Primary Site >> Colorectal Cancer
Gene >> BCL2L1
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Ref: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. PMID: 8625322 Ref: Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells. PMID: 9000137 Ref: The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. PMID: 9003774 |
Ref: Expression of bcl-2, bax, and bcl-XL proteins in azoxymethane-induced rat colonic adenocarcinomas. PMID: 9180925 |
Ref: Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. PMID: 9443418 Ref: 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. PMID: 9792140 Ref: Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells. PMID: 9829751 Ref: Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. PMID: 9881495 Ref: Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells. PMID: 9881700 Ref: A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin. PMID: 9914786 Ref: Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. PMID: 10200499 |
Ref: Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. PMID: 10023006 |
Ref: Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. PMID: 10786699 Ref: Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. PMID: 10811474 Ref: Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. PMID: 10919656 Ref: Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. PMID: 10944610 Ref: Bcl-X(L) antisense sensitizes human colon cancer cell line to 5-fluorouracil. PMID: 10965024 Ref: Heterodimerization of Bcl-2 and Bcl-X(L) with Bax and Bad in colorectal cancer. PMID: 11041112 Ref: Role of BAX in the apoptotic response to anticancer agents. PMID: 11062132 Ref: Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). PMID: 11077039 |
Ref: Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. PMID: 11259472 Ref: c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings. PMID: 11290547 Ref: 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. PMID: 11300326 Ref: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. PMID: 11396178 Ref: Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. PMID: 11478840 Ref: Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. PMID: 11484952 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 Ref: Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells. PMID: 11487584 Ref: Expression of alpha-catenin in alpha-catenin-deficient cells increases resistance to sphingosine-induced apoptosis. PMID: 11489917 Ref: Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. PMID: 11557285 Ref: Synergistic interaction between topotecan and microtubule-interfering agents. PMID: 11592339 |
Ref: Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins. PMID: 11756218 Ref: Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. PMID: 11896073 Ref: Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells. PMID: 11906168 Ref: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). PMID: 11912124 Ref: Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines. PMID: 11918083 Ref: Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. PMID: 11920608 Ref: Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape. PMID: 12033956 Ref: Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells. PMID: 12131661 Ref: Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. PMID: 12215894 Ref: Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. PMID: 12384529 |
Ref: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. PMID: 12471619 Ref: Butyrate induced Caco-2 cell apoptosis is mediated via the mitochondrial pathway. PMID: 12477768 Ref: The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. PMID: 12482325 Ref: Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. PMID: 12512030 Ref: Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. PMID: 12663524 Ref: Co-expression of bfl-1 enhances host response in the herpes simplex virus-thymidine kinase/ganciclovir gene therapy system. PMID: 12670475 Ref: Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. PMID: 12670866 Ref: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. PMID: 12818369 Ref: Induction of apoptosis by hydroxydibenzoylmethane through coordinative modulation of cyclin D3, Bcl-X(L), and Bax, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 12822933 Ref: Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis. PMID: 12837981 Ref: 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. PMID: 12842827 Ref: Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. PMID: 12855666 Ref: Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. PMID: 12866025 Ref: Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK. PMID: 12898509 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. PMID: 12934082 Ref: Bcl-x(L) antisense oligonucleotides radiosensitise colon cancer cells. PMID: 14520471 Ref: Direct effects of octreotide, galanin and serotonin on human colon cancer cells. PMID: 14534685 Ref: Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL. PMID: 14551511 Ref: [Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma]. PMID: 14613639 Ref: Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. PMID: 14633695 Ref: Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents. PMID: 14645680 Ref: Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin. PMID: 14695155 |
