Primary Site >> Stomach Cancer
Gene >> AKT1
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Ref: SEREX analysis of gastric cancer antigens. PMID: 10950146 Ref: Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. PMID: 11085546 |
Ref: Promoter methylation and silencing of PTEN in gastric carcinoma. PMID: 11896207 Ref: Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. PMID: 12101188 Ref: K252a inhibits the oncogenic properties of Met, the HGF receptor. PMID: 12118367 |
Ref: Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. PMID: 12618892 Ref: P38 MAPK pathway is involved in the urokinase plasminogen activator expression in human gastric SNU-638 cells. PMID: 12883725 Ref: Antiproliferative effect of octreotide on gastric cancer cells mediated by inhibition of Akt/PKB and telomerase. PMID: 14562414 Ref: A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. PMID: 14612533 Ref: Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. PMID: 14662022 Ref: Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis. PMID: 14678019 |
Ref: Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. PMID: 14605879 Ref: Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. PMID: 14747535 Ref: Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells. PMID: 15067346 Ref: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. PMID: 15077160 Ref: Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells. PMID: 15208668 Ref: Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line. PMID: 15309882 Ref: Regulation of vascular endothelial growth factor expression in human gastric cancer cells by interleukin-1beta. PMID: 15349119 Ref: Preclinical evaluation of antisense bcl-2 as a chemosensitizer for patients with gastric carcinoma. PMID: 15476281 Ref: RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival. PMID: 15520203 |
Ref: NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. PMID: 15561713 Ref: Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. PMID: 15681438 Ref: A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. PMID: 15751984 Ref: REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer. PMID: 15765400 Ref: COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines. PMID: 15767780 Ref: Helicobacter pylori-dependent NF-kappa B activation in newly established Mongolian gerbil gastric cancer cell lines. PMID: 15771620 Ref: Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma. PMID: 15786421 Ref: Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells. PMID: 15809062 Ref: Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells. PMID: 15809724 Ref: Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer. PMID: 15814628 Ref: Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. PMID: 15831900 Ref: Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. PMID: 15900596 Ref: Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention. PMID: 15922857 Ref: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. PMID: 16086234 Ref: PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells. PMID: 16264263 Ref: Epithelial-mesenchymal transition in gastric cancer (Review). PMID: 16273224 Ref: Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. PMID: 16393120 |
Ref: Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. PMID: 16183075 Ref: Analysis of common gene expression patterns in four human tumor cell lines exposed to camptothecin using cDNA microarray: identification of topoisomerase-mediated DNA damage response pathways. PMID: 16368568 Ref: Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. PMID: 16371352 Ref: Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. PMID: 16489019 Ref: Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells. PMID: 16527552 Ref: How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions. PMID: 16627973 Ref: Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells. PMID: 16641552 Ref: Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. PMID: 16707418 Ref: Significance of Akt phosphorylation on tumor growth and vascular endothelial growth factor expression in human gastric carcinoma. PMID: 16785763 Ref: CAGE, a novel cancer/testis antigen gene, promotes cell motility by activation ERK and p38 MAPK and downregulating ROS. PMID: 16819299 Ref: CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K/Akt pathway. PMID: 16865270 Ref: Porphyran induces apoptosis related signal pathway in AGS gastric cancer cell lines. PMID: 16876203 Ref: Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma. PMID: 16963731 Ref: Induction of apoptosis by L-NMMA, via FKHRL1/ROCK pathway in human gastric cancer cells. PMID: 17044646 Ref: Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas. PMID: 17047397 Ref: Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. PMID: 17050876 Ref: Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. PMID: 17088902 Ref: A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. PMID: 17101326 Ref: Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA. PMID: 17310852 |
Ref: Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. PMID: 17186543 Ref: Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway. PMID: 17257745 Ref: Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy. PMID: 17334718 Ref: A polysaccharide of the marine alga Capsosiphon fulvescens induces apoptosis in AGS gastric cancer cells via an IGF-IR-mediated PI3K/Akt pathway. PMID: 17344071 Ref: Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. PMID: 17363505 Ref: Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS. PMID: 17409275 Ref: Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo. PMID: 17495522 Ref: AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. PMID: 17505008 Ref: Structural basis for depletion of heat shock protein 90 client proteins by deguelin. PMID: 17565155 Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. PMID: 17568183 Ref: Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway. PMID: 17582000 Ref: Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. PMID: 17646428 Ref: RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. PMID: 17659701 Ref: [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. PMID: 17680526 Ref: 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. PMID: 17680560 Ref: Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. PMID: 17725107 Ref: Antitumor effects and drug interactions of the proteasome inhibitor bortezomib (PS341) in gastric cancer cells. PMID: 17762396 Ref: Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells. PMID: 17823871 Ref: Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2. PMID: 18025257 |
Ref: Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. PMID: 17935137 Ref: A hypoxia-independent up-regulation of hypoxia-inducible factor-1 by AKT contributes to angiogenesis in human gastric cancer. PMID: 17984117 Ref: REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. PMID: 18024479 Ref: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. PMID: 18097546 Ref: t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism. PMID: 18199533 Ref: Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells. PMID: 18226852 Ref: Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. PMID: 18258606 Ref: Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. PMID: 18339873 Ref: Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells. PMID: 18375114 Ref: Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. PMID: 18378261 Ref: Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines. PMID: 18378393 Ref: Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation. PMID: 18379876 Ref: Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. PMID: 18381294 Ref: Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. PMID: 18395088 Ref: The effect of polysaccharide extracted from the marine alga Capsosiphon fulvescens on ethanol administration. PMID: 18524446 Ref: Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway. PMID: 18604870 Ref: Mammalian target of rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines. PMID: 18622747 Ref: A small interfering RNA targeting osteopontin as gastric cancer therapeutics. PMID: 18694621 Ref: Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. PMID: 18713840 Ref: NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis. PMID: 18824170 Ref: Glibenclamide exerts an antitumor activity through reactive oxygen species-c-jun NH2-terminal kinase pathway in human gastric cancer cell line MGC-803. PMID: 18840412 Ref: Activated Akt as an indicator of prognosis in gastric cancer. PMID: 18841391 Ref: Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells. PMID: 18849546 Ref: HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. PMID: 18974395 Ref: [Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin]. PMID: 19062713 |
