Primary Site >> Colorectal Cancer
Gene >> AKT1
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Ref: Characteristics of two cancer cell lines derived from metastatic foci in liver and peritoneum of a patient with colon cancer. PMID: 9853557 |
Ref: Activity of glycogen synthase kinase-3beta is down-regulated during transient differentiation of human colon cancer HT-29 cells. PMID: 10373664 |
Ref: Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. PMID: 10639160 Ref: Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. PMID: 10930401 Ref: Asef, a link between the tumor suppressor APC and G-protein signaling. PMID: 10947987 Ref: Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. PMID: 10962573 Ref: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. PMID: 10972292 Ref: Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. PMID: 11085546 |
Ref: Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. PMID: 11313939 Ref: Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. PMID: 11358818 Ref: A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells. PMID: 11431370 Ref: Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. PMID: 11478840 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 Ref: Interleukin-15 expression is associated with malignant potential in colon cancer cells. PMID: 11752902 Ref: Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. PMID: 11806247 Ref: Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides. PMID: 12467236 |
Ref: AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. PMID: 11756242 Ref: Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. PMID: 11791178 Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. PMID: 11920634 Ref: Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. PMID: 12058282 Ref: The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells. PMID: 12060641 Ref: A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis. PMID: 12067982 Ref: Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. PMID: 12115344 Ref: Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. PMID: 12140294 Ref: Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. PMID: 12145277 Ref: PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. PMID: 12163369 Ref: Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. PMID: 12189136 Ref: Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties. PMID: 12191615 Ref: Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice. PMID: 12207005 Ref: Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. PMID: 12360481 Ref: Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). PMID: 12374696 Ref: Src activation regulates anoikis in human colon tumor cell lines. PMID: 12420216 Ref: Therapeutics targeting signal transduction for patients with colorectal carcinoma. PMID: 12421735 Ref: Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. PMID: 12473596 Ref: Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate. PMID: 12503617 |
Ref: Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. PMID: 12571082 Ref: Differential effects between amphoterin and advanced glycation end products on colon cancer cells. PMID: 12640679 Ref: Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. PMID: 12727858 Ref: Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist. PMID: 12761337 Ref: Signaling inhibition with radiation in colorectal cancer: clinical trials. PMID: 12802796 Ref: Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. PMID: 12824187 Ref: Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. PMID: 12839952 Ref: Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. PMID: 12851702 Ref: A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. PMID: 12855618 Ref: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 12888657 Ref: Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. PMID: 12939401 Ref: Induction of macrophage migration inhibitory factor by lysophosphatidic acid: relevance to tumor growth and angiogenesis. PMID: 12964047 Ref: Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells. PMID: 12970141 Ref: Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. PMID: 14581351 Ref: Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway. PMID: 14583467 Ref: Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. PMID: 14605666 Ref: Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. PMID: 14625550 Ref: Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. PMID: 14633695 Ref: The in vitro effects of H-89, a specific inhibitor of protein kinase A, in the human colonic carcinoma cell line Caco-2. PMID: 14639124 Ref: Additive interaction of oxaliplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines results from inhibition of nuclear factor kappaB signaling. PMID: 14695170 Ref: Inhibition of the biologic response to insulin-like growth factor I in MCF-7 breast cancer cells by a new monoclonal antibody to the insulin-like growth factor-I receptor. The importance of receptor down-regulation. PMID: 14710368 |
Ref: Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. PMID: 14578160 Ref: Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion. PMID: 14630701 Ref: An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B. PMID: 14691449 Ref: PTEN mutations are common in sporadic microsatellite stable colorectal cancer. PMID: 14724591 Ref: Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3. PMID: 14744783 Ref: Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. PMID: 14760102 Ref: ARK5 expression in colorectal cancer and its implications for tumor progression. PMID: 14982852 Ref: Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. PMID: 15059917 Ref: Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. PMID: 15093540 Ref: Pak-1 expression increases with progression of colorectal carcinomas to metastasis. PMID: 15161701 Ref: Cripto: a novel target for antibody-based cancer immunotherapy. PMID: 15173016 Ref: COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer. PMID: 15179622 Ref: Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma. PMID: 15183529 Ref: Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase. PMID: 15210862 Ref: CD44 promotes resistance to apoptosis in human colon cancer cells. PMID: 15215046 Ref: Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. PMID: 15252137 Ref: Regulation of caspase-6 and FLIP by the AMPK family member ARK5. PMID: 15273717 Ref: Rapid signalling pathway activation by androgens in epithelial and stromal cells. PMID: 15288763 Ref: Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. PMID: 15294912 Ref: Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-qu inolinium pamoate salt, showing preferential cytotoxicity during glucose starvation. PMID: 15298733 Ref: Inhibition of alpha5 integrin decreases PI3K activation and cell adhesion of human colon cancers. PMID: 15300173 Ref: MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. PMID: 15322085 Ref: Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. PMID: 15353307 Ref: Strong association of ARK5 with tumor invasion and metastasis. PMID: 15354411 Ref: CRIPTO-1: a novel target for therapeutic intervention in human carcinoma. PMID: 15375551 Ref: Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. PMID: 15377673 Ref: Akt: a potential target for thyroid cancer therapy. PMID: 15379721 Ref: Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. PMID: 15380519 Ref: Transactivation of E-cadherin is not involved in the activity of EGF receptor in colorectal carcinoma cells. PMID: 15492839 Ref: Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. PMID: 15516977 Ref: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo. PMID: 15517892 Ref: PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. PMID: 15520163 Ref: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. PMID: 15548175 Ref: In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316. PMID: 15559765 Ref: Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. PMID: 15570007 Ref: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines]. PMID: 15577750 Ref: Epidermal growth factor receptor-related peptide inhibits growth of PC-3 prostate cancer cells. PMID: 15634655 |
Ref: The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein. PMID: 15467762 Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. PMID: 15592509 Ref: Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. PMID: 15605394 Ref: Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. PMID: 15655348 Ref: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. PMID: 15655524 Ref: The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. PMID: 15657050 Ref: TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. PMID: 15665513 Ref: The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells. PMID: 15677629 Ref: Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis. PMID: 15688011 Ref: H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. PMID: 15713896 Ref: CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model. PMID: 15720820 Ref: LPA2 receptor mediates mitogenic signals in human colon cancer cells. PMID: 15728708 Ref: Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. PMID: 15741050 Ref: Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling. PMID: 15749637 Ref: Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. PMID: 15774489 Ref: Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. PMID: 15788691 Ref: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. PMID: 15808505 Ref: (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells. PMID: 15814656 Ref: Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. PMID: 15841378 Ref: The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells. PMID: 15846119 Ref: Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. PMID: 15867367 Ref: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. PMID: 15867384 Ref: Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. PMID: 15888491 Ref: HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. PMID: 15899817 Ref: Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyri din-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxami PMID: 15901852 Ref: Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling. PMID: 15908515 Ref: Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. PMID: 15914572 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: Functional analysis of PIK3CA gene mutations in human colorectal cancer. PMID: 15930273 Ref: Mutant PIK3CA promotes cell growth and invasion of human cancer cells. PMID: 15950905 Ref: Stability of phosphoprotein as a biological marker of tumor signaling. PMID: 15958615 Ref: AKT activation and response