Primary Site >> Colorectal Cancer
Gene >> APC
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Ref: Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. PMID: 1310068 Ref: Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. PMID: 1338691 Ref: Frequent somatic mutations of the APC gene in human pancreatic cancer. PMID: 1423316 Ref: APC mutations occur early during colorectal tumorigenesis. PMID: 1528264 |
Ref: Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. PMID: 7903889 Ref: Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. PMID: 8242739 Ref: Dimer formation by an N-terminal coiled coil in the APC protein. PMID: 8248216 |
Ref: CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation. PMID: 7513984 Ref: Aberrations of the APC gene in primary breast carcinoma. PMID: 7798298 Ref: Slippage--misalignment: to what extent does it contribute to mammalian cell mutagenesis? PMID: 7837971 Ref: Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations. PMID: 7864589 Ref: [Genes, heredity and colorectal cancer]. PMID: 7878358 Ref: Mutations of the adenomatous polyposis coli gene in the mutation cluster region: comparison of human pancreatic and colorectal cancers. PMID: 7927902 Ref: Correlation of cellular differentiation in human colorectal carcinoma and adenoma cell lines with metabolite profiles determined by 1H magnetic resonance spectroscopy. PMID: 7927926 Ref: A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. PMID: 8090754 Ref: Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. PMID: 8187091 Ref: Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus. PMID: 8208405 |
Ref: Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation. PMID: 7496034 Ref: Human homologue of a candidate for the Mom1 locus, the secretory type II phospholipase A2 (PLA2S-II), maps to 1p35-36.1/D1S199. PMID: 7585622 Ref: APC binds to the novel protein EB1. PMID: 7606712 Ref: Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5;10)(q22;q25) responsible for familial adenomatous polyposis in a Dutch pedigree. PMID: 7669739 Ref: Genetic predispositions to colorectal cancer. PMID: 7675542 Ref: The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. PMID: 7781071 Ref: Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. PMID: 7846077 Ref: Calcium and the prevention of colon cancer. PMID: 8538212 Ref: Molecular biology of colon polyps and colon cancer. PMID: 8607008 |
Ref: Establishment and characterization of a human colon cancer cell line, OUMS-23, from a patient with familial adenomatous polyposis. PMID: 8576285 Ref: Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. PMID: 8601608 Ref: Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. PMID: 8638125 Ref: Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. PMID: 8653697 Ref: MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis. PMID: 8674041 Ref: The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. PMID: 8698812 Ref: Expression of the APC tumor suppressor protein in oligodendroglia. PMID: 8776583 Ref: Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adenomatous polyposis. PMID: 8834176 Ref: Introduction of human adenomatous polyposis coli gene into Min mice via cationic liposomes. PMID: 8862382 Ref: Genetic aspects of colorectal cancer: the surgeon's view. PMID: 8898451 Ref: Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse. PMID: 8946200 |
Ref: A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo. PMID: 8990193 Ref: Ornithine decarboxylase and polyamines in familial adenomatous polyposis. PMID: 9000553 Ref: Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: an animal model for CEA-directed tumor immunotherapy. PMID: 9212243 Ref: [Genetic and environmental factors in colorectal cancer. Mutations in the familial adenomatous polyposis gene]. PMID: 9235686 Ref: [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. PMID: 9244653 Ref: Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. PMID: 9268294 Ref: [APC, beta-catenin, DLG]. PMID: 9309137 Ref: Suppression of intestinal polyp development by low-fat and high-fiber diet in Apc(delta716) knockout mice. PMID: 9363991 Ref: The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. PMID: 9407954 Ref: Molecular biology of colorectal cancer. PMID: 9438104 Ref: AOM-induced mouse colon tumors do not express full-length APC protein. PMID: 9450492 Ref: Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene. PMID: 9465918 Ref: Cadherin and catenin biology represent a global mechanism for epithelial cancer progression. PMID: 9536277 Ref: [Current data on the role of APC protein in the origin of colorectal cancer]. PMID: 9536987 Ref: New rodent models for studies of chemopreventive agents. PMID: 9589360 Ref: [The application of molecular technics in the management of colorectal cancer]. PMID: 9772989 |