Ref: Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway. PMID: 18723843 Ref: Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation. PMID: 18782353 Ref: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. PMID: 18823436 Ref: Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. PMID: 18996844 Ref: A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. PMID: 19015244 Ref: Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER-2 heterodimerization and activation. PMID: 19082474 Ref: Signaling components involved in Bcl-w-induced migration of gastric cancer cells. PMID: 19097687 Ref: Reg IV enhances peritoneal metastasis in gastric carcinomas. PMID: 19143768 Ref: Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cells. PMID: 19143835 Ref: Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. PMID: 19148483 Ref: Obestatin stimulates Akt signalling in gastric cancer cells through beta-arrestin-mediated epidermal growth factor receptor transactivation. PMID: 19153210 Ref: Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. PMID: 19154985 Ref: Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. PMID: 19199544 Ref: Relation between outcomes and localisation of p-mTOR expression in gastric cancer. PMID: 19223902 Ref: The expression of protein kinase B in gastric cancer cell apoptosis induced by 12-O-tetradecanoylphorbol-1, 3-acetate. PMID: 19238332 Ref: Midkine positively regulates the proliferation of human gastric cancer cells. PMID: 19250738 Ref: Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells. PMID: 19274672 Ref: PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells. PMID: 19343001 Ref: Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle. PMID: 19360331 Ref: Gastric cancer in the era of molecularly targeted agents: current drug development strategies. PMID: 19363621 Ref: Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. PMID: 19424592 Ref: Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation. PMID: 19457607 Ref: Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation. PMID: 19473897 Ref: Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells. PMID: 19497102 Ref: Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals. PMID: 19508871 Ref: Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. PMID: 19513567 Ref: Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. PMID: 19533808 Ref: A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. PMID: 19545448 Ref: Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR. PMID: 19550116 Ref: Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1alpha up-regulation and MMP9 activation. PMID: 19602039 Ref: AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer. PMID: 19723882 Ref: Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. PMID: 19755509 Ref: Overexpression of YKL-40 is an independent prognostic marker in gastric cancer. PMID: 19765801 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 Ref: The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells. PMID: 19863226 Ref: Suppression of Akt1 expression by small interference RNA inhibits SGC7901 cell growth in vitro and in vivo. PMID: 19885581 Ref: Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway. PMID: 19924065 Ref: Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway. PMID: 19938192 |
Ref: Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. PMID: 19680787 Ref: The role of Reg IV gene and its encoding product in gastric carcinogenesis. PMID: 19740514 Ref: BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. PMID: 19835871 Ref: Analysis of anti-proliferative and chemosensitizing effects of sunitinib on human esophagogastric cancer cells: Synergistic interaction with vandetanib via inhibition of multi-receptor tyrosine kinase pathways. PMID: 20039326 Ref: Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. PMID: 20046046 Ref: MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. PMID: 20145145 Ref: BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer. PMID: 20170541 Ref: Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. PMID: 20179222 Ref: Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. PMID: 20198349 Ref: MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. PMID: 20215506 Ref: Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells. PMID: 20336665 Ref: KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. PMID: 20358631 Ref: Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. PMID: 20406949 Ref: Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. PMID: 20428833 Ref: 12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis. PMID: 20428959 Ref: Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. PMID: 20494139 Ref: PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. PMID: 20506484 Ref: Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. PMID: 20514448 Ref: Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. PMID: 20514451 Ref: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. PMID: 20522955 Ref: 19-peptide, a fragment of tumstatin, inhibits the growth of poorly differentiated gastric carcinoma cells in vitro and in vivo. PMID: 20546447 Ref: Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. PMID: 20547161 Ref: Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway. PMID: 20560677 Ref: Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer. PMID: 20566745 Ref: The sequence-dependent cytotoxic effect of trastuzumab in combination with 5-Fluorouracil or cisplatin on gastric cancer cell lines. PMID: 20590442 Ref: Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals. PMID: 20600540 Ref: Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. PMID: 20633512 Ref: LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. PMID: 20704765 Ref: The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway. PMID: 20727916 Ref: Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. PMID: 20804754 Ref: Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer. PMID: 20811676 Ref: Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics. PMID: 20836672 Ref: Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. PMID: 20876799 Ref: Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: the role of reactive oxygen species and Akt. PMID: 20878083 Ref: Blocking of PI3K/AKT induces apoptosis by its effect on NF-kappaB activity in gastric carcinoma cell line SGC7901. PMID: 20947290 Ref: Up-regulation of PIK3CA promotes metastasis in gastric carcinoma. PMID: 20954287 Ref: Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Kruppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation. PMID: 21075859 Ref: Induction of metastatic gastric cancer by peroxisome proliferator-activated receptordelta activation. PMID: 21318167 Ref: Phosphoinositide 3-kinase/Akt and nuclear factor kappaB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. PMID: 21472268 |
Ref: Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. PMID: 20300973 Ref: Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. PMID: 20585984 Ref: Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer. PMID: 20839260 Ref: Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells. PMID: 21042278 Ref: BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells. PMID: 21171085 Ref: LY294002 potentiates the anti-cancer effect of oxaliplatin for gastric cancer via death receptor pathway. PMID: 21245990 Ref: Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45. PMID: 21264842 Ref: Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. PMID: 21266357 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells. PMID: 21287681 Ref: A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. PMID: 21364753 Ref: [Expression and clinical significance of epidermal growth factor receptor and protein kinase B in gastric carcinoma]. PMID: 21365510 Ref: P27(Kip1), regulated by glycogen synthase kinase-3beta, results in HMBA-induced differentiation of human gastric cancer cells. PMID: 21439087 Ref: Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins. PMID: 21453385 Ref: A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer. PMID: 21538018 Ref: Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-kappaB pathway, and MMP-9 expression. PMID: 21570392 Ref: beta-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis. PMID: 21595977 Ref: Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. PMID: 21610320 Ref: Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake. PMID: 21712451 Ref: Protective autophagy antagonizes oxaliplatin-induced apoptosis in gastric cancer cells. PMID: 21718595 Ref: DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. PMID: 21741919 Ref: Nitric oxide inhibits gastric cancer cell growth through the modulation of the Akt pathway. PMID: 21769431 Ref: Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways. PMID: 21786165 Ref: The XAF1 tumor suppressor induces autophagic cell death via upregulation of Beclin-1 and inhibition of Akt pathway. PMID: 21788101 Ref: Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. PMID: 21826665 Ref: Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers. PMID: 21898090 Ref: Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells. PMID: 21943213 Ref: Co-expression of erythropoietin receptor with human epidermal growth factor 2 may counteract trastuzumab inhibition in gastric cancer. PMID: 21944379 Ref: Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. PMID: 21975935 Ref: RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells. PMID: 21990951 Ref: Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update. PMID: 21997759 Ref: Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). PMID: 22152101 Ref: Targeting AKT protein kinase in gastric cancer. PMID: 22199303 |