Ref: Transcriptional regulation of TNF family receptors and Bcl-2 family by chemotherapeutic agents in murine CT26 cells. PMID: 14743399 Ref: Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. PMID: 14754875 Ref: Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. PMID: 14760102 Ref: Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. PMID: 14871845 Ref: Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect. PMID: 14985457 Ref: Inactivating mutations of proapoptotic Bad gene in human colon cancers. PMID: 15033904 Ref: Role of caspase activation in butyrate-induced terminal differentiation of HT29 colon carcinoma cells. PMID: 15047183 Ref: LIGHT sensitizes IFN-gamma-mediated apoptosis of HT-29 human carcinoma cells through both death receptor and mitochondria pathways. PMID: 15115612 Ref: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. PMID: 15122344 Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 Ref: CD44 negatively regulates apoptosis in murine colonic epithelium via the mitochondrial pathway. PMID: 15126101 Ref: Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. PMID: 15162527 Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 Ref: CD44 promotes resistance to apoptosis in human colon cancer cells. PMID: 15215046 Ref: Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. PMID: 15259066 Ref: IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. PMID: 15284182 Ref: Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. PMID: 15314290 Ref: Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. PMID: 15326164 Ref: Angiotensin II activates MAP kinase and NF-kappaB through angiotensin II type I receptor in human pancreatic cancer cells. PMID: 15375532 Ref: Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 15453709 Ref: Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue. PMID: 15484295 Ref: Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats. PMID: 15522837 Ref: Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. PMID: 15572300 Ref: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. PMID: 15604280 |
Ref: Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. PMID: 15365767 Ref: The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein. PMID: 15467762 Ref: Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. PMID: 15596295 Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. PMID: 15711178 Ref: Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells. PMID: 15767554 Ref: Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer. PMID: 15770735 Ref: Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. PMID: 15824729 Ref: alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation. PMID: 15843897 Ref: Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. PMID: 15914572 Ref: Oxaliplatin, a potent inhibitor of survivin, enhances paclitaxel-induced apoptosis and mitotic catastrophe in colon cancer cells. PMID: 16024531 Ref: Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. PMID: 16049281 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. PMID: 16083714 Ref: Bcl-xL/Bax ratio is altered by IFNgamma in TNFalpha- but not in TRAIL-induced apoptosis in colon cancer cell line. PMID: 16085058 Ref: Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. PMID: 16127422 Ref: Novel rapid tissue lysis method to evaluate cancer proteins: correlation between elevated Bcl-X(L) expression and colorectal cancer cell proliferation. PMID: 16127746 Ref: Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. PMID: 16129903 Ref: Enterolactone induces apoptosis and inhibits growth of Colo 201 human colon cancer cells both in vitro and in vivo. PMID: 16158974 Ref: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. PMID: 16192633 Ref: Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. PMID: 16204024 Ref: [Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway]. PMID: 16321305 |
Ref: Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. PMID: 16082389 Ref: Antitumor activity and downregulation of pro-angiogenic molecules in human prostate cancer cells by a novel thiazolidione compound. PMID: 16302260 Ref: An overview of apoptosis and the prevention of colorectal cancer. PMID: 16326109 Ref: Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. PMID: 16401477 Ref: Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. PMID: 16407826 Ref: The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. PMID: 16426830 Ref: Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. PMID: 16497702 Ref: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. PMID: 16500682 Ref: Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family members. PMID: 16574665 Ref: PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. PMID: 16608847 Ref: Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis. PMID: 16612624 Ref: A "field change" of inhibited apoptosis occurs in colorectal mucosa adjacent to colorectal adenocarcinoma. PMID: 16679352 Ref: Differential expression of Bcl-2, Bcl-XL and p53 in colorectal cancer. PMID: 16824061 Ref: p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). PMID: 16863993 Ref: Anticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts. PMID: 16894569 Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 Ref: Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells. PMID: 17016662 Ref: 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. PMID: 17085668 Ref: [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. PMID: 17086696 Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 Ref: Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. PMID: 17106246 Ref: Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. PMID: 17201150 Ref: Insulin-like growth factor-I receptor correlates with connexin 26 and Bcl-xL expression in human colorectal cancer. PMID: 17384270 |
