Primary Site >> Colorectal Cancer
Gene >> BRD4
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Ref: Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer. PMID: 22120039 Ref: BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. PMID: 22509028 |
Ref: BRD4 inhibitor inhibits colorectal cancer growth and metastasis. PMID: 25603177 Ref: Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. PMID: 26586936 |
Ref: CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. PMID: 26752646 Ref: Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. PMID: 26983878 |
Ref: Uncommon somatic mutations in metastatic NUT midline carcinoma. PMID: 28967088 Ref: Sequencing of Lynch syndrome tumors reveals the importance of epigenetic alterations. PMID: 29296220 |
Ref: Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. PMID: 29507187 Ref: TIP60 represses activation of endogenous retroviral elements. PMID: 30053221 Ref: RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. PMID: 30076409 Ref: PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma. PMID: 30172011 |