Ref: PTP1B expression contributes to gastric cancer progression. PMID: 21442314 Ref: MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. PMID: 21822301 Ref: Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer. PMID: 21841827 Ref: Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers. PMID: 22050138 Ref: Molecular targeted agents for gastric and gastroesophageal junction cancer. PMID: 22127535 Ref: Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. PMID: 22135232 Ref: Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. PMID: 22139054 Ref: Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells. PMID: 22139134 Ref: Multi-parametric approach to identify coffee components that regulate mechanisms of gastric acid secretion. PMID: 22147653 Ref: NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. PMID: 22159814 Ref: Paclitaxel/tetrandrine coloaded nanoparticles effectively promote the apoptosis of gastric cancer cells based on "oxidation therapy". PMID: 22171565 Ref: RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. PMID: 22231444 Ref: MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells. PMID: 22238368 Ref: RON is associated with tumor progression via the inhibition of apoptosis and cell cycle arrest in human gastric cancer. PMID: 22243783 Ref: Downregulation of Id1 by small interfering RNA in gastric cancer inhibits cell growth via the Akt pathway. PMID: 22245935 Ref: Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo. PMID: 22246223 Ref: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. PMID: 22292935 Ref: miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer. PMID: 22293682 Ref: E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. PMID: 22322152 Ref: Regulation of SHP2 by PTEN/AKT/GSK-3beta signaling facilitates IFN-gamma resistance in hyperproliferating gastric cancer. PMID: 22325465 Ref: Targeted therapy in the management of advanced gastric cancer: are we making progress in the era of personalized medicine? PMID: 22334453 Ref: Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. PMID: 22337890 Ref: Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells. PMID: 22359623 Ref: RNAi knockdown of the Akt1 gene increases the chemosensitivity of gastric cancer cells to cisplatin both in vitro and in vivo. PMID: 22387880 Ref: IQGAP2, A candidate tumour suppressor of prostate tumorigenesis. PMID: 22406297 Ref: Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells. PMID: 22408359 Ref: The roles of REIC gene and its encoding product in gastric carcinoma. PMID: 22421143 Ref: miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. 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PMID: 25596089 Ref: Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells. PMID: 25609923 Ref: HER-2-induced PI3K signaling pathway was involved in the pathogenesis of gastric cancer. PMID: 25613482 Ref: KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis. PMID: 25628922 Ref: 3,3'-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade. PMID: 25633416 Ref: The functional sites of miRNAs and lncRNAs in gastric carcinogenesis. PMID: 25636450 Ref: Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer. PMID: 25638174 Ref: Inactivation of the phosphatidylinositol 3-kinase/Akt pathway is involved in BMP9-mediated tumor-suppressive effects in gastric cancer cells. PMID: 25640278 Ref: A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions. PMID: 25646814 Ref: Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells. PMID: 25652794 Ref: Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2. PMID: 25652880 Ref: Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop. PMID: 25669984 Ref: G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro. PMID: 25673461 Ref: ACK1 promotes gastric cancer epithelial-mesenchymal transition and metastasis through AKT-POU2F1-ECD signalling. PMID: 25678401 Ref: Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer. PMID: 25683757 Ref: Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. PMID: 25697906 Ref: C23 protein meditates bone morphogenetic protein-2-mediated EMT via up-regulation of Erk1/2 and Akt in gastric cancer. PMID: 25698539 Ref: Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway. PMID: 25701378 Ref: Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis. PMID: 25703932 Ref: TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance. PMID: 25724180 Ref: Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-kappaB signaling pathway for gastric cancer metastasis. PMID: 25727320 Ref: Silencing profilin-1 inhibits gastric cancer progression via integrin beta1/focal adhesion kinase pathway modulation. PMID: 25741138 Ref: The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4. PMID: 25753202 Ref: Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis. PMID: 25759527 Ref: Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and N PMID: 25767376 Ref: Hyperglycemia Promotes Human Gastric Carcinoma Progression via Aquaporin 3. PMID: 25777259 Ref: Cisplatin-mediated c-myc overexpression and cytochrome c (cyt c) release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase 3 and caspase 9, likely responsible for the TRAIL-sensitizing effect of cisplatin. PMID: 25796504 Ref: Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients. PMID: 25809930 Ref: Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005). PMID: 25827820 Ref: Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients. PMID: 25831050 Ref: Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. PMID: 25837881 Ref: Anthocyanins From the Fruit of Vitis coignetiae Pulliat Potentiate the Cisplatin Activity by Inhibiting PI3K/Akt Signaling Pathways in Human Gastric Cancer Cells. PMID: 25853103 Ref: Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells. PMID: 25872479 Ref: CDX2 inhibits invasion and migration of gastric cancer cells by phosphatase and tensin homologue deleted from chromosome 10/Akt signaling pathway. PMID: 25881601 Ref: Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. PMID: 25884175 Ref: Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo. PMID: 25888009 Ref: The role of TGFBI (betaig-H3) in gastrointestinal tract tumorigenesis. PMID: 25889002 Ref: Role of mimic of manganese superoxide dismutase in proliferation and apoptosis of gastric carcinoma BGC-823 cells in vitro and in vivo. PMID: 25889634 Ref: A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer. PMID: 25894376 Ref: Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer. PMID: 25909166 Ref: MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. PMID: 25914465 Ref: Junctional adhesion molecule-A promotes proliferation and inhibits apoptosis of gastric cancer. PMID: 25916097 Ref: Blockade of CXCR6 reduces invasive potential of gastric cancer cells through inhibition of AKT signaling. PMID: 25921630 Ref: MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression. PMID: 25927670 Ref: Secreted protein acidic and rich in cysteine antagonizes bufalin-induced apoptosis in gastric cancer cells. PMID: 25936899 Ref: MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. PMID: 25945841 Ref: Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer. PMID: 25965823 Ref: Loss of TFF1 promotes Helicobacter pylori-induced beta-catenin activation and gastric tumorigenesis. PMID: 25980439 Ref: ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression. PMID: 25980581 Ref: Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. PMID: 25981581 Ref: Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8. PMID: 25986392 Ref: The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways. PMID: 26018507 Ref: Epigenetically downregulated Semaphorin 3E contributes to gastric cancer. PMID: 26036259 Ref: CrkL meditates CCL20/CCR6-induced EMT in gastric cancer. PMID: 26044596 Ref: KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78. PMID: 26045166 Ref: Metformin inhibits gastric cancer via the inhibition of HIF1alpha/PKM2 signaling. PMID: 26101707 Ref: Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance. PMID: 26108989 Ref: Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling. PMID: 26109806 Ref: Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro. PMID: 26111180 Ref: Targeting Notch signaling by gamma-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer. PMID: 26134677 Ref: Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil. PMID: 26136123 Ref: Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer. PMID: 26159923 Ref: Flavonoids isolated from Citrus platymamma induce mitochondrial-dependent apoptosis in AGS cells by modulation of the PI3K/AKT and MAPK pathways. PMID: 26165353 Ref: Protective Macroautophagy Is Involved in Vitamin E Succinate Effects on Human Gastric Carcinoma Cell Line SGC-7901 by Inhibiting mTOR Axis Phosphorylation. PMID: 26168048 Ref: Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. PMID: 26171059 Ref: MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway. PMID: 26186594 Ref: Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. PMID: 26201693 Ref: Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients. PMID: 26213461 Ref: Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the beta-Catenin Pathway. PMID: 26226629 Ref: [Retraction] Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways. PMID: 26238072 Ref: HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-kappaB activation. PMID: 26259977 Ref: Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. PMID: 26267324 Ref: Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas. PMID: 26296355 Ref: Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling. PMID: 26317215 Ref: Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer. PMID: 26317520 Ref: Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer. PMID: 26330014 Ref: Anticancer activities of self-assembled molecular bowls containing a phenanthrene-based donor and Ru(II) acceptors. PMID: 26347134 Ref: Auraptene, a Major Compound of Supercritical Fluid Extract of Phalsak (Citrus Hassaku Hort ex Tanaka), Induces Apoptosis through the Suppression of mTOR Pathways in Human Gastric Cancer SNU-1 Cells. PMID: 26351512 Ref: ODAM inhibits RhoA-dependent invasion in breast cancer. PMID: 26358398 Ref: The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis. PMID: 26366097 Ref: miR-125a regulates angiogenesis of gastric cancer by targeting vascular endothelial growth factor A. PMID: 26398444 Ref: The JAK/STAT signaling cascade in gastric carcinoma (Review). PMID: 26398764 Ref: Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway. PMID: 26420965 Ref: DNA methylation inhibitor, decitabine, promotes MGC803 gastric cancer cell migration and invasion via the upregulation of NEDD41. PMID: 26458406 Ref: [Molecular mechanism of cisplatin to enhance the ability of TRAIL in reversing multidrug resistance in gastric cancer cells]. PMID: 26463141 Ref: Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1). PMID: 26487493 Ref: Dysregulation of non-coding RNAs in gastric cancer. PMID: 26494954 Ref: Sulforaphane inhibits hypoxia-induced HIF-1alpha and VEGF expression and migration of human colon cancer cells. PMID: 26498863 Ref: Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway. PMID: 26538117 Ref: Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. PMID: 26557697 Ref: Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer. PMID: 26560145 Ref: [miR-29b Reduces Cisplatin Resistance of Gastric Cancer Cell by Targeting PI3K/Akt Pathway]. PMID: 26564501 Ref: Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? PMID: 26604635 Ref: Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis. PMID: 26608463 Ref: Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway. PMID: 26622467 Ref: AKT plays a crucial role in gastric cancer. PMID: 26622541 Ref: Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand. PMID: 26788199 |