Ref: Efficient tumor cell lysis mediated by a Bcl-X(L) specific T cell clone isolated from a breast cancer patient. PMID: 16850344 Ref: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. PMID: 16901994 Ref: Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells. PMID: 17186548 Ref: Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. PMID: 17258704 Ref: STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. PMID: 17264243 Ref: Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model. PMID: 17273826 Ref: Early apoptosis and cell death induced by ATX-S10Na (II)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells. PMID: 17278191 Ref: Down-regulation of PGE2 by physiologic levels of celecoxib is not sufficient to induce apoptosis or inhibit cell proliferation in human colon carcinoma cell lines. PMID: 17342386 Ref: Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines. PMID: 17389773 Ref: Significant coexpression of GLUT-1, Bcl-xL, and Bax in colorectal cancer. PMID: 17404017 Ref: Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. PMID: 17472962 Ref: The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL. PMID: 17490506 Ref: Cumulative expression of HIF-1-alpha, Bax, Bcl-xL and P53 in human colorectal cancer. PMID: 17558861 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. PMID: 17597109 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. PMID: 17609769 Ref: Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. PMID: 17645780 Ref: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. PMID: 17673978 |
Ref: Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins. PMID: 17936584 Ref: The role of signal transducers and activators of transcription in colon cancer. PMID: 17981761 Ref: Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. PMID: 18160396 Ref: Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells. PMID: 18200666 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. PMID: 18339878 Ref: Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. PMID: 18381954 Ref: 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. PMID: 18384088 Ref: Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer. PMID: 18388920 Ref: Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. PMID: 18455702 Ref: Significance of Bcl-xL in human colon carcinoma. PMID: 18494061 Ref: Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. PMID: 18521906 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. PMID: 18608213 Ref: Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. PMID: 18609706 Ref: [Overcoming acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand by Bcl-XL small interfering RNA in human colon cancer]. PMID: 18788624 Ref: Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation. PMID: 18789402 Ref: Evaluation of the immunohistochemical stain patterns of survivin, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon. PMID: 18795671 Ref: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. PMID: 18802399 Ref: Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. PMID: 18849542 Ref: NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells. PMID: 19003586 Ref: Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. PMID: 19088028 Ref: Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. PMID: 19568915 |
Ref: Immunosensitization with a Bcl-2 small molecule inhibitor. PMID: 18807035 Ref: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. PMID: 19038304 Ref: Antiproliferation and apoptosis on RKO colon cancer by Millingtonia hortensis. PMID: 19083098 Ref: In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF. PMID: 19105980 Ref: Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. PMID: 19116755 Ref: Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. PMID: 19119184 Ref: Sodium butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNF-alpha-dependent extrinsic apoptosis. PMID: 19130237 Ref: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. PMID: 19148542 Ref: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. PMID: 19154411 Ref: HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. PMID: 19179333 Ref: Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. PMID: 19219602 Ref: Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. PMID: 19229860 Ref: S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells. PMID: 19372210 Ref: Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. PMID: 19380879 Ref: Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. PMID: 19423215 Ref: A putative role for human BFK in DNA damage-induced apoptosis. PMID: 19557800 Ref: In vitro studies on the inhibition of colon cancer by butyrate and carnitine. PMID: 19619983 Ref: Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. PMID: 19623659 Ref: A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways. PMID: 19644355 Ref: Transforming growth factor-beta1 and regulators of apoptosis. PMID: 19723045 Ref: Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. PMID: 19735099 Ref: Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. PMID: 19735878 Ref: A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. PMID: 19767770 Ref: TNF-alpha downregulates E-cadherin and sensitizes response to gamma-irradiation in Caco-2 cells. PMID: 19809566 Ref: Immunoglobulin kappa and immunoglobulin lambda are required for expression of the anti-apoptotic molecule Bcl-xL in human colorectal cancer tissue. PMID: 19883274 |
