Primary Site >> Colorectal Cancer
Gene >> BMPR2
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Ref: Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. PMID: 14699493 |
Ref: Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. PMID: 17275810 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 |
Ref: The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. PMID: 18008360 Ref: The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. PMID: 18471510 |
Ref: Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability. PMID: 20955454 |
Ref: Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome). PMID: 21165777 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 |
Ref: Genetic variation in bone morphogenetic protein and colon and rectal cancer. PMID: 21387313 |
Ref: Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK. PMID: 24704720 |
Ref: A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. PMID: 26072521 Ref: Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation. PMID: 26247575 |
Ref: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. PMID: 28061442 Ref: Statin Use After Diagnosis of Colon Cancer and Patient Survival. PMID: 28512021 |