Primary Site >> Colorectal Cancer
Gene >> BUB1
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Ref: Mutations of mitotic checkpoint genes in human cancers. PMID: 9521327 |
Ref: Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. PMID: 10543255 |
Ref: Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. PMID: 10773412 Ref: Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. PMID: 10835495 Ref: Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer. PMID: 10969775 |
Ref: Mutation analysis of hBUB1, human mitotic checkpoint gene in multiple carcinomas. PMID: 11115566 Ref: A role for the Adenomatous Polyposis Coli protein in chromosome segregation. PMID: 11283619 Ref: No mutations of the Bub1 gene in human gastric carcinomas. PMID: 11410785 |
Ref: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. PMID: 11782350 |
Ref: Genomic instability and colon cancer. PMID: 15000146 Ref: Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. PMID: 15162061 |
Ref: Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. PMID: 17227893 Ref: Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PMID: 18159231 |
Ref: Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice. PMID: 19194513 |
Ref: Chromosome missegregation causes colon cancer by APC loss of heterozygosity. PMID: 20404532 Ref: Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. PMID: 20729907 Ref: Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer. PMID: 20811685 |
Ref: Absence of aneuploidy and gastrointestinal tumours in a man with a chromosomal 2q13 deletion and BUB1 monoallelic deficiency. PMID: 23440991 Ref: Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are risk factors for colorectal cancer. PMID: 23747338 |
Ref: Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. PMID: 26009897 |
Ref: Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. PMID: 26889953 Ref: Prevalence of germline mutations in the spindle assembly checkpoint gene BUB1B in individuals with early-onset colorectal cancer. PMID: 27239782 Ref: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis. PMID: 28105216 |
Ref: Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review. PMID: 27713038 Ref: Elucidating the molecular basis of MSH2-deficient tumors by combined germline and somatic analysis. PMID: 28577310 |
Ref: Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis. PMID: 29448935 Ref: Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer. PMID: 29701748 |