to interferon-beta in human cancer cells. PMID: 15970687 Ref: 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines. PMID: 15993848 Ref: ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. PMID: 16044163 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. PMID: 16103100 Ref: CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. PMID: 16125170 Ref: Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. PMID: 16127155 Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. PMID: 16127743 Ref: Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs. PMID: 16128748 Ref: Proteomic analysis of colonic myofibroblasts and effect on colon cancer cell proliferation. PMID: 16153451 Ref: Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). PMID: 16153452 Ref: Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer. PMID: 16166444 Ref: Somatic mutation and gain of copy number of PIK3CA in human breast cancer. PMID: 16168105 Ref: Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. PMID: 16199534 Ref: Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. PMID: 16204024 Ref: X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. PMID: 16278380 Ref: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. PMID: 16288056 Ref: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. PMID: 16293724 Ref: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation. PMID: 16294035 Ref: Assessment of Epidermal Growth Factor Receptor (EGFR) signaling in paired colorectal cancer and normal colon tissue samples using computer-aided immunohistochemical analysis. PMID: 16319527 Ref: The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. PMID: 16357171 Ref: Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. PMID: 16361624 Ref: Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. PMID: 16379552 Ref: EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. PMID: 16416603 |
Ref: Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. PMID: 16082389 Ref: Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells. PMID: 16113053 Ref: Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation. PMID: 16169935 Ref: Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues. PMID: 16202996 Ref: Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. PMID: 16215992 Ref: Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase. PMID: 16278684 Ref: ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. PMID: 16278819 Ref: Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. PMID: 16286461 Ref: The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1. PMID: 16288223 Ref: Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells. PMID: 16344270 Ref: Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas. PMID: 16353145 Ref: Oncogenic PI3K and its role in cancer. PMID: 16357568 Ref: Correlation of PIK3Ca mutations with gene expression and drug sensitivity in NCI-60 cell lines. PMID: 16376301 Ref: Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. PMID: 16397255 Ref: Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. PMID: 16401477 Ref: Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. PMID: 16401637 Ref: Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. PMID: 16428503 Ref: Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. PMID: 16432186 Ref: Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. PMID: 16442704 Ref: Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. PMID: 16448212 Ref: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. PMID: 16462766 Ref: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. PMID: 16475687 Ref: NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. PMID: 16488889 Ref: Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. PMID: 16489044 Ref: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling. PMID: 16505104 Ref: Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. PMID: 16508969 Ref: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. PMID: 16524888 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis. PMID: 16612624 Ref: Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis. PMID: 16618765 Ref: Cancer genetics of sporadic colorectal cancer: BRAF and PI3KCA mutations, their impact on signaling and novel targeted therapies. PMID: 16619509 Ref: Dietary fiber enhances a tumor suppressor signaling pathway in the gut. PMID: 16632996 Ref: Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis. PMID: 16677802 Ref: Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. PMID: 16697692 Ref: Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1. PMID: 16706817 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. PMID: 16731770 Ref: Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. PMID: 16737669 Ref: Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. PMID: 16772787 Ref: Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach. PMID: 16867865 Ref: Links between biology, prognosis and prediction of response to chemotherapy in colorectal cancer. PMID: 16874019 Ref: Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases. PMID: 16891475 Ref: TGF-beta inhibits Akt-induced transformation in intestinal epithelial cells. PMID: 16904986 Ref: Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity. PMID: 16928826 Ref: Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects. PMID: 16937523 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism. PMID: 17018624 Ref: Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates. PMID: 17034135 Ref: Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells. PMID: 17044774 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 Ref: NSAID activated gene (NAG-1), a modulator of tumorigenesis. PMID: 17129398 Ref: Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. PMID: 17148604 Ref: [Experimental study of effect of epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in combination with irinotecan]. PMID: 17236550 |
Ref: Insulin-like growth factors induce apoptosis as well as proliferation in LIM 1215 colon cancer cells. PMID: 16888814 Ref: MAGI-3 regulates LPA-induced activation of Erk and RhoA. PMID: 16904289 Ref: The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. PMID: 16912864 Ref: Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. PMID: 17072345 Ref: Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. PMID: 17149612 Ref: Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. PMID: 17175097 Ref: Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. PMID: 17201910 Ref: A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. PMID: 17234777 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis. PMID: 17265080 Ref: Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines. PMID: 17276526 Ref: Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. PMID: 17278192 Ref: Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. PMID: 17292358 Ref: FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. PMID: 17317726 Ref: Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects. PMID: 17382202 Ref: PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. PMID: 17409395 Ref: Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. PMID: 17410437 Ref: Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. PMID: 17449633 Ref: Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. PMID: 17452451 Ref: Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. PMID: 17472962 Ref: Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. PMID: 17488804 Ref: ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. PMID: 17513607 Ref: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways. PMID: 17531111 Ref: Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. PMID: 17545604 Ref: Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells. PMID: 17552361 Ref: Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. PMID: 17553685 Ref: Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells. PMID: 17569116 Ref: Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. PMID: 17575153 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options. 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PMID: 23732517 Ref: Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. PMID: 23737956 Ref: Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens. PMID: 23743569 Ref: Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin. PMID: 23744558 Ref: Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities. PMID: 23747344 Ref: Network quantification of EGFR signaling unveils potential for targeted combination therapy. PMID: 23752269 Ref: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. PMID: 23754208 Ref: Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. PMID: 23754252 Ref: Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation. PMID: 23769801 Ref: Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT. PMID: 23773626 Ref: Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells. PMID: 23786838 Ref: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer. PMID: 23803691 Ref: Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation. PMID: 23806981 Ref: Overexpression of peptide deformylase in breast, colon, and lung cancers. PMID: 23815882 Ref: Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PMID: 23826249 Ref: Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration. PMID: 23830189 Ref: Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways. PMID: 23843018 Ref: microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. PMID: 23846336 Ref: Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. PMID: 23851494 Ref: Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling. PMID: 23852390 Ref: Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. PMID: 23859040 Ref: Cleome arabica leaf extract has anticancer properties in human cancer cells. 