Primary Site >> Colorectal Cancer
Gene >> CCNC
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Ref: Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome. PMID: 15858123 |
Ref: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. PMID: 20454513 |
Ref: Dysregulation of CDK8 and Cyclin C in tumorigenesis. PMID: 22035865 |
Ref: Retroviral cyclin enhances cyclin-dependent kinase-8 activity. PMID: 22379099 |
Ref: Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas. PMID: 24980722 |
Ref: Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. PMID: 26985305 |
Ref: Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. PMID: 29440396 Ref: A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery. PMID: 29737445 |