Primary Site >> Stomach Cancer
Gene >> AURKA
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Ref: Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. PMID: 11259099 Ref: Genetic Alterations in Gastric Carcinomas and Adjacent Mucosa Detected by Comparative Genomic Hybridization (CGH). PMID: 26680801 |
Ref: MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain. PMID: 12739007 Ref: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. PMID: 14696419 |
Ref: Amplification/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesis. PMID: 15289843 |
Ref: Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression. PMID: 16412566 Ref: [Mitotic arrest of gastric cancer cells induced by silencing of STK15 gene]. PMID: 16630486 Ref: [Inhibition of serine/threonine kinase 15 gene expression induces apoptosis of gastric cancer cells]. PMID: 17043964 Ref: [Analysis of gene expression profiles in gastric cancer cell cycle]. PMID: 17236548 |
Ref: Aurora-A: the maker and breaker of spindle poles. PMID: 17715155 Ref: Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PMID: 17895985 |
Ref: The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain. PMID: 18335050 |
Ref: The aurora kinase A regulates GSK-3beta in gastric cancer cells. PMID: 19060929 Ref: CyclinD1 and interleukin-1 receptor antagonist polymorphisms are associated with prognosis in neoadjuvant-treated gastric carcinoma. PMID: 19822419 |
Ref: PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy. PMID: 20354118 |
Ref: Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression. PMID: 20585902 Ref: Aurora-A as an independent molecular prognostic marker in gastric cancer. PMID: 21479365 Ref: Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein. PMID: 21932983 Ref: Inhibition of proliferation, viability, migration and invasion of gastric cancer cells by Aurora-A deletion. PMID: 22320980 |
Ref: Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker. PMID: 22588468 Ref: Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization. PMID: 22691185 |
Ref: Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways. PMID: 23755206 Ref: Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. PMID: 23993973 Ref: Transcriptomic changes induced by mycophenolic acid in gastric cancer cells. PMID: 24349619 |
Ref: TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer. PMID: 24178904 Ref: HDM2 regulation by AURKA promotes cell survival in gastric cancer. PMID: 24240108 Ref: Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. PMID: 24439602 Ref: Detection of kinase amplifications in gastric adenocarcinomas. PMID: 25558650 |
Ref: Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells. PMID: 25609923 Ref: Correction: HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer. PMID: 25646184 Ref: Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis. PMID: 26608463 |
Ref: Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer. PMID: 26778597 Ref: AURKA induces EMT by regulating histone modification through Wnt/beta-catenin and PI3K/Akt signaling pathway in gastric cancer. PMID: 27121204 Ref: Association of the AURKA and AURKC gene polymorphisms with an increased risk of gastric cancer. PMID: 27270838 |
Ref: Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. PMID: 28218735 Ref: UBE2C induces EMT through Wnt/betacatenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A. PMID: 28260026 Ref: Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib. PMID: 28417568 Ref: Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility. PMID: 28843004 Ref: FAM83D, a microtubule-associated protein, promotes tumor growth and progression of human gastric cancer. PMID: 29088801 |
Ref: Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of pAURKA mediated by activation of AURKA. PMID: 29512701 Ref: Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer. PMID: 30013101 Ref: Role of PLK1 signaling pathway genes in gastrointestinal stromal tumors. PMID: 30127898 Ref: The Association Between AURKA Gene rs2273535 Polymorphism and Gastric Cancer Risk in a Chinese Population. PMID: 30174615 Ref: Expression profiles of histone modification genes in gastric cancer progression. PMID: 30250993 |