Primary Site >> Pancreatic Cancer
Gene >> BCL2
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Ref: Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma: analysis of estrogen receptors/progesterone receptors and expression of tumor-associated antigens. PMID: 9110301 |
Ref: Clinical contribution of bcl-2, p53 and Ki-67 proteins in pancreatic ductal adenocarcinoma. PMID: 9568186 Ref: Prognostic significance of molecular alterations in human pancreatic carcinoma--an immunohistological study. PMID: 9641888 Ref: An immunohistochemical study of bcl-2 and p53 protein expression in pancreatic carcinomas. PMID: 9648995 Ref: An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells. PMID: 9703910 Ref: Apoptotic index and apoptosis influencing proteins bcl-2, mcl-1, bax and caspases 3, 6 and 8 in pancreatic carcinoma. PMID: 9839167 Ref: bax, but not bcl-2, influences the prognosis of human pancreatic cancer. PMID: 9863489 Ref: [Prognostic value of molecular biologogy and immunologic parameters in human pancreatic carcinoma]. PMID: 14518215 |
Ref: Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers. PMID: 9885381 Ref: Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. PMID: 10340887 Ref: Induction of growth inhibition and apoptosis in pancreatic cancer cells by auristatin-PE and gemcitabine. PMID: 10341297 Ref: Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma. PMID: 10362119 Ref: Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods. PMID: 10365829 Ref: Epidermal growth factor receptor, somatostatin and bcl-2 in human pancreatic tumor xenografts. An immunohistochemical study. PMID: 10393368 Ref: Bak expression and cell death occur in peritumorous tissue but not in pancreatic cancer cells. PMID: 10457328 Ref: Molecular effects of taxol and caffeine on pancreatic cancer cells. PMID: 10534572 Ref: Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells. PMID: 10658530 Ref: An immunohistochemical study of the expression of bcl-2 and p53 oncoproteins in pancreatic intraepithelial neoplasia and pancreatic cancer. PMID: 10732293 |
Ref: Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma. PMID: 10766343 Ref: Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer. PMID: 10811472 Ref: Medroxyprogesterone acetate inhibits human pancreatic carcinoma cell growth by inducing apoptosis in association with Bcl-2 phosphorylation. PMID: 10813710 Ref: Immunohistochemical analysis of apoptosis-related proteins in human embryonic and fetal pancreatic tissues. PMID: 10862510 Ref: MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. PMID: 10972974 Ref: p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. PMID: 11020860 Ref: Medroxyprogesterone acetate and cancer cachexia: interleukin-6 involvement. PMID: 11029784 Ref: Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro. PMID: 11062701 Ref: Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. PMID: 11114725 |
Ref: Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins. PMID: 11226429 Ref: Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. PMID: 11234897 Ref: Apoptosis-induction and phosphorylation state in human pancreatic carcinoma xenografts following octreotide treatment. PMID: 11299782 Ref: Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death. PMID: 11451151 Ref: Immunohistochemical study of genetic alterations in intraductal and invasive ductal tumors of the pancreas. PMID: 11462947 Ref: Mechanism of growth-inhibitory effect of cisplatin on human pancreatic cancer cells and status of p53 gene. PMID: 11497278 Ref: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. PMID: 11513873 Ref: Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. PMID: 11516199 Ref: Bcl-2 expression in pancreas development and pancreatic cancer progression. PMID: 11523052 Ref: A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. PMID: 11526239 Ref: BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines. PMID: 11571724 Ref: Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells. PMID: 11724306 |
Ref: Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2. PMID: 11694525 Ref: Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases. PMID: 11812943 Ref: Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma. PMID: 11953819 Ref: Molecular prognostic markers in pancreatic cancer. PMID: 12021893 Ref: E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells. PMID: 12065845 Ref: Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. PMID: 12107556 Ref: Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. PMID: 12138244 Ref: Mixed ductal-pancreatic polypeptide-cell carcinoma of the pancreas. PMID: 12147089 Ref: Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. PMID: 12189556 Ref: Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. PMID: 12481414 Ref: Histopathological study of intraductal papillary mucinous tumor of the pancreas: special reference to the roles of Survivin and p53 in tumorigenesis of IPMT. PMID: 12794243 Ref: Expression of the bcl-2 gene and its significance in human pancreatic carcinoma. PMID: 14612291 |