Ref: APC gene: database of germline and somatic mutations in human tumors and cell lines. PMID: 9399850 Ref: [A case of hepatic metastasis of rectal cancer with familial adenomatous polyposis treated by transarterial administration of low-dose leucovorin and 5-FU]. PMID: 9492838 Ref: Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. PMID: 9501226 Ref: Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. PMID: 9515784 Ref: High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. PMID: 9515794 Ref: Absence of frequent involvement of modifier of Min(APC) in sporadic colorectal cancer. PMID: 9527272 Ref: A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients. PMID: 9591632 Ref: Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. PMID: 9600336 Ref: A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9. PMID: 9603437 Ref: Experimental chemical carcinogenesis in the stomach and colon. PMID: 9614437 Ref: Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. PMID: 9649126 Ref: Sequence-based design of a peptide probe for the APC tumor suppressor protein. PMID: 9663391 Ref: Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations. PMID: 9664904 Ref: The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions. PMID: 9684289 Ref: Aspirin prevents tumors in a murine model of familial adenomatous polyposis. PMID: 9706142 Ref: Identification of c-MYC as a target of the APC pathway. PMID: 9727977 Ref: Roles of COX-1 and COX-2 in gastrointestinal pathophysiology. PMID: 9773924 Ref: Long-term analysis of colonic aberrant crypt formation after treatment of Sprague-Dawley rats with azoxymethane. PMID: 9804274 Ref: Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. PMID: 9865728 |
Ref: Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. PMID: 9973276 Ref: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. PMID: 10021369 Ref: Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. PMID: 10188882 Ref: Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. PMID: 10204808 Ref: Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. PMID: 10213222 Ref: Exon 14-skipping of the adenomatous polyposis coli gene in purified epithelial cells of colonic mucosa and tumors. PMID: 10226605 Ref: Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. PMID: 10346819 Ref: Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps. PMID: 10359135 Ref: Neuronal localization of the Adenomatous polyposis coli tumor suppressor protein. PMID: 10366023 Ref: Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay. PMID: 10383126 Ref: K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma. PMID: 10391560 Ref: Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. PMID: 10392898 Ref: Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients. PMID: 10398435 Ref: Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma. PMID: 10404094 Ref: Optimizing the APC gene mutation analysis in archival colorectal tumor tissue. PMID: 10408788 Ref: [Familial cancer: recent advances]. PMID: 10410140 Ref: Reduced expression of APC and DCC gene protein in breast cancer. PMID: 10469217 Ref: Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC. PMID: 10526234 Ref: Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. PMID: 10545404 Ref: Mechanisms of APC-driven tumorigenesis: lessons from mouse models. PMID: 10545699 Ref: The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. PMID: 10590231 Ref: Preliminary report on pathology of colorectal cancer in Poland in 1995 and 1975: is it still the same disease? PMID: 10663894 Ref: APC and intestinal carcinogenesis. Insights from animal models. PMID: 10668480 Ref: Are intestinal tumours in Apc+/-mice a suitable model of colorectal carcinoma in man? PMID: 10703747 Ref: [Are there differences between ex adenoma and de novo colorectal carcinomas?]. PMID: 10714204 Ref: Carcinogenesis in the colon: interaction between luminal factors and genetic factors. PMID: 10772422 |
Ref: Loss of heterozygosity of adenomatous polyposis coli gene in cutaneous tumors as determined by using polymerase chain reaction and paraffin section preparations. PMID: 10674823 Ref: Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. PMID: 10706126 Ref: APC mutation and phenotypic spectrum of Singapore familial adenomatous polyposis patients. PMID: 10713886 Ref: Modulation by dietary factors in murine FAP models. PMID: 10720759 Ref: Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. PMID: 10766173 Ref: The relationship between frequencies of extracolonic manifestations and the position of APC germline mutation in patients with familial adenomatous polyposis. PMID: 10768871 Ref: Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. PMID: 10783313 Ref: Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. PMID: 10783317 Ref: Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. PMID: 10851078 Ref: Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. PMID: 10866310 Ref: Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. PMID: 10889164 Ref: Genetic testing for familial adenomatous polyposis. PMID: 10911904 Ref: Asef, a link between the tumor suppressor APC and G-protein signaling. PMID: 10947987 Ref: The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. PMID: 10951583 Ref: Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. PMID: 11035805 Ref: Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas. PMID: 11048797 Ref: Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues. PMID: 11062151 Ref: The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease. PMID: 11099951 Ref: A double germline mutations in the APC and p53 genes. PMID: 11263856 Ref: Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin. PMID: 11341469 Ref: Evaluation of colonoscopic sized biopsies for microsatellite instability and adenomatous polyposis coli (APC) variants. PMID: 23578122 |