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PMID: 25893829 Ref: Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. PMID: 25895029 Ref: IL13 Receptor alpha2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis. PMID: 25896327 Ref: mLST8 Promotes mTOR-Mediated Tumor Progression. PMID: 25906254 Ref: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells]. PMID: 25907934 Ref: BDE-99 (2,2',4,4',5-pentabromodiphenyl ether) triggers epithelial-mesenchymal transition in colorectal cancer cells via PI3K/Akt/Snail signaling pathway. PMID: 25908029 Ref: Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene. PMID: 25914533 Ref: ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. PMID: 25916654 Ref: MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms. PMID: 25919696 Ref: Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers. PMID: 25920435 Ref: Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. PMID: 25921151 Ref: High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. PMID: 25927939 Ref: Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway. PMID: 25936523 Ref: MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. PMID: 25945841 Ref: ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/beta-Catenin, Notch and PI3K/Akt Signaling Pathways. PMID: 25950950 Ref: AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis. PMID: 25961827 Ref: PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer. PMID: 25965911 Ref: Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target. PMID: 25973024 Ref: Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling. PMID: 25995820 Ref: Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways. PMID: 25998232 Ref: Chemoresistance of CD133(+) colon cancer may be related with increased survivin expression. PMID: 26002465 Ref: Atonal homolog 1 protein stabilized by tumor necrosis factor alpha induces high malignant potential in colon cancer cell line. PMID: 26017781 Ref: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation. PMID: 26017929 Ref: Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy. PMID: 26027741 Ref: Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway. PMID: 26028667 Ref: Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour. PMID: 26043921 Ref: Functional characterization of the nitrogen permease regulator-like-2 candidate tumor suppressor gene in colorectal cancer cell lines. PMID: 26044952 Ref: CSN5 silencing inhibits invasion and arrests cell cycle progression in human colorectal cancer SW480 and LS174T cells in vitro. PMID: 26045788 Ref: Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells. PMID: 26045985 Ref: Gene expression profiling of laterally spreading tumors. PMID: 26048755 Ref: Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer. PMID: 26054380 Ref: MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. PMID: 26055138 Ref: Expression of 3-phosphoinositide-dependent protein kinase 1 in colorectal cancer as a potential therapeutic target. PMID: 26055151 Ref: TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways. PMID: 26071104 Ref: The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma. PMID: 26077911 Ref: EGFR and beta1-integrin targeting differentially affect colorectal carcinoma cell radiosensitivity and invasion. PMID: 26096850 Ref: A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer. PMID: 26098881 Ref: MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1. PMID: 26107137 Ref: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. PMID: 26107252 Ref: Focal Adhesion Proteins alpha- and beta-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression. PMID: 26115385 Ref: NECTIN-4 increased the 5-FU resistance in colon cancer cells by inducing the PI3K-AKT cascade. PMID: 26122960 Ref: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. 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PMID: 26247730 Ref: Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. PMID: 26258407 Ref: SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression. PMID: 26258891 Ref: Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice. PMID: 26262998 Ref: Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition. PMID: 26269761 Ref: Hypothesis: Obesity Is Associated with a Lower Mutation Threshold in Colon Cancer. PMID: 26284133 Ref: Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. PMID: 26299305 Ref: Implication of Akt, ERK1/2 and alternative p38MAPK signalling pathways in human colon cancer cell apoptosis induced by green tea EGCG. 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PMID: 26366416 Ref: Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer. PMID: 26377365 Ref: Toosendanin inhibits growth and induces apoptosis in colorectal cancer cells through suppression of AKT/GSK-3beta/beta-catenin pathway. PMID: 26398368 Ref: PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells. PMID: 26399781 Ref: Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers. PMID: 26404261 Ref: Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo. PMID: 26404630 Ref: Retraction: MicroRNA-302a Functions as a Putative Tumor Suppressor in Colon Cancer by Targeting Akt. PMID: 26407228 Ref: Mechanism of Chemoprevention against Colon Cancer Cells Using Combined Gelam Honey and Ginger Extract via mTOR and Wnt/beta-catenin Pathways. PMID: 26434873 Ref: Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets. PMID: 26446703 Ref: Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3beta pathway in human colon cancer. PMID: 26452029 Ref: Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice. PMID: 26452385 Ref: Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. PMID: 26457069 Ref: MicroRNA-219-5p functions as a tumor suppressor partially by targeting platelet-derived growth factor receptor alpha in colorectal cancer. PMID: 26458304 Ref: Oleanolic acid modulates multiple intracellular targets to inhibit colorectal cancer growth. PMID: 26459864 Ref: Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acry lamide in human colorectal cancer cells in vitro and in vivo. PMID: 26462017 Ref: The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway. PMID: 26464652 Ref: Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PMID: 26469692 Ref: Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity. PMID: 26472352 Ref: Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks. PMID: 26476078 Ref: Role of retinoids in the prevention and treatment of colorectal cancer. PMID: 26483874 Ref: Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. PMID: 26485768 Ref: Sulforaphane inhibits hypoxia-induced HIF-1alpha and VEGF expression and migration of human colon cancer cells. PMID: 26498863 Ref: Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1alpha downregulation. PMID: 26503233 Ref: Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 26503559 Ref: Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion. PMID: 26504021 Ref: A set of defined oncogenic mutation alleles seems to better predict the response to cetuximab in CRC patient-derived xenograft than KRAS 12/13 mutations. PMID: 26512781 Ref: The Anti-Tumor Activity of Succinyl Macrolactin A Is Mediated through the beta-Catenin Destruction Complex via the Suppression of Tankyrase and PI3K/Akt. PMID: 26544726 Ref: Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. PMID: 26580959 Ref: Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. PMID: 26606169 Ref: Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1alpha and Induces Apoptosis in Human Colorectal Cancer Cells. PMID: 26610526 Ref: Greatwall promotes cell transformation by hyperactivating AKT in human malignancies. PMID: 26613407 Ref: Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail. PMID: 26632346 Ref: The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins. PMID: 26673327 Ref: Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo. PMID: 26674205 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 Ref: Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways. PMID: 26693061 Ref: Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation. PMID: 26704889 Ref: Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells. PMID: 26729093 Ref: Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways. PMID: 26770191 Ref: Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells. PMID: 26788191 Ref: Impact of prospero homeobox-1 on tumor cell behavior and prognosis in colorectal cancer. PMID: 26807311 Ref: The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. PMID: 27022656 Ref: The molecular background of mucinous carcinoma beyond MUC2. PMID: 27499889 Ref: Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies. PMID: 27595061 |
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PMID: 26646797 Ref: Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade. PMID: 26647806 Ref: Enhancement of CD3AK cell proliferation and killing ability by alpha-Thujone. PMID: 26655741 Ref: Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis. PMID: 26669864 Ref: A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells. PMID: 26673746 Ref: Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway. PMID: 26677144 Ref: Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells. 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PMID: 26718323 Ref: MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. PMID: 26718987 Ref: CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling. PMID: 26719016 Ref: Reactive oxygen species mediate oxaliplatin-induced epithelial-mesenchymal transition and invasive potential in colon cancer. PMID: 26733168 Ref: The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression. PMID: 26740252 Ref: Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. PMID: 26741506 Ref: Nanoproteomic analysis of ischemia-dependent changes in signaling protein phosphorylation in colorectal normal and cancer tissue. PMID: 26742633 Ref: Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells. PMID: 26747179 Ref: Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. PMID: 26750720 Ref: A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis. PMID: 26764221 Ref: The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. PMID: 26774105 Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Effective targeting of colorectal cancer cells using TORC1/2 kinase inhibitors in vitro and in vivo. PMID: 26776341 Ref: B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. PMID: 26787540 Ref: Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3beta Signaling Pathway. PMID: 26792278 Ref: Rab11-FIP2 promotes colorectal cancer migration and invasion by regulating PI3K/AKT/MMP7 signaling pathway. PMID: 26792722 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: [Application of molecular diagnostic techniques in precision medicine of personalized treatment for colorectal cancer]. PMID: 26797832 Ref: Obesity and colorectal cancer: molecular features of adipose tissue. PMID: 26801617 Ref: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. PMID: 26802026 Ref: SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIgamma/AKT-mediated pathway. PMID: 26803057 Ref: Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells. PMID: 26831668 Ref: Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment. PMID: 26840292 Ref: Overexpression of KiSS-1 reduces colorectal cancer cell invasion by downregulating MMP-9 via blocking PI3K/Akt/NF-kappaB signal pathway. PMID: 26847533 Ref: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway. PMID: 