Primary Site >> Pancreatic Cancer
Gene >> BRCA1
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Ref: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID: 20301425 |
Ref: Low incidence of BRCA2 mutations in breast carcinoma and other cancers. PMID: 8640236 Ref: Pancreatic adenocarcinoma: epidemiology and genetics. PMID: 8950667 |
Ref: Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. PMID: 8988179 Ref: Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing. PMID: 9134530 Ref: BRCA1 and BRCA2 Germline Mutations in Japanese with Hereditary Breast Cancer Families. PMID: 11091610 |
Ref: Characterization of a carboxy-terminal BRCA1 interacting protein. PMID: 9811458 |
Ref: Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations. PMID: 10667595 |
Ref: Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. PMID: 11196174 Ref: The role of genetic factors in the etiology of pancreatic adenocarcinoma: an update. PMID: 11291558 |
Ref: BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. PMID: 11879560 Ref: Cancer Incidence in BRCA1 mutation carriers. PMID: 12237281 Ref: BRCA2 and pancreatic cancer. PMID: 12622420 |
Ref: Epidemiology of pancreatic cancer: an overview. PMID: 12670518 Ref: Familial sarcoma: challenging pedigrees. PMID: 14584079 |
Ref: The genetics of FANCC and FANCG in familial pancreatic cancer. PMID: 14726700 Ref: Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature. PMID: 14966099 Ref: Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. PMID: 15162061 Ref: Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. PMID: 15173085 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: Inherited predisposition to cancer: a historical overview. PMID: 15264268 Ref: Familial pancreatic carcinoma in Jews. PMID: 15516847 Ref: Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing. PMID: 15550590 |
Ref: Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. PMID: 15781639 Ref: BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. PMID: 15796958 Ref: Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma. PMID: 16170025 |
Ref: Role of BRCA1 and BRCA2 mutations in pancreatic cancer. PMID: 16973716 Ref: Prophylactic salpingo-oophorectomy in a series of 89 women carrying a BRCA1 or a BRCA2 mutation. PMID: 17351952 |
Ref: Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers. PMID: 18281469 Ref: The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. PMID: 18349832 Ref: Predominant Ashkenazi BRCA1/2 mutations in families with pancreatic cancer. PMID: 18439109 Ref: Family history of pancreatic cancer in a high-risk cancer clinic: implications for risk assessment. PMID: 18581219 Ref: Germline BRCA1 mutations predispose to pancreatic adenocarcinoma. PMID: 18762988 Ref: International registries of families at high risk of pancreatic cancer. PMID: 18818508 Ref: Is there any relationship between BRCA1 gene mutation and pancreatic cancer development? PMID: 19140568 |
Ref: The impact of social roles on the experience of men in BRCA1/2 families: implications for counseling. PMID: 18688698 Ref: Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations. PMID: 18855126 Ref: Absence of germline BRCA1 mutations in familial pancreatic cancer patients. PMID: 19029836 Ref: cDNA analysis demonstrates that the BRCA2 intronic variant IVS4-12del5 is a deleterious mutation. PMID: 19070627 Ref: Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma. PMID: 19277124 Ref: Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature. PMID: 19433978 Ref: The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer. PMID: 19491823 Ref: Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. PMID: 19690177 Ref: Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells. PMID: 19768832 |
Ref: In situ protein expression of RRM1, ERCC1, and BRCA1 in metastatic breast cancer patients treated with gemcitabine-based chemotherapy. PMID: 19968494 Ref: Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells. PMID: 20455200 Ref: PALB2/FANCN: recombining cancer and Fanconi anemia. PMID: 20858716 Ref: Pancreatic cancer screening in a prospective cohort of high-risk patients: a comprehensive strategy of imaging and genetics. PMID: 20876795 |
Ref: PALB2 analysis in BRCA2-like families. PMID: 20582465 Ref: Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer. PMID: 21135251 Ref: Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. PMID: 21183737 Ref: A novel in vitro pancreatic carcinogenesis model. PMID: 21256203 Ref: Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer. PMID: 21285249 Ref: PALB2 mutations in familial breast and pancreatic cancer. PMID: 21365267 Ref: Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy. PMID: 21613821 Ref: Increased expression of DNA repair genes in invasive human pancreatic cancer cells. PMID: 21633318 Ref: Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. PMID: 22042785 Ref: Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1. PMID: 22134241 |