Ref: Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. PMID: 12490654 Ref: Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. PMID: 12618762 Ref: Vitamin K(2) selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol. PMID: 12618894 Ref: Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis. PMID: 12619896 Ref: AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. PMID: 12865934 Ref: Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. PMID: 12883267 Ref: Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells. PMID: 12890991 Ref: Growth-inhibitory effect of phosphatidylinositol 3-kinase inhibitor on human pancreatic cancer cells and expression of Bcl-2 family. PMID: 12894518 Ref: Schedule-dependent molecular effects of the proteasome inhibitor bortezomib and gemcitabine in pancreatic cancer. PMID: 12943815 Ref: [Expression and significance of cyclooxygenase-2 in human pancreatic carcinomas]. PMID: 12948419 Ref: [Apoptosis and expression of bcl-2 protein in invasive ductal adenocarcinoma of the pancreas]. PMID: 14663927 Ref: Oil A induces apoptosis of pancreatic cancer cells via caspase activation, redistribution of cell cycle and GADD expression. PMID: 14669326 |
Ref: Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer. PMID: 15051014 Ref: Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells. PMID: 15117814 Ref: [Mechanisms of inhibition of growth of human pancreatic carcinoma implanted in nude mice by somatostatin receptor subtype 2]. PMID: 15200918 Ref: Altered glucose metabolism and proteolysis in pancreatic cancer cell conditioned myoblasts: searching for a gene expression pattern with a microarray analysis of 5000 skeletal muscle genes. PMID: 15247186 Ref: Mechanisms of inhibition of growth of human pancreatic carcinoma implanted in nude mice by somatostatin receptor subtype 2. PMID: 15257106 Ref: Expression of Survivin in pancreatic cancer and its correlation to expression of Bcl-2. PMID: 15309737 Ref: Arsenic trioxide causes redistribution of cell cycle, caspase activation, and GADD expression in human colonic, breast, and pancreatic cancer cells. PMID: 15493360 Ref: Acute changes in U937 nuclear Ca2+ preceding type 1 "apoptotic" programmed cell death due to MK 886. PMID: 15517864 |
Ref: Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. PMID: 15781649 Ref: Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). PMID: 15803185 Ref: Chromic-P32 phosphate treatment of implanted pancreatic carcinoma: mechanism involved. PMID: 15810075 Ref: Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. PMID: 15837765 Ref: Bcl-XL protein levels determine apoptotic index in pancreatic carcinoma. PMID: 15841044 Ref: Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer. PMID: 15884114 Ref: Neutral lipid isolated from endosperm of Job's tears inhibits the growth of pancreatic cancer cells via apoptosis, G2/M arrest, and regulation of gene expression. PMID: 15955213 Ref: Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. PMID: 16044151 Ref: Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. PMID: 16093438 Ref: Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer. PMID: 16099798 Ref: Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways. PMID: 16109447 Ref: Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. PMID: 16115953 Ref: Molecular prognostic markers in pancreatic cancer: a systematic review. PMID: 16146690 Ref: Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. PMID: 16258364 |
Ref: SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. PMID: 16009488 Ref: Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma. PMID: 16173075 Ref: Investigation of the mechanisms by which EB1089 abrogates apoptosis induced by 9-cis retinoic acid in pancreatic cancer cells. PMID: 16340750 Ref: Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. PMID: 16385419 Ref: PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. PMID: 16446371 Ref: Anticancer effects of phenoxazine derivatives combined with tumor necrosis factor-related apoptosis-inducing ligand on pancreatic cancer cell lines, KLM-1 and MIA-PaCa-2. PMID: 16525669 Ref: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. PMID: 16546962 Ref: Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. PMID: 16818496 Ref: Bcl-XL antisense oligonucleotides coupled with antennapedia enhances radiation-induced apoptosis in pancreatic cancer. PMID: 16904964 Ref: Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line Capan-2. PMID: 16929163 Ref: Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells. PMID: 17054996 Ref: Assessment of celecoxib pharmacodynamics in pancreatic cancer. PMID: 17172427 Ref: Histamine inhibits cell proliferation and modulates the expression of Bcl-2 family proteins via the H2 receptor in human pancreatic cancer cells. PMID: 17201167 |