Ref: APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews. PMID: 11159880 Ref: Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. PMID: 11166179 Ref: Early detection of 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon. PMID: 11181456 Ref: Altered distribution of beta-catenin, and its binding proteins E-cadherin and APC, in ulcerative colitis-related colorectal cancers. PMID: 11211307 Ref: Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. PMID: 11212250 Ref: Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. PMID: 11244511 Ref: Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. PMID: 11245490 Ref: APC I1307K and E1317Q variants are rare or do not occur in Swedish colorectal cancer patients. PMID: 11267860 Ref: Detection of APC and k-ras mutations in the serum of patients with colorectal cancer. PMID: 11270422 Ref: PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. PMID: 11274170 Ref: A role for the Adenomatous Polyposis Coli protein in chromosome segregation. PMID: 11283619 Ref: Mutations in the APC tumour suppressor gene cause chromosomal instability. PMID: 11283620 Ref: Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development. PMID: 11285204 Ref: Nine novel APC mutations in Italian FAP patients. PMID: 11317365 Ref: Mutations at the APC exon 15 in the colorectal neoplastic tissues of serial array. PMID: 11355315 Ref: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. PMID: 11382316 Ref: [Colorectal carcinoma in Cronkhite-Canada syndrome]. PMID: 11413916 Ref: Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. PMID: 11437404 Ref: Beta-catenin activation through mutation is rare in rectal cancer. PMID: 11454429 Ref: Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. PMID: 11507063 Ref: Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. PMID: 11521200 Ref: Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. PMID: 11585736 Ref: ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A. PMID: 11585828 Ref: Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. PMID: 11588890 Ref: Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. PMID: 11668620 Ref: Studies on human colon cancer gene APC by targeted expression in Drosophila. PMID: 11687966 Ref: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. PMID: 11751682 Ref: APC, signal transduction and genetic instability in colorectal cancer. PMID: 11900252 |
Ref: Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet. PMID: 11756241 Ref: Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. PMID: 11756652 Ref: Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. PMID: 11818965 Ref: Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. PMID: 11923210 Ref: The APC gene in colorectal cancer. PMID: 11978510 Ref: The subcellular destinations of APC proteins. PMID: 11988767 Ref: Genetic and clinical characterisation of familial adenomatous polyposis: a population based study. PMID: 12010888 Ref: The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots. PMID: 12036944 Ref: Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation. PMID: 12049812 Ref: Intestinal adenomas can develop with a stable karyotype and stable microsatellites. PMID: 12060718 Ref: Teenagers with familial adenomatous polyposis: what is their risk for colorectal cancer? PMID: 12130875 Ref: Challenge in the differentiation between attenuated familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer: case report with review of the literature. PMID: 12135043 Ref: Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. PMID: 12145803 Ref: [Recent notions on intestinal cancerogenesis, their implications in genetic risk screening and preventive action of non-steroid anti-inflammatory agents]. PMID: 12145848 Ref: [Desmoid tumors in patients with familial adenomatous polyposis]. PMID: 12162172 Ref: No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. PMID: 12183405 Ref: The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. PMID: 12198702 Ref: Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. PMID: 12297097 Ref: Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. PMID: 12297098 Ref: Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. PMID: 12359363 Ref: APC-dependent suppression of colon carcinogenesis by PPARgamma. PMID: 12370429 Ref: Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells. PMID: 12372335 Ref: Mutations of the APC gene in human sporadic colorectal cancers. PMID: 12374230 Ref: Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. PMID: 12384519 Ref: Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. PMID: 12387883 Ref: Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice. PMID: 12438216 Ref: Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane. PMID: 12458338 Ref: Short chain fatty acids and colon cancer. PMID: 12468628 Ref: Pathogenesis of colorectal cancer. PMID: 12507199 Ref: Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. PMID: 12664576 |
Ref: Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas. PMID: 12527714 Ref: Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. PMID: 12566320 Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. PMID: 12584607 Ref: Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription. PMID: 12606575 Ref: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. PMID: 12622871 Ref: Chemoprevention of colon cancer by Korean food plant components. PMID: 12628507 Ref: Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers. PMID: 12647217 Ref: Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. PMID: 12663524 Ref: [Familial adenomatous polyposis: review of the literature and report of 3 cases]. PMID: 12728797 Ref: Rapidly progressive adenomatous polyposis in a patient with germline mutations in both the APC and MLH1 genes: the worst of two worlds. PMID: 12740349 Ref: Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. PMID: 12749762 Ref: P53 and beta-catenin in colorectal cancer progression. PMID: 12871177 Ref: Rofecoxib (Vioxx), a specific cyclooxygenase-2 inhibitor, is chemopreventive in a mouse model of colon cancer. PMID: 12902858 Ref: Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. PMID: 12955080 Ref: Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. PMID: 14522940 Ref: Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. PMID: 14625550 Ref: Colon cancer-associated DNA mutations: marker selection for the detection of proximal colon cancer. PMID: 14639104 Ref: [Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms]. PMID: 14685680 Ref: [Predictive molecular marker of distant metastasis in colorectal cancer]. PMID: 15027705 |
