Primary Site >> Colorectal Cancer
Gene >> BECN1
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Ref: [Analysis of cell cycle inhibition by novel tumor suppressor gene Beclin 1 in human colon cancer cells]. PMID: 14574891 |
Ref: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. PMID: 16799551 |
Ref: Somatic mutations of BECN1, an autophagy-related gene, in human cancers. PMID: 17550384 Ref: Beclin 1 gene inhibits tumor growth in colon cancer cell lines. PMID: 17595761 Ref: Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. PMID: 18184403 |
Ref: Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. PMID: 18048384 Ref: Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. PMID: 18495205 |
Ref: The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. PMID: 19066461 Ref: Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. PMID: 19483104 Ref: Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy. PMID: 19765849 Ref: Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis. PMID: 20130808 |
Ref: Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PMID: 20090905 Ref: Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. PMID: 20536712 Ref: Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. PMID: 20842118 Ref: Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. PMID: 20876807 |
Ref: Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. PMID: 21444671 Ref: Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells. PMID: 21538483 Ref: Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. PMID: 21763418 Ref: L-securinine induced the human colon cancer SW480 cell autophagy and its molecular mechanism. PMID: 21907765 Ref: Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer. PMID: 22147978 |
Ref: Direct molecular interactions between HMGB1 and TP53 in colorectal cancer. PMID: 22647615 Ref: Autophagy is active in normal colon mucosa. PMID: 22652752 Ref: DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. PMID: 22719072 Ref: Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PMID: 23226467 |
Ref: Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation. PMID: 23088850 Ref: Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. PMID: 23461901 Ref: Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse. PMID: 23589074 Ref: Downregulation of Beclin 1 and impairment of autophagy in a small population of colorectal cancer. PMID: 23812859 Ref: A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. PMID: 23907464 Ref: BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production. PMID: 24322755 |
Ref: Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. PMID: 24309100 Ref: VMP1 related autophagy and apoptosis in colorectal cancer cells: VMP1 regulates cell death. PMID: 24365149 Ref: Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. PMID: 24486574 Ref: Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PMID: 24587252 Ref: Absence of autophagy-related proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma. PMID: 24723943 Ref: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. PMID: 24733045 Ref: Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. PMID: 24956373 Ref: Prognostic significance of Beclin-1 expression in colorectal cancer: a meta-analysis. PMID: 24969889 Ref: Novel diet-related mouse model of colon cancer parallels human colon cancer. PMID: 25024814 Ref: Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells. PMID: 25156145 Ref: Beclin 1 expression is closely linked to colorectal carcinogenesis and distant metastasis of colorectal carcinoma. PMID: 25196438 Ref: Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. PMID: 25356873 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 |
Ref: Modulation of imatinib cytotoxicity by selenite in HCT116 colorectal cancer cells. PMID: 24930392 Ref: High expression of Beclin-1 predicts favorable prognosis for patients with colorectal cancer. PMID: 25130795 Ref: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. PMID: 25216025 Ref: Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells. PMID: 25427639 Ref: Sann-Joong-Kuey-Jian-Tang decreases the protein expression of mammalian target of rapamycin but increases microtubule associated protein II light chain 3 expression to inhibit human BxPC3 pancreatic carcinoma cells. PMID: 25516264 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Association of beclin 1 expression with response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal carcinoma. PMID: 25708267 Ref: BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. PMID: 25715028 Ref: Autophagy-based survival prognosis in human colorectal carcinoma. PMID: 25762626 Ref: Differential regulation of autophagy and cell viability by ceramide species. PMID: 25803131 Ref: Chloroquine-enhanced efficacy of cisplatin in the treatment of hypopharyngeal carcinoma in xenograft mice. PMID: 25923669 Ref: Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. PMID: 26097572 Ref: Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. PMID: 26306675 Ref: Autophagy-related genes Raptor, Rictor, and Beclin1 expression and relationship with multidrug resistance in colorectal carcinoma. PMID: 26363527 Ref: Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling. PMID: 26585594 Ref: Autophagy in colorectal cancer: An important switch from physiology to pathology. PMID: 26600927 |
Ref: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. PMID: 26802026 Ref: Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. PMID: 26821367 Ref: miR-409-3p sensitizes colon cancer cells to oxaliplatin by inhibiting Beclin-1-mediated autophagy. PMID: 26935807 Ref: Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo. PMID: 27020593 Ref: Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice. PMID: 27085036 Ref: Colorectal cancer cells are resistant to anti-EGFR monoclonal antibody through adapted autophagy. PMID: 27158405 Ref: Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer. PMID: 27173217 Ref: RNF216 contributes to proliferation and migration of colorectal cancer via suppressing BECN1-dependent autophagy. PMID: 27203674 Ref: Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. PMID: 27444698 Ref: Co-expression of autophagic markers following photodynamic therapy in SW620 human colon adenocarcinoma cells. PMID: 27485939 Ref: ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. PMID: 27559856 Ref: Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. PMID: 27748934 Ref: miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts. PMID: 27793031 |
Ref: Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells. PMID: 27737524 Ref: The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer. PMID: 28035578 Ref: AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. PMID: 28103582 Ref: Role of the pretreatment (18)F-fluorodeoxyglucose positron emission tomography maximal standardized uptake value in predicting outcomes of colon liver metastases and that value's association with Beclin-1 expression. PMID: 28250335 Ref: Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines. PMID: 28560460 Ref: Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis. PMID: 28651493 Ref: Beclin 1 and LC3 as predictive biomarkers for metastatic colorectal carcinoma. PMID: 28938618 Ref: The preclinical analysis of TW-37 as a potential anti-colorectal cancer cell agent. PMID: 29065135 Ref: Phosphoinositide-specific phospholipase Cgamma1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells. PMID: 29066806 Ref: Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells. PMID: 29088823 Ref: Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. PMID: 29245915 Ref: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. PMID: 29273065 Ref: Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26. PMID: 29457036 |
Ref: Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC. PMID: 28294332 Ref: In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells. PMID: 29174024 Ref: Hyperthermia enhances radiosensitivity of colorectal cancer cells through ROS inducing autophagic cell death. PMID: 29240246 Ref: Codonopis bulleynana Forest ex Diels inhibits autophagy and induces apoptosis of colon cancer cells by activating the NF-kappaB signaling pathway. PMID: 29286074 Ref: Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells. PMID: 29355734 Ref: Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner. PMID: 29492901 Ref: Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex. PMID: 29669822 Ref: Knockdown of Beclin-1 impairs epithelial-mesenchymal transition of colon cancer cells. PMID: 29738069 Ref: Blue light-emitting diodes induce autophagy in colon cancer cells by Opsin 3. PMID: 29863164 Ref: Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy inhibition enhances the artesunateinduced apoptosis. PMID: 29901098 Ref: miR-212 and mTOR form a regulation loop to modulate autophagy in colorectal adenoma HT-29 cells. PMID: 30021100 Ref: Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity. PMID: 30091749 Ref: Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively. PMID: 30148861 Ref: Neratinib augments the lethality of [regorafenib + sildenafil]. PMID: 30203445 Ref: Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells. PMID: 30322062 |