Primary Site >> Colorectal Cancer
Gene >> BID
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Ref: Clinical development of eniluracil: current status. PMID: 9830627 |
Ref: Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study. PMID: 10715306 |
Ref: Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. PMID: 11245478 Ref: Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. PMID: 11494135 |
Ref: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). PMID: 11912124 Ref: Phase II study of capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancer. PMID: 11919232 Ref: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. PMID: 12203115 Ref: Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. PMID: 12351595 Ref: Defining characteristics of Types I and II apoptotic cells in response to TRAIL. PMID: 12407450 |
Ref: The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. PMID: 12482325 Ref: Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. PMID: 12649185 Ref: Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. PMID: 12660816 Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis. PMID: 12730681 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 |
Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. PMID: 15024076 Ref: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. PMID: 15155747 Ref: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis. PMID: 15219941 Ref: A phase I clinical and pharmacokinetic study of Ro 31-7453 given as a 7- or 14-day oral twice daily schedule every 4 weeks in patients with solid tumors. PMID: 15240525 Ref: Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. PMID: 15259066 Ref: Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. PMID: 15312680 Ref: Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis. PMID: 15527805 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 Ref: Apoptosis inducing effects of 6-methoxydihydrosanguinarine in HT29 colon carcinoma cells. PMID: 15646800 |
Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines. PMID: 15688023 Ref: A phase I study of 5-fluorouracil, leucovorin, and celecoxib in patients with incurable colorectal cancer. PMID: 15789623 Ref: HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. PMID: 15846298 Ref: Biweekly oxaliplatin combined with oral capecitabine (OXXEL regimen) as first-line treatment of metastatic colorectal cancer patients: a Southern Italy Cooperative Oncology Group phase II study. PMID: 15902461 Ref: Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. PMID: 15918186 Ref: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. PMID: 15929791 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Characteristics of apoptosis in HCT116 colon cancer cells induced by deoxycholic acid. PMID: 16091589 Ref: TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. PMID: 16157217 Ref: Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies. PMID: 16314634 |
Ref: Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. PMID: 16617056 Ref: Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. PMID: 16886631 Ref: Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines. PMID: 17012835 Ref: [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. PMID: 17086696 |
Ref: Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. PMID: 17182797 Ref: Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. PMID: 17273769 Ref: Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells. PMID: 17431792 Ref: 4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line. PMID: 17436592 Ref: 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. PMID: 17513605 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. PMID: 17645780 Ref: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. PMID: 17673978 Ref: Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. PMID: 17876056 Ref: A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers. PMID: 17897953 Ref: A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule. PMID: 17922560 |
Ref: Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). PMID: 18084318 Ref: Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. PMID: 18377873 Ref: A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours. PMID: 18414469 Ref: The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis. PMID: 18437576 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: Proapoptotic Bad and Bid protein expression predict survival in stages II and III colon cancers. PMID: 18593990 Ref: Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer. PMID: 18648372 Ref: Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. PMID: 18726190 Ref: [Overcoming acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand by Bcl-XL small interfering RNA in human colon cancer]. PMID: 18788624 Ref: Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. PMID: 18955103 |
Ref: Phase I trial of neoadjuvant chemoradiotherapy (CRT) with capecitabine and weekly irinotecan followed by laparoscopic total mesorectal excision (LTME) in rectal cancer patients. PMID: 18923810 Ref: Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain. PMID: 19014919 Ref: Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. PMID: 19054763 Ref: Sodium butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNF-alpha-dependent extrinsic apoptosis. PMID: 19130237 Ref: Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. PMID: 19219602 Ref: Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. PMID: 19232820 Ref: S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells. PMID: 19372210 Ref: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. PMID: 19426686 Ref: Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells. PMID: 19446247 Ref: Anti-proliferative effects of Lethariella zahlbruckneri extracts in human HT-29 human colon cancer cells. PMID: 19501127 Ref: A putative role for human BFK in DNA damage-induced apoptosis. PMID: 19557800 Ref: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. PMID: 19638488 Ref: Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells. PMID: 19845353 |
