Primary Site >> Colorectal Cancer
Gene >> AURKA
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Ref: A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. PMID: 9606188 Ref: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. PMID: 9771714 |
Ref: Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design. PMID: 12657723 Ref: Structure-based design of novel anti-cancer agents targeting aurora kinases. PMID: 12678912 Ref: Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers. PMID: 12708489 Ref: Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. PMID: 12881723 Ref: The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas. PMID: 12883693 Ref: Chromosome arm 20q gains and other genomic alterations in esophageal squamous cell carcinoma, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization. PMID: 14696419 |
Ref: Genomic instability and colon cancer. PMID: 15000146 |
Ref: Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. PMID: 15802297 |
Ref: Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers. PMID: 16049965 Ref: Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer. PMID: 16402339 Ref: Chromosomal instability, colorectal cancer and taxane resistance. PMID: 16628000 Ref: [Association between genetic polymorphism in STK15 and risk of colorectal cancer in a Chinese population]. PMID: 16737620 Ref: Case-control, kin-cohort and meta-analyses provide no support for STK15 F31I as a low penetrance colorectal cancer allele. PMID: 17003782 |
Ref: Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. PMID: 17219423 Ref: A simple method for the routine detection of somatic quantitative genetic alterations in colorectal cancer. PMID: 17258723 Ref: The FBXW7 beta-form is suppressed in human glioma cells. PMID: 17274947 Ref: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. PMID: 17322345 Ref: High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. PMID: 17457043 Ref: The role of Aurora-A inhibitors in cancer therapy. PMID: 17591831 Ref: Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. PMID: 17999753 Ref: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. PMID: 18075315 |
Ref: Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. PMID: 18027856 Ref: Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells. PMID: 18669163 Ref: Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. PMID: 18699967 Ref: Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor. PMID: 19259408 |
Ref: Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. PMID: 18829976 Ref: Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints. PMID: 18977806 Ref: Development and biological evaluation of a novel aurora A kinase inhibitor. PMID: 19199284 Ref: Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. PMID: 19359472 Ref: Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. PMID: 19412426 Ref: Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells. PMID: 19584233 Ref: Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers. PMID: 19648887 Ref: Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. PMID: 19690386 Ref: Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. PMID: 19690970 Ref: Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells. PMID: 19768832 Ref: A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. PMID: 19801554 Ref: Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. PMID: 20003375 Ref: Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. PMID: 20032382 |
Ref: SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. PMID: 19649632 Ref: Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. PMID: 19686703 Ref: Translational up-regulation of Aurora-A in EGFR-overexpressed cancer. PMID: 19799648 Ref: HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. PMID: 20068165 Ref: Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression. PMID: 20358421 Ref: Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. PMID: 20420387 Ref: Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. PMID: 20423983 Ref: Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. PMID: 20460511 Ref: Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression. PMID: 20929925 |
Ref: Pharmacogenetic profiling of Aurora kinase B is associated with overall survival in metastatic colorectal cancer. PMID: 20368716 Ref: Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy. PMID: 20473860 Ref: Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I). PMID: 21798738 Ref: Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53. PMID: 22157150 |
Ref: Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. PMID: 21785464 Ref: Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population. PMID: 22001602 Ref: BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. PMID: 22009326 Ref: TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. PMID: 22207630 Ref: An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. PMID: 22222631 Ref: Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. PMID: 22306067 Ref: Cell cycle proteins predict recurrence in stage II and III colon cancer. PMID: 22311118 Ref: Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index. PMID: 22380736 Ref: Preferential killing of p53-deficient cancer cells by reversine. PMID: 22592527 |
Ref: Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. PMID: 23610398 Ref: A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment. PMID: 23678290 Ref: Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis. PMID: 24104968 Ref: Expression profiling based on graph-clustering approach to determine colon cancer pathway. PMID: 24125984 Ref: Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. PMID: 24195668 |
Ref: STK15 rs2273535 polymorphism and cancer risk: a meta-analysis of 74,896 subjects. PMID: 24252226 Ref: Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. PMID: 24338023 Ref: Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers. PMID: 24876664 Ref: Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. PMID: 24976383 Ref: Cytotoxicity of Eupatorium cannabinum L. ethanolic extract against colon cancer cells and interactions with Bisphenol A and Doxorubicin. PMID: 25056133 Ref: A growing role for Aurora A in chromosome instability. PMID: 25082197 Ref: Prognostic role of Aurora-A expression in metastatic colorectal cancer patients. PMID: 25261653 |
Ref: Serine/threonine kinase 15 gene polymorphism and risk of digestive system cancers: A meta-analysis. PMID: 25452806 Ref: Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression. PMID: 25596657 Ref: The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC. PMID: 25632068 Ref: Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression. PMID: 25882311 Ref: Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells. PMID: 25912878 Ref: Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro. PMID: 26198005 Ref: Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. PMID: 26259750 Ref: Bisphenol A at the reference level counteracts doxorubicin transcriptional effects on cancer related genes in HT29 cells. PMID: 26320837 Ref: [The anti-tumor activity and molecular mechanisms of an Aurora kinase inhibitor ZLJ213 in suppressing colon cancer growth]. PMID: 26552147 Ref: Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells. PMID: 26729093 |
Ref: The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. PMID: 26423403 Ref: Molecular imaging of aurora kinase A (AURKA) expression: Synthesis and preclinical evaluation of radiolabeled alisertib (MLN8237). PMID: 26432753 Ref: A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9. PMID: 26497206 Ref: Tanshinone I induces human colorectal cancer cell apoptosis: The potential roles of Aurora A-p53 and survivin-mediated signaling pathways. PMID: 27279458 Ref: Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. PMID: 27329586 Ref: Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer. PMID: 27385211 Ref: Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review. PMID: 27470380 Ref: Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition. PMID: 27764771 |
Ref: Identification of key genes in colorectal cancer using random walk with restart. PMID: 28000901 Ref: Copy number variations in DCC/18q and ERBB2/17q are associated with disease-free survival in microsatellite stable colon cancer. PMID: 28006840 Ref: Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma. PMID: 28013532 Ref: Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer. PMID: 28079881 Ref: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. PMID: 28178649 Ref: Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells. PMID: 28458622 Ref: Aurora kinase A inhibitor TCS7010 demonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells. PMID: 29163689 |
Ref: Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition. PMID: 29656197 Ref: Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer. PMID: 29760449 Ref: Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound. PMID: 29769406 Ref: Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. PMID: 30097580 Ref: PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A. PMID: 30118842 Ref: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer. PMID: 30191522 Ref: Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1. PMID: 30342037 |