Primary Site >> Pancreatic Cancer
Gene >> BRCA2
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Ref: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID: 20301425 |
Ref: An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. PMID: 7553631 Ref: Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. PMID: 7597059 |
Ref: Low incidence of BRCA2 mutations in breast carcinoma and other cancers. PMID: 8640236 Ref: A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. PMID: 8673089 Ref: Mutations in the BRCA2 gene in hepatocellular carcinomas. PMID: 8840963 Ref: Pancreatic adenocarcinoma: epidemiology and genetics. PMID: 8950667 Ref: Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. PMID: 8968085 |
Ref: Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. PMID: 8988179 Ref: Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing. PMID: 9134530 Ref: Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. PMID: 9140390 Ref: Study of a single BRCA2 mutation with high carrier frequency in a small population. PMID: 9150155 Ref: Molecular advances in pancreatic cancer. PMID: 9438601 Ref: Hereditary pancreatitis and familial pancreatic cancer. PMID: 9438603 Ref: BRCA1 and BRCA2 Germline Mutations in Japanese with Hereditary Breast Cancer Families. PMID: 11091610 |
Ref: Genetics of pancreatic cancer. From genes to families. PMID: 9443984 Ref: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. PMID: 9560268 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 |
Ref: Cancer risks in BRCA2 mutation carriers. PMID: 10433620 Ref: Progress in cancer genetics: lessons from pancreatic cancer. PMID: 10436774 Ref: Pathology of incipient pancreatic cancer. PMID: 10436775 Ref: Familial pancreatic cancer. PMID: 10436789 Ref: Molecular genetics and related developments in pancreatic cancer. PMID: 17023981 |
Ref: Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations. PMID: 10667595 Ref: BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications. PMID: 10793087 Ref: Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients? PMID: 11075991 Ref: Molecular genetics of ductal pancreatic neoplasia. PMID: 17031113 |
Ref: Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. PMID: 11196174 Ref: The rate of the 6174delT founder Jewish mutation in BRCA2 in patients with non-colonic gastrointestinal tract tumours in Israel. PMID: 11207041 Ref: Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. PMID: 11385254 Ref: Molecular diagnosis of pancreatic cancer. PMID: 11490843 Ref: Familial pancreatic cancer. PMID: 11561603 Ref: Hereditary pancreatic cancer. PMID: 12120226 Ref: Update of familial pancreatic cancer in Germany. PMID: 12120230 Ref: Pancreatic cancer genetics. PMID: 12120238 Ref: An Epidemiological Overview of Environmental and Genetic Risk Factors of Pancreatic Cancer. PMID: 12718618 |
Ref: BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. PMID: 11879560 Ref: Inhibition of cancer cell growth by BRCA2. PMID: 11888897 Ref: Family history of cancer and germline BRCA2 mutations in sporadic exocrine pancreatic cancer. PMID: 11950811 Ref: [Genetics of pancreatic cancer: recent advances in molecular diagnosis]. PMID: 12094699 Ref: Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. PMID: 12097290 Ref: German national case collection of familial pancreatic cancer - clinical-genetic analysis of the first 21 families. PMID: 12119461 Ref: Evidence for a major gene influencing risk of pancreatic cancer. PMID: 12214307 Ref: Pancreatic cancer: epidemiology, genetics, and approaches to screening. PMID: 12520639 Ref: Premalignant conditions of the pancreas. PMID: 12555988 Ref: BRCA2 and pancreatic cancer. PMID: 12622420 |
Ref: BRCA2 germline mutations in familial pancreatic carcinoma. PMID: 12569143 Ref: Epidemiology of pancreatic cancer: an overview. PMID: 12670518 Ref: Fanconi anemia gene mutations in young-onset pancreatic cancer. PMID: 12750283 Ref: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. PMID: 12837831 |
Ref: The genetics of FANCC and FANCG in familial pancreatic cancer. PMID: 14726700 Ref: Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature. PMID: 14966099 Ref: A delayed chemically induced tumorigenesis in Brca2 mutant mice. PMID: 14981540 Ref: Functional screen of the fanconi anemia pathway in cancer cells by Fancd2 immunoblot. PMID: 15107617 Ref: Functional screen of the fanconi anemia pathway in cancer cells by Fancd2 immunoblot. PMID: 15107817 Ref: Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background. PMID: 15112280 Ref: Cancer variation associated with the position of the mutation in the BRCA2 gene. PMID: 15131399 Ref: Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. PMID: 15162061 Ref: Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. PMID: 15173085 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: Epidemiology and prevention of pancreatic cancer. PMID: 15231857 Ref: Inherited predisposition to cancer: a historical overview. PMID: 15264268 Ref: Functional defects in the fanconi anemia pathway in pancreatic cancer cells. PMID: 15277238 Ref: Familial pancreatic carcinoma in Jews. PMID: 15516847 Ref: Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing. PMID: 15550590 |