Ref: Intraductal papillary mucinous neoplasm of the pancreas: associated cancers, family history, genetic predisposition? PMID: 21975290 Ref: Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy. PMID: 21989927 Ref: Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated. PMID: 22166947 Ref: The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. PMID: 22212556 Ref: Molecular and clinical characterization of an in frame deletion of uncertain clinical significance in the BRCA2 gene. PMID: 22228431 Ref: PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. PMID: 22331464 Ref: CDKN2A is the main susceptibility gene in Italian pancreatic cancer families. PMID: 22368299 Ref: Recurrent germline mutations in BRCA1 and BRCA2 genes in high risk families in Israel. PMID: 22399190 Ref: [What management for the asymptomatic men carriers of BRCA1 or 2 mutation? Results of a survey in the French oncogenetic centers]. PMID: 22429936 Ref: AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway. PMID: 22722139 Ref: Genetic testing by cancer site: pancreas. PMID: 22846737 Ref: Associations between BRCA Mutations in High-Risk Breast Cancer Patients and Familial Cancers Other than Breast or Ovary. PMID: 23091540 Ref: The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers. PMID: 23099806 Ref: Inherited pancreatic cancer syndromes. PMID: 23187834 |
Ref: Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. PMID: 23204224 Ref: Risk of pancreatic cancer in breast cancer families from the breast cancer family registry. PMID: 23456555 Ref: Systemic treatment for hereditary cancers: a 2012 update. PMID: 23548133 Ref: Systematic tracking of dysregulated modules identifies novel genes in cancer. PMID: 23613489 Ref: Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. PMID: 23657012 Ref: High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions. PMID: 23658460 Ref: Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer. PMID: 23774697 Ref: Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases. PMID: 23935836 Ref: Network-based analysis of omics with multi-objective optimization. PMID: 24121459 |
Ref: Delineating the effects BRCA1 and BRCA2 loss of heterozygosity in pancreatic cancer progression. PMID: 24147435 Ref: PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. PMID: 24225019 Ref: Characteristics of individuals with breast cancer rearrangements in BRCA1 and BRCA2. PMID: 24522996 Ref: Epigenetic changes associated with neoplasms of the exocrine and endocrine pancreas. PMID: 24534469 Ref: BRCA1 and BRCA2 germline mutations are frequently demonstrated in both high-risk pancreatic cancer screening and pancreatic cancer cohorts. PMID: 24737347 Ref: The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. PMID: 24775809 Ref: [Hereditary predisposition to cancers of the digestive tract, breast, gynecological and gonadal: focus on the Peutz-Jeghers]. PMID: 25036236 Ref: Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. PMID: 25072261 Ref: PARP-inhibitors in BRCA-associated pancreatic cancer. PMID: 25076338 |
Ref: Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian. PMID: 25224030 Ref: BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study. PMID: 25356972 Ref: Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. PMID: 25366685 Ref: Basaloid carcinoma of the pancreas--clinicopathological presentation and oncogenetic snapshot of a rare entity. PMID: 25432630 Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: Analysis of PALB2 in a cohort of Italian breast cancer patients: identification of a novel PALB2 truncating mutation. PMID: 25666743 Ref: Whole genomes redefine the mutational landscape of pancreatic cancer. PMID: 25719666 Ref: Cancer risks in Jewish male BRCA1 and BRCA2 mutation carriers. PMID: 25788227 Ref: Short-term Results of a Magnetic Resonance Imaging-Based Swedish Screening Program for Individuals at Risk for Pancreatic Cancer. PMID: 25853369 Ref: Autoimmune response to PARP and BRCA1/BRCA2 in cancer. PMID: 25865228 Ref: Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial. PMID: 25896973 Ref: BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing. PMID: 25948675 Ref: Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer. PMID: 25987697 Ref: Predicting the Pathogenic Potential of BRCA1 and BRCA2 Gene Variants Identified in Clinical Genetic Testing. PMID: 26052455 Ref: Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines. PMID: 26087898 Ref: Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. PMID: 26098869 Ref: BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. PMID: 26180923 Ref: PanGen-Fam: Spanish registry of hereditary pancreatic cancer. PMID: 26212471 Ref: Pancreatic cancer: BRCA mutation and personalized treatment. PMID: 26402249 Ref: Identification of germline genetic mutations in patients with pancreatic cancer. PMID: 26440929 Ref: MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways. PMID: 26505547 Ref: A mutational signature in gastric cancer suggests therapeutic strategies. PMID: 26511885 |
