Primary Site >> Colorectal Cancer
Gene >> ATM
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Ref: A rapid and simple in vitro method for evaluating human colorectal epithelial proliferation. PMID: 1695838 |
Ref: Influence of ATM function on telomere metabolism. PMID: 9400992 |
Ref: Loss of heterozygosity at the ATM locus in colorectal carcinoma. PMID: 10203610 Ref: Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. PMID: 10490633 |
Ref: Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability. PMID: 10738255 Ref: Influence of ATM function on interactions between telomeres and nuclear matrix. PMID: 10931683 Ref: A polymorphism in the ATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer. PMID: 11093816 |
Ref: Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. PMID: 11323103 Ref: Cancer risk in heterozygotes for ataxia-telangiectasia. PMID: 11410879 Ref: Frequent allelic imbalance at the ATM locus in DNA multiploid colorectal carcinomas. PMID: 11593417 Ref: Analysis of the CHK2 gene in lymphoid malignancies. PMID: 11699418 |
Ref: Human MRE11 is inactivated in mismatch repair-deficient cancers. PMID: 11850399 Ref: Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. PMID: 12032824 Ref: ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation. PMID: 12151394 |
Ref: Gene expression profile of metastatic colon cancer cells resistant to cisplatin-induced apoptosis. PMID: 12579322 Ref: Detection of hotspot mutations and polymorphisms using an enhanced PCR-RFLP approach. PMID: 12673796 Ref: Brostallicin (PNU-166196)--a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells. PMID: 14562032 |
Ref: DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study. PMID: 12827413 Ref: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. PMID: 15122344 Ref: Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. PMID: 15199542 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: ATM-dependent CHK2 activation induced by anticancer agent, irofulven. PMID: 15269203 Ref: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. PMID: 15326376 Ref: CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. PMID: 15367709 Ref: 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells. PMID: 15374972 Ref: Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. PMID: 15386372 |
Ref: Cancer risks and mortality in heterozygous ATM mutation carriers. PMID: 15928302 Ref: ATM expression in rectal cancers with or without preoperative radiotherapy. PMID: 16012708 Ref: ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States). PMID: 16049814 |
Ref: CtIP, a candidate tumor susceptibility gene is a team player with luminaries. PMID: 16249056 Ref: Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. PMID: 16456034 Ref: Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. PMID: 16533773 Ref: Radiosensitization of tumor cells by modulation of ATM kinase. PMID: 16690595 Ref: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. PMID: 16905549 Ref: Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. PMID: 16952553 Ref: Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives. PMID: 17000706 Ref: 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. PMID: 17085668 |
Ref: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. PMID: 16936775 Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. PMID: 17143621 Ref: Evidence for the receipt of DNA damage stimuli by PML nuclear domains. PMID: 17206596 Ref: 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. PMID: 17241873 Ref: Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. PMID: 17312387 Ref: Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. PMID: 17378912 Ref: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. PMID: 17510082 Ref: Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer. PMID: 18056440 |
Ref: Atm is a negative regulator of intestinal neoplasia. PMID: 17700532 Ref: Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. PMID: 17999988 Ref: Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells. PMID: 18024214 Ref: Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. PMID: 18053307 Ref: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. PMID: 18097482 Ref: p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. PMID: 18223691 Ref: Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. PMID: 18347191 Ref: AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. PMID: 18413665 Ref: Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil. PMID: 18506996 Ref: Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions. PMID: 18641004 Ref: Colorectal cancers in patients with the (9A/6A) polymorphism of TGFBR1 exhibit lesser inter-(simple sequence repeat) PCR genomic instability and present clinically at greater age. PMID: 18778720 Ref: Deficiency of Bloom syndrome helicase activity is radiomimetic. PMID: 18787401 Ref: Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. PMID: 18804090 |
Ref: Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis. PMID: 19028473 Ref: Ascochlorin activates p53 in a manner distinct from DNA damaging agents. PMID: 19253369 Ref: Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. PMID: 19536092 Ref: Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21. PMID: 19738433 Ref: Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. PMID: 19881958 |
Ref: Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. PMID: 20709524 Ref: Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells. PMID: 20709753 Ref: Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21. PMID: 21078189 Ref: The "Mutated in Colorectal Cancer" Protein Is a Novel Target of the UV-Induced DNA Damage Checkpoint. PMID: 21779472 |
Ref: A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. PMID: 21338495 Ref: Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. PMID: 21390062 Ref: Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells. PMID: 21526346 Ref: Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. PMID: 21567080 Ref: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells. PMID: 21616090 Ref: Dual role of insulin-like growth factor-1 in acetyl-CoA carboxylase-alpha activity in human colon cancer cells HCT-8: downregulating its expression and phosphorylation. PMID: 21638027 Ref: DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. PMID: 21674128 Ref: AMPK regulates metabolism and survival in response to ionizing radiation. PMID: 21715037 Ref: Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. PMID: 21747117 Ref: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. PMID: 21860067 Ref: Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PMID: 22022355 Ref: Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PMID: 22194930 Ref: Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. PMID: 22977515 |
Ref: Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines. PMID: 21830942 Ref: The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. PMID: 21964066 Ref: Combination of quercetin with radiotherapy enhances tumor radiosensitivity in vitro and in vivo. PMID: 22119371 Ref: Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells. PMID: 22434045 Ref: Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant. PMID: 22474491 Ref: Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. PMID: 22552540 Ref: Hyperbaric oxygen therapy reduces COX-2 expression in a dimethylhydrazine-induced rat model of colorectal carcinogenesis. PMID: 22670549 Ref: Recurrent R-spondin fusions in colon cancer. PMID: 22895193 Ref: Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. PMID: 23097684 Ref: Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. PMID: 23154512 Ref: CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families. PMID: 23329222 Ref: Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway. PMID: 23397046 |
