Primary Site >> Colorectal Cancer
Gene >> ALDH1A1
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Ref: Genetic polymorphism and activities of human colon alcohol and aldehyde dehydrogenases: no gender and age differences. PMID: 7847616 |
Ref: Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays. PMID: 16583981 |
Ref: Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PMID: 18560594 |
Ref: Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. PMID: 19336570 Ref: Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of rat colonic crypts. PMID: 19465005 |
Ref: ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients. PMID: 20135722 Ref: Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PMID: 20422001 Ref: Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. PMID: 20606680 Ref: Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors. PMID: 21176222 |
Ref: Colon cancer stem cells: implications in carcinogenesis. PMID: 21196254 Ref: Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. PMID: 21216231 Ref: Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. PMID: 21435460 Ref: Isolation and characterization of spheroid cells from the HT29 colon cancer cell line. PMID: 21670985 Ref: Common cancer stem cell gene variants predict colon cancer recurrence. PMID: 21918173 Ref: Colorectal cancer stem cell: a potential therapeutic target. PMID: 22126725 Ref: Overexpression of CYP3A4 in a COLO 205 Colon Cancer Stem Cell Model in vitro. PMID: 24212669 |
Ref: Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. PMID: 21940137 Ref: The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors. PMID: 22101256 Ref: EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine. PMID: 22281474 Ref: Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer. PMID: 22405917 Ref: A Pilot Study Assessing the Potential Role of non-CD133 Colorectal Cancer Stem Cells as Biomarkers. PMID: 22670157 Ref: Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy. PMID: 22878609 |
Ref: Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice. PMID: 23001810 Ref: Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells. PMID: 23060121 Ref: Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model. PMID: 23193035 Ref: MiR-125a/b regulates the activation of cancer stem cells in paclitaxel-resistant colon cancer. PMID: 23327190 Ref: ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer. PMID: 23332924 Ref: ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell lines. PMID: 23358684 Ref: Kruppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells. PMID: 23418515 Ref: Expression of aldehyde dehydrogenase 1 in colon cancer. PMID: 23768832 Ref: [CD133(+) Colo205 colorectal cancer cells express high levels of ALDH1 in serum-free culture]. PMID: 23803205 Ref: The secretome of colon cancer stem cells contains drug-metabolizing enzymes. PMID: 23835434 Ref: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. PMID: 23916687 Ref: Colorectal adenoma stem-like cell populations: associations with adenoma characteristics and metachronous colorectal neoplasia. PMID: 24008128 |
Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: ALDH1 is an independent prognostic factor for patients with stages II-III rectal cancer after receiving radiochemotherapy. PMID: 24327017 Ref: Expression and prognostic value of tumor stem cell markers ALDH1 and CD133 in colorectal carcinoma. PMID: 24396478 Ref: TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-beta1. PMID: 24402192 Ref: Altered expression of multiple genes involved in retinoic acid biosynthesis in human colorectal cancer. PMID: 24599561 Ref: P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer. PMID: 24708484 Ref: Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer. PMID: 24786601 Ref: The impact of Aldehyde dehydrogenase 1 expression on prognosis for metastatic colon cancer. PMID: 24953984 Ref: Distinct patterns of ALDH1A1 expression predict metastasis and poor outcome of colorectal carcinoma. PMID: 25031716 Ref: Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture. PMID: 25075203 Ref: Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT. PMID: 25238234 Ref: Colon cancer: cancer stem cells markers, drug resistance and treatment. PMID: 25458789 |
Ref: ALDH1 is a prognostic factor for patients treated with neoadjuvant chemoradiotherapy and radical resection for stage III rectal cancer. PMID: 25270363 Ref: Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers. PMID: 25427913 Ref: Aldehyde dehydrogenase 1: a specific cancer stem cell marker for human colorectal carcinoma. PMID: 25585687 Ref: Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. PMID: 25788273 Ref: A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer. PMID: 26098881 Ref: Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors. PMID: 26185002 Ref: Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells. PMID: 26185996 Ref: Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis. PMID: 26230297 Ref: Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells. PMID: 26238079 Ref: Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line. PMID: 26634106 Ref: Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. PMID: 26682730 Ref: [Prognostic values of the clinical, morphological and molecular biological characteristics of colon adenocarcinoma]. PMID: 26978017 |
