref: Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1. PMID: 24719318 Ref: Influence of interferon-alpha on the expression of the cancer stem cell markers in pancreatic carcinoma cells. PMID: 24726912 Ref: Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer. PMID: 24734907 Ref: Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer. PMID: 24842335 Ref: Pancreatic cancer stem cells: association with cell surface markers, prognosis, resistance, metastasis and treatment. PMID: 24925031 Ref: Targeted nanogel conjugate for improved stability and cellular permeability of curcumin: synthesis, pharmacokinetics, and tumor growth inhibition. PMID: 25072100 Ref: An epithelial cell adhesion molecule- and CD3-bispecific antibody plus activated T-cells can eradicate chemoresistant cancer stem-like pancreatic carcinoma cells in vitro. PMID: 25075094 Ref: The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases. PMID: 25081383 Ref: A miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancer. PMID: 25184537 Ref: Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy. PMID: 25240521 Ref: Accumulation and biological effects of cobalt ferrite nanoparticles in human pancreatic and ovarian cancer cells. PMID: 25458961 Ref: A bioengineered murine model using CD24(+)CD44(+) pancreatic cancer stem cells for chemotherapy study. PMID: 25532534 Ref: A concise review on the current understanding of pancreatic cancer stem cells. PMID: 26451384 |
Ref: Pancreatic cancer immunotherapy using a tumor lysate vaccine, engineered to express alpha-gal epitopes, targets pancreatic cancer stem cells. PMID: 25354268 Ref: Targeting cancer stem cells in solid tumors by vitamin D. PMID: 25460302 Ref: Pancreatic cancer cells express CD44 variant 9 and multidrug resistance protein 1 during mitosis. PMID: 25481101 Ref: CD44 regulates pancreatic cancer invasion through MT1-MMP. PMID: 25566991 Ref: Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. PMID: 25681441 Ref: Establishment of a pancreatic cancer stem cell model using the SW1990 human pancreatic cancer cell line in nude mice. PMID: 25684468 Ref: Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo. PMID: 25849939 Ref: Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes. PMID: 25852272 Ref: The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion. PMID: 25886367 Ref: Molecular mechanism of local drug delivery with Paclitaxel-eluting membranes in biliary and pancreatic cancer: new application for an old drug. PMID: 25983747 Ref: Cancer stem cell marker-expressing cell-rich spheroid fabrication from PANC-1 cells using alginate microcapsules with spherical cavities templated by gelatin microparticles. PMID: 26013961 Ref: Retinoic Acid Reduces Stem Cell-Like Features in Pancreatic Cancer Cells. PMID: 26035122 Ref: A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. PMID: 26077342 Ref: MicroRNA-200c overexpression plays an inhibitory role in human pancreatic cancer stem cells by regulating epithelial-mesenchymal transition. PMID: 26081037 Ref: Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence. PMID: 26244163 Ref: Expression of CD44 in pancreatic cancer and its significance. PMID: 26261555 Ref: Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells. PMID: 26302089 Ref: NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype. PMID: 26363055 Ref: Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer. PMID: 26395574 Ref: Cantharidin and norcantharidin impair stemness of pancreatic cancer cells by repressing the beta-catenin pathway and strengthen the cytotoxicity of gemcitabine and erlotinib. PMID: 26398277 Ref: Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and beta-catenin signaling. PMID: 26440150 Ref: Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3,4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells. PMID: 26440757 Ref: Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine. PMID: 26458814 Ref: LIN28B suppresses microRNA let-7b expression to promote CD44+/LIN28B+ human pancreatic cancer stem cell proliferation and invasion. PMID: 26609473 Ref: Expression and significance of CD44 and p-AKT in pancreatic head cancer. PMID: 26666511 |