Ref: Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer. PMID: 26411315 Ref: Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy. PMID: 26439702 Ref: Prevalence of Pathogenic Mutations in Cancer Predisposition Genes among Pancreatic Cancer Patients. PMID: 26483394 Ref: Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. PMID: 26641009 Ref: [Recommended Extension of Indication Criteria for Genetic Testing of BRCA1 and BRCA2 Mutations in Hereditary Breast and Ovarian Cancer Syndrome]. PMID: 26691937 Ref: [Hereditary Breast and Ovarian Cancer Syndrome]. PMID: 26691938 Ref: [PALB2 as Another Candidate Gene for Genetic Testing in Patients with Hereditary Breast Cancer in Czech Republic]. PMID: 26691940 Ref: Biweekly gemcitabine and low-dose cisplatin in the treatment of locally advanced or metastatic pancreatic cancer patients: a single institute experience. PMID: 26696390 Ref: Statewide Retrospective Review of Familial Pancreatic Cancer in Delaware, and Frequency of Genetic Mutations in Pancreatic Cancer Kindreds. PMID: 26727920 Ref: Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches. PMID: 26881472 Ref: Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancreatic Cancer Cells. PMID: 27014871 Ref: Do founder mutations characteristic of some cancer sites also predispose to pancreatic cancer? PMID: 27038244 Ref: Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations. PMID: 27069714 Ref: Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers. PMID: 27114589 Ref: Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers. PMID: 27306910 Ref: Hormone therapy after prophylactic risk-reducing bilateral salpingo-oophorectomy in women who have BRCA gene mutation. PMID: 27426853 Ref: Analysis of Founder Mutations in Rare Tumors Associated With Hereditary Breast/Ovarian Cancer Reveals a Novel Association of BRCA2 Mutations with Ampulla of Vater Carcinomas. PMID: 27532258 Ref: Is it time to split strategies to treat homologous recombinant deficiency in pancreas cancer? PMID: 27747088 Ref: Prevention and Screening in Hereditary Breast and Ovarian Cancer. PMID: 27753056 |
Ref: The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome. PMID: 27488870 Ref: Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer. PMID: 28183138 Ref: Identification, genetic testing, and management of hereditary melanoma. PMID: 28283772 Ref: HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. PMID: 28288110 Ref: BRCA1 missense polymorphisms are associated with poor prognosis of pancreatic cancer patients in a Chinese population. PMID: 28415599 Ref: Application of Panel-Based Tests for Inherited Risk of Cancer. PMID: 28504904 Ref: Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews. PMID: 28754795 Ref: Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. PMID: 28767289 Ref: DNA Repair Dysfunction in Pancreatic Cancer: A Clinically Relevant Subtype for Drug Development. PMID: 28784866 Ref: The Role of PALB2 in the DNA Damage Response and Cancer Predisposition. PMID: 28858227 Ref: Germline mutations in pancreatic cancer and potential new therapeutic options. PMID: 29069866 |
Ref: Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history. PMID: 28726808 Ref: Development of a high risk pancreatic screening clinic using 3.0 T MRI. PMID: 29101607 Ref: Pancreatic cancer screening in high-risk individuals with germline genetic mutations. PMID: 29309780 Ref: Male BRCA mutation carriers: clinical characteristics and cancer spectrum. PMID: 29433453 Ref: Comparison of Practice Guidelines, BRCAPRO, and Genetic Counselor Estimates to Identify Germline BRCA1 and BRCA2 Mutations in Pancreatic Cancer. PMID: 29441441 Ref: Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms. PMID: 29506128 Ref: Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer. PMID: 29731985 Ref: Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer. PMID: 29774075 Ref: Emerging strategies in BRCA-positive pancreatic cancer. PMID: 29777302 Ref: Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. PMID: 29922827 Ref: Mutations in Known and Novel cancer Susceptibility Genes in Young Patients with Pancreatic Cancer. PMID: 29940740 Ref: Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative. PMID: 29954777 Ref: Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. PMID: 29961768 Ref: Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation. PMID: 30051098 Ref: Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts. PMID: 30113427 Ref: Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX. PMID: 30131383 Ref: Chronic pancreatitis changes in high-risk individuals for pancreatic ductal adenocarcinoma. PMID: 30145314 Ref: Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data. PMID: 30246169 Ref: High Prevalence of Hereditary Cancer Syndromes and Outcomes in Adults with Early-Onset Pancreatic Cancer. PMID: 30274973 |