Ref: Whole-genome methylation analysis of benign and malignant colorectal tumours. PMID: 23096130 Ref: The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin. PMID: 23149213 Ref: MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells. PMID: 23229340 Ref: MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PMID: 23437304 Ref: Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. PMID: 23686257 Ref: Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imbalance. PMID: 23758064 Ref: TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells. PMID: 23909892 Ref: Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. PMID: 24190430 Ref: Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells. PMID: 24260532 |
Ref: miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. PMID: 24145123 Ref: Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer. PMID: 24277452 Ref: Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. PMID: 24858802 Ref: Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence. PMID: 25091577 Ref: Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients. PMID: 25368522 Ref: High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs. PMID: 25409711 Ref: Distinct DNA damage determines differential phosphorylation of Chk2. PMID: 25535901 |
Ref: 5FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53mutated colon cancer cells. PMID: 25310623 Ref: Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. PMID: 25450478 Ref: Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer. PMID: 25479140 Ref: Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. PMID: 25497009 Ref: Targeting BRG1 chromatin remodeler via its bromodomain for enhanced tumor cell radiosensitivity in vitro and in vivo. PMID: 25504753 Ref: Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival. PMID: 25668003 Ref: Systematic search for rare variants in Finnish early-onset colorectal cancer patients. PMID: 25749350 Ref: P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers. PMID: 25757624 Ref: Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis. PMID: 25952326 Ref: Loss-of-function variants in ATM confer risk of gastric cancer. PMID: 26098866 Ref: Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan. PMID: 26257651 Ref: Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer. PMID: 26528635 Ref: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. PMID: 26595875 |
Ref: Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma. PMID: 26631035 Ref: The risk for developing cancer in Israeli ATM, BLM, and FANCC heterozygous mutation carriers. PMID: 26778106 Ref: Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters. PMID: 26784695 Ref: Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PMID: 27097159 Ref: Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. PMID: 27197284 Ref: Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition. PMID: 27446907 Ref: Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer. PMID: 27499037 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. PMID: 27602502 Ref: Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. PMID: 27690730 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 Ref: MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response. PMID: 27930716 Ref: [Study on the Effect of Overexpression of miR-18a on Cellular Proliferation and Migration by Targeting ATM in Human Colorectal Cancer Cells]. PMID: 28591941 Ref: Somatic mutation detection using various targeted detection assays in paired samples of circulating tumor DNA, primary tumor and metastases from patients undergoing resection of colorectal liver metastases. PMID: 28949453 |
Ref: Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer. PMID: 27169843 Ref: MUC13 protects colorectal cancer cells from death by activating the NF-kappaB pathway and is a potential therapeutic target. PMID: 27399336 Ref: 53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway. PMID: 27838786 Ref: Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. PMID: 27978560 Ref: The depletion of ATM inhibits colon cancer proliferation and migration via B56gamma2-mediated Chk1/p53/CD44 cascades. PMID: 28093285 Ref: Whole-exome sequencing identified mutational profiles of high-grade colon adenomas. PMID: 28179590 Ref: ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. PMID: 28182994 Ref: ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer. PMID: 28199979 Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma. PMID: 28476018 Ref: NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy. PMID: 28574504 Ref: Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer. PMID: 28794688 Ref: Methyleugenol and selected oxidative metabolites affect DNA-Damage signalling pathways and induce apoptosis in human colon tumour HT29 cells. PMID: 28818686 Ref: AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells. PMID: 28837154 Ref: Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. PMID: 28928376 Ref: Expanding the spectrum of germline variants in cancer. PMID: 28975465 Ref: MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis. PMID: 29048575 Ref: Erratum to epigenetics of colorectal cancer: emerging circulating diagnostic and prognostic biomarkers. PMID: 29057241 Ref: XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer. PMID: 29082250 Ref: GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. PMID: 29137421 Ref: Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer. PMID: 29344228 |
Ref: CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells. PMID: 28389531 Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: Insight into the role of PIKK family members and NF-small ka, CyrillicB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells. PMID: 29352261 Ref: 53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells. PMID: 29388453 Ref: Inherited DNA-Repair Defects in Colorectal Cancer. PMID: 29478780 Ref: Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. PMID: 29575536 Ref: Racial Disparities in the Molecular Landscape of Cancer. PMID: 29599344 Ref: Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome. PMID: 29710228 Ref: Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/gammaH2AX pathway. PMID: 29849127 Ref: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PMID: 29870526 Ref: Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. PMID: 29921885 Ref: Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population. PMID: 29928473 Ref: Geminin ablation in vivo enhances tumorigenesis through increased genomic instability. PMID: 29952003 Ref: Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. PMID: 29963241 Ref: A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer. PMID: 30032112 Ref: Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer. PMID: 30042009 Ref: Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series. PMID: 30042065 Ref: Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells. PMID: 30085332 Ref: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. PMID: 30214601 Ref: ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer. PMID: 30316683 Ref: pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. PMID: 30385821 |