Ref: Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer. PMID: 26358078 Ref: Cancer stem cells in human digestive tract malignancies. PMID: 26446457 Ref: Clinical influence of cancer stem cells on residual disease after preoperative chemoradiotherapy for rectal cancer. PMID: 26456957 Ref: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. PMID: 26785732 Ref: Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer. PMID: 27152521 Ref: PO-52 - Effect of tissue factor expression by colorectal cancer on cancer stem cell activity. PMID: 27161739 Ref: Combination Therapy of Lactobacillus plantarum Supernatant and 5-Fluouracil Increases Chemosensitivity in Colorectal Cancer Cells. PMID: 27221111 Ref: Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. PMID: 27234655 Ref: Nuclear aldehyde dehydrogenase 1A1 (ALDH1A1) expression is a favorable prognostic indicator in colorectal carcinoma. PMID: 27461829 Ref: Metastasis-associated in colon cancer-1 and aldehyde dehydrogenase 1 are metastatic and prognostic biomarker for non-small cell lung cancer. PMID: 27832750 Ref: Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine. PMID: 27863474 Ref: Microarray analysis of differentially-expressed genes and linker genes associated with the molecular mechanism of colorectal cancer. PMID: 27899990 Ref: Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer. PMID: 28503055 |
Ref: Role of Stem Cells in Colorectal Cancer Progression and Prognostic and Predictive Characteristics of Stem Cell Markers in Colorectal Cancer. PMID: 27593447 Ref: Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas. PMID: 27813511 Ref: The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer. PMID: 28237538 Ref: Evaluation of the Role of ALDH1 as Cancer Stem Cell Marker in Colorectal Carcinoma: An Immunohistochemical Study. PMID: 28273973 Ref: Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study. PMID: 28394276 Ref: Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma. PMID: 28431527 Ref: Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence. PMID: 28484082 Ref: Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients. PMID: 28570747 Ref: Synergy between Auraptene, Ionizing Radiation, and Anticancer Drugs in Colon Adenocarcinoma Cells. PMID: 28675489 Ref: Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer. PMID: 28881356 Ref: ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells. PMID: 28981387 Ref: The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3. PMID: 29102042 Ref: Reduction of NANOG Mediates the Inhibitory Effect of Aspirin on Tumor Growth and Stemness in Colorectal Cancer. PMID: 29179207 Ref: CEACAM1 is associated with recurrence after hepatectomy for colorectal liver metastasis. PMID: 29180203 |
Ref: Overexpression of HOXA4 and HOXA9 genes promotes self-renewal and contributes to colon cancer stem cell overpopulation. PMID: 28464221 Ref: CD133 expression predicts post-operative recurrence in patients with colon cancer with peritoneal metastasis. PMID: 29328371 Ref: Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers. PMID: 29343849 Ref: Molecular profiling of ALDH1(+) colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways. PMID: 29568377 Ref: Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer. PMID: 29627827 Ref: Assessing stemness and proliferation properties of the newly established colon cancer 'stem' cell line, CSC480 and novel approaches to identify dormant cancer cells. PMID: 29693155 Ref: The miR-371 approximately 373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis. PMID: 29748374 Ref: Expression of Aldehyde Dehydrogenase 1A1 (ALDH1A1) as a Prognostic Biomarker in Colorectal Cancer Using Immunohistochemistry. PMID: 29748529 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene. PMID: 29869821 Ref: ALDH1A inhibition sensitizes colon cancer cells to chemotherapy. PMID: 29902974 Ref: Cancer Stemness, Immune Cells, and Epithelial-Mesenchymal Transition Cooperatively Predict Prognosis in Colorectal Carcinoma. PMID: 29921496 Ref: Resveratrol Chemosensitizes TNF-beta-Induced Survival of 5-FU-Treated Colorectal Cancer Cells. PMID: 30002278 Ref: Melatonin and 5-fluorouracil co-suppress colon cancer stem cells by regulating cellular prion protein-Oct4 axis. PMID: 30091203 Ref: Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway. PMID: 30118845 Ref: Effect of As2O3 on colorectal CSCs stained with ALDH1 in primary cell culture in vitro. PMID: 30128021 Ref: The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma. PMID: 30136202 Ref: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer. PMID: 30144515 Ref: High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling. PMID: 30166520 Ref: Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1. PMID: 30174443 Ref: Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/beta-Catenin Pathway. PMID: 30257507 Ref: Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression. PMID: 30272331 Ref: Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture. PMID: 30284085 Ref: ALDH1A1 expression is associated with poor differentiation, 'right-sidedness' and poor survival in human colorectal cancer. PMID: 30308036 |