Primary Site >> Colorectal Cancer
Gene >> AIM2
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Ref: The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers. PMID: 17726700 |
Ref: Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile. PMID: 19293232 |
Ref: Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. PMID: 19795419 Ref: Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation. PMID: 19852062 Ref: Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome. PMID: 19957108 |
Ref: Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers. PMID: 21804607 |
Ref: Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients. PMID: 24729378 |
Ref: Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters. PMID: 25816162 Ref: Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. PMID: 26095253 Ref: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. PMID: 26107252 Ref: AIMing 2 Curtail Cancer. PMID: 26140588 Ref: AIM2 Blocks Colon Cancer in Three Ways. PMID: 26198813 Ref: Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components. PMID: 26378020 |
Ref: AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity. PMID: 26626159 Ref: Absent in melanoma 2 proteins in the development of cancer. PMID: 27328971 |
Ref: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. PMID: 27524110 Ref: Inflammasomes and Cancer. PMID: 28093447 Ref: Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis. PMID: 28224203 Ref: AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway. PMID: 28243117 Ref: An evolving function of DNA-containing exosomes in chemotherapy-induced immune response. PMID: 28524163 |