26847718 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: Baicalein inhibits the migration and invasion of colorectal cancer cells via suppression of the AKT signaling pathway. PMID: 26870267 Ref: Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways. PMID: 26879868 Ref: Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells. PMID: 26883103 Ref: Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer. PMID: 26893778 Ref: In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. PMID: 26915975 Ref: AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin. PMID: 26918349 Ref: Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA. PMID: 26925673 Ref: Physcion 8-O-beta-glucopyranoside prevents hypoxia-induced epithelial-mesenchymal transition in colorectal cancer HCT116 cells by modulating EMMPRIN. PMID: 26925795 Ref: Palmitoylethanolamide Exerts Antiproliferative Effect and Downregulates VEGF Signaling in Caco-2 Human Colon Carcinoma Cell Line Through a Selective PPAR-alpha-Dependent Inhibition of Akt/mTOR Pathway. PMID: 26929026 Ref: Antitumor effects of calgranulin B internalized in human colon cancer cells. PMID: 26933915 Ref: Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. PMID: 26936429 Ref: CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo. PMID: 26946942 Ref: Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development. PMID: 26965998 Ref: Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model. PMID: 26970558 Ref: Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice. PMID: 26973250 Ref: Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. PMID: 26984550 Ref: Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells. PMID: 26988990 Ref: Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. PMID: 26989024 Ref: Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells. PMID: 26992638 Ref: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. PMID: 27004568 Ref: DDX3 enhances oncogenic KRASinduced tumor invasion in colorectal cancer via the betacatenin/ZEB1 axis. PMID: 27007150 Ref: Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo. PMID: 27020593 Ref: Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer. PMID: 27026198 Ref: Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. PMID: 27028006 Ref: [Alpha-1 Antitrypsin Affects U0126-Induced Cytotoxicity in Colon Cancer Cell Line (HCT116)]. PMID: 27028823 Ref: Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4. PMID: 27033953 Ref: Lentivirus-mediated somatic recombination and development of a novel mouse model for sporadic colorectal cancer. PMID: 27037682 Ref: Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells. PMID: 27044819 Ref: High expression of Rab3D predicts poor prognosis and associates with tumor progression in colorectal cancer. PMID: 27046094 Ref: Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer. PMID: 27050145 Ref: Dehydroglyasperin D Inhibits the Proliferation of HT-29 Human Colorectal Cancer Cells Through Direct Interaction With Phosphatidylinositol 3-kinase. PMID: 27051646 Ref: Bioinformatic exploration of MTA1-regulated gene networks in colon cancer. PMID: 27052252 Ref: CCL21 Facilitates Chemoresistance and Cancer Stem Cell-Like Properties of Colorectal Cancer Cells through AKT/GSK-3beta/Snail Signals. PMID: 27057280 Ref: Visfatin is involved in promotion of colorectal carcinoma malignancy through an inducing EMT mechanism. PMID: 27058759 Ref: Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells. PMID: 27059026 Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: NFkappaB-Associated Pathways in Progression of Chemoresistance to 5-Fluorouracil in an In Vitro Model of Colonic Carcinoma. PMID: 27069140 Ref: TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/beta-catenin and MAPK signalling. PMID: 27071482 Ref: Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. PMID: 27082059 Ref: Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia. PMID: 27085776 Ref: Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice. PMID: 27086950 Ref: Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-kappaB signalling pathway. PMID: 27091625 Ref: miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling. PMID: 27095166 Ref: MicroRNA-204 modulates colorectal cancer cell sensitivity in response to 5-fluorouracil-based treatment by targeting high mobility group protein A2. PMID: 27095441 Ref: Predictive microRNAs for lymph node metastasis in endoscopically resectable submucosal colorectal cancer. PMID: 27096956 Ref: IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-kappaB-Mediated MMP Expression. PMID: 27098148 Ref: SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline. PMID: 27102434 Ref: Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-kappaB activation through PI3K/Akt pathway. PMID: 27102438 Ref: KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes. PMID: 27117408 Ref: ZKSCAN3 Facilitates Liver Metastasis of Colorectal Cancer Associated with CEA-expressing Tumor. PMID: 27127149 Ref: Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway. PMID: 27144580 Ref: The co-stimulatory molecule B7-H3 promotes the epithelial-mesenchymal transition in colorectal cancer. PMID: 27145365 Ref: Loss of the 14-3-3sigma is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway. PMID: 27156963 Ref: BRD7: a novel tumor suppressor gene in different cancers. PMID: 27158366 Ref: IL-13 induces the expression of 11betaHSD2 in IL-13Ralpha2 dependent manner and promotes the malignancy of colorectal cancer. PMID: 27158392 Ref: Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells. PMID: 27163731 Ref: The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells. PMID: 27167250 Ref: Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach. PMID: 27180984 Ref: Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance. PMID: 27186286 Ref: microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway. PMID: 27191497 Ref: Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells. PMID: 27192488 Ref: Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC. PMID: 27197306 Ref: Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. PMID: 27203214 Ref: Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. PMID: 27207671 Ref: Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. PMID: 27210058 Ref: Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. PMID: 27221553 Ref: Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects. PMID: 27224059 Ref: Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. PMID: 27225481 Ref: Stanniocalcin 2 induces oxaliplatin resistance in colorectal cancer cells by upregulating P-glycoprotein. PMID: 27245421 Ref: Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice. PMID: 27270323 Ref: Comparison of KRAS mutation status between primary tumor and metastasis in Chinese colorectal cancer patients. PMID: 27270901 Ref: Regulation of the RhoA/ROCK/AKT/beta-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma. PMID: 27277835 Ref: Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway. PMID: 27279570 Ref: Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells. PMID: 27294206 Ref: PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. PMID: 27296289 Ref: Antitumor effect of manumycin on colorectal cancer cells by increasing the reactive oxygen species production and blocking PI3K-AKT pathway. PMID: 27307747 Ref: Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells. PMID: 27313783 Ref: Autophagy regulation and its role in gastric cancer and colorectal cancer. PMID: 27314289 Ref: Interactions between the colonic transcriptome, metabolome, and microbiome in mouse models of obesity-induced intestinal cancer. PMID: 27317588 Ref: Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. PMID: 27321283 Ref: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. PMID: 27323826 Ref: EphA4-mediated signaling regulates the aggressive phenotype of irradiation survivor colorectal cancer cells. PMID: 27323967 Ref: Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis. PMID: 27344176 Ref: Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. PMID: 27347133 Ref: Oncolytic herpes simplex virus kills stem-like tumor-initiating colon cancer cells. PMID: 27347556 Ref: MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer. PMID: 27350731 Ref: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. PMID: 27351224 Ref: Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3beta. PMID: 27354597 Ref: Tounong Powder () extracts induce G1 cell cycle arrest and apoptosis in LoVo cells. PMID: 27358203 Ref: Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody. PMID: 27364553 Ref: Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. PMID: 27391062 Ref: Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERbeta/MiR-95 and IGF-1R, PI3K/Akt signaling pathways. PMID: 27393650 Ref: Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells. PMID: 27395829 Ref: Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer. PMID: 27409167 Ref: Thyroid hormone receptor beta1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells. PMID: 27431682 Ref: Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity. PMID: 27431918 Ref: CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer. PMID: 27435270 Ref: Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis. PMID: 27436848 Ref: Role of periostin in esophageal, gastric and colon cancer. PMID: 27446351 Ref: Sporadic early-onset colon cancer expresses unique molecular features. PMID: 27451894 Ref: A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway. PMID: 27460008 Ref: Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development. PMID: 27460083 Ref: Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells. PMID: 27461218 Ref: Lentivirus-mediated shRNA interference of ghrelin receptor blocks proliferation in the colorectal cancer cells. PMID: 27464938 Ref: Sur8 mediates tumorigenesis and metastasis in colorectal cancer. PMID: 27469030 Ref: Inactivation of the FoxO3a transcription factor is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated senescence in human colon cancer and breast cancer cells. PMID: 27470586 Ref: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling. PMID: 27472445 Ref: Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. PMID: 27472952 Ref: Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. PMID: 27494849 Ref: Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer. PMID: 27511117 Ref: DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling. PMID: 27517319 Ref: Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells. PMID: 27517495 Ref: Erythropoietin