Primary Site >> Colorectal Cancer

Gene >> BTRC

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Ref: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
PMID: 10228155
 Ref: A protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
PMID: 14516475
 Ref: Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer.
PMID: 15292388
 Ref: Comparative genomics on FGF8, FGF17, and FGF18 orthologs.
PMID: 16077960
 Ref: The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.
PMID: 16510874
Ref: CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.
PMID: 16778892
 Ref: Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.
PMID: 19106159
Ref: The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.
PMID: 19297328
Ref: beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
PMID: 19797085
 Ref: Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma.
PMID: 20027638
Ref: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.
PMID: 20090422
 Ref: Phosphorylation of beta-catenin results in lack of beta-catenin signaling in melanoma.
PMID: 21584489
 Ref: Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription.
PMID: 24060489
 Ref: Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.
PMID: 24500709
Ref: TRIB2 inhibits Wnt/beta-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, beta-TrCP, COP1 and Smurf1, in liver cancer cells.
PMID: 25311538
 Ref: Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.
PMID: 26124443
Ref: ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
PMID: 26267535
Ref: FAK/PYK2 promotes the Wnt/beta-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3beta.
PMID: 26274564
 Ref: TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
PMID: 28416184
 Ref: Ube2s stabilizes beta-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.
PMID: 29674637