Ref: Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. PMID: 19139819 Ref: Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. PMID: 19900450 Ref: Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. PMID: 19921695 Ref: Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X(L) in colorectal cancer cells. PMID: 20039318 Ref: Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PMID: 20090905 Ref: Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. PMID: 20104024 Ref: PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. PMID: 20150631 Ref: Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. PMID: 20371690 Ref: Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. PMID: 20392997 Ref: Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells. PMID: 20534983 Ref: Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1. PMID: 20653974 Ref: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. PMID: 20682650 Ref: Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. PMID: 20726007 Ref: The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway. PMID: 20727916 Ref: Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PMID: 20808790 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: Suberoylanilide hydroxamic acid induces apoptosis and sub-G1 arrest of 320 HSR colon cancer cells. PMID: 20846458 Ref: GLUT1 and Bcl-xL in relation to erythropoietin in human colorectal adenocarcinomas. PMID: 21033220 Ref: [Effect of APRIL on growth and apoptosis in transplanted tumor with human colorectal cancer cell line SW480 in nude mice]. PMID: 21122406 Ref: Correlation between Mcl-1 and pAKT protein expression in colorectal cancer. PMID: 21151390 Ref: Establishment and characterization of irinotecan-resistant human non-small cell lung cancer A549 cells. PMID: 21472350 |
Ref: Bcl-2 family interaction with the mitochondrial morphogenesis machinery. PMID: 20671748 Ref: Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. PMID: 20886344 Ref: Zebrafish stem cell differentiation stage factors suppress Bcl-xL release and enhance 5-Fu-mediated apoptosis in colon cancer cells. PMID: 21043999 Ref: Apoptosis-inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. PMID: 21122037 Ref: Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cells. PMID: 21161336 Ref: CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53. PMID: 21240465 Ref: TNFalpha cooperates with IFN-gamma to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis. PMID: 21264227 Ref: Prognostic significance of Bcl-xL gene expression in human colorectal cancer. PMID: 21277008 Ref: ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PMID: 21347233 Ref: miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. PMID: 21354697 Ref: Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. PMID: 21370894 Ref: Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status. PMID: 21380817 Ref: Oxaliplatin sensitizes human colon cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL. PMID: 21683075 Ref: Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. PMID: 21826595 Ref: Novel selective Cox-2 inhibitors induce apoptosis in Caco-2 colorectal carcinoma cell line. PMID: 21939759 Ref: Adenovirus-mediated siRNA targeting Bcl-xL inhibits proliferation, reduces invasion and enhances radiosensitivity of human colorectal cancer cells. PMID: 21970601 Ref: Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis. PMID: 21980434 Ref: The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells. PMID: 22006676 Ref: STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells. PMID: 22074823 Ref: Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer. PMID: 22171132 |
Ref: Re: Prognostic significance of Bcl-xL gene expression in human colorectal cancer. PMID: 21439611 Ref: Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice. PMID: 21544082 Ref: Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. PMID: 21702037 Ref: Apoptotic proteins as prognostic markers and indicators of radiochemosensitivity in stage II/III rectal cancers. PMID: 21848899 Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats. PMID: 21956158 Ref: BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. PMID: 22009326 Ref: shRNA against CD44 inhibits cell proliferation, invasion and migration, and promotes apoptosis of colon carcinoma cells. PMID: 22076607 Ref: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA. PMID: 22170570 Ref: MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PMID: 22235338 Ref: The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response. PMID: 22342343 Ref: Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PMID: 22389673 Ref: [Anti-tumor effect of adenovirus-mediated Bcl-XL shRNA in vitro]. PMID: 22454181 Ref: Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo. PMID: 22461695 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. PMID: 22552631 Ref: Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. PMID: 22592084 Ref: Deguelin, an Akt inhibitor, down-regulates NF-kappaB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. PMID: 