accelerates tumor growth through increase of erythropoietin receptor (EpoR) as well as by the stimulation of angiogenesis in DLD-1 and Ht-29 xenografts. PMID: 27543111 Ref: Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer. PMID: 27543779 Ref: MiR-29a Regulates Radiosensitivity in Human Intestinal Cells by Targeting PTEN Gene. PMID: 27548517 Ref: Effect of a chemical inhibitor of human phosphatidylethanolamine-binding protein 4 on radiosensitivity of rectal cancer cells. PMID: 27553494 Ref: Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma. PMID: 27556502 Ref: Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells. PMID: 27557491 Ref: Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells. PMID: 27558478 Ref: High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer. PMID: 27562229 Ref: mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity. PMID: 27565731 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway. PMID: 27581375 Ref: Specific inhibition of p110alpha subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers. PMID: 27602501 Ref: The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition. PMID: 27617642 Ref: Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents. PMID: 27625151 Ref: Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. PMID: 27626684 Ref: Telomere Length, TERT, and miRNA Expression. PMID: 27627813 Ref: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. PMID: 27629794 Ref: Linc00152 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer. PMID: 27633443 Ref: Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways. PMID: 27634156 Ref: CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3beta signaling pathway. PMID: 27634891 Ref: TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway. PMID: 27644693 Ref: The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer. PMID: 27650539 Ref: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer. PMID: 27657889 Ref: Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. PMID: 27661110 Ref: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. PMID: 27662663 Ref: Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. PMID: 27664007 Ref: The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells. PMID: 27668882 Ref: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways. PMID: 27669982 Ref: Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway. PMID: 27671687 Ref: Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. PMID: 27688749 Ref: Curcumin targets the TFEB-lysosome pathway for induction of autophagy. PMID: 27689333 Ref: Odontogenic ameloblast-associated protein (ODAM) inhibits human colorectal cancer growth by promoting PTEN elevation and inactivating PI3K/AKT signaling. PMID: 27694004 Ref: Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. PMID: 27698814 Ref: Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy. PMID: 27708223 Ref: 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. PMID: 27710830 Ref: Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation. PMID: 27716613 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. PMID: 27748879 Ref: Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. PMID: 27748934 Ref: Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer. PMID: 27750216 Ref: Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase. PMID: 27764698 Ref: [Overexpression of aplysia Ras homolog I (ARHI) increases apoptosis in colon cancer SW480 cells]. PMID: 27774944 Ref: Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway. PMID: 27779692 Ref: Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application. PMID: 27780923 Ref: Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cells. PMID: 27780925 Ref: Probing the PI3K/Akt/mTor pathway using (31)P-NMR spectroscopy: routes to glycogen synthase kinase 3. PMID: 27811956 Ref: LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384. PMID: 27822419 Ref: The role of testosterone in colorectal carcinoma: pathomechanisms and open questions. PMID: 27833666 Ref: Gankyrin sustains PI3K/GSK-3beta/beta-catenin signal activation and promotes colorectal cancer aggressiveness and progression. PMID: 27835604 Ref: Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer. PMID: 27835884 Ref: Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling. PMID: 27863385 Ref: Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway. PMID: 27874952 Ref: Negative feedback between TAp63 and Mir-133b mediates colorectal cancer suppression. PMID: 27894087 Ref: Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells. PMID: 27895729 Ref: [New Classification for Advanced Colorectal Cancer Using CancerPlex(R)Genomic Tests]. 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PMID: 27729429 Ref: Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC(min/+) Mouse Models of Experimental Colon Cancer. PMID: 27730672 Ref: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. PMID: 27793841 Ref: Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. PMID: 27811010 Ref: Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity. PMID: 27833053 Ref: Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. PMID: 27840966 Ref: MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells. PMID: 27840990 Ref: Microcystin-LR promotes epithelial-mesenchymal transition in colorectal cancer cells through PI3-K/AKT and SMAD2. 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PMID: 27890432 Ref: Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/beta-catenin signaling pathways in hepatocellular and colorectal carcinoma cells. PMID: 27901475 Ref: Erythropoietin Enhances the Cytotoxic Effect of Hydrogen Peroxide on Colon Cancer Cells. PMID: 27903235 Ref: Is Metformin a Therapeutic Paradigm for Colorectal Cancer: Insight into the Molecular Pathway? PMID: 27919208 Ref: Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis. PMID: 27924057 Ref: Ketogenesis contributes to intestinal cell differentiation. PMID: 27935584 Ref: Evolution and heterogeneity of non-hereditary colorectal cancer revealed by single-cell exome sequencing. PMID: 27941887 Ref: CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells. PMID: 27959393 Ref: Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets. PMID: 27997180 Ref: cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. PMID: 27998725 Ref: LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. PMID: 27999210 Ref: Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells. PMID: 28002807 Ref: High early growth response 1 (EGR1) expression correlates with resistance to anti-EGFR treatment in vitro and with poorer outcome in metastatic colorectal cancer patients treated with cetuximab. PMID: 28005260 Ref: Idelalisib induces PUMA-dependent apoptosis in colon cancer cells. PMID: 28008149 Ref: LncRNA NEAT1 Impacts Cell Proliferation and Apoptosis of Colorectal Cancer via Regulation of Akt Signaling. PMID: 28013491 Ref: Functional Effects of AKT3 on Aurora Kinase Inhibitor-induced Aneuploidy. PMID: 28028179 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. PMID: 28031534 Ref: Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells. PMID: 28032592 Ref: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway. PMID: 28049091 Ref: The RNA-binding protein ESRP1 promotes human colorectal cancer progression. PMID: 28052020 Ref: miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway. PMID: 28061765 Ref: Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis. PMID: 28068324 Ref: Poly(C)-binding protein 1 mediates drug resistance in colorectal cancer. PMID: 28076324 Ref: AT7867 Inhibits Human Colorectal Cancer Cells via AKT-Dependent and AKT-Independent Mechanisms. PMID: 28081222 Ref: Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. PMID: 28082369 Ref: Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells. PMID: 28101572 Ref: Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. PMID: 28107519 Ref: The miR-487b-3p/GRM3/TGFbeta signaling axis is an important regulator of colon cancer tumorigenesis. PMID: 28114282 Ref: MIF/CD74 axis is a target for novel therapies in colon carcinomatosis. 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PMID: 28154202 Ref: Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine. PMID: 28159918 Ref: Variable Levels of Long Noncoding RNA Expression in DNA Mismatch Repair-Proficient Early-Stage Colon Cancer. PMID: 28160106 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells. PMID: 28179998 Ref: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. PMID: 28188923 Ref: Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. PMID: 28197625 Ref: TGF-beta1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells. PMID: 28197642 Ref: Molecular Testing for Gastrointestinal Cancer. PMID: 28219002 Ref: Inflammatory cytokines IL-17 and TNF-alpha up-regulate PD-L1 expression in human prostate and colon cancer cells. PMID: 28223102 Ref: The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target. PMID: 28223542 Ref: AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway. PMID: 28243117 Ref: Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer. PMID: 28243201 Ref: Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis. PMID: 28245338 Ref: Angiogenesis and Oxidative Stress in Metastatic Tumor Progression: Pathogenesis and Novel Therapeutic Approach of Colon Cancer. PMID: 28245762 Ref: CXCL8 induces epithelial-mesenchymal transition in colon cancer cells via the PI3K/Akt/NF-kappaB signaling pathway. PMID: 28259918 Ref: Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis. PMID: 28260110 Ref: Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PMID: 28273117 Ref: Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. PMID: 28275297 Ref: Prognostic Relevance and Function of MSX2 in Colorectal Cancer. PMID: 28286778 Ref: PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407. PMID: 28300833 Ref: Enhancement of NK cells proliferation and function by Shikonin. PMID: 28303727 Ref: Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model. PMID: 28315345 Ref: Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. PMID: 28316102 Ref: Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways. PMID: 28320104 Ref: STAT1 Inhibits MiR-181a Expression to Suppress Colorectal Cancer Cell Proliferation Through PTEN/Akt. PMID: 28322462 Ref: Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer. PMID: 28323034 Ref: Apigenin-induced lysosomal degradation of beta-catenin in Wnt/beta-catenin signaling. PMID: 28337019 Ref: p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. PMID: 28339031 Ref: p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage. PMID: 