Primary Site >> Pancreatic Cancer
Gene >> AURKA
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Ref: Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. PMID: 12631597 Ref: Structure-based design of novel anti-cancer agents targeting aurora kinases. PMID: 12678912 |
Ref: The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer. PMID: 15078988 |
Ref: RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. PMID: 15805292 Ref: AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. PMID: 15860351 Ref: Aurora kinases. PMID: 15896667 |
Ref: Molecular mechanisms of pancreatic carcinogenesis. PMID: 16367914 Ref: AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. PMID: 16532023 |
Ref: Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. PMID: 17505013 |
Ref: Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. PMID: 18044730 Ref: MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases. PMID: 18322951 Ref: Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice. PMID: 18815537 |
Ref: Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells. PMID: 19768832 |
Ref: SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. PMID: 19649632 Ref: Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. PMID: 20423983 |
Ref: A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex. PMID: 22560880 Ref: Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. PMID: 22899799 Ref: Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. PMID: 23037716 |
Ref: The histone deacetylase SIRT2 stabilizes Myc oncoproteins. PMID: 23175188 Ref: Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: potential role in therapy. PMID: 23523869 |
Ref: The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. PMID: 24775809 |
Ref: The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. PMID: 25912306 |
Ref: The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma. PMID: 28167680 Ref: Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer. PMID: 28193222 Ref: An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. PMID: 28220783 Ref: Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. PMID: 28442587 Ref: Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. PMID: 28764929 |
Ref: Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. PMID: 29682330 |