22623043 Ref: Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. PMID: 22832932 Ref: Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses. PMID: 22869582 Ref: Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation. PMID: 22895172 Ref: AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells. PMID: 22922496 Ref: Effect of beta,beta-dimethylacrylshikonin on inhibition of human colorectal cancer cell growth in vitro and in vivo. PMID: 22942759 Ref: Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. PMID: 22965228 Ref: The role of Bcl-xL in synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia on human colon cancer. PMID: 23051936 Ref: Suppressing the growth of rectal cancer xenografts derived from patient tumors by an adenovector expressing small hairpin RNA targeting Bcl-XL. PMID: 23169477 Ref: Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. PMID: 23193914 Ref: [Detection and clinical significance of apoptosis related protein in local advanced rectal cancer patients with preoperative neoadjuvant therapy]. PMID: 23302463 |
Ref: Oncogenic RAS simultaneously protects against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR signaling blockade. PMID: 22797062 Ref: MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. PMID: 22824797 Ref: Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. PMID: 23135489 Ref: Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. PMID: 23188704 Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 Ref: T-18, a stemonamide synthetic intermediate inhibits Pim kinase activity and induces cell apoptosis, acting as a potent anticancer drug. PMID: 23314349 Ref: Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. PMID: 23353574 Ref: External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-kB and induces cell cycle arrest and apoptosis in colorectal cancer cells. PMID: 23363659 Ref: IL-22 is related to development of human colon cancer by activation of STAT3. PMID: 23379788 Ref: Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways. PMID: 23451189 Ref: Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. PMID: 23514434 Ref: The novel BH3 alpha-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. PMID: 23680104 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: 2-deprenyl-rheediaxanthone B isolated from Metaxya rostrata induces active cell death in colorectal tumor cells. PMID: 23776538 Ref: HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells. PMID: 23840275 Ref: Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. PMID: 23848964 Ref: Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells. PMID: 23887890 Ref: The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. PMID: 23983126 Ref: Midazolam induces cellular apoptosis in human cancer cells and inhibits tumor growth in xenograft mice. PMID: 24008365 Ref: Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells. PMID: 24013390 Ref: Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737. PMID: 24030153 Ref: Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. PMID: 24055891 Ref: [Study on functions and mechanism of curcumin in inducing colorectal carcinoma cells LoVo apoptosis]. PMID: 24079252 Ref: Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. PMID: 24098503 Ref: Characterization of oleanolic acid derivative for colon cancer targeting with positron emission tomography. PMID: 24219340 Ref: Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells. PMID: 24317430 Ref: ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-kappaB pathway. PMID: 24335275 Ref: Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. PMID: 24399733 |
Ref: Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NFkappaB. PMID: 24173769 Ref: Total alkaloids of Tripterygium hypoglaucum (levl.) Hutch inhibits tumor growth both in vitro and in vivo. PMID: 24212079 Ref: Expression of apoptosis regulating proteins identifies stage II and III colon cancer patients with high risk of recurrence. PMID: 24249458 Ref: Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. PMID: 24412611 Ref: Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. PMID: 24481553 Ref: Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells. PMID: 24484372 Ref: Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. PMID: 24486574 Ref: Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. PMID: 24556425 Ref: Bax protein may influence the invasion of colorectal cancer. PMID: 24574804 Ref: Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells. PMID: 24682005 Ref: Flavonoids identified from Korean Scutellaria baicalensis induce apoptosis by ROS generation and caspase activation on human fibrosarcoma cells. PMID: 24707875 Ref: LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells. PMID: 24789370 Ref: Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells. PMID: 24812029 Ref: Cracking the cytotoxicity code: apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction. PMID: 24857964 Ref: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. PMID: 24890449 Ref: Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. PMID: 24892549 Ref: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. PMID: 24930757 Ref: Expression of apoptotic proteins in human colorectal cancer and metastatic lymph nodes. PMID: 24939147 Ref: Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells. PMID: 25008568 Ref: Cytotoxicity of Eupatorium cannabinum L. ethanolic extract against colon cancer cells and interactions with Bisphenol A and Doxorubicin. PMID: 25056133 Ref: 6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells. PMID: 25066282 Ref: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. PMID: 25096910 Ref: Variable NF-kappaB pathway responses in colon cancer cells treated with chemotherapeutic drugs. PMID: 25134433 Ref: Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells. PMID: 25156145 Ref: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. PMID: 25187386 Ref: Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PMID: 25192188 Ref: EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. PMID: 25198428 Ref: Methanol extract of Flacourtia indica aerial parts induces apoptosis via generation of ROS and activation of caspases in human colon cancer HCT116 cells. PMID: 25227831 Ref: Synergistic association of Notch and NFkappaB signaling and role of Notch signaling in modulating epithelial to mesenchymal transition in colorectal adenocarcinoma. PMID: 25257945 Ref: Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak. PMID: 25304383 Ref: Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. PMID: 25342273 Ref: Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. PMID: 25386076 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 Ref: Effect of Bcl-xL gene expression silenced by RNA interference on invasion of human colorectal cancer cells. PMID: 25536597 |
Ref: Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis. PMID: 25187324 Ref: Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. PMID: 25335113 Ref: BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer. PMID: 25388617 Ref: The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells. PMID: 25542230 Ref: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. PMID: 25548100 Ref: Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-kappaB pathway. PMID: 25555669 Ref: Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. PMID: 25565667 Ref: miRNA expression in human intestinal Caco-2 cells is comparably regulated by cis- and trans-fatty acids. PMID: 25612549 Ref: Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. PMID: 25652758 Ref: MUC1-C activates the TAK1 inflammatory pathway in colon cancer. PMID: 25659581 Ref: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. PMID: 25684945 Ref: BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. PMID: 25715028 Ref: Autophagy-based survival prognosis in human colorectal carcinoma. PMID: 25762626 Ref: Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. PMID: 25833196 Ref: Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells. PMID: 25889965 Ref: Biocompatible iota-carrageenan-gamma-maghemite nanocomposite for biomedical applications - synthesis, characterization and in vitro anticancer efficacy. PMID: 25890231 Ref: Acetylcarnitine potentiates the anticarcinogenic effects of butyrate on SW480 colon cancer cells. PMID: 26043725 Ref: Gene expression profiling of laterally spreading tumors. PMID: 26048755 Ref: Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer. PMID: 26134786 Ref: The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. PMID: 26245900 Ref: Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29). PMID: 26248310 Ref: Bisphenol A at the reference level counteracts doxorubicin transcriptional effects on cancer related genes in HT29 cells. PMID: 26320837 Ref: Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53. PMID: 26354682 Ref: Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 26503559 Ref: Identification of a novel compound (beta-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin. PMID: 26521943 Ref: The role of Reg IV in colorectal cancer, as a potential therapeutic target. PMID: 26557771 Ref: Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy. PMID: 26561209 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 Ref: Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways. PMID: 26770191 |
Ref: Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells. PMID: 25483065 Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. PMID: 26183715 Ref: Regulatory effects of DeltaFosB on proliferation and apoptosis of MCF-7 breast cancer cells. PMID: 26608367 Ref: Knockdown of MACC1 expression increases cisplatin sensitivity in cisplatin-resistant epithelial ovarian cancer cells. PMID: 26794135 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. PMID: 26915975 Ref: Chalcone derivatives cause accumulation of colon cancer cells in the G2/M phase and induce apoptosis. PMID: 26916824 Ref: The TGF-beta pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells. PMID: 26956045 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: Luffa echinata Roxb. Induced Apoptosis in Human Colon Cancer Cell (SW-480) in the Caspase-dependent Manner and Through a Mitochondrial Apoptosis Pathway. PMID: 27019558 Ref: Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links. PMID: 27051585 Ref: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. PMID: 27058823 Ref: JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy. PMID: 27216154 Ref: Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. PMID: 27271587 Ref: Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells. PMID: 27395829 Ref: Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. PMID: 27447597 Ref: Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. PMID: 27472952 Ref: Bcl-xL is an oncogenic driver in colorectal cancer. PMID: 27537525 Ref: N-end rule pathway inhibition assists colon tumor regression via necroptosis. PMID: 27556106 Ref: Long noncoding RNA CCAT1 acts as an oncogene and promotes chemoresistance in docetaxel-resistant lung adenocarcinoma cells. PMID: 27566568 Ref: Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1. PMID: 27581253 Ref: Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. PMID: 27841296 Ref: RhoA regulates resistance to irinotecan by regulating membrane transporter and apoptosis signaling in colorectal cancer. PMID: 27888624 Ref: STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A. PMID: 27913706 |
