Primary Site >> Colorectal Cancer
Gene >> CAV1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. PMID: 9801158 |
Ref: Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. PMID: 10962573 Ref: Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. PMID: 11059785 Ref: Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. PMID: 11114180 |
Ref: The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. PMID: 12414992 Ref: Caveolae and caveolae-like membrane domains in cellular signaling and disease: identification of downstream targets for the tumor suppressor protein caveolin-1. PMID: 12415732 Ref: Caveolin-1-mediated post-transcriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells. PMID: 12415733 |
Ref: Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. PMID: 12813462 Ref: Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells. PMID: 14965444 |
Ref: ATP-binding cassette transporters are enriched in non-caveolar detergent-insoluble glycosphingolipid-enriched membrane domains (DIGs) in human multidrug-resistant cancer cells. PMID: 14627714 Ref: Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines. PMID: 15069532 Ref: Promoter CpG methylation of caveolin-1 in sporadic colorectal cancer. PMID: 15274335 Ref: 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. PMID: 15342379 |
Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. PMID: 15769846 Ref: 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. PMID: 15798084 Ref: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. PMID: 15929791 Ref: Bile acid induces hydrophobicity-dependent membrane alterations. PMID: 15951237 Ref: 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-infl PMID: 16155208 |
Ref: Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues. PMID: 16202996 Ref: Deoxycholic acid induces intracellular signaling through membrane perturbations. PMID: 16547009 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. PMID: 16731770 Ref: Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines. PMID: 16817319 Ref: Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer. PMID: 16820915 Ref: A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer. PMID: 16952549 |
Ref: Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. PMID: 17395984 Ref: Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. PMID: 17513608 Ref: 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. PMID: 17724373 Ref: E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription. PMID: 17785436 |
Ref: Regulation of tumor phenotypes by caveolin-1 and sphingolipid-controlled membrane signaling complexes. PMID: 17889439 Ref: Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis. PMID: 18176934 Ref: Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells. PMID: 18283336 Ref: IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. PMID: 18294957 Ref: Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc. PMID: 18444242 Ref: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. PMID: 18507034 Ref: Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. PMID: 18694510 Ref: Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. PMID: 18922892 Ref: Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling. PMID: 19763245 |
Ref: Caveolin-1 as a prognostic marker for local control after preoperative chemoradiation therapy in rectal cancer. PMID: 19131184 Ref: Sawhorse-type diruthenium tetracarbonyl complexes containing porphyrin-derived ligands as highly selective photosensitizers for female reproductive cancer cells. PMID: 19241094 Ref: Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. PMID: 19244345 Ref: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. PMID: 19787257 |
Ref: Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. PMID: 19823826 Ref: Caveolin-1 facilitates cyclooxygenase-2 protein degradation. PMID: 19960513 Ref: Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. PMID: 20522643 Ref: Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane. PMID: 20671195 Ref: Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan. PMID: 21160894 |
Ref: Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells. PMID: 20959118 |
Ref: Estrogen receptor-beta protects against colitis-associated neoplasia in mice. PMID: 22488198 Ref: Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. PMID: 22706202 Ref: Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. PMID: 22745744 Ref: CAV1/caveolin 1 enhances aerobic glycolysis in colon cancer cells via activation of SLC2A3/GLUT3 transcription. PMID: 22874559 |
Ref: Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis. PMID: 23280667 Ref: Vascular endothelial growth factor receptors 1,3 and caveolin-1 are implicated in colorectal cancer aggressiveness and prognosis--correlations with epidermal growth factor receptor, CD44v6, focal adhesion kinase, and c-Met. PMID: 23580180 Ref: Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. PMID: 23585443 Ref: Multitargeted low-dose GLAD combination chemoprevention: a novel and promising approach to combat colon carcinogenesis. PMID: 23633920 Ref: Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. PMID: 23637463 Ref: Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis. PMID: 23640045 Ref: Differential caveolin-1 expression in colon carcinoma and its relation to E-cadherin-beta-catenin complex. PMID: 23830349 Ref: Network cluster analysis of protein-protein interaction network identified biomarker for early onset colorectal cancer. PMID: 24197691 |
Ref: The clinicopathological significance of miR-133a in colorectal cancer. PMID: 25104873 |
Ref: Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival. PMID: 25632186 Ref: Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. PMID: 25842166 Ref: Differentiation of high-risk stage I and II colon tumors based on evaluation of CAV1 gene expression. PMID: 26251082 Ref: IFITM1 promotes the metastasis of human colorectal cancer via CAV-1. PMID: 26259513 Ref: Correlation of caveolin-1 expression with microlymphatic vessel density in colorectal adenocarcinoma tissues and its correlation with prognosis. PMID: 26321520 |
Ref: Epigenetic drift towards histone modifications regulates CAV1 gene expression in colon cancer. PMID: 26794448 Ref: Is Serum Caveolin-1 a Useful Biomarker for Progression in Patients with Colorectal Cancer?. PMID: 27156330 Ref: Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer. PMID: 27698803 Ref: Interferon-induced transmembrane protein 1 (IFITM1) is required for the progression of colorectal cancer. PMID: 27852071 |
Ref: Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells. PMID: 27940194 Ref: Downregulation of caveolin-1 increases the sensitivity of drug-resistant colorectal cancer HCT116 cells to 5-fluorouracil. PMID: 28123586 Ref: The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells. PMID: 28346422 Ref: Caveolin-1 is Markedly Downregulated in Patients with Early-Stage Colorectal Cancer. PMID: 28560511 Ref: miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling. PMID: 28594651 Ref: Copper(ii) complexes of functionalized 2,2':6',2''-terpyridines and 2,6-di(thiazol-2-yl)pyridine: structure, spectroscopy, cytotoxicity and catalytic activity. PMID: 28702618 Ref: Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. PMID: 29340103 |
Ref: Butyrate and docosahexaenoic acid interact in alterations of specific lipid classes in differentiating colon cancer cells. PMID: 29274292 Ref: A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells. PMID: 29321581 Ref: Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor. PMID: 29339715 Ref: Quantitative self-assembly prediction yields targeted nanomedicines. PMID: 29403054 Ref: Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis. PMID: 29430186 Ref: Construction of key signal regulatory network in metastatic colorectal cancer. PMID: 29464057 Ref: Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways. PMID: 29643986 Ref: Synthesis, characterization and biological activity of new cyclometallated platinum(iv) complexes containing a para-tolyl ligand. PMID: 29922789 Ref: ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone. PMID: 30098223 |