Ref: Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. PMID: 19577358 Ref: A phase I study of capecitabine, irinotecan, celecoxib, and radiation as neoadjuvant therapy of patients with locally advanced rectal cancer. PMID: 19806036 Ref: Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. PMID: 20107900 Ref: Role of fatty acid chain length on the induction of apoptosis by newly synthesized catechin derivatives. PMID: 20206613 Ref: Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. PMID: 20664949 Ref: Fucoidan present in brown algae induces apoptosis of human colon cancer cells. PMID: 20727207 Ref: Correlation between Mcl-1 and pAKT protein expression in colorectal cancer. PMID: 21151390 Ref: Aloe-emodin, an anthraquinone, in vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells. PMID: 22966340 |
Ref: Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. PMID: 21107704 Ref: Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer. PMID: 21516509 Ref: The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. PMID: 21524306 Ref: Effects of alpha-mangostin on apoptosis induction of human colon cancer. PMID: 21547127 Ref: Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. PMID: 21557998 Ref: Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells. PMID: 21737934 Ref: Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. PMID: 21779837 |
Ref: PEG-liposomal oxaliplatin induces apoptosis in human colorectal cancer cells via Fas/FasL and caspase-8. PMID: 21888623 Ref: Phase I trial of sorafenib in combination with 5-fluorouracil/leucovorin in advanced solid tumors. PMID: 22232731 Ref: A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. PMID: 22269384 Ref: Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. PMID: 22579651 Ref: (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation. PMID: 22791152 Ref: Effect of beta,beta-dimethylacrylshikonin on inhibition of human colorectal cancer cell growth in vitro and in vivo. PMID: 22942759 Ref: Stichoposide C induces apoptosis through the generation of ceramide in leukemia and colorectal cancer cells and shows in vivo antitumor activity. PMID: 23132899 |
Ref: Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer. PMID: 23647753 Ref: Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction. PMID: 23660334 Ref: hClock gene expression in human colorectal carcinoma. PMID: 23970287 Ref: Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells. PMID: 23973282 Ref: Midazolam induces cellular apoptosis in human cancer cells and inhibits tumor growth in xenograft mice. PMID: 24008365 Ref: Diffusion-weighted magnetic resonance imaging for predicting the response of rectal cancer to neoadjuvant concurrent chemoradiation. PMID: 24023496 |
Ref: Down-regulation of BAX gene during carcinogenesis and acquisition of resistance to 5-FU in colorectal cancer. PMID: 24122668 Ref: The fermented non-digestible fraction of common bean (Phaseolus vulgaris L.) triggers cell cycle arrest and apoptosis in human colon adenocarcinoma cells. PMID: 24293398 Ref: Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. PMID: 24549175 Ref: Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways. PMID: 24573532 Ref: Mortality of major cancers in Guangxi, China: sex, age and geographical differences from 1971 and 2005. PMID: 24641369 Ref: Laminarin-induced apoptosis in human colon cancer LoVo cells. PMID: 24765209 Ref: Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. PMID: 24957706 Ref: Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway. PMID: 25113506 Ref: NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide. PMID: 25168151 Ref: Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial). PMID: 25421252 |
Ref: Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis. PMID: 25232032 Ref: Dihydroartemisinin-Induced Apoptosis is Associated with Inhibition of Sarco/Endoplasmic Reticulum Calcium ATPase Activity in Colorectal Cancer. PMID: 25701954 Ref: Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. PMID: 25761243 Ref: New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. PMID: 26235743 |
Ref: Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells. PMID: 26751572 Ref: Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. PMID: 27053107 Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line. PMID: 27070314 Ref: Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. PMID: 27098859 Ref: Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. PMID: 27221553 Ref: Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. PMID: 27268964 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. PMID: 27447597 Ref: Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. PMID: 27464624 Ref: Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. PMID: 27622714 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 |
Ref: Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. PMID: 27959417 Ref: miR-20a-directed regulation of BID is associated with the TRAIL sensitivity in colorectal cancer. PMID: 28004114 Ref: CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PMID: 28068431 |
Ref: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. PMID: 28438053 Ref: A Case of Capecitabine-induced Hyperammonemia in a Patient with Colon Cancer. PMID: 28782476 Ref: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-alpha-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. PMID: 29115534 Ref: A Phase I Study of Irinotecan, Capecitabine (Xeloda), and Oxaliplatin in Patients With Advanced Colorectal Cancer. PMID: 29330005 Ref: Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase II study. PMID: 29375747 Ref: Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. PMID: 29423046 Ref: Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen). PMID: 29464799 Ref: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. PMID: 29531808 Ref: Reactive oxygen species-mediated phosphorylation of p38 signaling is critically involved in apoptotic effect of Tanshinone I in colon cancer cells. PMID: 29876988 Ref: Randomized, double-blind, phase two study of ruxolitinib plus regorafenib in patients with relapsed/refractory metastatic colorectal cancer. PMID: 30123970 Ref: Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. PMID: 30130653 |