Ref: MUC13 protects colorectal cancer cells from death by activating the NF-kappaB pathway and is a potential therapeutic target. PMID: 27399336 Ref: BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers. PMID: 27447746 Ref: CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells. PMID: 27959393 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration. PMID: 28049506 Ref: Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival. PMID: 28184012 Ref: Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling. PMID: 28331523 Ref: Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis. PMID: 28340475 Ref: Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy. PMID: 28479604 Ref: Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. PMID: 28504908 Ref: Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. PMID: 28522946 Ref: A Novel Combination Treatment Targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified Colorectal Cancers. PMID: 28611106 Ref: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types. PMID: 28611196 Ref: Down-regulation of liver-intestine cadherin enhances noscapine-induced apoptosis in human colon cancer cells. PMID: 28622054 Ref: Evaluation of in vitro cytotoxicity, biocompatibility, and changes in the expression of apoptosis regulatory proteins induced by cerium oxide nanocrystals. PMID: 28634498 Ref: YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. PMID: 28740556 Ref: MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma. PMID: 28802228 Ref: The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer. PMID: 29053012 Ref: Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. PMID: 29078261 Ref: Involvement of autophagy in the outcome of mitotic catastrophe. PMID: 29109414 Ref: Bromoethylindole (BEI-9) redirects NF-kappaB signaling induced by camptothecin and TNFalpha to promote cell death in colon cancer cells. PMID: 29116428 Ref: Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. PMID: 29245915 Ref: Autophagy-related gene expression in colorectal cancer patients. PMID: 29254294 Ref: Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer. PMID: 29312593 Ref: Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737. PMID: 29372687 Ref: Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis. PMID: 29403306 |
Ref: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines. PMID: 28438053 Ref: Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component. PMID: 29073716 Ref: Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939Mediated Transcriptional Repression of Bcl-xL. PMID: 29081216 Ref: LOC285629 regulates cell proliferation and motility in colorectal cancer cells. PMID: 29098557 Ref: Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. PMID: 29253766 Ref: Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway. PMID: 29288563 Ref: Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let7c targeting of antiapoptotic BCL2L1. PMID: 29393430 Ref: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. PMID: 29394130 Ref: Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen). PMID: 29464799 Ref: Viwithan, a Standardized Withania somnifera Root Extract Induces Apoptosis in Murine Melanoma Cells. PMID: 29491636 Ref: Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. PMID: 29512707 Ref: A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells. PMID: 29545333 Ref: Food Additive Sodium Benzoate (NaB) Activates NFkappaB and Induces Apoptosis in HCT116 Cells. PMID: 29565269 Ref: Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer. PMID: 29568398 Ref: Upregulation of let-7f-5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro-apoptotic proteins. PMID: 29805607 Ref: Expression profile of NF-kappaB regulated genes in sporadic colorectal cancer patients. PMID: 29849793 Ref: [Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells]. PMID: 29891445 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression. PMID: 29940575 Ref: MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/beta-catenin signaling. PMID: 30068336 Ref: Hypertonicity-imposed BCL-XL addiction primes colorectal cancer cells for death. PMID: 30075205 Ref: A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways. PMID: 30088202 Ref: Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. PMID: 30130653 Ref: Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. PMID: 30143543 Ref: Galla Rhois water extract inhibits lung metastasis by inducing AMPKmediated apoptosis and suppressing metastatic properties of colorectal cancer cells. PMID: 30365120 Ref: Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling. PMID: 30378164 |