Ref: A novel copper complex of 3-benzoyl-alpha methyl benzene acetic acid with antitumor activity mediated via cyclooxygenase pathway. PMID: 17131340 Ref: Antisense oligonucleotides: target validation and development of systemically delivered therapeutic nanoparticles. PMID: 17172711 Ref: Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models. PMID: 17190770 Ref: Tumour suppressor protein (p53), apoptosis inhibiting protein (Bcl-2) and proliferating cell nuclear antigen (PCNA) expressions in a rat pancreatic tumour model. PMID: 17352211 Ref: Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. PMID: 17372229 Ref: bcl-2-specific siRNAs restore gemcitabine sensitivity in human pancreatic cancer cells. PMID: 17378914 Ref: Leukotriene B4 receptor antagonist LY293111 induces S-phase cell cycle arrest and apoptosis in human pancreatic cancer cells. PMID: 17414622 Ref: Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines. PMID: 17434678 Ref: Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. PMID: 17440100 Ref: FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. PMID: 17462818 Ref: Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells. PMID: 17616686 Ref: Solitary fibrous tumor of the pancreas: a case report. PMID: 17652547 Ref: The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. PMID: 17671683 Ref: Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. PMID: 17695548 Ref: Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion. PMID: 17726369 Ref: CCAAT/enhancer binding protein-beta promotes the survival of intravascular rat pancreatic tumor cells via antiapoptotic effects. PMID: 17727681 Ref: BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer. PMID: 17960583 Ref: Rare case of Castleman disease involving the pancreas. PMID: 18186391 |
Ref: Effects of the proteasome inhibitor bortezomib on gene expression profiles of pancreatic cancer cells. PMID: 17714734 Ref: The immunocytokine scFv23/TNF targeting HER-2/neu induces synergistic cytotoxic effects with 5-fluorouracil in TNF-resistant pancreatic cancer cell lines. PMID: 18082672 Ref: Apoptosis of human pancreatic cancer cells induced by Triptolide. PMID: 18330938 Ref: Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription. PMID: 18357592 Ref: Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. PMID: 18413748 Ref: BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. PMID: 18413764 Ref: Synergy of gemcitabine and lidamycin associated with NF-kappaB downregulation in pancreatic carcinoma cells. PMID: 18430374 Ref: Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report. PMID: 18437074 Ref: Benzoylurea derivatives as a novel class of antimitotic agents: synthesis, anticancer activity, and structure-activity relationships. PMID: 18457382 Ref: Human tumor nanoparticles induce apoptosis of pancreatic cancer cells. PMID: 18511551 Ref: TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer. PMID: 18528859 Ref: Synergistic effects of multiple natural products in pancreatic cancer cells. PMID: 18640131 Ref: Solitary fibrous tumor of the pancreas: case report with cytologic and surgical pathology correlation and review of the literature. PMID: 18648147 Ref: Anti-tumor activity of erlotinib in the BxPC-3 pancreatic cancer cell line. PMID: 18803351 Ref: Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. PMID: 18829553 Ref: Review of the apoptosis pathways in pancreatic cancer and the anti-apoptotic effects of the novel sea cucumber compound, Frondoside A. PMID: 18837899 Ref: Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. PMID: 18842418 Ref: Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival. PMID: 18853313 Ref: In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. PMID: 19002586 Ref: Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB. PMID: 19025644 |
Ref: Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. PMID: 19056168 Ref: ERK/BCL-2 pathway in the resistance of pancreatic cancer to anoikis. PMID: 19062038 Ref: BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells. PMID: 19118042 Ref: Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. PMID: 19208826 Ref: Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. PMID: 19209030 Ref: Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer. PMID: 19209227 Ref: Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice. PMID: 19266598 Ref: Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase. PMID: 19286308 Ref: TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. PMID: 19318573 Ref: Interleukin-32 expression in the pancreas. PMID: 19386602 Ref: BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. PMID: 19483105 