Primary Site >> Pancreatic Cancer
Gene >> ATM
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Ref: Expression of ATM protein and its relationship with p53 in pancreatic carcinoma with tissue array. PMID: 15097860 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. PMID: 15485651 Ref: Familial pancreatic carcinoma in Jews. PMID: 15516847 |
Ref: Neutral lipid isolated from endosperm of Job's tears inhibits the growth of pancreatic cancer cells via apoptosis, G2/M arrest, and regulation of gene expression. PMID: 15955213 Ref: [Mucinous noncystic (colloid) adenocarcinoma of the pancreas]. PMID: 16251039 Ref: [Expression and clinical significance of P53 pathway-associated proteins in pancreatic carcinoma]. PMID: 16552971 |
Ref: Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. PMID: 16520463 |
Ref: Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. PMID: 17312387 Ref: Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. PMID: 17431503 Ref: Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone. PMID: 17638905 |
Ref: Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. PMID: 18381943 |
Ref: DNA repair gene polymorphisms and risk of pancreatic cancer. PMID: 19147782 Ref: Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. PMID: 19401701 |
Ref: Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. PMID: 20501833 Ref: Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. PMID: 20838624 |
Ref: Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer. PMID: 20306339 |
Ref: Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. PMID: 21898405 Ref: Association between ATM polymorphisms and cancer risk: a meta-analysis. PMID: 22203481 Ref: A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. PMID: 22536950 Ref: A role for ATM in hereditary pancreatic cancer. PMID: 22585162 Ref: ATM mutations in patients with hereditary pancreatic cancer. PMID: 22585167 Ref: Familial pancreatic cancer--current knowledge. PMID: 22664588 Ref: Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. PMID: 23103869 Ref: Inherited pancreatic cancer syndromes. PMID: 23187834 Ref: Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. PMID: 23222511 |
Ref: Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells. PMID: 23943154 Ref: Influence of MRE11, RAD50 and NIBRIN protein expression on survival in pancreatic carcinoma after curative resection. PMID: 23954013 |
Ref: Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. PMID: 24293293 Ref: Familial pancreatic cancer: genetic advances. PMID: 24395243 Ref: ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. PMID: 24469230 Ref: Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis. PMID: 24486587 Ref: APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM. PMID: 24763056 |
Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial. PMID: 25896973 Ref: The Effects of Metformin and EGCG On PANC-1 Cell Survival. PMID: 25996744 Ref: PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer. PMID: 26013168 Ref: Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. PMID: 26098869 Ref: Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition. PMID: 26220524 |
Ref: Reliable Detection of Somatic Mutations in Fine Needle Aspirates of Pancreatic Cancer With Next-generation Sequencing: Implications for Surgical Management. PMID: 26020105 Ref: Prevalence of Pathogenic Mutations in Cancer Predisposition Genes among Pancreatic Cancer Patients. PMID: 26483394 Ref: Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. PMID: 26658419 Ref: Statewide Retrospective Review of Familial Pancreatic Cancer in Delaware, and Frequency of Genetic Mutations in Pancreatic Cancer Kindreds. PMID: 26727920 Ref: Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy. PMID: 27034805 Ref: Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. PMID: 27197284 Ref: Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations. PMID: 27449771 Ref: Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer. PMID: 27621574 Ref: Germline mutations in Japanese familial pancreatic cancer patients. PMID: 27732944 |
Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. PMID: 28344092 Ref: Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers. PMID: 28412751 Ref: Susceptibility of ATM-deficient pancreatic cancer cells to radiation. PMID: 28453388 Ref: The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. PMID: 28558031 Ref: Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. PMID: 28767289 Ref: The Role of PALB2 in the DNA Damage Response and Cancer Predisposition. PMID: 28858227 Ref: ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer. PMID: 28894253 Ref: Germline mutations in pancreatic cancer and potential new therapeutic options. PMID: 29069866 Ref: Caveolin-1 is involved in DNA damage and repair signaling in X-irradiated Chang liver cells. PMID: 29270591 Ref: Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer. PMID: 29348875 |
Ref: The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genes. PMID: 28687971 Ref: Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history. PMID: 28726808 Ref: Development of a high risk pancreatic screening clinic using 3.0 T MRI. PMID: 29101607 Ref: Pancreatic cancer screening in high-risk individuals with germline genetic mutations. PMID: 29309780 Ref: Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells. PMID: 29434894 Ref: Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway. PMID: 29463243 Ref: Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms. PMID: 29506128 Ref: Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. PMID: 29615613 Ref: Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance. PMID: 29661773 Ref: Germline variants in pancreatic cancer patients with a personal or family history of cancer fulfilling the revised Bethesda guidelines. PMID: 29667044 Ref: Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer. PMID: 29731985 Ref: Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. PMID: 29922827 Ref: Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative. PMID: 29954777 Ref: Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. PMID: 29961768 Ref: Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer. PMID: 30062048 Ref: Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts. PMID: 30113427 Ref: Chronic pancreatitis changes in high-risk individuals for pancreatic ductal adenocarcinoma. PMID: 30145314 Ref: Targeting Defects in the Cellular DNA Damage Response for the Treatment of Pancreatic Ductal Adenocarcinoma. PMID: 30286473 |