Ref: Overview of linkage analysis: application to pancreatic cancer. PMID: 15542915 Ref: Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. PMID: 15695377 Ref: Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. PMID: 15781639 Ref: BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. PMID: 15796958 Ref: Increased prevalence of the BRCA2 polymorphic stop codon K3326X among individuals with familial pancreatic cancer. PMID: 15806175 Ref: Risk factors for pancreatic cancer. PMID: 15849724 Ref: Treatment of familial pancreatic cancer and its precursors. PMID: 16162302 Ref: Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects. PMID: 16183479 Ref: In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. PMID: 16243825 |
Ref: Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers. PMID: 16417627 Ref: Familial pancreatic cancer syndromes. PMID: 16632103 Ref: Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. PMID: 16648548 Ref: [Familial pancreatic cancer]. PMID: 16888680 |
Ref: Characterizing a rat Brca2 knockout model. PMID: 16964288 Ref: Role of BRCA1 and BRCA2 mutations in pancreatic cancer. PMID: 16973716 Ref: Germline mutations in the BRCA2 gene and susceptibility to hereditary prostate cancer. PMID: 17289875 Ref: The prevalence of BRCA2 mutations in familial pancreatic cancer. PMID: 17301269 Ref: Linkage analysis of chromosome 4 in families with familial pancreatic cancer. PMID: 17312386 Ref: Prophylactic salpingo-oophorectomy in a series of 89 women carrying a BRCA1 or a BRCA2 mutation. PMID: 17351952 Ref: Molecular genetics of pancreatic intraepithelial neoplasia. PMID: 17520196 Ref: Cancer risk among the relatives of patients with pancreatic ductal adenocarcinoma. PMID: 17912010 Ref: Familial pancreatic cancer: from genes to improved patient care. PMID: 19072437 Ref: Familial pancreatic cancer: current status. PMID: 23489306 |
Ref: Resistance to therapy caused by intragenic deletion in BRCA2. PMID: 18264088 Ref: Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers. PMID: 18281469 Ref: The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. PMID: 18349832 Ref: BRCA2 mutations as a universal risk factor for pancreatic cancer has a limited role in Korean ethnic group. PMID: 18437078 Ref: Predominant Ashkenazi BRCA1/2 mutations in families with pancreatic cancer. PMID: 18439109 Ref: Pancreatic cancer: a plea for good and comprehensive morphological studies. PMID: 18617774 Ref: Counseling for male BRCA mutation carriers: a review. PMID: 18657973 Ref: Screening and surveillance approaches in familial pancreatic cancer. PMID: 18674702 Ref: Germline BRCA1 mutations predispose to pancreatic adenocarcinoma. PMID: 18762988 Ref: Amplification of EMSY gene in a subset of sporadic pancreatic adenocarcinomas. PMID: 18787609 Ref: International registries of families at high risk of pancreatic cancer. PMID: 18818508 Ref: Is there any relationship between BRCA1 gene mutation and pancreatic cancer development? PMID: 19140568 |
Ref: Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations. PMID: 18855126 Ref: cDNA analysis demonstrates that the BRCA2 intronic variant IVS4-12del5 is a deleterious mutation. PMID: 19070627 Ref: Genetic predisposition and environmental risk factors to pancreatic cancer: A review of the literature. PMID: 19150414 Ref: Familial pancreatic cancer. PMID: 19260742 Ref: Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma. PMID: 19277124 Ref: Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature. PMID: 19433978 Ref: The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer. PMID: 19491823 Ref: Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer. PMID: 19635604 Ref: Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. PMID: 19690177 Ref: Robotic resection of intraductal neoplasm of the pancreas. PMID: 19698031 Ref: Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas. PMID: 19720778 Ref: Familial association of pancreatic cancer with other malignancies in Swedish families. PMID: 19826425 Ref: Differentiating neoplastic from benign lesions of the pancreas: translational techniques. PMID: 19896100 Ref: Incidence of multiple primary malignancies in women diagnosed with breast cancer. PMID: 20099499 |