Ref: Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein. PMID: 19523441 Ref: Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. PMID: 19549912 Ref: [A case of solitary fibrous tumor of the pancreas]. PMID: 19578317 Ref: Interstitial chemotherapy with ricin-loaded thermosensitive hydrogel in pancreatic cancer xenograft. PMID: 19666413 Ref: The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. PMID: 19668230 Ref: PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells. PMID: 19675098 Ref: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PMID: 19714243 Ref: Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. PMID: 19736394 Ref: Solitary fibrous tumor of the pancreas. PMID: 19751911 Ref: The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target. PMID: 19834624 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 Ref: Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma. PMID: 19920820 Ref: [Study on anticancer effect of dihydroartemisinin on pancreatic cancer]. PMID: 19957812 |
Ref: G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. PMID: 19755960 Ref: Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells. PMID: 19823097 Ref: Downregulation of nuclear factor-kappaB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer. PMID: 19880242 Ref: Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. PMID: 19908231 Ref: Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity. PMID: 19966835 Ref: Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. PMID: 20065042 Ref: Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. PMID: 20103639 Ref: Blocking angiotensin II Type 1 receptor triggers apoptotic cell death in human pancreatic cancer cells. PMID: 20118823 Ref: Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. PMID: 20137856 Ref: The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis. PMID: 20143389 Ref: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. PMID: 20154087 Ref: Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling. PMID: 20182390 Ref: Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. PMID: 20224296 Ref: Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells. PMID: 20232307 Ref: Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. PMID: 20301194 Ref: [An experimental study of gemcitabine inducing pancreatic cancer cell apoptosis potentiated by nuclear factor-kappa B P65 siRNA]. PMID: 20302733 Ref: Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. PMID: 20331621 Ref: Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway. PMID: 20367887 Ref: PAR-4 as a possible new target for pancreatic cancer therapy. PMID: 20426700 Ref: Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer. PMID: 20426791 Ref: CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. PMID: 20442202 Ref: Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer. PMID: 20452611 Ref: Upregulated histone deacetylase 1 expression in pancreatic ductal adenocarcinoma and specific siRNA inhibits the growth of cancer cells. PMID: 20467347 Ref: Combination effects of bortezomib with gemcitabine and EMAP II in experimental pancreatic cancer. PMID: 20495354 Ref: Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells. PMID: 20523344 Ref: Knockdown of hTERT by SiRNA suppresses growth of Capan-2 human pancreatic cancer cell via the inhibition of expressions of Bcl-2 and COX-2. PMID: 20579221 Ref: Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. PMID: 20590594 Ref: Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). PMID: 20626591 Ref: Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis. PMID: 20646298 Ref: [Experimental study of the function and mechanism combining dihydroartemisinin and gemcitabine in treating pancreatic cancer]. PMID: 20646665 Ref: Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. PMID: 20660371 Ref: Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro. PMID: 20698986 Ref: {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. PMID: 20864511 Ref: Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo. PMID: 20930385 Ref: Antiproliferative effect of resveratrol in pancreatic cancer cells. PMID: 21031621 Ref: [Influence of betulinic acid on proliferation, migration, cell cycle and apoptosis of pancreatic cancer cells]. PMID: 21355282 Ref: Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity. PMID: 21472302 Ref: MicroRNA-mediated regulation of pancreatic cancer cell proliferation. PMID: 22966344 Ref: The role of apoptosis in the pathology of pancreatic cancer. PMID: 24212603 |
