Primary Site >> Colorectal Cancer
Gene >> AURKB
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Ref: A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. PMID: 9606188 |
Ref: Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers. PMID: 11050471 |
Ref: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. PMID: 11453556 |
Ref: Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability. PMID: 12234980 |
Ref: Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design. PMID: 12657723 |
Ref: AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. PMID: 17575233 Ref: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. PMID: 18075315 |
Ref: Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. PMID: 18699967 |
Ref: Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. PMID: 19479993 Ref: Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells. PMID: 19584233 Ref: Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. PMID: 20032382 |
Ref: SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. PMID: 19649632 Ref: Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. PMID: 20175926 Ref: RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance. PMID: 20362665 Ref: Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. PMID: 20420387 |
Ref: Pharmacogenetic profiling of Aurora kinase B is associated with overall survival in metastatic colorectal cancer. PMID: 20368716 Ref: Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. PMID: 21710690 |
Ref: Frequent increased gene copy number and high protein expression of tRNA (cytosine-5-)-methyltransferase (NSUN2) in human cancers. PMID: 22136356 Ref: An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. PMID: 22222631 Ref: Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. PMID: 22306067 Ref: Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. PMID: 22382783 Ref: Preferential killing of p53-deficient cancer cells by reversine. PMID: 22592527 Ref: Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. PMID: 22783401 |
Ref: Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. PMID: 23376641 Ref: 212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpoint. PMID: 23632482 Ref: Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. PMID: 24195668 |
Ref: Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy. PMID: 24476310 |
Ref: In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor. PMID: 25462247 Ref: Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas. PMID: 25680570 Ref: Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression. PMID: 25882311 Ref: Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells. PMID: 26148251 Ref: Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. PMID: 26259750 |
Ref: The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. PMID: 26423403 Ref: Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PMID: 27097159 |
Ref: Functional Effects of AKT3 on Aurora Kinase Inhibitor-induced Aneuploidy. PMID: 28028179 Ref: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. PMID: 28178649 |
Ref: PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells. PMID: 29549256 Ref: Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition. PMID: 29656197 Ref: Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. PMID: 29731963 Ref: Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing. PMID: 29844865 |