Ref: Clinical and genetic analysis of 18 pancreatic carcinoma/melanoma-prone families. PMID: 20041885 Ref: Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families. PMID: 20195775 Ref: Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future. PMID: 20201734 Ref: Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. PMID: 20423983 Ref: Pancreatic cancer risk counselling and screening: impact on perceived risk and psychological functioning. PMID: 20623197 Ref: PALB2/FANCN: recombining cancer and Fanconi anemia. PMID: 20858716 Ref: Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. PMID: 20871615 Ref: [The epidemiology of pancreatic cancer]. PMID: 20961843 Ref: Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer. PMID: 21056012 |
Ref: PALB2 analysis in BRCA2-like families. PMID: 20582465 Ref: Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer. PMID: 21135251 Ref: Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. PMID: 21183737 Ref: Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice. PMID: 21199651 Ref: German national case collection for familial pancreatic cancer (FaPaCa): ten years experience. PMID: 21207249 Ref: Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer. PMID: 21285249 Ref: Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor. PMID: 21289082 Ref: Timing is everything: Brca2 and p53 mutations in pancreatic cancer. PMID: 21352873 Ref: PALB2 mutations in familial breast and pancreatic cancer. PMID: 21365267 Ref: Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive pancreatic ductal adenocarcinomas in mice: a mouse model of familial pancreatic cancer. PMID: 21455033 Ref: Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer. PMID: 21508395 Ref: Brca2 deficiency and Trp53 deregulation in pancreatic cancer: implications for therapeutic targeting. PMID: 21610317 Ref: Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy. PMID: 21613821 Ref: Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer. PMID: 21750719 Ref: Molecular pathogenesis of pancreatic cancer and clinical perspectives. PMID: 22116519 |
Ref: Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer. PMID: 21598239 Ref: Moderators of cancer-related distress and worry after a pancreatic cancer genetic counseling and screening intervention. PMID: 21774034 Ref: Familial intraductal papillary mucinous neoplasms of the pancreas. PMID: 21824831 Ref: Intraductal papillary mucinous neoplasm of the pancreas: associated cancers, family history, genetic predisposition? PMID: 21975290 Ref: Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy. PMID: 21989927 Ref: Genetic susceptibility to pancreatic cancer. PMID: 22162228 Ref: The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. PMID: 22212556 Ref: Molecular and clinical characterization of an in frame deletion of uncertain clinical significance in the BRCA2 gene. PMID: 22228431 Ref: PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. PMID: 22331464 Ref: CDKN2A is the main susceptibility gene in Italian pancreatic cancer families. PMID: 22368299 Ref: Recurrent germline mutations in BRCA1 and BRCA2 genes in high risk families in Israel. PMID: 22399190 Ref: [What management for the asymptomatic men carriers of BRCA1 or 2 mutation? Results of a survey in the French oncogenetic centers]. PMID: 22429936 Ref: Mouse models of pancreatic cancer. PMID: 22493542 Ref: Familial pancreatic cancer--current knowledge. PMID: 22664588 Ref: Genetic testing by cancer site: pancreas. PMID: 22846737 Ref: The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers. PMID: 23099806 Ref: Inherited pancreatic cancer syndromes. PMID: 23187834 Ref: Etiology and oncogenesis of pancreatic carcinoma. PMID: 23213974 |
Ref: BRCA2 dysfunction promotes malignant transformation of pancreatic intraepithelial neoplasia. PMID: 22934697 Ref: International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. PMID: 23135763 Ref: Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity. PMID: 23148997 Ref: Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer. PMID: 23299404 Ref: Risk of pancreatic cancer in breast cancer families from the breast cancer family registry. PMID: 23456555 Ref: BRCA-associated pancreatic cancer: the evolving management. PMID: 23474559 Ref: Systematic tracking of dysregulated modules identifies novel genes in cancer. PMID: 23613489 Ref: Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. PMID: 23657012 Ref: High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions. PMID: 23658460 Ref: Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. PMID: 23696131 Ref: Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases. PMID: 23935836 |
