Primary Site >> Liver Cancer
Gene >> AXIN1
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Ref: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. PMID: 10700176 |
Ref: Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. PMID: 11375957 Ref: Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. PMID: 11526492 |
Ref: Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. PMID: 12101426 Ref: P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells. PMID: 12439747 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 |
Ref: Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. PMID: 12668978 |
Ref: Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. PMID: 15067328 |
Ref: Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. PMID: 15723355 |
Ref: Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. PMID: 16964294 |
Ref: Genetic alterations of Wnt signaling pathway-associated genes in hepatocellular carcinoma. PMID: 18171349 Ref: Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. PMID: 18592156 |
Ref: Mutations in the AXIN1 gene in advanced prostate cancer. PMID: 18514389 |
Ref: Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. PMID: 21182948 |
Ref: Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. PMID: 22561517 Ref: Kruppel-like factor 8 is a new Wnt/beta-catenin signaling target gene and regulator in hepatocellular carcinoma. PMID: 22761862 |
Ref: Genetics and epigenetics of liver cancer. PMID: 23392071 Ref: Somatic changes in primary liver cancer in Russia: a pilot study. PMID: 23830926 Ref: Alterations of axis inhibition protein 1 (AXIN1) in hepatitis B virus-related hepatocellular carcinoma and overexpression of AXIN1 induces apoptosis in hepatocellular cancer cells. PMID: 23879168 Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID: 24379610 |
Ref: Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. PMID: 24798001 Ref: Diverse modes of genomic alteration in hepatocellular carcinoma. PMID: 25159915 Ref: A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma. PMID: 25502816 Ref: Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. PMID: 25526364 |
Ref: Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas. PMID: 25021421 Ref: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. PMID: 25822088 Ref: Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma. PMID: 26034368 Ref: Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. PMID: 26099527 Ref: Tankyrase inhibitors attenuate WNT/beta-catenin signaling and inhibit growth of hepatocellular carcinoma cells. PMID: 26246473 |
Ref: 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing beta-catenin. PMID: 26474915 Ref: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. PMID: 26553052 Ref: Genetic polymorphisms in the Wnt/beta-catenin pathway genes as predictors of tumor development and survival in patients with hepatitis B virus-associated hepatocellular carcinoma. PMID: 26968103 Ref: Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of beta-Catenin Signaling. PMID: 27851986 |
Ref: Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer. PMID: 27838634 Ref: The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration. PMID: 28075444 Ref: The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling. PMID: 28627706 Ref: TRIM65 triggers beta-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma. PMID: 28754688 Ref: The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. PMID: 28854942 |
Ref: AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of beta-catenin activation. PMID: 29525529 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Multi-modal meta-analysis of 1494 hepatocellular carcinoma samples reveals significant impact of consensus driver genes on phenotypes. PMID: 30242023 Ref: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling. PMID: 30257989 |