Primary Site >> Colorectal Cancer
Gene >> BCL2L11
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Ref: The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. PMID: 15767553 |
Ref: Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver. PMID: 18806828 Ref: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. PMID: 19088028 |
Ref: Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models. PMID: 19174560 Ref: Relative resistance of SGK1 knockout mice against chemical carcinogenesis. PMID: 19548318 Ref: RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells. PMID: 19571605 Ref: Differentiation-related gene-1 decreases Bim stability by proteasome-mediated degradation. PMID: 19622774 Ref: A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. PMID: 19767770 |
Ref: The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. PMID: 20348947 Ref: CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. PMID: 20877573 |
Ref: Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. PMID: 21454688 Ref: miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer. PMID: 21883694 |
Ref: Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055). PMID: 22271687 Ref: MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells. PMID: 22322955 Ref: The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. PMID: 22399804 |
Ref: Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. PMID: 22308110 Ref: The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance. PMID: 23234544 Ref: Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling. PMID: 23441183 Ref: [Role of BH3-only gene in the oxaliplatin-induced apoptosis of colon cancer cells]. PMID: 23801206 Ref: The effects of silencing of PI3K p85alpha on 5-FU-induced colorectal cancer cells apoptosis. PMID: 23990352 Ref: [Relationship between PUMA and BIM expression in colorectal cancer and tumor invasion, metastasis and prognosis]. PMID: 24091272 |
Ref: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. PMID: 24163374 Ref: Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38alpha modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. PMID: 24215867 Ref: Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. PMID: 24495951 Ref: Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3. PMID: 24685132 Ref: Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. PMID: 24825889 Ref: Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells. PMID: 25289048 |
Ref: miRNA expression in human intestinal Caco-2 cells is comparably regulated by cis- and trans-fatty acids. PMID: 25612549 Ref: The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. PMID: 26245900 |
Ref: Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress. PMID: 26832792 Ref: Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. PMID: 26871659 Ref: In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. PMID: 26915975 Ref: Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. PMID: 27098859 Ref: Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. PMID: 27268964 Ref: Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. PMID: 27277338 |
Ref: DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal cancer. PMID: 28782576 Ref: Aurora kinase A inhibitor TCS7010 demonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells. PMID: 29163689 |
Ref: Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. PMID: 29274585 Ref: Food Additive Sodium Benzoate (NaB) Activates NFkappaB and Induces Apoptosis in HCT116 Cells. PMID: 29565269 Ref: POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. PMID: 29573636 Ref: Effects of miR-223 on colorectal cancer cell proliferation and apoptosis through regulating FoxO3a/BIM. PMID: 29949152 Ref: Knockdown of Mir-135b Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Apoptosis Through Increase of FOXO1. PMID: 30071508 |