Ref: Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt. PMID: 26201869 Ref: The involvement of survivin in insulin-like growth factor 1-induced epithelial-mesenchymal transition in gastric cancer. PMID: 26271669 Ref: Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro. PMID: 26333304 Ref: miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. PMID: 26458815 Ref: TIPE2 functions as a metastasis suppressor via negatively regulating beta-catenin through activating GSK3beta in gastric cancer. PMID: 26530498 Ref: Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway. PMID: 26530632 Ref: Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage. PMID: 26556626 Ref: Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway. PMID: 26565812 Ref: Smilax glabra Roxb targets Akt(p-Thr308) and inhibits Akt-mediated signaling pathways in SGC7901 cells. PMID: 26607178 Ref: TRAF6 promotes the invasion and metastasis and predicts a poor prognosis in gastric cancer. PMID: 26627263 Ref: 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, a polymethoxyflavone, exerts antitumor effect on PI3K/Akt signaling pathway in human gastric cancer cell BGC-7901. PMID: 26671739 Ref: HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials. PMID: 26690310 Ref: Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers. PMID: 26701847 Ref: Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells. PMID: 26718492 Ref: Integrated analysis of the miRNA, gene and pathway regulatory network in gastric cancer. PMID: 26719093 Ref: Upregulation of microRNA-31 targeting integrin alpha5 suppresses tumor cell invasion and metastasis by indirectly regulating PI3K/AKT pathway in human gastric cancer SGC7901 cells. PMID: 26729197 Ref: GNA13 as a prognostic factor and mediator of gastric cancer progression. PMID: 26735177 Ref: Substitution of Heavy Complementarity Determining Region 3 (CDR-H3) Residues Can Synergistically Enhance Functional Activity of Antibody and Its Binding Affinity to HER2 Antigen. PMID: 26743905 Ref: Dual HER2 Targeting with Trastuzumab and Liposomal-Encapsulated Doxorubicin (MM-302) Demonstrates Synergistic Antitumor Activity in Breast and Gastric Cancer. PMID: 26759238 Ref: The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells. PMID: 26768614 Ref: DCT015, a new sorafenib derivate, inhibits tumor growth and angiogenesis in gastric cancer models. PMID: 26768619 Ref: Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer. PMID: 26769843 Ref: Discovery of signature genes in gastric cancer associated with prognosis. PMID: 26774142 Ref: Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway. PMID: 26780727 Ref: Silencing A7-nAChR levels increases the sensitivity of gastric cancer cells to ixabepilone treatment. PMID: 26790437 Ref: LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway. PMID: 26797416 Ref: Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells. PMID: 26801760 Ref: Helicobacter pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3beta in human gastric cancer cells. PMID: 26808296 Ref: Lentivirus-mediated PLCgamma1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma. PMID: 26811493 Ref: A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population. PMID: 26818920 Ref: Various ARID1A expression patterns and their clinical significance in gastric cancers. PMID: 26826411 Ref: AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo. PMID: 26828267 Ref: CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells. PMID: 26830684 Ref: Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice. PMID: 26839577 Ref: Differences in TGF-beta1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer. PMID: 26846663 Ref: Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer. PMID: 26847684 Ref: Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFkappaB pathway in gastric cancer development. PMID: 26848521 Ref: C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. PMID: 26855187 Ref: Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells. PMID: 26877709 Ref: Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. PMID: 26893622 Ref: Upregulation of microRNA-375 increases the cisplatin-sensitivity of human gastric cancer cells by regulating ERBB2. PMID: 26893657 Ref: Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. PMID: 26893664 Ref: Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating alpha5-nAChR/AKT Signaling in Human Gastric Cancer Cells. PMID: 26909550 Ref: Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells. PMID: 26931432 Ref: An increase in galectin-3 causes cellular unresponsiveness to IFN-gamma-induced signal transduction and growth inhibition in gastric cancer cells. PMID: 26934444 Ref: Helicobacter pylori upregulates Nanog and Oct4 via Wnt/beta-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. PMID: 26940070 Ref: APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. PMID: 26942872 Ref: MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-kappaB axis. PMID: 26949090 Ref: Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway. PMID: 26960693 Ref: Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition. PMID: 26967563 Ref: PlGF knockdown inhibited tumor survival and migration in gastric cancer cell via PI3K/Akt and p38MAPK pathways. PMID: 26968576 Ref: The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer. PMID: 26968988 Ref: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. PMID: 26980572 Ref: CXCR1 promotes malignant behavior of gastric cancer cells in vitro and in vivo in AKT and ERK1/2 phosphorylation. PMID: 26983663 Ref: Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling. PMID: 26987289 Ref: Overexpression of Endoplasmic Reticulum Oxidoreductin 1-alpha (ERO1L) Is Associated with Poor Prognosis of Gastric Cancer. PMID: 26987398 Ref: miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway. PMID: 26998071 Ref: Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric cancer cells. PMID: 26998277 Ref: Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer. PMID: 27009837 Ref: DDR2 Induces Gastric Cancer Cell Activities via Activating mTORC2 Signaling and Is Associated with Clinicopathological Characteristics of Gastric Cancer. PMID: 27010547 Ref: Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway. PMID: 27013200 Ref: Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal. PMID: 27017226 Ref: DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. PMID: 27026201 Ref: Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells. PMID: 27040446 Ref: Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma. PMID: 27058427 Ref: Upregulation of miR-34a by diallyl disulfide suppresses invasion and induces apoptosis in SGC-7901 cells through inhibition of the PI3K/Akt signaling pathway. PMID: 27073535 Ref: Oleanolic acid induces autophagic death in human gastric cancer cells in vitro and in vivo. PMID: 27079177 Ref: DT-13, a saponin monomer of dwarf lilyturf tuber, induces autophagy and potentiates anti-cancer effect of nutrient deprivation. PMID: 27079642 Ref: Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition and analysis of their phosphorylation signaling pathways. PMID: 27102302 Ref: Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. PMID: 27121055 Ref: AURKA induces EMT by regulating histone modification through Wnt/beta-catenin and PI3K/Akt signaling pathway in gastric cancer. PMID: 27121204 Ref: TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression. PMID: 27121319 Ref: Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/beta-catenin pathway to enhance the stemness of gastric cancer. PMID: 27146881 Ref: PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells. PMID: 27147579 Ref: The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines. PMID: 27156070 Ref: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. PMID: 27157613 Ref: BRD7: a novel tumor suppressor gene in different cancers. PMID: 27158366 Ref: Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase. PMID: 27158402 Ref: JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients. PMID: 27167206 Ref: Evodiamine sensitizes BGC-823 gastric cancer cells to radiotherapy in vitro and in vivo. PMID: 27176933 Ref: Overexpression of SASH1 Inhibits TGF-beta1-Induced EMT in Gastric Cancer Cells. PMID: 27178818 Ref: M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers. PMID: 27197184 Ref: Recent updates of precision therapy for gastric cancer: Towards optimal tailored management. PMID: 27217696 Ref: An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients. PMID: 27267856 Ref: Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. PMID: 27277844 Ref: Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling. PMID: 27278820 Ref: The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo. PMID: 27288917 Ref: Autophagy regulation and its role in gastric cancer and colorectal cancer. PMID: 27314289 Ref: The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer. PMID: 27317872 Ref: Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. PMID: 27323812 Ref: Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3beta signaling in gastric cancer. PMID: 27323966 Ref: Overexpression of RRM2 in gastric cancer cell promotes their invasiveness via AKT/NF-kappaB signaling pathway. PMID: 27348973 Ref: Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer. PMID: 27349176 Ref: Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells. PMID: 27357249 Ref: Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer. PMID: 27387652 Ref: Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review. PMID: 27388016 Ref: Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation. PMID: 