Primary Site >> Colorectal Cancer
Gene >> CASP8
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Ref: Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells. PMID: 10200495 |
Ref: Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. PMID: 10075697 |
Ref: p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. PMID: 10694497 Ref: Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis. PMID: 10784420 Ref: Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. PMID: 10864208 Ref: Characterization of bile salt-induced apoptosis in colon cancer cell lines. PMID: 10945641 Ref: Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). PMID: 11077039 Ref: The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. PMID: 11103780 |
Ref: PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics. PMID: 11156952 Ref: Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. PMID: 11245478 Ref: Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. PMID: 11309352 Ref: Sensitization of human colon cancer cells to TRAIL-mediated apoptosis. PMID: 11309649 Ref: p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. PMID: 11313989 Ref: Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma. PMID: 11381362 Ref: The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. PMID: 11439335 Ref: A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. PMID: 11514566 Ref: Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. PMID: 11606398 Ref: Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. PMID: 11746819 Ref: Interferon-gamma modulates TRAIL-mediated apoptosis in human colon carcinoma cells. PMID: 11911240 |
Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells. PMID: 11906168 Ref: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). PMID: 11912124 Ref: Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand. PMID: 11935314 Ref: Distinct intracellular signaling in tumor necrosis factor-related apoptosis-inducing ligand- and CD95 ligand-mediated apoptosis. PMID: 11980895 Ref: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. PMID: 12203115 Ref: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. PMID: 12208739 Ref: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. PMID: 12414664 Ref: Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. PMID: 12507932 |
Ref: The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. PMID: 12482325 Ref: Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. PMID: 12566305 Ref: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. PMID: 12589031 Ref: Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells. PMID: 12618891 Ref: Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. PMID: 12649185 Ref: Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. PMID: 12660816 Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: 5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells. PMID: 12692863 Ref: Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist. PMID: 12761337 Ref: Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines. PMID: 12763222 Ref: Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines. PMID: 12865931 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: Inactivating mutations of caspase-8 gene in colorectal carcinomas. PMID: 12949717 Ref: [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. PMID: 14532729 Ref: Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. PMID: 14645705 |
Ref: Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. PMID: 14871845 Ref: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. PMID: 15073169 Ref: Effects of estrogen on messenger ribonucleic acid expression patterns of extracellular matrix proteases in the primate colon. PMID: 15108029 Ref: LIGHT sensitizes IFN-gamma-mediated apoptosis of HT-29 human carcinoma cells through both death receptor and mitochondria pathways. PMID: 15115612 Ref: Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. PMID: 15120327 Ref: IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. PMID: 15144569 Ref: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. PMID: 15155747 Ref: The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites. PMID: 15161716 Ref: Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. PMID: 15192017 Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 Ref: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. PMID: 15219941 Ref: Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. PMID: 15382069 Ref: Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis. PMID: 15527805 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 |
Ref: Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. PMID: 15611081 Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. PMID: 15671246 Ref: Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines. PMID: 15688023 Ref: Induction of apoptosis in human colon cancer HCT116 cells treated with an extract of the plant product, Chios mastic gum. PMID: 15796160 Ref: Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer. PMID: 15832422 Ref: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PMID: 15846298 Ref: Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. PMID: 15905197 Ref: Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. PMID: 15918186 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. PMID: 15995977 Ref: Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line. PMID: 16036110 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways. PMID: 16098252 Ref: Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. PMID: 16103097 Ref: Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). PMID: 16153452 Ref: Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. PMID: 16158974 Ref: A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. PMID: 16204039 Ref: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. PMID: 16227396 Ref: Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. PMID: 16373718 Ref: Irinotecan/5-fluorouracil combination induces alterations in mitochondrial membrane potential and caspases on colon cancer cell lines. PMID: 16491956 Ref: Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway. PMID: 16507412 |
