Primary Site >> Colorectal Cancer
Gene >> CCL2
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Ref: Sensitization of nitrosourea-resistant Mer+ human tumor cells to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea by mild (41 degrees C) hyperthermia. PMID: 3342391 |
Ref: Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells. PMID: 7954525 |
Ref: Suppression of tumor growth and metastasis of murine renal adenocarcinoma by syngeneic fibroblasts genetically engineered to secrete the JE/MCP-1 cytokine. PMID: 7553238 |
Ref: Effects of thymic peptides, in vitro, on the impaired immunocytotoxicity of peripheral blood mononuclear cells from tumor patients. PMID: 21533400 |
Ref: Lens culinaris, Phaseolus vulgaris and vicia faba lectins specifically trigger IL-8 production by the human colon carcinoma cell line CACO-2. PMID: 10930314 |
Ref: NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer. PMID: 15254653 Ref: Cytokines and chemokines are expressed at different levels in small and large murine colon-26 tumors following intratumoral injections of CpG ODN. PMID: 15548360 |
Ref: Inhibition of NF-kappaB activation and chemokine expression by the leukocyte glycoprotein, CD43, in colon cancer cells. PMID: 16465375 Ref: Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. PMID: 16529829 Ref: Polymorphisms within inflammatory genes and colorectal cancer. PMID: 17062130 |
Ref: Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer. PMID: 17390111 Ref: Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice. PMID: 17631136 Ref: Eotaxin-2 and colorectal cancer: a potential target for immune therapy. PMID: 17908961 |
Ref: Decreased expression of monocyte chemoattractant protein-1 predicts poor prognosis following curative resection of colorectal cancer. PMID: 18633677 Ref: Optimal amount of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy against hepatocellular carcinoma by M1 macrophage activation. PMID: 19016769 |
Ref: Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. PMID: 19229991 Ref: Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer. PMID: 19601807 Ref: Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. PMID: 19706805 Ref: Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. PMID: 19773434 |
Ref: Tumor microenvironments direct the recruitment and expansion of human Th17 cells. PMID: 20026736 Ref: Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling. PMID: 20054232 Ref: Genetic ablation of Tnfalpha demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis. PMID: 20079348 Ref: CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice. PMID: 20222120 Ref: CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice. PMID: 20222126 Ref: Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. PMID: 20400974 Ref: Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. PMID: 20693423 |
Ref: Curcumin's effect on intestinal inflammation and tumorigenesis in the ApcMin/+ mouse. PMID: 20950131 Ref: In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2. PMID: 21450101 Ref: The colorectal tumor microenvironment: the next decade. PMID: 21735168 Ref: Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. PMID: 21909876 Ref: Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer. PMID: 22125641 |
Ref: [Perioperative immunologic changes in colorectal cancer patients]. PMID: 22480118 Ref: Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. PMID: 22789541 Ref: Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion. PMID: 23028941 Ref: Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer. PMID: 23094762 Ref: Plasma soluble receptor for advanced glycation end-products and risk of colorectal adenoma. PMID: 23205181 |
Ref: Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. PMID: 22469976 Ref: Interplay between T(h)1 and T(h)17 effector T-cell pathways in the pathogenesis of spontaneous colitis and colon cancer in the Galphai2-deficient mouse. PMID: 22962436 Ref: Cripto-1 enhances the canonical Wnt/beta-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. PMID: 23022962 Ref: Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis. PMID: 23081697 Ref: Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line. PMID: 23092829 Ref: Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab. PMID: 23634291 Ref: Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance. PMID: 23726839 Ref: Circulating midkine in malignant and non-malignant colorectal diseases. PMID: 23899719 Ref: [The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder]. PMID: 23905422 Ref: FGFR4 promotes stroma-induced epithelial-to-mesenchymal transition in colorectal cancer. PMID: 23943801 Ref: Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. PMID: 24025712 Ref: A two-hybrid approach to identify inhibitors of the RAS-RAF interaction. PMID: 25033807 |
Ref: Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway. PMID: 24232001 Ref: The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018). PMID: 25510341 |
Ref: PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. PMID: 25679762 Ref: Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Delta716) mice involves stromal COX-2. PMID: 25855137 Ref: Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related factors. PMID: 25875151 Ref: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation. PMID: 26017929 Ref: Preoperative serum chemokine (C-C motif) ligand 2 levels and prognosis in colorectal cancer. PMID: 26020569 Ref: Nampt/PBEF/visfatin upregulation in colorectal tumors, mirrored in normal tissue and whole blood of colorectal cancer patients, is associated with metastasis, hypoxia, IL1beta, and anemia. PMID: 26075243 Ref: Spatiotemporal expression of Rhomboid domain containing 2 (Rhbdd2) during rat development. PMID: 26093883 Ref: CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. PMID: 26146082 Ref: CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner. PMID: 26358505 Ref: Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese. PMID: 26515597 |
Ref: Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells. PMID: 25666195 Ref: Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. PMID: 26364612 Ref: An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer. PMID: 26679377 Ref: Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines. PMID: 26713365 Ref: Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT. PMID: 26762412 Ref: Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer. PMID: 26859579 Ref: Ectopic expression of the chemokine CXCL17 in colon cancer cells. PMID: 26889977 Ref: Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis. PMID: 27058904 Ref: Prognostic relevance of genetic variants involved in immune checkpoints in patients with colorectal cancer. PMID: 27339628 Ref: Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation. PMID: 27513864 Ref: Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages. PMID: 27622061 Ref: Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer. PMID: 27739445 |
Ref: FAP positive fibroblasts induce immune checkpoint blockade resistance in colorectal cancer via promoting immunosuppression. PMID: 28302482 Ref: Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment. PMID: 28347237 Ref: Oral delivery of tumor microparticle vaccines activates NOD2 signaling pathway in ileac epithelium rendering potent antitumor T cell immunity. PMID: 28405506 Ref: The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis. PMID: 28698550 Ref: Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer. PMID: 28710487 Ref: Danshen improves survival of patients with colon cancer and dihydroisotanshinone I inhibit the proliferation of colon cancer cells via apoptosis and skp2 signaling pathway. PMID: 28807849 Ref: IL-32alpha-induced inflammation constitutes a link between obesity and colon cancer. PMID: 28811968 Ref: Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. PMID: 28928376 Ref: An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence. PMID: 29154245 Ref: EphA2 signaling is impacted by carcinoembryonic antigen cell adhesion molecule 1-L expression in colorectal cancer liver metastasis in a cell context-dependent manner. PMID: 29262644 |
Ref: Subsite heterogeneity in the profiles of circulating cytokines in colorectal cancer. PMID: 29801973 Ref: Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer. PMID: 29879147 Ref: Circulating Inflammatory Markers and Colorectal Cancer Risk: A Prospective Case-cohort Study in Japan. PMID: 30132835 Ref: Recruitment of CCR2(+) tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer. PMID: 30228938 Ref: Peritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients. PMID: 30284380 Ref: MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth. PMID: 30298062 |