Primary Site >> Colorectal Cancer
Gene >> CA9
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Ref: Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. PMID: 9665489 |
Ref: Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. PMID: 11680594 |
Ref: Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma. PMID: 12767076 |
Ref: Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. PMID: 15054467 Ref: (177)Lu-Benzyl-diethylenetriamine pentaacetic acid-anti-carbonic anhydrase IX small immunoprotein A3 PMID: 20641383 Ref: (89)Zr-N-Succinyldesferal-chimeric monoclonal antibody G250 PMID: 20641994 Ref: (124)I-Chimeric monoclonal antibody G250 PMID: 20641997 Ref: (125)I-Labeled mouse anti-human carbonic anhydrase IX monoclonal antibody PMID: 22675743 |
Ref: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. PMID: 15596295 Ref: Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa. PMID: 15849821 Ref: A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. PMID: 16061869 Ref: Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. PMID: 16103077 |
Ref: Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer. PMID: 16242253 Ref: A new approach to the validation of tissue microarrays. PMID: 16435284 Ref: Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers. PMID: 16618579 Ref: EMAP-II-dependent lymphocyte killing is associated with hypoxia in colorectal cancer. PMID: 16929248 |
Ref: Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole. PMID: 17172824 Ref: Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. PMID: 17308115 Ref: Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. PMID: 17452775 Ref: MN/CA9: a potential gene marker for detection of malignant cells in effusions. PMID: 17536770 Ref: Hypoxia upregulates carcinoembryonic antigen expression in cancer cells. PMID: 17657737 Ref: Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. PMID: 17855694 |
Ref: Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. PMID: 18351386 Ref: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. PMID: 18619649 Ref: LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. PMID: 18695874 Ref: Poorer outcome in stromal HIF-2 alpha- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis. PMID: 18728663 Ref: Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers. PMID: 18922936 |
Ref: Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines. PMID: 18608752 Ref: Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. PMID: 19008051 Ref: Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. PMID: 19017360 Ref: Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study. PMID: 19050903 Ref: Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer. PMID: 19240720 Ref: Immunohistochemical detection of changes in tumor hypoxia. PMID: 19251089 Ref: The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. PMID: 19458084 Ref: Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer. PMID: 19568246 Ref: Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. PMID: 19844231 |
Ref: Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiography. PMID: 19921184 Ref: Carbonic anhydrase IX expression in prostate cancer. PMID: 20038959 Ref: Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts. PMID: 20523727 Ref: Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain. PMID: 20819068 Ref: A new peptide ligand for targeting human carbonic anhydrase IX, identified through the phage display technology. PMID: 21209841 |
Ref: Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. PMID: 21368208 Ref: LDH-A influences hypoxia-inducible factor 1alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo. PMID: 21660559 Ref: Carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological PMID: 22199327 |
Ref: The histological growth pattern of colorectal cancer liver metastases has prognostic value. PMID: 22476470 Ref: hERG1 Channels and Glut-1 as Independent Prognostic Indicators of Worse Outcome in Stage I and II Colorectal Cancer: A Pilot Study. PMID: 22496927 Ref: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. PMID: 22498007 Ref: HIF-1alpha-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. PMID: 22745382 Ref: Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer. PMID: 22843905 Ref: Amide derivatives of benzene-sulfonanilide, pharmaceutical composition thereof and method for cancer treatment using the same (US20120095092). PMID: 22849544 Ref: Hypoxia-related proteins in patients with rectal cancer undergoing neoadjuvant combined modality therapy. PMID: 22874607 Ref: Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. PMID: 22943412 Ref: Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members. PMID: 23148666 Ref: Binding of the phage display derived peptide CaIX-P1 on human colorectal carcinoma cells correlates with the expression of carbonic anhydrase IX. PMID: 23202936 Ref: Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis. PMID: 23316475 |
Ref: Investigation of possible endogenous hypoxia markers in colorectal cancer. PMID: 22852555 Ref: Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach. PMID: 23325291 Ref: Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake? PMID: 23348791 Ref: Activation of AMP-Activated Protein Kinase alpha and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells. PMID: 23589723 Ref: Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs. PMID: 23849171 |
Ref: Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking. PMID: 24321995 Ref: Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model. PMID: 24700751 Ref: Blood biomarkers are helpful in the prediction of response to chemoradiation in rectal cancer: a prospective, hypothesis driven study on patients with locally advanced rectal cancer. PMID: 24746569 |
Ref: An exploratory biomarker study in metastatic tumors from colorectal cancer patients treated with bevacizumab. PMID: 24980447 Ref: Tumour budding is associated with hypoxia at the advancing front of colorectal cancer. PMID: 25381897 Ref: Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer. PMID: 25782664 Ref: Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial. PMID: 25867261 Ref: 6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells. PMID: 25875209 Ref: Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer. PMID: 26205955 Ref: Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors. PMID: 26249175 Ref: Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment. PMID: 26416246 Ref: Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo. PMID: 26447758 Ref: Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. PMID: 26569228 |
Ref: Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells. PMID: 26244271 Ref: Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base. PMID: 26648507 Ref: Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents. PMID: 26774930 Ref: Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy. PMID: 26782212 Ref: PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with (68)Ga-Labeled Benzenesulfonamides. PMID: 26866675 Ref: Dynamic Contrast Enhanced MRI Assessing the Antiangiogenic Effect of Silencing HIF-1alpha with Targeted Multifunctional ECO/siRNA Nanoparticles. PMID: 27264671 Ref: Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1alpha Accumulation. PMID: 27803454 Ref: Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine. PMID: 27863474 |
Ref: Integrative genomic approaches to dissect clinically-significant relationships between the VDR cistrome and gene expression in primary colon cancer. PMID: 28027912 Ref: Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells. PMID: 28055960 Ref: Design, synthesis and evaluation of (18)F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging. PMID: 28385087 Ref: Clinicopathologic and prognostic significance of immunohistochemical expression of HIF-1alpha, CXCR4 and CA9 in colorectal carcinoma. PMID: 28554753 Ref: Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis. PMID: 28929255 Ref: Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. PMID: 29259754 |
Ref: The cytotoxic, apoptotic and oxidative effects of carbonic anhydrase IX inhibitor on colorectal cancer cells. PMID: 29520697 Ref: Biologic Response of Colorectal Cancer Xenograft Tumors to Sequential Treatment with Panitumumab and Bevacizumab. PMID: 29802988 Ref: Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer. PMID: 30219719 |