Ref: NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice. PMID: 14697260 Ref: Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. PMID: 15019166 Ref: MUC1 can interact with adenomatous polyposis coli in breast cancer. PMID: 15020226 Ref: Molecular analysis of the APC and MYH genes in Czech families affected by FAP or multiple adenomas: 13 novel mutations. PMID: 15024739 Ref: Somatic mutations of APC gene in carcinomas from hereditary non-polyposis colorectal cancer patients. PMID: 15040027 Ref: Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. PMID: 15063141 Ref: Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype. PMID: 15131404 Ref: [Genetic aspects of colorectal carcinogenesis]. PMID: 15181754 Ref: Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers. PMID: 15185002 Ref: Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. PMID: 15210940 Ref: Pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth. PMID: 15213719 Ref: Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. PMID: 15502862 Ref: Genetic factors and colorectal cancer in Ashkenazi Jews. PMID: 15516844 Ref: Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. PMID: 15561772 |
Ref: Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. PMID: 15548520 Ref: Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS. PMID: 15684716 Ref: Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells. PMID: 15688382 Ref: Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. PMID: 15716339 Ref: The I1307K APC mutation in a high-risk clinic setting: a follow-up study. PMID: 15733272 Ref: APC germ-line mutations in southern Spanish patients with familial adenomatous polyposis: genotype-phenotype correlations and identification of eight novel mutations. PMID: 15857185 Ref: Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis. PMID: 15924290 Ref: A homozygous mutation in MSH6 causes Turcot syndrome. PMID: 16000562 Ref: Loss of adenomatous polyposis coli gene function disrupts thymic development. PMID: 16025118 Ref: Who takes the lead in the development of ulcerative colitis-associated colorectal cancers: mutator, suppressor, or methylator pathway? PMID: 16157203 Ref: Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. PMID: 16174748 Ref: Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). PMID: 16184469 Ref: Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein. PMID: 16185824 Ref: [Multivisceral resections of extracolorectal lesions in familial adenomatous polyposis]. PMID: 16242660 Ref: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. PMID: 16356174 Ref: CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. PMID: 16357143 Ref: Pinealoblastoma in a patient with familial adenomatous polyposis: variant of Turcot syndrome type 2? Report of a case and review of the literature. PMID: 16400511 Ref: [From gene to disease; MutYH-associated polyposis coli (MAP)]. PMID: 16425850 Ref: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. PMID: 16787331 |
Ref: NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)delta expression in APC(min/+) mice proportionally to their tumor inhibitory effect: Implications for the role of PPARdelta in carcinogenesis. PMID: 16141240 Ref: Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients. PMID: 16287072 Ref: Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. PMID: 16293616 Ref: Identification of the IFITM family as a new molecular marker in human colorectal tumors. PMID: 16488993 Ref: Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan. PMID: 16569251 Ref: [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in patient management. Hereditary colorectal cancers]. PMID: 16579336 Ref: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. PMID: 16597643 Ref: Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. PMID: 16606335 Ref: Mouse models of gastrointestinal tumors. PMID: 16630131 Ref: Novel germline mutations in the APC gene of Cypriot patients with familial and sporadic adenomatous polyposis. PMID: 16650078 Ref: Prevention of early-onset familial/hereditary colon cancer: new models and mechanistic biomarkers (review). PMID: 16685453 Ref: The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. PMID: 16699180 Ref: Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. PMID: 16709231 Ref: Uranyl nitrilotriacetate, a stabilized salt of uranium, is genotoxic in nontransformed human colon cells and in the human colon adenoma cell line LT97. PMID: 16840563 Ref: The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features. PMID: 16875934 Ref: Congenital hypertrophy of the retinal pigment epithelium (CHRPE) in familial colorectal cancer. PMID: 16944273 Ref: Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. PMID: 16959882 Ref: Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. PMID: 17047044 Ref: Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector. PMID: 17047077 Ref: Dietary folate and APC mutations in sporadic colorectal cancer. PMID: 17116713 Ref: Colorectal cancer and genetic alterations in the Wnt pathway. PMID: 17143297 Ref: The role of the APC tumor suppressor in chromosomal instability. PMID: 18724059 |
