Primary Site >> Colorectal Cancer
Gene >> APEX1
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Ref: Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. PMID: 8065332 |
Ref: Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence. PMID: 9135024 Ref: [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. PMID: 9244653 |
Ref: The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. PMID: 14679184 |
Ref: [Study on significance of single nucleotide polymorphisms in the redox domain of aprimidinic/apurinic endonuclease/redox factor-1 gene in Chinese sporadic colorectal cancer]. PMID: 14767913 Ref: Sexual function after rectal excision. PMID: 15043737 |
Ref: Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH. PMID: 15661655 |
Ref: Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcit PMID: 16481390 |
Ref: Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma. PMID: 17283177 Ref: Base excision DNA repair defect in Gadd45a-deficient cells. PMID: 17599061 Ref: Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. PMID: 18091433 |
Ref: Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer. PMID: 17949784 Ref: DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic. PMID: 17991492 Ref: Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. PMID: 18208837 Ref: Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo. PMID: 18535621 Ref: Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population. PMID: 18823566 |
Ref: Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues. PMID: 18948225 Ref: The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies. PMID: 19762350 Ref: A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells. PMID: 19996303 |
Ref: Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. PMID: 20534734 Ref: Aberrant repair of etheno-DNA adducts in leukocytes and colon tissue of colon cancer patients. PMID: 20600828 Ref: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. PMID: 20720310 Ref: Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. PMID: 21037106 |
Ref: Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. PMID: 21081487 Ref: DNA polymerase beta as a novel target for chemotherapeutic intervention of colorectal cancer. PMID: 21311763 Ref: Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population. PMID: 21561390 Ref: Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PMID: 22194930 |
Ref: Prognostic significance of human apurinic/apyrimidinic endonuclease (APE/Ref-1) expression in rectal cancer treated with preoperative radiochemotherapy. PMID: 21075552 Ref: Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas. PMID: 22966016 |
Ref: Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population. PMID: 23430444 Ref: The influence of XPD, APE1, XRCC1, and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays. PMID: 23669291 Ref: Colon cancer progression is driven by APEX1-mediated upregulation of Jagged. PMID: 23863623 Ref: Apurinic/apyrimidinic endonuclease 1, the sensitive marker for DNA deterioration in dextran sulfate sodium-induced acute colitis. PMID: 23883737 Ref: Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study. PMID: 24065530 |
Ref: 8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients. PMID: 23832862 Ref: The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: a meta-analysis. PMID: 24254302 Ref: Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair. PMID: 24788673 Ref: Aberrant expression of redox protein Ape1 in colon cancer stem cells. PMID: 24944672 Ref: APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans. PMID: 25024628 Ref: Ultra low resection versus abdomino-perineal excision in low rectal cancer. PMID: 25103000 Ref: Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer. PMID: 25268610 Ref: Letter regarding Shen et al. entitled "The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: a meta-analysis". PMID: 25384510 Ref: Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1. PMID: 25395832 Ref: [Extralevator abdominoperineal excision versus traditional abdominoperineal excision in the treatment of low rectal cancer]. PMID: 25421770 |
Ref: Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated in Apc. PMID: 25257656 Ref: Susceptibility and REF1 gene polymorphism towards colorectal cancer. PMID: 25344644 Ref: Impact of APEX Ile64val Gene Polymorphisms of DNA Repair Ber System on Modulation of the Risk of Colorectal Cancer in the Polish Population. PMID: 26146106 |
Ref: Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan. PMID: 27022219 |
Ref: Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions. PMID: 28106284 Ref: Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer. PMID: 28360037 Ref: Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene. PMID: 28386271 Ref: The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis. PMID: 28749454 |
Ref: Clinical value of combined detection of serum APE1-Aabs and CEACAM-1 in the diagnosis of colorectal cancer. PMID: 29565485 Ref: Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome. PMID: 29664240 |