Ref: Familial pancreatic cancer--status quo. PMID: 23948969 Ref: Delineating the effects BRCA1 and BRCA2 loss of heterozygosity in pancreatic cancer progression. PMID: 24147435 Ref: Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivation. PMID: 24268522 Ref: Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. PMID: 24293293 Ref: Familial pancreatic cancer: genetic advances. PMID: 24395243 Ref: Characteristics of individuals with breast cancer rearrangements in BRCA1 and BRCA2. PMID: 24522996 Ref: The function of EMSY in cancer development. PMID: 24609898 Ref: Promising outcomes of screening for pancreatic cancer by genetic testing and endoscopic ultrasound. PMID: 24622079 Ref: The clinical utility of biomarkers in the management of pancreatic adenocarcinoma. PMID: 24635863 Ref: BRCA1 and BRCA2 germline mutations are frequently demonstrated in both high-risk pancreatic cancer screening and pancreatic cancer cohorts. PMID: 24737347 Ref: Familial pancreatic cancer: challenging diagnostic approach and therapeutic management. PMID: 24756831 Ref: The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. PMID: 24775809 Ref: Exploring the roles of PALB2 at the crossroads of DNA repair and cancer. PMID: 24870022 Ref: Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. PMID: 24959366 Ref: [Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: focus on the Peutz-Jeghers]. PMID: 25036236 Ref: Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. PMID: 25072261 Ref: PARP-inhibitors in BRCA-associated pancreatic cancer. PMID: 25076338 |
Ref: Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. PMID: 25224030 Ref: BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study. PMID: 25356972 Ref: Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. PMID: 25366685 Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: Analysis of PALB2 in a cohort of Italian breast cancer patients: identification of a novel PALB2 truncating mutation. PMID: 25666743 Ref: Whole genomes redefine the mutational landscape of pancreatic cancer. PMID: 25719666 Ref: Cancer risks in Jewish male BRCA1 and BRCA2 mutation carriers. PMID: 25788227 Ref: Short-term Results of a Magnetic Resonance Imaging-Based Swedish Screening Program for Individuals at Risk for Pancreatic Cancer. PMID: 25853369 Ref: Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. PMID: 25864590 Ref: Autoimmune response to PARP and BRCA1/BRCA2 in cancer. PMID: 25865228 Ref: Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial. PMID: 25896973 Ref: BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing. PMID: 25948675 Ref: Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer. PMID: 25987697 Ref: Reply to BRCA2-associated pancreatic cancer and current screening guidelines. PMID: 26018033 Ref: BRCA2-associated pancreatic cancer and current screening guidelines. PMID: 26018189 Ref: Predicting the Pathogenic Potential of BRCA1 and BRCA2 Gene Variants Identified in Clinical Genetic Testing. PMID: 26052455 Ref: Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. PMID: 26098869 Ref: BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. PMID: 26180923 Ref: PanGen-Fam: Spanish registry of hereditary pancreatic cancer. PMID: 26212471 Ref: Familial Pancreatic Adenocarcinoma. PMID: 26226902 Ref: Methods and outcomes of screening for pancreatic adenocarcinoma in high-risk individuals. PMID: 26240684 Ref: Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. PMID: 26310895 Ref: Identification of germline genetic mutations in patients with pancreatic cancer. PMID: 26440929 Ref: A mutational signature in gastric cancer suggests therapeutic strategies. PMID: 26511885 Ref: Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair. PMID: 26585231 Ref: Familial risk of melanoma and links with other cancers. PMID: 30190834 |
Ref: Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer. PMID: 26411315 Ref: Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy. PMID: 26439702 Ref: Prevalence of Pathogenic Mutations in Cancer Predisposition Genes among Pancreatic Cancer Patients. PMID: 26483394 Ref: Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. PMID: 26641009 Ref: Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. PMID: 26658419 Ref: [Recommended Extension of Indication Criteria for Genetic Testing of BRCA1 and BRCA2 Mutations in Hereditary Breast and Ovarian Cancer Syndrome]. PMID: 26691937 Ref: [Hereditary Breast and Ovarian Cancer Syndrome]. PMID: 26691938 Ref: [PALB2 as Another Candidate Gene for Genetic Testing in Patients with Hereditary Breast Cancer in Czech Republic]. PMID: 26691940 Ref: Biweekly gemcitabine and low-dose cisplatin in the treatment of locally advanced or metastatic pancreatic cancer patients: a single institute