Ref: Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells. PMID: 20683663 Ref: E-cadherin contributes to the bystander effect of TK/GCV suicide therapy and enhances its antitumoral activity in pancreatic cancer models. PMID: 20720574 Ref: The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro. PMID: 21161403 Ref: New hedgehog/GLI-signaling inhibitors from Adenium obesum. PMID: 21170436 Ref: Recent patents concerning targeted therapy of apoptosis resistance in pancreatic cancer. PMID: 21194411 Ref: Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. PMID: 21196331 Ref: Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos. PMID: 21250700 Ref: Promoted cancer growth by stimulating cell proliferation and decreasing apoptosis using a lentivirus-based EphB2 RNAi in pancreatic carcinoma CFPAC-1 cells. PMID: 21292437 Ref: Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PMID: 21304978 Ref: Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis. PMID: 21305255 Ref: Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells. PMID: 21376256 Ref: Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. PMID: 21448172 Ref: Dysregulation of the cell cycle and chromosomal imbalances in juxtaglomerular cell tumors - a comparative study with endocrine tumors of the pancreas. PMID: 21482036 Ref: Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. PMID: 21515913 Ref: [Role of nuclear factor-kappaB on emodin-induced sensitization of pancreatic cancer to gemcitabine]. PMID: 21542284 Ref: beta2-adrenoceptor blocker synergizes with gemcitabine to inhibit the proliferation of pancreatic cancer cells via apoptosis induction. PMID: 21570961 Ref: Anticancer effect of dihydroartemisinin (DHA) in a pancreatic tumor model evaluated by conventional methods and optical imaging. PMID: 21617209 Ref: Systematic review of immunohistochemical biomarkers to identify prognostic subgroups of patients with pancreatic cancer. PMID: 21644238 Ref: Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. PMID: 21714853 Ref: Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PMID: 21720559 Ref: Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma. PMID: 21730974 Ref: Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy. PMID: 21760983 Ref: Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation. PMID: 21805032 Ref: Apoptosis in lymphocytes of pancreatic cancer patients: influence of preoperative enteral immunonutrition and extensive surgery. PMID: 21818634 Ref: Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression. PMID: 21880146 Ref: Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism. PMID: 21904657 Ref: Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PMID: 21909380 Ref: Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles. PMID: 21931488 Ref: A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PMID: 22069448 Ref: Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PMID: 22087285 Ref: beta2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFkappaB pathway. PMID: 22118662 Ref: Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PMID: 22132131 Ref: Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-kappaB and Bcl-2 families. PMID: 22190866 Ref: Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. PMID: 22301921 |
Ref: The therapeutic potential of RNA interference: novel approaches for cancer treatment. PMID: 21605072 Ref: Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics. PMID: 21796625 Ref: Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. PMID: 21935918 Ref: ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer. PMID: 22100174 Ref: Matrine inhibits proliferation and induces apoptosis of the androgenindependent prostate cancer cell line PC-3. PMID: 22159447 Ref: Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. PMID: 22159556 Ref: The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines. PMID: 22170433 Ref: Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells. PMID: 22246103 Ref: Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in pancreatic cancer both in vitro and in vivo. PMID: 22270965 Ref: Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines. PMID: 22314265 Ref: MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. PMID: 22384141 Ref: miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro. PMID: 22487517 Ref: In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution. PMID: 22505651 Ref: RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer. PMID: 22509328 Ref: Enhanced antitumor effect of combination therapy with gemcitabine and guggulsterone in pancreatic cancer. PMID: 22513291 Ref: CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis. PMID: 22532602 Ref: Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. PMID: 22532787 Ref: Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells. PMID: 22552257 Ref: Regarding article 'Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells'. PMID: 22560983 Ref: Induction of pancreatic cancer cell apoptosis and enhancement of gemcitabine sensitivity by RAP80 siRNA. PMID: 22573342 Ref: Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells. 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