Ref: Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines. PMID: 15975650 Ref: PKCdelta-mediated regulation of FLIP expression in human colon cancer cells. PMID: 16052516 Ref: Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. PMID: 16082389 Ref: Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis. PMID: 16217767 Ref: c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. PMID: 16247474 Ref: Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. PMID: 16337741 Ref: The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. PMID: 16426830 Ref: Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. PMID: 16617056 Ref: Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. PMID: 16619028 Ref: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. PMID: 16619034 Ref: Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells. PMID: 16628468 Ref: Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1. PMID: 16706817 Ref: Apoptotic effects of over-expressed estrogen receptor-beta on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. PMID: 16830793 Ref: TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. PMID: 16857810 Ref: PPARgamma is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2. PMID: 16927016 Ref: Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas. PMID: 16948818 Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 Ref: Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines. PMID: 17012835 |
Ref: Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. PMID: 17182797 Ref: A highly polar xanthophyll of 9'-cis-neoxanthin induces apoptosis in HCT116 human colon cancer cells through mitochondrial dysfunction. PMID: 17186379 Ref: Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells. PMID: 17186548 Ref: Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis. PMID: 17191116 Ref: Apoptosis signalling mechanisms in human cancer cells induced by Calphostin-PDT. PMID: 17273754 Ref: Induction of apoptosis in DLD-1 human colon cancer cells by peridinin isolated from the dinoflagellate, Heterocapsa triquetra. PMID: 17420600 Ref: Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells. PMID: 17431792 Ref: Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. PMID: 17510406 Ref: Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells. PMID: 17569116 Ref: c-FLIP: a key regulator of colorectal cancer cell death. PMID: 17575142 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. PMID: 17673978 Ref: Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas. PMID: 17726263 Ref: Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. PMID: 17785559 Ref: Effect of methanolic extract from silkworm droppings on proliferation and caspase activity in HT-29 human colon cancer cells. PMID: 17887940 Ref: A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers. PMID: 17897953 Ref: Human allogeneic and murine xenogeneic dendritic cells are cytotoxic to human tumor cells via two distinct pathways. PMID: 17979570 Ref: Induction of apoptosis in HT-29 colon cancer cells by phloretin. PMID: 18158826 |
Ref: Systematic high-content proteomic analysis reveals substantial immunologic changes in colorectal cancer. PMID: 18245490 Ref: DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. PMID: 18245494 Ref: CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population. PMID: 18362937 Ref: Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. PMID: 18377873 Ref: Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells. PMID: 18381232 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. PMID: 18460448 Ref: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. PMID: 18485277 Ref: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. PMID: 18544567 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: Growth inhibition and apoptosis induction by tanshinone IIA in human colon adenocarcinoma cells. PMID: 18622903 Ref: Anti-proliferative and pro-apoptotic effect of CPT13, a novel camptothecin analog, on human colon cancer HCT8 cell line. PMID: 18708040 Ref: Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer. PMID: 18716417 Ref: Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. PMID: 18726190 Ref: [Overcoming acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand by Bcl-XL small interfering RNA in human colon cancer]. PMID: 18788624 Ref: Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. PMID: 18955103 Ref: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. PMID: 19088028 Ref: Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. PMID: 19189638 |
Ref: Combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces Survivin protein level. PMID: 18774638 Ref: Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells. PMID: 18820704 Ref: Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain. PMID: 19014919 Ref: Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. PMID: 19054763 Ref: Comparison of caspase genes for the induction of apoptosis following gene delivery. PMID: 19067254 Ref: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. PMID: 19264955 Ref: S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells. PMID: 19372210 Ref: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. PMID: 19426686 Ref: Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells. PMID: 19446247 Ref: Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells. PMID: 19464056 Ref: Anti-proliferative effects of Lethariella zahlbruckneri extracts in human HT-29 human colon cancer cells. PMID: 19501127 Ref: Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver. PMID: 19524576 Ref: Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer. PMID: 19609961 Ref: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. PMID: 19638488 Ref: A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways. PMID: 19644355 Ref: Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells. PMID: 19845353 |
