Primary Site >> Pancreatic Cancer
Gene >> CASP8
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Ref: Apoptotic index and apoptosis influencing proteins bcl-2, mcl-1, bax and caspases 3, 6 and 8 in pancreatic carcinoma. PMID: 9839167 |
Ref: Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. PMID: 11114725 |
Ref: Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. PMID: 11234897 Ref: Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells. PMID: 11497260 Ref: Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer. PMID: 11590320 Ref: Gene expression profiles of pancreatic cancer and stromal desmoplasia. PMID: 11704875 |
Ref: Analysis of the cytochrome c-dependent apoptosis apparatus in cells from human pancreatic carcinoma. PMID: 11953820 Ref: Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. PMID: 12107556 Ref: Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death. PMID: 12219002 Ref: Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. PMID: 12481414 Ref: Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells. PMID: 12630765 |
Ref: Synergistic cytotoxic effect of TRAIL and gemcitabine in pancreatic cancer cells. PMID: 12680221 |
Ref: Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis. PMID: 14750167 Ref: Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. PMID: 15028947 |
Ref: Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand. PMID: 15645141 Ref: Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. PMID: 15942716 Ref: Gemcitabine-mediated apoptosis is associated with increased CD95 surface expression but is not inhibited by DN-FADD in Colo357 pancreatic cancer cells. PMID: 16112422 Ref: Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-kappaB inhibitor. PMID: 16211219 Ref: Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase. PMID: 16288043 |
Ref: 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. PMID: 16332727 Ref: Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. PMID: 16385419 Ref: Differential gene expression profiles of radioresistant pancreatic cancer cell lines established by fractionated irradiation. PMID: 16465376 Ref: Interferon receptors and the caspase cascade regulate the antitumor effects of interferons on human pancreatic cancer cell lines. PMID: 16490547 Ref: Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family. PMID: 16618756 |
Ref: Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death. PMID: 17410536 Ref: Leukotriene B4 receptor antagonist LY293111 induces S-phase cell cycle arrest and apoptosis in human pancreatic cancer cells. PMID: 17414622 Ref: Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells. PMID: 17444865 Ref: Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells. PMID: 17693058 Ref: Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. PMID: 17767167 Ref: Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer. PMID: 17875786 |
Ref: Functional variants in cell death pathway genes and risk of pancreatic cancer. PMID: 18483392 Ref: Human tumor nanoparticles induce apoptosis of pancreatic cancer cells. PMID: 18511551 Ref: Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95. PMID: 18790746 Ref: Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation. PMID: 18813778 Ref: Metformin induces apoptosis of pancreatic cancer cells. PMID: 19084933 |
Ref: Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death. PMID: 19082499 Ref: Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell. PMID: 19106745 Ref: BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. PMID: 19118042 Ref: Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. PMID: 19176377 Ref: Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells. PMID: 19466993 Ref: BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. PMID: 19483105 Ref: Association of breast cancer susceptibility variants with risk of pancreatic cancer. PMID: 19843670 Ref: Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells. PMID: 20110748 |
Ref: Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. PMID: 20388793 Ref: HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells. PMID: 20398369 Ref: Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model. PMID: 20811662 |
Ref: Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells. PMID: 21331750 Ref: Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody. PMID: 21813632 Ref: A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PMID: 22069448 Ref: Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis. PMID: 22241962 |
Ref: IFN-gamma combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells. PMID: 22104728 Ref: Induction of pancreatic cancer cell apoptosis and enhancement of gemcitabine sensitivity by RAP80 siRNA. PMID: 22573342 Ref: Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-kappaB pathways. PMID: 22641480 Ref: Pancreatic cancer cells retain the epithelial-related phenotype and modify mitotic spindle microtubules after the administration of ukrain in vitro. PMID: 22700003 Ref: The antitumor activity of recombinant antitumor antiviral protein and the associated molecular mechanism in pancreatic tumor cells. PMID: 22783925 Ref: HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells. PMID: 22785201 Ref: Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. PMID: 22829912 |
Ref: Combination chemotherapy of serine protease inhibitor nafamostat mesilate with oxaliplatin targeting NF-kappaB activation for pancreatic cancer. PMID: 23348695 Ref: Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells. PMID: 23538603 Ref: Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl1 and TCTP and increases that of TNF-alpha and Bax in BxPC3 pancreatic carcinoma cells. PMID: 23652631 Ref: Upregulation of extrinsic apoptotic pathway in curcumin-mediated antiproliferative effect on human pancreatic carcinogenesis. PMID: 23794119 Ref: PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy. PMID: 23833311 Ref: Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells. PMID: 23993850 Ref: Absence of FLICE-inhibitory protein is a novel independent prognostic marker for very short survival in pancreatic ductal adenocarcinoma. PMID: 24005232 |
Ref: Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells. PMID: 24353313 Ref: Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway. PMID: 24662747 Ref: Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo. PMID: 24799381 Ref: Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction. PMID: 25484045 |
Ref: Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis. PMID: 25331547 Ref: PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer. PMID: 26013168 Ref: Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer. PMID: 26320171 Ref: Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma. PMID: 26373551 |
Ref: Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. PMID: 26516023 Ref: Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells. PMID: 26998093 Ref: The preclinical evaluation of TIC10/ONC201 as an anti-pancreatic cancer agent. PMID: 27233611 |
Ref: Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells. PMID: 29036189 |
Ref: TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor. PMID: 29278689 Ref: IL-33 notably inhibits the growth of colon cancer cells. PMID: 29963144 Ref: Enhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells. PMID: 30127620 Ref: A novel TRAIL mutant-TRAIL-Mu3 enhances the antitumor effects by the increased affinity and the up-expression of DR5 in pancreatic cancer. PMID: 30167846 Ref: Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-kappaB Signaling Pathway. PMID: 30192158 |