Primary Site >> Pancreatic Cancer
Gene >> ALOX5
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Ref: Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. PMID: 10405349 Ref: Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells. PMID: 10600514 |
Ref: Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. PMID: 11238189 Ref: Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase? PMID: 11462800 |
Ref: 5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue. PMID: 12163367 Ref: Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. PMID: 12481414 |
Ref: Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer. PMID: 14707447 |
Ref: Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients. PMID: 15239141 |
Ref: A novel anti-pancreatic cancer agent, LY293111. PMID: 15846111 Ref: 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. PMID: 16024599 Ref: Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase. PMID: 16037546 |
Ref: Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. PMID: 17369849 Ref: Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines. PMID: 17434678 Ref: 15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth. PMID: 18030360 |
Ref: Effect of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2. PMID: 18442195 Ref: The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer. PMID: 19190780 |
Ref: Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model. PMID: 21713446 Ref: Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice. PMID: 22916251 |
Ref: Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase. PMID: 25152576 |
Ref: Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells. PMID: 25483364 Ref: 5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-alpha secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells. PMID: 25642980 |
Ref: Loss of natural killer T cells promotes pancreatic cancer in LSL-Kras(G12D/+) mice. PMID: 28419443 |
Ref: Evidence for the anti-inflammatory activity of Bupleurum marginatum (Apiaceae) extracts using in vitro and in vivo experiments supported by virtual screening. PMID: 29611204 |