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Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Gender-specific modulation of tumorigenesis by folic acid supply in the Apc mouse during early neonatal life. PMID: 17868491 Ref: Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor. PMID: 18097612 Ref: Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. PMID: 18160396 Ref: Reproducibility of tumor volume measurement at microCT colonography in living mice. PMID: 18280931 Ref: Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. PMID: 18403596 Ref: Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse. PMID: 18411292 Ref: The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. PMID: 18474248 Ref: Genetic and epigenetic changes in colon cancer. PMID: 18482722 Ref: The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. PMID: 18502210 Ref: Apc mice: models, modifiers and mutants. PMID: 18538487 Ref: Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. PMID: 18539961 Ref: Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. PMID: 18612690 Ref: [Single nucleotide c.645+32c>T substitution in the APC gene is a non-pathogenic polymorphism appearing in about 16% of the Czech population]. PMID: 18630182 Ref: Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. PMID: 18632633 Ref: A critical role for Apc in hematopoietic stem and progenitor cell survival. PMID: 18725524 Ref: Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice. PMID: 18725892 Ref: Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. PMID: 18794118 Ref: One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. PMID: 18794146 Ref: Prognostic and therapeutic implications of Apc mutations in colorectal cancer. PMID: 19110823 Ref: Identification of mucin depleted foci in the human colon. PMID: 19139006 Ref: Sex modulates intestinal transformation by the tumor-suppressor GCC. PMID: 20443837 |
Ref: No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer. PMID: 18343606 Ref: Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background. PMID: 18613032 Ref: Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas. PMID: 19002110 Ref: Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. PMID: 19035518 Ref: Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice. PMID: 19174418 Ref: Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. PMID: 19240248 Ref: The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. PMID: 19248780 Ref: Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2. PMID: 19261806 Ref: Initial results of colorectal polyposis research in Latvia. PMID: 19331226 Ref: Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. PMID: 19415698 Ref: 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model. PMID: 19420017 Ref: Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. PMID: 19482027 Ref: Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. PMID: 19525225 Ref: Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease. PMID: 19543899 Ref: A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PMID: 19578404 Ref: Relative role of APC and MUTYH mutations in the pathogenesis of familial adenomatous polyposis. PMID: 19593690 Ref: APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates. PMID: 19657225 Ref: Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. PMID: 19694754 Ref: Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. PMID: 19755659 Ref: Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways. PMID: 19759415 Ref: Familial adenomatous polyposis. PMID: 19822006 Ref: The role of mTORC1 pathway in intestinal tumorigenesis. PMID: 19855161 Ref: Nuclear APC. PMID: 19928349 Ref: APC and its modifiers in colon cancer. PMID: 19928355 Ref: Tissue-specific tumour suppression by APC. PMID: 19928356 Ref: Polymorphisms in the adenomatous polyposis coli gene in Slovak families suspected of FAP. PMID: 20027139 |
Ref: Loss of GDF-15 abolishes sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancer. PMID: 19784846 Ref: Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients. PMID: 19847890 Ref: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. PMID: 19861162 Ref: An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. PMID: 19931261 Ref: Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons. PMID: 19951906 Ref: Complete deletion of Apc results in severe polyposis in mice. PMID: 20010873 Ref: A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. PMID: 20051132 Ref: SGK1-dependent intestinal tumor growth in APC-deficient mice. PMID: 20110688 Ref: A new conditional Apc-mutant mouse model for colorectal cancer. PMID: 20176656 Ref: Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy. PMID: 20368985 Ref: Metabolic bioactivation of oestradiol-17beta (E2beta) in mouse colon epithelial cells bearing ApcMin mutation. PMID: 20417221 Ref: Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice. PMID: 20442768 Ref: ERbeta expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis. PMID: 20446826 Ref: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. PMID: 