Primary Site >> Colorectal Cancer
Gene >> ATF4
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Ref: Effect on tumor cells of blocking survival response to glucose deprivation. PMID: 15339968 |
Ref: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. PMID: 17283163 |
Ref: Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. PMID: 18470880 |
Ref: Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. PMID: 19754954 |
Ref: Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. PMID: 20232300 Ref: ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol. PMID: 20587662 |
Ref: Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation. PMID: 21683813 Ref: Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling implies endoplasmic reticulum stress. PMID: 22027281 |
Ref: AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells. PMID: 22435535 |
Ref: 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells. PMID: 22819556 Ref: Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma. PMID: 23123298 Ref: The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. PMID: 24104354 Ref: Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. PMID: 24113185 |
Ref: Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells. PMID: 24378333 Ref: A new tellurium-containing amphiphilic molecule induces apoptosis in HCT116 colon cancer cells. PMID: 24530428 Ref: Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells. PMID: 24530917 Ref: Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-re PMID: 24939851 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 |
Ref: Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice. PMID: 26233333 |
Ref: TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways. PMID: 26212606 Ref: Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. PMID: 27321283 Ref: Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression. PMID: 27468213 Ref: Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines. PMID: 28459519 |
Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Smad7 knockdown activates protein kinase RNA-associated eIF2alpha pathway leading to colon cancer cell death. PMID: 28300830 Ref: Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. PMID: 28551635 |
Ref: Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response. PMID: 29420561 Ref: beta-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. PMID: 29453334 |