Primary Site >> Colorectal Cancer

Gene >> ARHGEF4

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Ref: Asef, a link between the tumor suppressor APC and G-protein signaling.
PMID: 10947987
 Ref: Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element.
PMID: 17145773
Ref: Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism.
PMID: 17190834
Ref: Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.
PMID: 17588722
Ref: Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.
PMID: 17599059
Ref: Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
PMID: 17704816
 Ref: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.
PMID: 19151759
Ref: Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.
PMID: 19525225
 Ref: The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.
PMID: 19897489
Ref: Proteomic analysis of differentially expressed proteins involving in liver metastasis of human colorectal carcinoma.
PMID: 20382585
 Ref: Structural basis for the recognition of Asef by adenomatous polyposis coli.
PMID: 21788986
 Ref: Differences in the localization of the adenomatous polyposis coli-Asef/Asef2 complex between adenomatous polyposis coli wild-type and mutant cells.
PMID: 23910005
Ref: The miR-1-NOTCH3-Asef pathway is important for colorectal tumor cell migration.
PMID: 24244701
 Ref: CDC42 inhibition suppresses progression of incipient intestinal tumors.
PMID: 25113996
 Ref: Aberrant DNA Methylation: Implications in Racial Health Disparity.
PMID: 27111221
 Ref: Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
PMID: 28759015
 Ref: Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation.
PMID: 29866653
Ref: Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (APC)-Rho-Guanine-Nucleotide-Exchange-Factor-4 (Asef) Interaction.
PMID: 30095910