Primary Site >> Colorectal Cancer
Gene >> BUB1B
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Ref: Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. PMID: 10773412 Ref: Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. PMID: 10835495 |
Ref: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. PMID: 11782350 |
Ref: Genomic instability and colon cancer. PMID: 15000146 Ref: Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. PMID: 15159543 |
Ref: Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. PMID: 15767571 |
Ref: Chromosomal instability, colorectal cancer and taxane resistance. PMID: 16628000 |
Ref: Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. PMID: 17227893 Ref: c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability. PMID: 17297307 Ref: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. PMID: 17322345 Ref: Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells. PMID: 17464181 Ref: APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. PMID: 17570218 Ref: Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PMID: 18159231 |
Ref: Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. PMID: 18699967 |
Ref: Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice. PMID: 19194513 Ref: Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. PMID: 20032382 |
Ref: Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells. PMID: 19931410 Ref: Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis. PMID: 20661832 |
Ref: 212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpoint. PMID: 23632482 |
Ref: Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer. PMID: 25275037 |
Ref: Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. PMID: 26009897 |
Ref: Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. PMID: 26889953 Ref: Prevalence of germline mutations in the spindle assembly checkpoint gene BUB1B in individuals with early-onset colorectal cancer. PMID: 27239782 Ref: Phyllanthus emblica Fruit Extract Activates Spindle Assembly Checkpoint, Prevents Mitotic Aberrations and Genomic Instability in Human Colon Epithelial NCM460 Cells. PMID: 27598149 Ref: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis. PMID: 28105216 |
Ref: The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. PMID: 27875818 |
Ref: Identification of genes involved in the four stages of colorectal cancer: Gene expression profiling. PMID: 29179987 Ref: Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID: 29641532 |