Primary Site >> Pancreatic Cancer
Gene >> ATR
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Ref: Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. PMID: 18381943 |
Ref: Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. PMID: 20501833 |
Ref: Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. PMID: 22120667 |
Ref: The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. PMID: 22825331 Ref: Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. PMID: 23222511 |
Ref: Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress. PMID: 25965828 |
Ref: In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. PMID: 27320920 Ref: Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks. PMID: 27601467 Ref: Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer. PMID: 27621574 |
Ref: Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine. PMID: 28440428 Ref: The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. PMID: 28558031 Ref: The Role of PALB2 in the DNA Damage Response and Cancer Predisposition. PMID: 28858227 |
Ref: Vildagliptin loaded triangular DNA nanospheres coated with eudragit for oral delivery and better glycemic control in type 2 diabetes mellitus. PMID: 29145151 Ref: 3F-Box protein 32 degrades ataxia telangiectasia and Rad3-related and regulates DNA damage response induced by gemcitabine in pancreatic cancer. PMID: 29805624 |