Ref: Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. PMID: 19728331 Ref: The ethyl acetate extract of Phellinus linteus grown on germinated brown rice induces G0/G1 cell cycle arrest and apoptosis in human colon carcinoma HT29 cells. PMID: 19998418 Ref: Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: caspase-8 and caspase-9 is associated with poor prognosis. PMID: 20013803 Ref: The Ca(2+) channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells. PMID: 20094800 Ref: Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells. PMID: 20227390 Ref: Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. PMID: 20388793 Ref: Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer. PMID: 20570920 Ref: In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201. PMID: 20633731 Ref: Inhibition of cell growth and potentiation of tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells. PMID: 20674553 Ref: Fucoidan present in brown algae induces apoptosis of human colon cancer cells. PMID: 20727207 Ref: Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines. PMID: 20811726 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: [Impact of fragile histidine triad gene transfection on the proliferation and apoptosis of human colorectal cancer cell]. PMID: 20878579 Ref: Sann-Joong-Kuey-Jian-Tang up-regulates the protein expression of Fas and TNF-alpha in colo 205 cells in vivo and in vitro. PMID: 21472201 Ref: GREEN TEA POLYPHENOLS MEDIATED APOPTOSIS IN INTESTINAL EPITHELIAL CELLS BY A FADD-DEPENDENT PATHWAY. PMID: 21687829 |
Ref: Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance. PMID: 20734047 Ref: Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. PMID: 21037225 Ref: Zebrafish stem cell differentiation stage factors suppress Bcl-xL release and enhance 5-Fu-mediated apoptosis in colon cancer cells. PMID: 21043999 Ref: Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. PMID: 21107704 Ref: Apoptosis-inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. PMID: 21122037 Ref: Death receptor 5-mediated TNFR family signaling pathways modulate gamma-humulene-induced apoptosis in human colorectal cancer HT29 cells. PMID: 21152878 Ref: Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome). PMID: 21165777 Ref: TNFalpha cooperates with IFN-gamma to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis. PMID: 21264227 Ref: EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. PMID: 21266352 Ref: Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5. PMID: 21272366 Ref: Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis. PMID: 21338095 Ref: Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53. PMID: 21348775 Ref: Methylation profiling of rectal cancer identifies novel markers of early-stage disease. PMID: 21360524 Ref: Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. PMID: 21362627 Ref: Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. PMID: 21444671 Ref: Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity. PMID: 21486277 Ref: LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. PMID: 21491996 Ref: High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde. PMID: 21513580 Ref: Polymorphisms of caspase 8 and caspase 9 gene and colorectal cancer susceptibility and prognosis. PMID: 21538054 Ref: Effects of alpha-mangostin on apoptosis induction of human colon cancer. PMID: 21547127 Ref: Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29). PMID: 21548803 Ref: Lobaplatin suppresses proliferation and induces apoptosis in the human colorectal carcinoma cell Line LOVO in vitro. PMID: 21612887 Ref: The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. PMID: 21620827 Ref: Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation. PMID: 21653830 Ref: Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-kappaB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells. PMID: 21656672 Ref: Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFkappaB survival axis downstream of Death receptor-3. PMID: 21722370 Ref: Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells. PMID: 21737934 Ref: Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. PMID: 21779837 Ref: Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. PMID: 21789651 Ref: 2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression. PMID: 21817114 Ref: 6-Substituted imidazo[1,2-a]pyridines: synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2. PMID: 21843907 Ref: Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3. PMID: 21868755 Ref: GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation. PMID: 22027835 Ref: [Study of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic and inflammatory gene expressions in colon cancer cell line]. PMID: 22030783 |
Ref: PEG-liposomal oxaliplatin induces apoptosis in human colorectal cancer cells via Fas/FasL and caspase-8. PMID: 21888623 Ref: Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. PMID: 21941373 Ref: A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer. PMID: 22027693 Ref: Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. PMID: 22218562 Ref: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. PMID: 22322857 Ref: Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. PMID: 22426808 Ref: Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer. PMID: 22500158 Ref: CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50,112 subjects. PMID: 22513478 Ref: HIV-1 viral protein R (Vpr) induction of apoptosis and cell cycle arrest in multidrug-resistant colorectal cancer cells. PMID: 22552851 Ref: Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. PMID: 22579651 Ref: The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. PMID: 22617025 Ref: The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivo. PMID: 22653662 Ref: Escherichia coli STb toxin induces apoptosis in intestinal epithelial cell lines. PMID: 22771838 Ref: Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer. PMID: 22859720 Ref: Anticancer effects of KI-10F: a novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer. PMID: 22941304 Ref: Stichoposide C induces apoptosis through the generation of ceramide in leukemia and colorectal cancer cells and shows in vivo antitumor activity. PMID: 23132899 Ref: (3S)-1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acid from Cichorium endivia. L induces apoptosis of human colorectal cancer HCT-8 cells. PMID: 23275050 |