27437872 Ref: Role of periostin in esophageal, gastric and colon cancer. PMID: 27446351 Ref: ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3K/AKT signaling pathway. PMID: 27449034 Ref: PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer. PMID: 27458157 Ref: Dopamine D2 receptor suppresses gastric cancer cell invasion and migration via inhibition of EGFR/AKT/MMP-13 pathway. PMID: 27468100 Ref: CXCL10/CXCR3 axis promotes the invasion of gastric cancer via PI3K/AKT pathway-dependent MMPs production. PMID: 27470388 Ref: Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells. PMID: 27472346 Ref: Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer. PMID: 27499479 Ref: MK-2206 co-treatment with 5-fluorouracil or doxorubicin enhances chemosensitivity and apoptosis in gastric cancer by attenuation of Akt phosphorylation. PMID: 27499633 Ref: Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway. PMID: 27513187 Ref: MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer. PMID: 27518872 Ref: T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death. PMID: 27537872 Ref: The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer. PMID: 27539855 Ref: Oncogenic NanogP8 expression regulates cell proliferation and migration through the Akt/mTOR signaling pathway in human gastric cancer - SGC-7901cell line. PMID: 27563247 Ref: Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. PMID: 27569081 Ref: RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer. PMID: 27572296 Ref: PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. PMID: 27572739 Ref: Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer. PMID: 27573785 Ref: A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway. PMID: 27581375 Ref: Cross-linked hyaluronic acid gel inhibits metastasis and growth of gastric and hepatic cancer cells: in vitro and in vivo studies. PMID: 27589842 Ref: MicroRNA-21 promotes TGF-beta1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression. PMID: 27611950 Ref: Bone marrow-derived mesenchymal stem cells increase drug resistance in CD133-expressing gastric cancer cells by regulating the PI3K/AKT pathway. PMID: 27619680 Ref: Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents. PMID: 27625151 Ref: Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs. PMID: 27644439 Ref: Effects for Sequential Treatment of siAkt and Paclitaxel on Gastric Cancer Cell Lines. PMID: 27648001 Ref: Matrine Suppresses Proliferation and Invasion of SGC7901 Cells through Inactivation of PI3K/Akt/uPA Pathway. PMID: 27650610 Ref: Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. PMID: 27659528 Ref: Expression of early growth response gene-1 in precancerous lesions of gastric cancer. PMID: 27698846 Ref: Knockdown of Rap1b Enhances Apoptosis and Autophagy in Gastric Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 27712585 Ref: Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness. PMID: 27725900 Ref: HPIP promotes gastric cancer cell proliferation through activation of cap-dependent translation. PMID: 27748944 Ref: miR-590-5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway. PMID: 27757042 Ref: Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1. PMID: 27768588 Ref: [Retracted] Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo. PMID: 27779688 Ref: WIN 55,212-2 Inhibits the Epithelial Mesenchymal Transition of Gastric Cancer Cells via COX-2 Signals. PMID: 27802436 Ref: Sageone, a diterpene from Rosmarinus officinalis, synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells. PMID: 27823632 Ref: PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells. PMID: 27830001 Ref: Erratum: Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. PMID: 27837645 Ref: HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer. PMID: 27895401 Ref: PBX3 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition. PMID: 27900025 Ref: LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes. PMID: 27900563 Ref: Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer. PMID: 28005970 Ref: CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line. PMID: 28281969 |
Ref: Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer. PMID: 26832883 Ref: RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3. PMID: 27425596 Ref: Helicobacter pylori-induced cell death is counteracted by NF-kappaB-mediated transcription of DARPP-32. PMID: 27590997 Ref: miR-326 Inhibits Gastric Cancer Cell Growth Through Downregulating NOB1. PMID: 27733214 Ref: Akt/AMPK/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells. PMID: 27796683 Ref: CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin beta1/FAK/AKT signaling. PMID: 27832972 Ref: Fabrication of self-assembled chitosan-dispersed LDL nanoparticles for drug delivery with a one-step green method. PMID: 27845214 Ref: HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs. PMID: 27901487 Ref: Omental adipocytes enhance the invasiveness of gastric cancer cells by oleic acid-induced activation of the PI3K-Akt signaling pathway. PMID: 27956048 Ref: Irisin suppresses the migration, proliferation, and invasion of lung cancer cells via inhibition of epithelial-to-mesenchymal transition. PMID: 27986567 Ref: MET4 expression predicts poor prognosis of gastric cancers with Helicobacter pylori infection. PMID: 28012218 Ref: Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition. PMID: 28028034 Ref: Positive feedback loop of IL-1beta/Akt/RARalpha/Akt signaling mediates oncogenic property of RARalpha in gastric carcinoma. PMID: 28035062 Ref: miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. PMID: 28057912 Ref: Liver X receptor alpha (LXRalpha) promoted invasion and EMT of gastric cancer cells by regulation of NF-kappaB activity. PMID: 28091828 Ref: Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. PMID: 28102288 Ref: 3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-kappaB Pathway. PMID: 28109078 Ref: MicroRNA-133a Inhibits Proliferation of Gastric Cancer Cells by Downregulating ERBB2 Expression. PMID: 28109082 Ref: Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer. PMID: 28114950 Ref: Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells. PMID: 28117748 Ref: Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer. PMID: 28126034 Ref: Pseudolaric acid B inhibits gastric cancer cell metastasis in vitro and in haematogenous dissemination model through PI3K/AKT, ERK1/2 and mitochondria-mediated apoptosis pathways. PMID: 28132880 Ref: Proteomic analysis of cell cycle arrest and differentiation induction caused by ATPR, a derivative of all-trans retinoic acid, in human gastric cancer SGC-7901 cells. PMID: 28164444 Ref: Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition. PMID: 28186089 Ref: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. PMID: 28188923 Ref: Role of the PEBP4 protein in the development and metastasis of gastric cancer. PMID: 28193908 Ref: Cordycepin induces apoptosis in SGC7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. PMID: 28197639 Ref: Molecular Testing for Gastrointestinal Cancer. PMID: 28219002 Ref: Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. PMID: 28222070 Ref: Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition. PMID: 28223426 Ref: Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. PMID: 28236621 Ref: MicroRNA-320 inhibits invasion and induces apoptosis by targeting CRKL and inhibiting ERK and AKT signaling in gastric cancer cells. PMID: 28255248 Ref: Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer. PMID: 28255993 Ref: MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3. PMID: 28260021 Ref: UBE2C induces EMT through Wnt/betacatenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A. PMID: 28260026 Ref: Octreotide inhibits the proliferation of gastric cancer cells through P300-HAT activity and the interaction of ZAC and P300. PMID: 28260048 Ref: Dysregulation of mRNA profile in cisplatin-resistant gastric cancer cell line SGC7901. PMID: 28275299 Ref: Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells. PMID: 28299464 Ref: MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2. PMID: 28327189 Ref: Introducing crucial protein panel of gastric adenocarcinoma disease. PMID: 28331560 Ref: E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. PMID: 28334634 Ref: Reduction of miR1323p contributes to gastric cancer proliferation by targeting MUC13. PMID: 28339011 Ref: FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1. PMID: 28339036 Ref: Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment. PMID: 28344324 Ref: Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3beta activation. PMID: 28345638 Ref: Anti-metastatic activity of fangchinoline in human gastric cancer AGS cells. PMID: 28356942 Ref: Calycosin Enhances Some Chemotherapeutic Drugs Inhibition of Akt Signaling Pathway in Gastric Cells. PMID: 28368679 Ref: Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice. PMID: 28374157 Ref: Expression and function of Uc.160+, a transcribed ultraconserved region, in gastric cancer. PMID: 28382457 Ref: NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization. PMID: 28388537 Ref: A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer. PMID: 28404966 Ref: Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer. PMID: 28407749 Ref: Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells. PMID: 28407783 Ref: Complementary utility of targeted next-generation sequencing and immunohistochemistry panels as a screening platform to select targeted therapy for advanced gastric cancer. PMID: 28418920 Ref: Synthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells. PMID: 28420180 Ref: Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor b signaling pathway. PMID: 28423550 Ref: Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer. PMID: 28423564 Ref: The SNAIL/miR-128 axis regulated growth, invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer. PMID: 28424413 Ref: TCRP1 promotes