experience. PMID: 26696390 Ref: Statewide Retrospective Review of Familial Pancreatic Cancer in Delaware, and Frequency of Genetic Mutations in Pancreatic Cancer Kindreds. PMID: 26727920 Ref: Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice. PMID: 26916719 Ref: Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. PMID: 27069714 Ref: Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic. PMID: 27106063 Ref: Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers. PMID: 27114589 Ref: Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin. PMID: 27165126 Ref: Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. PMID: 27197284 Ref: Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers. PMID: 27306910 Ref: Hormone therapy after prophylactic risk-reducing bilateral salpingo-oophorectomy in women who have BRCA gene mutation. PMID: 27426853 Ref: BRCA2 functions: from DNA repair to replication fork stabilization. PMID: 27530658 Ref: Analysis of Founder Mutations in Rare Tumors Associated With Hereditary Breast/Ovarian Cancer Reveals a Novel Association of BRCA2 Mutations with Ampulla of Vater Carcinomas. PMID: 27532258 Ref: First case report of an adrenocortical carcinoma caused by a BRCA2 mutation. PMID: 27603373 Ref: WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner. PMID: 27616351 Ref: Can Molecular Biomarkers Change the Paradigm of Pancreatic Cancer Prognosis? PMID: 27689078 Ref: Synchronous Onset of Breast and Pancreatic Cancers: Results of Germline and Somatic Genetic Analysis. PMID: 27721756 Ref: Prevention and Screening in Hereditary Breast and Ovarian Cancer. PMID: 27753056 Ref: Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts. PMID: 28033382 Ref: The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer. PMID: 28078281 |
Ref: Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor. PMID: 27838800 Ref: Male Breast Cancer. PMID: 28171879 Ref: Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer. PMID: 28183138 Ref: HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. PMID: 28288110 Ref: BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer. PMID: 28291774 Ref: BRCA1 missense polymorphisms are associated with poor prognosis of pancreatic cancer patients in a Chinese population. PMID: 28415599 Ref: Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer. PMID: 28454122 Ref: Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair. PMID: 28507103 Ref: BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. PMID: 28591715 Ref: Targeting reactive nitrogen species suppresses hereditary pancreatic cancer. PMID: 28630313 Ref: Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews. PMID: 28754795 Ref: Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. PMID: 28767289 Ref: Germline mutations in pancreatic cancer and potential new therapeutic options. PMID: 29069866 Ref: Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors. PMID: 29259370 |
Ref: IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. PMID: 27797936 Ref: The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genes. PMID: 28687971 Ref: Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history. PMID: 28726808 Ref: Exome-Wide Association Study of Pancreatic Cancer Risk. PMID: 29074453 Ref: Development of a high risk pancreatic screening clinic using 3.0 T MRI. PMID: 29101607 Ref: BRCA1 and BRCA2 expression patterns and prognostic significance in digestive system cancers. PMID: 29126833 Ref: Familial pancreatic cancer asociated to germline mutation of BRCA2. PMID: 29162271 Ref: Pancreatic cancer screening in high-risk individuals with germline genetic mutations. PMID: 29309780 Ref: Male BRCA mutation carriers: clinical characteristics and cancer spectrum. PMID: 29433453 Ref: Comparison of Practice Guidelines, BRCAPRO, and Genetic Counselor Estimates to Identify Germline BRCA1 and BRCA2 Mutations in Pancreatic Cancer. PMID: 29441441 Ref: MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models. PMID: 29545922 Ref: Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer. PMID: 29731985 Ref: Emerging strategies in BRCA-positive pancreatic cancer. PMID: 29777302 Ref: Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. PMID: 29922827 Ref: Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. PMID: 29961768 Ref: Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. PMID: 30051098 Ref: Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts. PMID: 30113427 Ref: Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX. PMID: 30131383 Ref: [PALB2, a major susceptibility gene for breast cancer]. PMID: 30243941 Ref: Targeting Defects in the Cellular DNA Damage Response for the Treatment of Pancreatic Ductal Adenocarcinoma. PMID: 30286473 |