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Ref: The novel heterocyclic trioxirane [(1,3,5-tris oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione (TATT)] exhibits a better anticancer effect than platinum-based chemotherapy by induction of apoptosis and curcumin further enhances its chemosensitivity. PMID: 24078402 Ref: Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. PMID: 24338023 Ref: Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study. PMID: 24465592 Ref: Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. PMID: 24486574 Ref: CASP8 -652 6N del polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis. PMID: 24498403 Ref: Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway. PMID: 24519064 Ref: Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. PMID: 24549175 Ref: Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways. PMID: 24573532 Ref: The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. PMID: 24577083 Ref: Laminarin-induced apoptosis in human colon cancer LoVo cells. PMID: 24765209 Ref: Antibody against N-terminal domain of phospholipid scramblase 1 induces apoptosis in colorectal cancer cells through the intrinsic apoptotic pathway. PMID: 24766818 Ref: DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes. PMID: 24811787 Ref: BaxDelta2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. PMID: 24842234 Ref: microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. PMID: 24885920 Ref: Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells. PMID: 24905183 Ref: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. PMID: 24930757 Ref: A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8. PMID: 24934366 Ref: Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. PMID: 24957706 Ref: Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells. PMID: 25070748 Ref: Activation of JNK/p38 pathway is responsible for alpha-methyl-n-butylshikonin induced mitochondria-dependent apoptosis in SW620 human colorectal cancer cells. PMID: 25124618 Ref: NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide. PMID: 25168151 Ref: Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. PMID: 25342273 Ref: Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. PMID: 25356873 Ref: Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction. PMID: 25484045 |
Ref: Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction. PMID: 25407898 Ref: Water stress proteins from Nostoc commune Vauch. exhibit anti-colon cancer activities in vitro and in vivo. PMID: 25524246 Ref: Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells. PMID: 25535473 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. PMID: 25761243 Ref: HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL. PMID: 25813020 Ref: Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms. PMID: 25886453 Ref: The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. PMID: 25892545 Ref: Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. PMID: 25906152 Ref: Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways. PMID: 26034354 Ref: Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/beta-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon c PMID: 26122204 Ref: Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. PMID: 26180579 Ref: New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. PMID: 26235743 Ref: Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. PMID: 26287184 Ref: Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells. PMID: 26287512 Ref: Aberrant Apoptotic Response of Colorectal Cancer Cells to Novel Nucleoside Analogues. PMID: 26390405 Ref: Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B. PMID: 26561202 Ref: Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice. PMID: 26693068 Ref: Mechanism of Action of the Novel Nickel(II) Complex in Simultaneous Reactivation of the Apoptotic Signaling Networks Against Human Colon Cancer Cells. PMID: 26858642 |
Ref: TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways. PMID: 26212606 Ref: Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells. PMID: 26495895 Ref: Guarana a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation. PMID: 26673759 Ref: Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells. PMID: 26751572 Ref: The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death. PMID: 26757822 Ref: The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. PMID: 26771233 Ref: Cooperative TRAIL production mediates IFNalpha/Smac mimetic-induced cell death in TNFalpha-resistant solid cancer cells. PMID: 26788912 Ref: Long non-coding RNA AK027294 involves in the process of proliferation, migration, and apoptosis of colorectal cancer cells. PMID: 26820130 Ref: Synergistic anti-tumor activity and mechanisms of total glycosides from Cimicifuga dahurica in combination with cisplatin. PMID: 26825081 Ref: Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. PMID: 26848703 Ref: Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. PMID: 26859520 Ref: SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy. PMID: 26940565 Ref: Synergistic cytotoxic effects of combined delta-tocotrienol and jerantinine B on human brain and colon cancers. PMID: 26947901 Ref: Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line. PMID: 27016270 Ref: Polyphenol stabilized colloidal gold nanoparticles from Abutilon indicum leaf extract induce apoptosis in HT-29 colon cancer cells. PMID: 27038915 Ref: Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. PMID: 27053107 Ref: Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line. PMID: 27070314 Ref: Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. PMID: 27098859 Ref: Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. PMID: 27197191 Ref: Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. PMID: 27221553 Ref: Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. PMID: 27268964 Ref: Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells. PMID: 27378626 Ref: Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis. PMID: 27439439 Ref: The anti-oncogenic influence of ellagic acid on colon cancer cells in leptin-enriched microenvironment. PMID: 27460082 Ref: Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes. PMID: 27487939 Ref: Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer. PMID: 27507139 Ref: mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity. PMID: 27565731 Ref: Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. PMID: 27622714 Ref: Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. PMID: 27699933 Ref: Evaluation of anti-tumorigenic activity of BP3B against colon cancer with patient-derived tumor xenograft model. PMID: 27863496 Ref: Water extract of Galla Rhois with steaming process enhances apoptotic cell death in human colon cancer cells. PMID: 28462130 Ref: Effect of ethanol extract of HPRS, a Traditional Chinese Medicine formula, on HCT116 cell Line. PMID: 29949709 |