NIH/3T3 cell transformation by over-activating PDK1 and AKT1. PMID: 28436990 Ref: Long Noncoding RNA AFAP1-AS1 Promotes Cell Proliferation and Apoptosis of Gastric Cancer Cells via PTEN/p-AKT Pathway. PMID: 28451917 Ref: Inhibition of CYFIP2 promotes gastric cancer cell proliferation and chemoresistance to 5-fluorouracil through activation of the Akt signaling pathway. PMID: 28454373 Ref: Retraction Note: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. PMID: 28468640 Ref: Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer. PMID: 28476678 Ref: Anticancer activities of harmine by inducing a pro-death autophagy and apoptosis in human gastric cancer cells. PMID: 28478808 Ref: Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells. PMID: 28498433 Ref: MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway. PMID: 28498460 Ref: Inhibition of cell proliferation and induction of autophagy by KDM2B/FBXL10 knockdown in gastric cancer cells. PMID: 28506929 Ref: Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance. PMID: 28507275 Ref: Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer. PMID: 28550907 Ref: Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. PMID: 28569779 Ref: PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer. PMID: 28588255 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: miR-200b inhibits CD133(+) glioma cells by targeting the AKT pathway. PMID: 28599471 Ref: MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells. PMID: 28601080 Ref: Downregulation of Notch1 inhibits the invasion and metastasis of human gastric cancer cells SGC7901 and MKN74 in vitro through PTEN activation and dephosphorylation of Akt and FAK. PMID: 28627671 Ref: MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. PMID: 28632723 Ref: S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways. PMID: 28642133 Ref: Gankyrin promotes the proliferation of gastric cancer and is associated with chemosensitivity. PMID: 28653901 Ref: The Wnt/beta-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation. PMID: 28671020 Ref: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/beta-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. PMID: 28677721 Ref: Overexpression of SET oncoprotein is associated with tumor progression and poor prognosis in human gastric cancer. PMID: 28677734 Ref: miR-944 inhibits metastasis of gastric cancer by preventing the epithelial-mesenchymal transition via MACC1/Met/AKT signaling. PMID: 28680805 Ref: Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. PMID: 28713919 Ref: MicroRNA-379 inhibits metastasis and epithelial-mesenchymal transition via targeting FAK/AKT signaling in gastric cancer. PMID: 28713929 Ref: [Curcumin induces apoptosis and protective autophagy in human gastric cancer cells with different degree of differentiation]. PMID: 28728293 Ref: SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells. PMID: 28731194 Ref: MicroRNA-302b-3p Suppresses Cell Proliferation Through AKT Pathway by Targeting IGF-1R in Human Gastric Cancer. PMID: 28743112 Ref: Research on the mechanism of HP mediated PI3K/AKT/GSK3beta pathways in gastric cancer. PMID: 28745795 Ref: Correction: Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer. PMID: 28753909 Ref: CXCL12/SDF-1alpha induces migration via SRC-mediated CXCR4-EGFR cross-talk in gastric cancer cells. PMID: 28781651 Ref: ERas is constitutively expressed in full term placenta of pregnant cows. PMID: 28787666 Ref: Luteolin induces apoptosis in vitro through suppressing the MAPK and PI3K signaling pathways in gastric cancer. PMID: 28789432 Ref: [Quinalizarin induces apoptosis in gastric cancer AGS cells via MAPK and Akt signaling pathway]. PMID: 28801290 Ref: In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines. PMID: 28819369 Ref: Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway. PMID: 28847482 Ref: A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness. PMID: 28854418 Ref: CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway. PMID: 28857517 Ref: AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells. PMID: 28860825 Ref: ERp29 controls invasion and metastasis of gastric carcinoma by inhibition of epithelial-mesenchymal transition via PI3K/Aktsignaling pathway. PMID: 28874138 Ref: Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway. PMID: 28881639 Ref: siRNA-mediated inactivation of HER3 improves the antitumour activity and sensitivity of gefitinib in gastric cancer cells. PMID: 28881753 Ref: Bcl-2 and Bcl-xL mediate resistance to receptor tyrosine kinase-targeted therapy in lung and gastric cancer. PMID: 28885267 Ref: Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines. PMID: 28894280 Ref: SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population. PMID: 28924391 Ref: p-Akt as a potential poor prognostic factor for gastric cancer: a systematic review and meta-analysis. PMID: 28938690 Ref: Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN. PMID: 28950928 Ref: Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel. PMID: 28951460 Ref: HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer. PMID: 28963677 Ref: Targeting mTORC2 component rictor inhibits cell proliferation and promotes apoptosis in gastric cancer. PMID: 28979705 Ref: FAM196B acts as oncogene and promotes proliferation of gastric cancer cells through AKT signaling pathway. PMID: 28980917 Ref: TWIST mediates resistance to paclitaxel by regulating Akt and Bcl-2 expression in gastric cancer cells. PMID: 28982309 Ref: Antitumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways. PMID: 28990045 Ref: PTEN Gene Induces Cell Invasion and Migration via Regulating AKT/GSK-3beta/beta-Catenin Signaling Pathway in Human Gastric Cancer. PMID: 29030742 Ref: MiR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer. PMID: 29035829 Ref: Clinical implications of progranulin in gastric cancer and its regulation via a positive feedback loop involving AKT and ERK signaling pathways. PMID: 29039535 Ref: Profiling cancer-associated genetic alterations and molecular classification of cancer in Korean gastric cancer patients. PMID: 29050249 Ref: Identification of core genes and outcome in gastric cancer using bioinformatics analysis. PMID: 29050278 Ref: MicroRNA-937 inhibits cell proliferation and metastasis in gastric cancer cells by downregulating FOXL2. PMID: 29060929 Ref: MGr1-Antigen/37 kDa laminin receptor precursor promotes cellular prion protein induced multi-drug-resistance of gastric cancer. PMID: 29069734 Ref: B7-H3 promotes gastric cancer cell migration and invasion. PMID: 29069741 Ref: The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer. PMID: 29069776 Ref: Histone acetyltransferase p300/CBP inhibitor C646 blocks the survival and invasion pathways of gastric cancer cell lines. PMID: 29075795 Ref: Apatinib has anti-tumor effects and induces autophagy in colon cancer cells. PMID: 29085592 Ref: The GAS5/miR-222 Axis Regulates Proliferation of Gastric Cancer Cells Through the PTEN/Akt/mTOR Pathway. PMID: 29098549 Ref: Atractylenolide II Inhibits Proliferation, Motility and Induces Apoptosis in Human Gastric Carcinoma Cell Lines HGC-27 and AGS. PMID: 29099789 Ref: Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway. PMID: 29100311 Ref: ERp29 inhibits tumorigenicity by suppressing epithelial mesenchymal transition in gastric cancer. PMID: 29108263 Ref: Mcl-1 stabilization confers resistance to taxol in human gastric cancer. PMID: 29137317 Ref: Expression of the beta3 subunit of Na(+)/K(+)-ATPase is increased in gastric cancer and regulates gastric cancer cell progression and prognosis via the PI3/AKT pathway. PMID: 29137423 Ref: Combined aspirin and apatinib treatment suppresses gastric cancer cell proliferation. PMID: 29142602 Ref: Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both in vitro and in vivo by Thymoquinone targeting PTEN gene. PMID: 29156767 Ref: [Knockdown of AKT1 gene enhances the sensitivity of gastric cancer xenografts of nude mice to doxorubicin]. PMID: 29169420 Ref: [IL-6 promotes gastric cancer cell proliferation and EMT through regulating miR-152/PIK3R3 pathway]. PMID: 29187649 Ref: PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancer. PMID: 29207615 Ref: Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway. PMID: 29212166 Ref: Mangiferin prevents the growth of gastric carcinoma by blocking the PI3K-Akt signalling pathway. PMID: 29215373 Ref: DNA Methylation-Mediated Silencing of Regenerating Protein 1 Alpha (REG1A) Affects Gastric Cancer Prognosis. PMID: 29222406 Ref: Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway. PMID: 29229873 Ref: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients. PMID: 29233126 Ref: Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. PMID: 29237412 Ref: Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways. PMID: 29237470 Ref: Long non-coding RNA CRNDE is a novel tumor promoter by modulating PI3K/AKT signal pathways in human gastric cancer. PMID: 29243780 Ref: Kruppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling. PMID: 29245984 Ref: LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway. PMID: 29282102 Ref: MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines. PMID: 29285287 Ref: Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing. PMID: 29307989 Ref: Imperatorin shows selective antitumor effects in SGC-7901 human gastric adenocarcinoma cells by inducing apoptosis, cell cycle arrest and targeting PI3K/Akt/m-TOR signalling pathway. PMID: 29332340 Ref: Study on the association between PI3K/AKT/mTOR signaling pathway gene polymorphism and susceptibility to gastric cancer. PMID: 29332342 Ref: Combination of cecropinXJ and LY294002 induces synergistic cytotoxicity, and apoptosis in human gastric cancer cells via inhibition of the PI3K/Akt signaling pathway. PMID: 29344198 Ref: Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3beta/beta-Catenin Signaling Pathway. PMID: 29358963 Ref: Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells. PMID: 29371922 |