28339062 Ref: Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis. PMID: 28351943 Ref: TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K/AKT signaling. PMID: 28352192 Ref: Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells. PMID: 28355296 Ref: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways. PMID: 28356111 Ref: Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation. PMID: 28360012 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells. PMID: 28388571 Ref: Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus. PMID: 28391699 Ref: Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. PMID: 28392376 Ref: High expression of P2X7R is an independent postoperative indicator of poor prognosis in colorectal cancer. PMID: 28412208 Ref: Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells. PMID: 28412728 Ref: Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer. PMID: 28412748 Ref: Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy. PMID: 28416456 Ref: MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop. PMID: 28422727 Ref: Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway. PMID: 28427191 Ref: Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. PMID: 28432271 Ref: Effects of Scutellaria barbata polysaccharide on the proliferation, apoptosis and EMT of human colon cancer HT29 Cells. PMID: 28433181 Ref: Oncogenic beta-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. PMID: 28442534 Ref: Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion. PMID: 28453235 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: TrkC promotes colorectal cancer growth and metastasis. PMID: 28455963 Ref: AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling. PMID: 28475127 Ref: mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. PMID: 28475179 Ref: Ileocaecal and transverse colonic tuberculosis mimicking colonic malignancy - A case report. PMID: 28486175 Ref: Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine. PMID: 28486761 Ref: Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer. PMID: 28492544 Ref: Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways. PMID: 28496003 Ref: miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. PMID: 28498456 Ref: Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy. PMID: 28507280 Ref: A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer. PMID: 28512242 Ref: An Oncolytic Adenovirus Expressing SNORD44 and GAS5 Exhibits Antitumor Effect in Colorectal Cancer Cells. PMID: 28530127 Ref: AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress. PMID: 28530706 Ref: Isofraxidin inhibited proliferation and induced apoptosis via blockage of Akt pathway in human colorectal cancer cells. PMID: 28531803 Ref: Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells. PMID: 28534975 Ref: TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway. PMID: 28534983 Ref: AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes. PMID: 28536078 Ref: Killing effects of Huaier Granule combined with DC-CIK on nude mice transplanted with colon carcinoma cell line. PMID: 28537906 Ref: MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway. PMID: 28549468 Ref: FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma. PMID: 28559972 Ref: The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cells. PMID: 28560069 Ref: Silencing of type Igamma phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion. PMID: 28560454 Ref: EphA2 receptor activation with ephrin-A1 ligand restores cetuximab efficacy in NRAS-mutant colorectal cancer cells. PMID: 28560458 Ref: A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells. PMID: 28573382 Ref: Role of a novel benzoxazine derivative in the chemosensitization of colon cancer. PMID: 28577196 Ref: SIX4 promotes metastasis via activation of the PI3K-AKT pathway in colorectal cancer. PMID: 28584719 Ref: Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line. PMID: 28586741 Ref: Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. PMID: 28587064 Ref: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts. PMID: 28592228 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor. PMID: 28596013 Ref: Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer. PMID: 28597984 Ref: NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer. PMID: 28598238 Ref: SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner. PMID: 28618450 Ref: High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma. PMID: 28624786 Ref: 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. PMID: 28627461 Ref: Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies. PMID: 28640835 Ref: MFG-E8 overexpression promotes colorectal cancer progression via AKT/MMPs signalling. PMID: 28653875 Ref: 18 beta-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration. PMID: 28656212 Ref: Induction of apoptosis by Dae-Hwang-Mok-Dan-Tang in HCT-116 colon cancer cells through activation of caspases and inactivation of the phosphatidylinositol 3-kinase/Akt signaling. PMID: 28664141 Ref: LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression. PMID: 28664914 Ref: HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway. PMID: 28667026 Ref: Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis. PMID: 28675857 Ref: Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells. PMID: 28676397 Ref: Inhibition of B7-H3 reverses oxaliplatin resistance in human colorectal cancer cells. PMID: 28676400 Ref: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/beta-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. PMID: 28677721 Ref: Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer. PMID: 28678173 Ref: Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/beta-catenin signaling pathways in human colon cancer cells. PMID: 28688953 Ref: Cellular prion protein (PrP(C)) in the development of Merlin-deficient tumours. PMID: 28692055 Ref: MicroRNA-215 acts as a tumor suppressor in breast cancer by targeting AKT serine/threonine kinase 1. PMID: 28693279 Ref: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. PMID: 28706417 Ref: Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment. PMID: 28708103 Ref: Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells. PMID: 28712871 Ref: The aspirin metabolite salicylate inhibits lysine acetyltransferases and MUC1 induced epithelial to mesenchymal transition. PMID: 28717171 Ref: Role of GSK-3beta in Regulation of Canonical Wnt/beta-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer. PMID: 28718684 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy. PMID: 28729397 Ref: PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. PMID: 28729699 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: ANP32A modulates cell growth by regulating p38 and Akt activity in colorectal cancer. PMID: 28731192 Ref: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. PMID: 28737825 Ref: LncRNA AB073614 regulates proliferation and metastasis of colorectal cancer cells via the PI3K/AKT signaling pathway. PMID: 28738539 Ref: miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. PMID: 28739727 Ref: The Axis of CXCR4/SDF-1 Plays a Role in Colon Cancer Cell Adhesion Through Regulation of the AKT and IGF1R Signalling Pathways. PMID: 28739729 Ref: Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice. PMID: 28745498 Ref: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. PMID: 28751160 Ref: Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway. PMID: 28767179 Ref: Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors. PMID: 28767654 Ref: miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway. PMID: 28771224 Ref: microRNA-219-5p inhibits epithelial-mesenchymal transition and metastasis of colorectal cancer by targeting lymphoid enhancer-binding factor 1. PMID: 28771881 Ref: A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis. PMID: 28775144 Ref: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. PMID: 28781653 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in ApcMin/+ mice. PMID: 28786349 Ref: Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes? PMID: 28799785 Ref: Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3beta/beta-catenin pathway. PMID: 28803443 Ref: Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer. PMID: 28810597 Ref: Fibroblast-derived CXCL12/SDF-1alpha promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer. PMID: 28811711 Ref: Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. PMID: 28819438 Ref: The C-terminal region of the focal adhesion kinase F1 domain binds Akt1 and inhibits pressure-induced cell adhesion. PMID: 28820394 Ref: Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-kappaB/AKT/PTEN/MAPK pathways. PMID: 28821160 Ref: AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells. PMID: 28837154 Ref: Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles. PMID: 28842968 Ref: Scutellaria barbata D. Don inhibits 5-fluorouracil resistance in colorectal cancer by regulating PI3K/AKT pathway. PMID: 28849113 Ref: XB130 enhances invasion and migration of human colorectal cancer cells by promoting epithelialmesenchymal transition. PMID: 28849225 Ref: Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors. PMID: 28853539 Ref: Mathematical models in cancer therapy. PMID: 28866047 Ref: Sushi repeat-containing protein X-linked 2 promotes angiogenesis through the urokinase-type plasminogen activator receptor dependent integrin alphavbeta3/focal adhesion kinase pathways. PMID: 28867754 Ref: Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer. PMID: 28869531 Ref: GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer Cells. PMID: 28870916 Ref: Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis. PMID: 28881576 Ref: Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells. PMID: 28881770 Ref: Inositol hexaphosphate hydrolysate competitively binds to AKT to inhibit the proliferation of colon carcinoma. PMID: 28901472 Ref: Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells. PMID: 28912474 Ref: Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy. PMID: 28920928 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: Catalpol promotes cellular apoptosis in human HCT116 colorectal cancer cells via microRNA-200 and the downregulation of PI3K-Akt signaling pathway. PMID: 28927141 Ref: The Impact of Cetuximab Plus AKT- or mTOR- Inhibitor in a Patient-Derived Colon Cancer Cell Model with Wild-Type RAS and PIK3CA Mutation. PMID: 28928860 Ref: MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor. PMID: 28932920 Ref: TRAIL enhances quinacrine-mediated apoptosis in breast cancer cells through