Ref: siRNA-Mediated Silencing of HMGA2 Induces Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma. PMID: 27629422 Ref: Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. PMID: 27959417 Ref: miR-20a-directed regulation of BID is associated with the TRAIL sensitivity in colorectal cancer. PMID: 28004114 Ref: CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PMID: 28068431 Ref: Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways. PMID: 28169560 Ref: A novel cycloartane triterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells. PMID: 28260002 Ref: Synthesis and Characterization of a New Benzoindole Derivative with Apoptotic Activity Against Colon Cancer Cells. PMID: 28325143 Ref: Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma. PMID: 28349837 Ref: Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. PMID: 28476895 Ref: Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines. PMID: 28477945 Ref: Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo. PMID: 28542135 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. PMID: 28560697 Ref: Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. PMID: 28611052 Ref: 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. PMID: 28627461 Ref: Induction of apoptosis by Dae-Hwang-Mok-Dan-Tang in HCT-116 colon cancer cells through activation of caspases and inactivation of the phosphatidylinositol 3-kinase/Akt signaling. PMID: 28664141 Ref: Plant Sterol Esters in Extruded Food Model Inhibits Colon Carcinogenesis by Suppressing Inflammation and Stimulating Apoptosis. PMID: 28692412 Ref: Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect. PMID: 28955240 Ref: A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells. PMID: 28981103 Ref: Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. PMID: 29085228 Ref: Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer PMID: 29151331 Ref: Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum. PMID: 29204990 Ref: ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line. PMID: 29242562 Ref: Analysis of 12 variants in the development of gastric and colorectal cancers. PMID: 29358861 |
Ref: Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component. PMID: 29073716 Ref: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer. PMID: 29233910 Ref: Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. PMID: 29276946 Ref: Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts. PMID: 29290768 Ref: BaxDelta2 sensitizes colorectal cancer cells to proteasome inhibitor-induced cell death. PMID: 29291406 Ref: Synergistic role of Caspase-8 and Caspase-3 expressions: Prognostic and predictive biomarkers in colorectal cancer. PMID: 29355114 Ref: Drug-like dietary vanilloids induce anticancer activity through proliferation inhibition and regulation of bcl-related apoptotic proteins. PMID: 29464796 Ref: Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo. PMID: 29574877 Ref: The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-kappaB translocation. PMID: 29636600 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: Detection of pro-apoptotic Bax2 proteins in the human cerebellum. PMID: 29663074 Ref: Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells. PMID: 29684585 Ref: Effects of Recombinant Circularly Permuted Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) (Recombinant Mutant Human TRAIL) in Combination with 5-Fluorouracil in Human Colorectal Cancer Cell Lines HCT116 and SW480. PMID: 29695684 Ref: Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53-p21(CIP1/WAF1) in human colorectal HCT116 cells. PMID: 29754265 Ref: Expression Level of Caspase Genes in Colorectal Cancer PMID: 29801534 Ref: Knock-down of LRP/LR promotes apoptosis in early and late stage colorectal carcinoma cells via caspase activation. PMID: 29843646 Ref: Genistein and daidzein induce apoptosis of colon cancer cells by inhibiting the accumulation of lipid droplets. PMID: 29849534 Ref: Reactive oxygen species-mediated phosphorylation of p38 signaling is critically involved in apoptotic effect of Tanshinone I in colon cancer cells. PMID: 29876988 Ref: Calotroposid A: a Glycosides Terpenoids from Calotropis gigantea Induces Apoptosis of Colon Cancer WiDr Cells through Cell Cycle Arrest G2/M and Caspase 8 Expression PMID: 29936715 Ref: Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam. PMID: 29950999 Ref: IL-33 notably inhibits the growth of colon cancer cells. PMID: 29963144 Ref: A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk. PMID: 30057371 Ref: Bortezomib Targets Sp Transcription Factors in Cancer Cells. PMID: 30115673 Ref: Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels. PMID: 30195524 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Intestinal Inflammation and Dysregulated Immunity in Patients with Inherited Caspase-8 Deficiency. PMID: 30267714 Ref: Cytotoxic effect of methanolic extract, alkaloid and terpenoid fractions of Stachys pilifera against HT-29 cell line. PMID: 30271442 Ref: Isoliquiritigenin-mediated p62/SQSTM1 induction regulates apoptotic potential through attenuation of caspase-8 activation in colorectal cancer cells. PMID: 30339814 Ref: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells. PMID: 30363706 |