Ref: p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. PMID: 26546043 Ref: Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling. PMID: 26597578 Ref: Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells. PMID: 26673007 Ref: Reduced proliferation and increased apoptosis of the SGC7901 gastric cancer cell line on exposure to GDC0449. PMID: 26676867 Ref: Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition. PMID: 26781210 Ref: KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. PMID: 26880805 Ref: MIA PaCa-2 and PANC-1 - pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors. PMID: 26884312 Ref: Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture. PMID: 27102771 Ref: Membranous CD24 drives the epithelial phenotype of pancreatic cancer. PMID: 27203385 Ref: CD44 SNPrs187115: A Novel Biomarker Signature that Predicts Survival in Resectable Pancreatic Ductal Adenocarcinoma. PMID: 27283965 Ref: FH535, a beta-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis. PMID: 27323403 Ref: Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5. PMID: 27330806 Ref: Role of SATB2 in human pancreatic cancer: Implications in transformation and a promising biomarker. PMID: 27472393 Ref: Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway. PMID: 27734340 Ref: STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. PMID: 27748818 |
Ref: Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. PMID: 26400206 Ref: 4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells. PMID: 27846148 Ref: The DNA aptamer binds stemness-enriched cancer cells in pancreatic cancer. PMID: 27891685 Ref: FOXO3 is essential for CD44 expression in pancreatic cancer cells. PMID: 27893718 Ref: Leptin-Notch signaling axis is involved in pancreatic cancer progression. PMID: 27999190 Ref: Analysis of the origin of anaplastic pancreatic cancer and the mechanism of its dedifferentiation. PMID: 28064441 Ref: Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer. PMID: 28388884 Ref: Asporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms. PMID: 28400334 Ref: Nodal signaling activates the Smad2/3 pathway to regulate stem cell-like properties in breast cancer cells. PMID: 28401007 Ref: Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer. PMID: 28490735 Ref: The FOXO3/PGC-1beta signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. PMID: 28507102 Ref: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. PMID: 28565875 Ref: Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase. PMID: 28602912 Ref: CD44(+)CD24(+) subset of PANC-1 cells exhibits radiation resistance via decreased levels of reactive oxygen species. PMID: 28789349 Ref: Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma. PMID: 28883702 Ref: LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9. PMID: 28947139 Ref: Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells. PMID: 29100320 Ref: The CD44 standard isoform contributes to radioresistance of pancreatic cancer cells. PMID: 29106581 |
Ref: IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. PMID: 27797936 Ref: Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells. PMID: 29107110 Ref: PRDM14 directly interacts with heat shock proteins HSP90alpha and glucose-regulated protein 78. PMID: 29178343 Ref: Electron microscopic analysis of different cell types in human pancreatic cancer spheres. PMID: 29434962 Ref: Circulating Microvesicles from Pancreatic Cancer Accelerate the Migration and Proliferation of PANC-1 Cells. PMID: 29494150 Ref: MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity. PMID: 29599309 Ref: Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. PMID: 29656202 Ref: CD44 overexpression related to lymph node metastasis and poor prognosis of pancreatic cancer. PMID: 29683068 Ref: Chronic ethanol exposure of human pancreatic normal ductal epithelial cells induces cancer stem cell phenotype through SATB2. PMID: 29761897 Ref: MicroRNA-30b targets Snail to impede epithelial-mesenchymal transition in pancreatic cancer stem cells. PMID: 29937934 Ref: Nano-Pulse Stimulation for the Treatment of Pancreatic Cancer and the Changes in Immune Profile. PMID: 29954062 Ref: Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo. PMID: 29985062 Ref: Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. PMID: 30154150 Ref: Expression of Smo in pancreatic cancer CD44(+)CD24(+)cells and construction of a lentiviral expression vector to silence Smo. PMID: 30250551 Ref: An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer. PMID: 30285798 Ref: Vasohibin 2 promotes malignant behaviors of pancreatic cancer cells by inducing epithelial-mesenchymal transition via Hedgehog signaling pathway. PMID: 30318866 Ref: Combination therapy for the treatment of pancreatic cancer through hyaluronic acid-decorated nanoparticles loaded with quercetin and gemcitabine: A preliminary in vitro study. PMID: 30334571 |