induction of autophagy via modulation of p21 and DR5 interactions. PMID: 28936683 Ref: Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival. PMID: 28936799 Ref: EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features. PMID: 28936923 Ref: Targeting progastrin enhances radiosensitization of colorectal cancer cells. PMID: 28938581 Ref: Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/beta-Catenin and PI3K/Akt Signaling. PMID: 28939743 Ref: MicroRNA212 inhibits colorectal cancer cell viability and invasion by directly targeting PIK3R3. PMID: 28944887 Ref: Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1alpha pathway. PMID: 28951129 Ref: MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer. PMID: 28957811 Ref: Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway. PMID: 28972559 Ref: Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. PMID: 28978031 Ref: Therapeutic efficacy of SYM004, a mixture of two anti-EGFR antibodies in human colorectal cancer with acquired resistance to cetuximab and MET activation. PMID: 28978055 Ref: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer. PMID: 28978118 Ref: The long non-coding RNA NONHSAT062994 inhibits colorectal cancer by inactivating Akt signaling. PMID: 28978149 Ref: Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer. PMID: 28979133 Ref: Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells. PMID: 28981110 Ref: SUMOylation of IQGAP1 promotes the development of colorectal cancer. PMID: 28987385 Ref: MACC1 facilitates chemoresistance and cancer stem celllike properties of colon cancer cells through the PI3K/AKT signaling pathway. PMID: 28990068 Ref: Induction of Anoikis in Human Colorectal Cancer Cells by Fucoxanthinol. PMID: 28990814 Ref: Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents. PMID: 28991196 Ref: Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk. PMID: 29023587 Ref: miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway. PMID: 29030743 Ref: MiR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer. PMID: 29035829 Ref: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b. PMID: 29036788 Ref: MicroRNA760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1mediated PTEN/AKT signalling pathway. PMID: 29039575 Ref: MicroRNA337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways. PMID: 29048669 Ref: Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells. PMID: 29069832 Ref: [Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN]. PMID: 29082697 Ref: Apatinib has anti-tumor effects and induces autophagy in colon cancer cells. PMID: 29085592 Ref: SODD promotes glucose uptake of colorectal cancer cells via AKT pathway. PMID: 29087604 Ref: Invitro Evaluation of Torin2 and 2, 6-Dihydroxyacetophenone in Colorectal Cancer Therapy. PMID: 29103204 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 Ref: Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. PMID: 29110726 Ref: Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model. PMID: 29112400 Ref: Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells. PMID: 29117108 Ref: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1. PMID: 29118671 Ref: Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling. PMID: 29130099 Ref: NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction. PMID: 29137323 Ref: Novel all-hydrocarbon stapled p110alpha[E545K] peptides as blockers of the oncogenic p110alpha[E545K]-IRS1 interaction. PMID: 29138025 Ref: PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells. PMID: 29138581 Ref: Uncoupling TORC2 from AGC kinases inhibits tumour growth. PMID: 29156676 Ref: Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells. PMID: 29160412 Ref: MicroRNA-497 inhibits tumor growth through targeting insulin receptor substrate 1 in colorectal cancer. PMID: 29163678 Ref: ADAMTS9 is Silenced by Epigenetic Disruption in Colorectal Cancer and Inhibits Cell Growth and Metastasis by Regulating Akt/p53 Signaling. PMID: 29186710 Ref: Characterizing the heterogeneity of tumor tissues from spatially resolved molecular measures. PMID: 29190747 Ref: miRNA-495 suppresses proliferation and migration of colorectal cancer cells by targeting FAM83D. PMID: 29221726 Ref: Inhibition of pressure-activated cancer cell adhesion by FAK-derived peptides. PMID: 29228673 Ref: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. PMID: 29233468 Ref: Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6. PMID: 29254159 Ref: Canadine from Corydalis turtschaninovii Stimulates Myoblast Differentiation and Protects against Myotube Atrophy. PMID: 29258243 Ref: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. PMID: 29273065 Ref: Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-beta/Smad signaling pathways. PMID: 29285087 Ref: NCOA5 promotes proliferation, migration and invasion of colorectal cancer cells via activation of PI3K/AKT pathway. PMID: 29296214 Ref: Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice. PMID: 29326691 Ref: Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways. PMID: 29344237 Ref: Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways. PMID: 29344262 Ref: ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway. PMID: 29348846 Ref: Network analysis of common genes related to esophageal, gastric, and colon cancers. PMID: 29379595 Ref: Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma. PMID: 29511478 |
Ref: Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. PMID: 27849558 Ref: Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress. PMID: 28230287 Ref: Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer. PMID: 28262927 Ref: Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC. PMID: 28294332 Ref: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway. PMID: 28684297 Ref: Anticancer effect of Polyphyllin Iota in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms. PMID: 28714320 Ref: CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. PMID: 28816021 Ref: Insulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17. PMID: 28819788 Ref: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway. PMID: 28822989 Ref: Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway. PMID: 28835319 Ref: Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway. PMID: 28884839 Ref: Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis. PMID: 28916526 Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. PMID: 28967905 Ref: Long non-coding RNA-422 acts as a tumor suppressor in colorectal cancer. PMID: 29050940 Ref: The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer. PMID: 29068474 Ref: Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation. PMID: 29074106 Ref: Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer. PMID: 29075780 Ref: CCR6 promotes tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer. PMID: 29097259 Ref: Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Senggang-Tang, inhibits TNF-alpha-induced epithelial-mesenchymal transition in HCT116 colorectal cancer cells. PMID: 29115450 Ref: Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. PMID: 29115462 Ref: Simultaneous use of erythropoietin and LFM-A13 as a new therapeutic approach for colorectal cancer. PMID: 29160911 Ref: RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. PMID: 29196555 Ref: Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways. PMID: 29207091 Ref: TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer. PMID: 29222171 Ref: COPS5 and LASP1 synergistically interact to downregulate 14-3-3sigma expression and promote colorectal cancer progression via activating PI3K/AKT pathway. PMID: 29226323 Ref: Insulin-like growth factor 1 inhibits autophagy of human colorectal carcinoma drug-resistant cells via the protein kinase B/mammalian target of rapamycin signaling pathway. PMID: 29257307 Ref: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. PMID: 29257314 Ref: Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer. PMID: 29260353 Ref: Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor. PMID: 29267844 Ref: DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in colorectal cancer. PMID: 29277893 Ref: Rational Approaches for Combination Therapy Strategies Targeting the MAP Kinase Pathway in Solid Tumors. PMID: 29295962 Ref: Downregulation of Annexin A11 (ANXA11) Inhibits Cell Proliferation, Invasion, and Migration via the AKT/GSK-3beta Pathway in Gastric Cancer. PMID: 29306955 Ref: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line. PMID: 29308053 Ref: Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. PMID: 29316426 Ref: MicroRNA-511 inhibits cellular proliferation and invasion in colorectal cancer by directly targeting hepatoma-derived growth factor. PMID: 29321086 Ref: Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells. PMID: 29328480 Ref: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 29328495 Ref: Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195. PMID: 29331856 Ref: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway. PMID: 29335887 Ref: TEMPORARY REMOVAL: Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway. PMID: 29339153 Ref: Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor. PMID: 29339715 Ref: miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition. PMID: 29339925 Ref: Effect of Akt activation and experimental pharmacological inhibition on responses to neoadjuvant chemoradiotherapy in rectal cancer. PMID: 29341150 Ref: Clinical Significance of Glycoprotein Non-metastatic B and Its Association with EGFR/HER2 in Gastrointestinal Cancer. PMID: 29344282 Ref: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway. PMID: 29344654 Ref: Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. PMID: 29348540 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Formyl peptide receptor 2 mediated chemotherapeutics drug resistance in colon cancer cells. PMID: 29364475 Ref: Does the use of melatonin overcome drug resistance in cancer chemotherapy? PMID: 29374563 Ref: Interplay between Trx-1 and S100P promotes colorectal cancer cell epithelial-mesenchymal transition by up-regulating S100A4 through AKT activation. PMID: 29383839 Ref: Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation. PMID: 29384527 Ref: BCL6B suppresses proliferation and migration of colorectal carcinoma cells through inhibition of the PI3K/AKT signaling pathway. PMID: 29393377 Ref: MicroRNA-204 Inhibits the Growth and Motility of Colorectal Cancer Cells by Downregulation of CXCL8. PMID: 29402343 Ref: KRAS and 2 rare PI3KCA mutations coexisting in a metastatic colorectal cancer patient with aggressive and resistant