20454513 Ref: Increased angiogenesis in Cdk4(R24C/R24C):Apc(+/Min) intestinal tumors. PMID: 20603602 Ref: Novel methylation panel for the early detection of colorectal tumors in stool DNA. PMID: 20643622 Ref: PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. PMID: 20696900 Ref: Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. PMID: 20708588 Ref: The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. PMID: 20724530 Ref: Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. PMID: 20736363 Ref: Prediction and testing of biological networks underlying intestinal cancer. PMID: 20824133 Ref: The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. PMID: 20886217 Ref: p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. PMID: 20976827 Ref: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis. PMID: 21103407 Ref: Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1. PMID: 24212608 |
Ref: Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. PMID: 21061267 Ref: Mutation analysis of the APC gene in unrelated Korean patients with FAP: four novel mutations with unusual phenotype. PMID: 21110124 Ref: SATB1 and colorectal cancer in Wnt/beta-catenin signaling: Is there a functional link? PMID: 21122998 Ref: Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis. PMID: 21205878 Ref: Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. PMID: 21224344 Ref: Cytokines, inflammation and colon cancer. PMID: 21247378 Ref: Loss of a single Hic1 allele accelerates polyp formation in Apc(Delta716) mice. PMID: 21297660 Ref: Detection of APC gene deletions in colorectal malignancies using quantitative PCR in a Chinese population. PMID: 21359685 Ref: Proteins and an inflammatory network expressed in colon tumors. PMID: 21366352 Ref: Dynamics of cancer cell subpopulations in primary and metastatic colorectal tumors. PMID: 21380628 Ref: Identification of Mom12 and Mom13, two novel modifier loci of Apc (Min) -mediated intestinal tumorigenesis. PMID: 21386660 Ref: Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer. PMID: 21398423 Ref: Preclinical in vitro models from genetically engineered mice for breast and colon cancer (Review). PMID: 21399881 Ref: Analysis of APC allelic imbalance/loss of heterozygosity and APC protein expression in cutaneous squamous cell carcinomas. PMID: 21518821 Ref: A new phenotypic manifestation of familial adenomatous polyposis. PMID: 21547505 Ref: Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. PMID: 21664290 Ref: Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. PMID: 21705482 Ref: Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. PMID: 21889923 Ref: Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PMID: 21901162 Ref: Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models. PMID: 21907701 Ref: 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron. PMID: 21967605 Ref: Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68. PMID: 22000517 Ref: The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP). PMID: 22103048 Ref: E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis. PMID: 22176698 |
Ref: Structural basis for the recognition of Asef by adenomatous polyposis coli. PMID: 21788986 Ref: Different phenotypic consequences of simultaneous versus stepwise Apc loss. PMID: 21892206 Ref: Increased variance in germline allele-specific expression of APC associates with colorectal cancer. PMID: 21995949 Ref: A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. PMID: 21996741 Ref: Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model. PMID: 22052467 Ref: Genetic deletion of 5-lipoxygenase increases tumor-infiltrating macrophages in Apc(Delta468) mice. PMID: 22072302 Ref: Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. PMID: 22308460 Ref: Essential requirement for beta-arrestin2 in mouse intestinal tumors with elevated Wnt signaling. PMID: 22315403 Ref: Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice. PMID: 22431924 Ref: Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. PMID: 22552011 Ref: The influence of folate and methionine on intestinal tumour development in the Apc(Min/+) mouse model. PMID: 22627043 Ref: Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain. PMID: 22637734 Ref: Hepatoblastoma in two siblings and familial adenomatous polyposis: causal nexus or coincidence? PMID: 22692730 Ref: Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4. PMID: 22740476 Ref: Perinatal detection of familial adenomatous polyposis. PMID: 22825279 Ref: The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. PMID: 22851318 Ref: A porcine model of familial adenomatous polyposis. PMID: 22864254 Ref: Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. PMID: 22864938 Ref: Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo. PMID: 22884366 Ref: Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay. PMID: 23031214 Ref: Lessons from the hepatoblastoma-familial polyposis connection. PMID: 23116752 Ref: [Expression of Wnt5a, APC, beta-catenin and their clinical significance in human colorectal adenocarcinoma]. PMID: 23159080 Ref: Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. PMID: 23172913 Ref: Inhibitory effects of calcium against intestinal cancer in human colon cancer cells and Apc(Min/+) mice. PMID: 23198018 Ref: Colon cancer prevention by detection of APC gene mutation in a family with attenuated familial adenomatous polyposis. PMID: 23244118 |
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