Ref: Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway. PMID: 28608528 Ref: ARHGEF39 promotes gastric cancer cell proliferation and migration via Akt signaling pathway. PMID: 28871449 Ref: Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. PMID: 28926094 Ref: Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3beta. PMID: 28978722 Ref: Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression. PMID: 29031586 Ref: Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT. PMID: 29052277 Ref: Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/beta-catenin signaling pathways by up-regulating miR-34a. PMID: 29080815 Ref: miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH. PMID: 29101039 Ref: CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2. PMID: 29106389 Ref: MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin. PMID: 29115517 Ref: The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer. PMID: 29115543 Ref: Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer. PMID: 29131081 Ref: Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway. PMID: 29143985 Ref: miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway. PMID: 29185784 Ref: Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway. PMID: 29208564 Ref: NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer. PMID: 29231994 Ref: Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro. PMID: 29239350 Ref: MicroRNA-28 promotes cell proliferation and invasion in gastric cancer via the PTEN/PI3K/AKT signalling pathway. PMID: 29257342 Ref: Chk1 activation attenuates sensitivity of lapatinib in HER2-positive gastric cancer. PMID: 29271513 Ref: F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT. PMID: 29278851 Ref: EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas. PMID: 29278885 Ref: Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway. PMID: 29286170 Ref: Downregulation of Annexin A11 (ANXA11) Inhibits Cell Proliferation, Invasion, and Migration via the AKT/GSK-3beta Pathway in Gastric Cancer. PMID: 29306955 Ref: Correlation of Gli1 and HER2 expression in gastric cancer: Identification of novel target. PMID: 29321573 Ref: The polycomb group protein EZH2 induces epithelial-mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter. PMID: 29335012 Ref: Long non-coding RNA GPR65-1 is up-regulated in gastric cancer and promotes tumor growth through the PTEN-AKT-slug signaling pathway. PMID: 29336198 Ref: Clinical Significance of Glycoprotein Non-metastatic B and Its Association with EGFR/HER2 in Gastrointestinal Cancer. PMID: 29344282 Ref: Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway. PMID: 29374144 Ref: Autophagy Induced by Naftopidil Inhibits Apoptosis of Human Gastric Cancer Cells. PMID: 29374705 Ref: Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy. PMID: 29401583 Ref: CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-kappaB-miR-21 pathways. PMID: 29422082 Ref: Association of mast cell infiltration with gastric cancer progression. PMID: 29422964 Ref: Interaction between CD133 and PI3K-p85 promotes chemoresistance in gastric cancer cells. PMID: 29423015 Ref: Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway. PMID: 29428665 Ref: Interference of P-REX2a may inhibit proliferation and reverse the resistance of SGC7901 cells to doxorubicin. PMID: 29435055 Ref: MiR-361-5p suppresses chemoresistance of gastric cancer cells by targeting FOXM1 via the PI3K/Akt/mTOR pathway. PMID: 29435149 Ref: LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3beta signaling. PMID: 29436606 Ref: Downregulation of leucine-rich repeats and immunoglobulin-like domains 1 by microRNA-20a modulates gastric cancer multidrug resistance. PMID: 29450946 Ref: The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells. PMID: 29455656 Ref: Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells. PMID: 29462183 Ref: Astragaloside IV inhibits TGF-beta1-induced epithelial-mesenchymal transition through inhibition of the PI3K/Akt/NF-kappaB pathway in gastric cancer cells. PMID: 29480652 Ref: Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway. PMID: 29484412 Ref: Knockdown of EPCR inhibits the proliferation and migration of human gastric cancer cells via the ERK1/2 pathway in a PAR-1-dependent manner. PMID: 29484413 Ref: Sauchinone prevents TGF-beta-induced EMT and metastasis in gastric cancer cells. PMID: 29499410 Ref: Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. PMID: 29512685 Ref: REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway. PMID: 29512686 Ref: Apoptin-derived peptide reverses cisplatin resistance in gastric cancer through the PI3K-AKT signaling pathway. PMID: 29522284 Ref: Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p. PMID: 29535266 Ref: CDK5RAP3 suppresses Wnt/beta-catenin signaling by inhibiting AKT phosphorylation in gastric cancer. PMID: 29540196 Ref: Autophagy flux inhibition augments gastric cancer resistance to the anti-human epidermal growth factor receptor 2 antibody trastuzumab. PMID: 29541179 Ref: Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway. PMID: 29541241 Ref: Acquired Resistance to a MET Antibody In Vivo Can Be Overcome by the MET Antibody Mixture Sym015. PMID: 29545332 Ref: The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells. PMID: 29549610 Ref: The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma. PMID: 29554921 Ref: PIAS1 inhibited the metastasis of gastric cancer cell by epithelial-mesenchymal transition regulation within the inflammatory microenvironment. PMID: 29556278 Ref: [Corrigendum] RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer. PMID: 29565451 Ref: Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E. PMID: 29567987 Ref: Inhibitory effects of CP on the growth of human gastric adenocarcinoma BGC-823 tumours in nude mice. PMID: 29569987 Ref: Osthole inhibits gastric cancer cell proliferation through regulation of PI3K/AKT. PMID: 29590128 Ref: Bioinformatic Analysis of GLI1 and Related Signaling Pathways in Chemosensitivity of Gastric Cancer. PMID: 29596399 Ref: ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. PMID: 29620274 Ref: Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib. PMID: 29637613 Ref: Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway. PMID: 29658590 Ref: Long non-coding RNA SNHG14 contributes to gastric cancer development through targeting miR-145/SOX9 axis. PMID: 29667771 Ref: Exosomes Released by Gastric Cancer Cells Induce Transition of Pericytes Into Cancer-Associated Fibroblasts. PMID: 29668670 Ref: CLIC1 Promotes the Progression of Gastric Cancer by Regulating the MAPK/AKT Pathways. PMID: 29669336 Ref: [beta-Lapachone combined with NVP-BEZ235 inhibit proliferation and migration of BGC-823 gastric cancer cells]. PMID: 29673455 Ref: miRNA-21 promotes gastric cancer growth by adjusting prostaglandin E2. PMID: 29687845 Ref: CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer. PMID: 29690901 Ref: Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the AktGSK3beta and MAPK/ERK signaling cascades. PMID: 29693162 Ref: Genomic Profiling of HER2-Positive Gastric Cancer: PI3K/Akt/mTOR Pathway as Predictor of Outcomes in HER2-Positive Advanced Gastric Cancer Treated with Trastuzumab. PMID: 29700210 Ref: PIK3CA Mutation Analysis in Iranian Patients with Gastric Cancer PMID: 29704890 Ref: Novel AKT1 mutations associated with cell-cycle abnormalities in gastric carcinoma. PMID: 29714127 Ref: microRNA-107 inhibits gastric cancer cell proliferation and metastasis by targeting PI3K/AKT pathway. PMID: 29715534 Ref: Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased in vivo anti-tumor efficacy. PMID: 29721065 Ref: CREBRF promotes the proliferation of human gastric cancer cells via the AKT signaling pathway. PMID: 29729692 Ref: Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Srcassociated signaling pathway activation and heat shock protein 70 expression. PMID: 29749547 Ref: High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer. PMID: 29767389 Ref: Anticancer activity of tetrandrine by inducing pro-death apoptosis and autophagy in human gastric cancer cells. PMID: 29770446 Ref: MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway. PMID: 29777710 Ref: Genetic variants in PI3K/Akt/mTOR pathway genes contribute to gastric cancer risk. PMID: 29802999 Ref: Long non-coding RNA-mediated regulation of signaling pathways in gastric cancer. PMID: 29804098 Ref: PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway in vitro and in vivo. PMID: 29805638 Ref: miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R. PMID: 29844688 Ref: Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. PMID: 29853970 Ref: (S)-crizotinib reduces gastric cancer growth through oxidative DNA damage and triggers pro-survival akt signal. PMID: 29855474 Ref: Inhibitor of growth 3 induces cell death by regulating cell proliferation, apoptosis and cell cycle arrest by blocking the PI3K/AKT pathway. PMID: 29855536 Ref: Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. PMID: 29864621 Ref: MicroRNA-129-5p Regulates Glycolysis and Cell Proliferation by Targeting the Glucose Transporter SLC2A3 in Gastric Cancer Cells. PMID: 29867504 Ref: LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway. PMID: 29872314 Ref: Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells. PMID: 29879757 Ref: Downregulation of HIF-1alpha inhibits the proliferation, migration and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression. PMID: 29899167 Ref: Overexpression of retinoblastomabinding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3kinase/protein kinase B pathway suppression. PMID: 29901205 Ref: Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN. PMID: 29902454 Ref: siRNA Targeting of the SNCG Gene Inhibits the Growth of Gastric Carcinoma SGC7901 Cells in vitro and in vivo by Downregulating the Phosphorylation of AKT/ERK. PMID: 29902801 Ref: HGF derived from