disease. PMID: 29409955 Ref: Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours. PMID: 29410498 Ref: Inhibition of Rac family protein impairs colitis and colitis-associated cancer in mice. PMID: 29416921 Ref: Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. PMID: 29422975 Ref: Novel Ligustrazine-Based Analogs of Piperlongumine Potently Suppress Proliferation and Metastasis of Colorectal Cancer Cells in Vitro and in Vivo. PMID: 29424539 Ref: Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. PMID: 29432917 Ref: mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway. PMID: 29435057 Ref: Osteopontin-integrin engagement induces HIF-1alpha-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. PMID: 29435158 Ref: Differential expression profiles of long noncoding RNA and mRNA in colorectal cancer tissues from patients with lung metastasis. PMID: 29436635 Ref: High expression of DJ-1 promotes growth and invasion via the PTEN-AKT pathway and predicts a poor prognosis in colorectal cancer. PMID: 29441725 Ref: MicroRNA-598 Inhibits Cell Proliferation and Invasion of Glioblastoma by Directly Targeting Metastasis Associated in Colon Cancer-1 (MACC1). PMID: 29444745 Ref: The G protein-coupled P2Y(6) receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis. PMID: 29454075 Ref: P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. PMID: 29454793 Ref: The role of miR-766-5p in cell migration and invasion in colorectal cancer. PMID: 29456660 Ref: Effects of PHA-665752 and vemurafenib combination treatment on in vitro and murine xenograft growth of human colorectal cancer cells with BRAF(V600E) mutations. PMID: 29456739 Ref: The Failing Heart Stimulates Tumor Growth by Circulating Factors. PMID: 29459363 Ref: Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. PMID: 29467273 Ref: Liquiritigenin inhibits colorectal cancer proliferation, invasion and epithelial to mesenchymal transition by decreasing expression of runt-related transcription factor 2. PMID: 29471888 Ref: Association of Genetic Variants of Small Non-Coding RNAs with Survival in Colorectal Cancer. PMID: 29483812 Ref: Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer. PMID: 29484387 Ref: Identification of candidate genes and long non-coding RNAs associated with the effect of ATP5J in colorectal cancer. PMID: 29484395 Ref: Coroglaucigenin induces senescence and autophagy in colorectal cancer cells. PMID: 29484762 Ref: AZD8055 Exerts Antitumor Effects on Colon Cancer Cells by Inhibiting mTOR and Cell-cycle Progression. PMID: 29491070 Ref: Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway. PMID: 29496262 Ref: Comprehensive analysis of miRNAs expression profiles revealed potential key miRNA/mRNAs regulating colorectal cancer stem cell self-renewal. PMID: 29496555 Ref: Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143. PMID: 29498789 Ref: Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. PMID: 29499765 Ref: Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress. PMID: 29500295 Ref: SRPX2 regulates colon cancer cell metabolism by miR-192/215 via PI3K-Akt. PMID: 29511442 Ref: High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer. PMID: 29511596 Ref: AQP8 inhibits colorectal cancer growth and metastasis by down-regulating PI3K/AKT signaling and PCDH7 expression. PMID: 29511597 Ref: Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis. PMID: 29517105 Ref: Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. PMID: 29519997 Ref: Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer. PMID: 29523145 Ref: Phosphorylation of p70 Ribosomal Protein S6 Kinase beta-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer. PMID: 29526493 Ref: Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer. PMID: 29531464 Ref: Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway. PMID: 29541215 Ref: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer. PMID: 29552187 Ref: [Killing effect of Huaier combined with DC-CIK on nude mice bearing colon cancer HT29 stem cells in vivo]. PMID: 29552828 Ref: Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway. PMID: 29553945 Ref: Codon misreading tRNAs promote tumor growth in mice. PMID: 29558247 Ref: Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway. PMID: 29560517 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo. PMID: 29574877 Ref: Reverting doxorubicin resistance in colon cancer by targeting a key signaling protein, steroid receptor coactivator. PMID: 29581735 Ref: TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [(18)F] fluorodeoxyglucose ((18)F-FDG PET). PMID: 29581845 Ref: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID: 29619072 Ref: Formononetin inhibits colon carcinoma cell growth and invasion by microRNA149mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways. PMID: 29620230 Ref: p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. PMID: 29620273 Ref: Anti-colon-cancer effects of polysaccharides: A mini-review of the mechanisms. PMID: 29627471 Ref: microRNA-532 suppresses the PI3K/Akt signaling pathway to inhibit colorectal cancer progression by directly targeting IGF-1R. PMID: 29636999 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: Pristimerin, a naturally occurring triterpenoid, attenuates tumorigenesis in experimental colitis-associated colon cancer. PMID: 29655682 Ref: AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. PMID: 29662189 Ref: Deptor Is a Novel Target of Wnt/beta-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth. PMID: 29666061 Ref: Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. PMID: 29668110 Ref: Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex. PMID: 29669822 Ref: Synergistic antitumor effects of cMet inhibitor in combination with anti-VEGF in colorectal cancer patient-derived xenograft models. PMID: 29675102 Ref: Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells. PMID: 29684851 Ref: Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-kappaB signaling pathways. PMID: 29689497 Ref: Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer. PMID: 29693156 Ref: Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. PMID: 29696632 Ref: Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased in vivo anti-tumor efficacy. PMID: 29721065 Ref: Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. PMID: 29724012 Ref: miR-486-5p regulates the migration and invasion of colorectal cancer cells through targeting PIK3R1. PMID: 29725442 Ref: Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells. PMID: 29731993 Ref: Metformin increases the cytotoxicity of oxaliplatin in human DLD-1 colorectal cancer cells through down-regulating HMGB1 expression. PMID: 29737584 Ref: Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology. PMID: 29740162 Ref: Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway. PMID: 29745074 Ref: Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience. PMID: 29755687 Ref: Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells. PMID: 29756328 Ref: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. PMID: 29761838 Ref: TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancer. PMID: 29767249 Ref: Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3sigma. PMID: 29768267 Ref: Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PMID: 29771951 Ref: Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. PMID: 29777330 Ref: MicroRNA-485 plays tumour-suppressive roles in colorectal cancer by directly targeting GAB2. PMID: 29781037 Ref: SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma. PMID: 29786668 Ref: lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line. PMID: 29791590 Ref: Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer. PMID: 29796120 Ref: Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells. PMID: 29805556 Ref: MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1. PMID: 29807462 Ref: miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP. PMID: 29844307 Ref: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells. PMID: 29845259 Ref: Dual mTOR/PI3K inhibitor NVPBEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4EBP1. PMID: 29845289 Ref: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. PMID: 29860266 Ref: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis. PMID: 29867200 Ref: Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. PMID: 29872506 Ref: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway. PMID: 29872721 Ref: The Effects of Different mTOR Inhibitors in EGFR Inhibitor Resistant Colon Carcinoma Cells. PMID: 29882195 Ref: IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells. PMID: 29886785 Ref: Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin. PMID: 29899208 Ref: PSMD4 is a novel therapeutic target in chemoresistant colorectal cancer activated by cytoplasmic localization of Nrf2. PMID: 29899863 Ref: uc.338 targets p21 and cyclin D1 via PI3K/AKT pathway activation to promote cell proliferation in colorectal cancer. PMID: 29901203 Ref: Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression. PMID: 29902863 Ref: Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations. PMID: 29907857 Ref: Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and beta1 integrin/FAK-mediated signalling. PMID: 29920241 Ref: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin. PMID: 29921293 Ref: Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells. PMID: 29921474 Ref: Down-regulated paxillin suppresses cell proliferation and invasion by inhibiting M2 macrophage polarization in colon cancer. PMID: 29924724 Ref: Cetuximab improves AZD6244 antitumor activity in colorectal cancer HT29 cells in vitro and in nude mice by attenuating HER3/Akt pathway activation. PMID: 29928418 Ref: Modelling Signalling Networks from Perturbation Data. PMID: 29931053 Ref: [Study of isobutyrylshikonin inhibiting proliferation of colon carcinoma cells through PI3K/Akt/m-TOR pathway]. PMID: 29945391 Ref: Patrinia scabiosaefolia Inhibits Growth of 5-FU-Resistant Colorectal Carcinoma Cells via Induction of Apoptosis and Suppression of AKT Pathway. PMID: 29948597 Ref: Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro. PMID: 29956741 Ref: Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. PMID: 29957460 Ref: Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation. PMID: 29961813 Ref: Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation. PMID: 29964008 Ref: Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. PMID: 29970122 Ref: Longan flower proanthocyanidins induce apoptosis in HT-29 colorectal carcinoma spheroids. 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