cancerassociated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling. PMID: 29917165 Ref: Chloroform fraction of Serratulae chinensis S. Moore suppresses proliferation and induces apoptosis via the phosphatidylinositide 3-kinase/Akt pathway in human gastric cancer cells. PMID: 29928328 Ref: MicroRNA-28-5p inhibits the migration and invasion of gastric cancer cells by suppressing AKT phosphorylation. PMID: 29928352 Ref: PKG II inhibits PDGF-BB triggered biological activities by phosphorylating PDGFRbeta in gastric cancer cells. PMID: 29935031 Ref: Anticancer effect of YWHAZ silencing via inducing apoptosis and autophagy in gastric cancer cells. PMID: 29940752 Ref: Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer. PMID: 29948506 Ref: MiR-592 Promotes Gastric Cancer Proliferation, Migration, and Invasion Through the PI3K/AKT and MAPK/ERK Signaling Pathways by Targeting Spry2. PMID: 29949784 Ref: MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer. PMID: 29973668 Ref: CD45(+)CD33(low)CD11b(dim) myeloid-derived suppressor cells suppress CD8(+) T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer. PMID: 29988030 Ref: CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer. PMID: 29989092 Ref: Autophagy plays a protective role against apoptosis induced by toxicarioside N via the Akt/mTOR pathway in human gastric cancer SGC-7901 cells. PMID: 29992400 Ref: Vasodilator-stimulated phosphoprotein (VASP), a novel target of miR-4455, promotes gastric cancer cell proliferation, migration, and invasion, through activating the PI3K/AKT signaling pathway. PMID: 30002604 Ref: EPCR promotes MGC803 human gastric cancer cell tumor angiogenesis in vitro through activating ERK1/2 and AKT in a PAR1-dependent manner. PMID: 30008838 Ref: miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop. PMID: 30012200 Ref: Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. PMID: 30013632 Ref: TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation. PMID: 30015980 Ref: NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway. PMID: 30015981 Ref: Yes-associated protein enhances proliferation and attenuates sensitivity to cisplatin in human gastric cancer cells. PMID: 30021363 Ref: Long non-coding RNA NEAT1 promotes viability and migration of gastric cancer cell lines through up-regulation of microRNA-17. PMID: 30024601 Ref: miR-5590-3p inhibited tumor growth in gastric cancer by targeting DDX5/AKT/m-TOR pathway. PMID: 30029874 Ref: DcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3beta/beta-catenin signaling pathway. PMID: 30050309 Ref: NOX4, A New Genetic Target for Anti-cancer Therapy in Digestive System Cancer. PMID: 30058122 Ref: Discovery of an Indirubin Derivative as a Novel c-Met Kinase Inhibitor with in vitro Anti-Tumor Effects. PMID: 30060294 Ref: Neogenin-1 Promotes Cell Proliferation, Motility, and Adhesion by Up-Regulation of Zinc Finger E-Box Binding Homeobox 1 Via Activating the Rac1/PI3K/AKT Pathway in Gastric Cancer Cells. PMID: 30064133 Ref: E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function. PMID: 30066183 Ref: Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. PMID: 30066879 Ref: Caveolin-1 contributes to anoikis resistance in human gastric cancer SGC-7901 cells via regulating Src-dependent EGFR-ITGB1 signaling. PMID: 30088837 Ref: Down-regulation of lncRNA ADAMTS9-AS2 contributes to gastric cancer development via activation of PI3K/Akt pathway. PMID: 30089248 Ref: Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway. PMID: 30096805 Ref: Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers. PMID: 30111747 Ref: [Wogonoside reverses cisplatin resistance in SGC7901/cDDP cells through inhibition of PI3K/Akt/Nrf2/ARE signaling pathway]. PMID: 30112565 Ref: Anti-neuropilin-1 monoclonal antibody suppresses the migration and invasion of human gastric cancer cells via Akt dephosphorylation. PMID: 30116312 Ref: Xanthohumol induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI3K/Akt/mTOR-kinase in human gastric cancer cells. PMID: 30119200 Ref: Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis. PMID: 30119963 Ref: TIMMDC1 Knockdown Inhibits Growth and Metastasis of Gastric Cancer Cells through Metabolic Inhibition and AKT/GSK3beta/beta-Catenin Signaling Pathway. PMID: 30123074 Ref: Anticancer effect of resibufogenin on gastric carcinoma cells through the phosphoinositide 3-kinase/protein kinase B/glycogen synthase kinase 3beta signaling pathway. PMID: 30127928 Ref: Knockdown of long noncoding RNA urothelial carcinoma-associated 1 inhibits cell viability, migration, and invasion by regulating microRNA-182 in gastric carcinoma. PMID: 30129054 Ref: High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer. PMID: 30131483 Ref: PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis. PMID: 30134988 Ref: Effects of Combination of Anti-CTLA-4 and Anti-PD-1 on Gastric Cancer Cells Proliferation, Apoptosis and Metastasis. PMID: 30138920 Ref: Long Noncoding RNA EGFR-AS1 Promotes Cell Proliferation by Increasing EGFR mRNA Stability in Gastric Cancer. PMID: 30138934 Ref: Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways. PMID: 30142546 Ref: Zeylenone Induces Mitochondrial Apoptosis and Inhibits Migration and Invasion in Gastric Cancer. PMID: 30150551 Ref: Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells. PMID: 30157801 Ref: Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through beta-catenin/Erk/Akt signaling in gastric cancer. PMID: 30165890 Ref: Bacillomycin D-C16 triggers apoptosis of gastric cancer cells through the PI3K/Akt and FoxO3a signaling pathways. PMID: 30169424 Ref: TRIM59 overexpression correlates with poor prognosis and contributes to breast cancer progression through AKT signaling pathway. PMID: 30175868 Ref: Geniposide suppresses growth, migration and invasion of MKN45 cells by down-regulation of lncRNA HULC. PMID: 30176223 Ref: MicroRNA-17 as a promising diagnostic biomarker of gastric cancer: An investigation combining TCGA, GEO, meta-analysis, and bioinformatics. PMID: 30186751 Ref: A Novel Mechanism of Doxorubicin Resistance and Tumorigenesis Mediated by MicroRNA-501-5p-Suppressed BLID. PMID: 30195794 Ref: Sorcin a Potential Molecular Target for Cancer Therapy. PMID: 30216763 Ref: Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-kappaB. PMID: 30217308 Ref: The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gast PMID: 30222185 Ref: miR-17-92 functions as an oncogene and modulates NF-kappaB signaling by targeting TRAF3 in MGC-803 human gastric cancer cells. PMID: 30226589 Ref: Increasing HER2 alpha2,6 sialylation facilitates gastric cancer progression and resistance via the Akt and ERK pathways. PMID: 30226606 Ref: Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. PMID: 30246429 Ref: Enah overexpression is correlated with poor survival and aggressive phenotype in gastric cancer. PMID: 30250066 Ref: Helicobacter pylori promotes gastric epithelial cell survival through the PLK1/PI3K/Akt pathway. PMID: 30254463 Ref: F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway. PMID: 30257389 Ref: MicroRNA495 regulates human gastric cancer cell apoptosis and migration through Akt and mTOR signaling. PMID: 30272336 Ref: TRIM14 promotes the migration and invasion of gastric cancer by regulating epithelialtomesenchymal transition via activation of AKT signaling regulated by miR1955p. PMID: 30272351 Ref: LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901. PMID: 30274346 Ref: Dual inhibitor of PI3K and mTOR (NVP-BEZ235) augments the efficacy of fluorouracil on gastric cancer chemotherapy. PMID: 30275715 Ref: USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer. PMID: 30296012 Ref: TCF21 inhibits proliferation and chemoresistance through the AKT pathway in human gastric cancer. PMID: 30296564 Ref: Long noncoding RNA HOTAIRM1 inhibits cell progression by regulating miR-17-5p/ PTEN axis in gastric cancer. PMID: 30302796 Ref: Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression. PMID: 30305610 Ref: Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/beta-catenin signaling pathways in gastric cancer progression. PMID: 30305727 Ref: Clinicopathological significance of RCAN2 production in gastric carcinoma. PMID: 30307052 Ref: HOXB9 inhibits proliferation in gastric carcinoma cells via suppression of phosphorylated-Akt and NF-kappaB-dependent Snail expression. PMID: 30314948 Ref: Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1. PMID: 30320337 Ref: The O-glycosylating enzyme GALNT2 suppresses the malignancy of gastric adenocarcinoma by reducing EGFR activities. PMID: 30323967 Ref: Hepatocyte growth factor-induced mesenchymal-epithelial transition factor activation leads to insulin-like growth factor 1 receptor inhibitor unresponsiveness in gastric cancer cells. PMID: 30333869 Ref: Methionine enkephalin (MENK) inhibits human gastric cancer through regulating tumor associated macrophages (TAMs) and PI3K/AKT/mTOR signaling pathway inside cancer cells. PMID: 30343258 Ref: Analysis of correlation between HP infection and activation of PI3K/Akt pathway in mucosal tissues of gastric cancer and precancerous lesions. PMID: 30344716 Ref: Knockdown of RAI14 suppresses the progression of gastric cancer. PMID: 30349303 Ref: Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1alpha signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo. PMID: 30349304 Ref: Deregulation of MicroRNA-375 Inhibits Proliferation and Migration in Gastric Cancer in Association With Autophagy-Mediated AKT/mTOR Signaling Pathways. PMID: 30355273 Ref: FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway. PMID: 30355943 Ref: NUCKS1 promotes gastric cancer cell aggressiveness by upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR signaling pathway. PMID: 30371738 Ref: Hepatocyte growth factor-induced mesenchymal-epithelial transition factor activation leads to insulin-like growth factor 1 receptor inhibitor unresponsiveness in gastric cancer cells. PMID: 30374835 |