Primary Site >> Colorectal Cancer
Gene >> AIFM1
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Ref: A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). PMID: 12135761 Ref: Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. PMID: 12381674 |
Ref: Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. PMID: 12941843 |
Ref: Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. PMID: 14604899 Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 |
Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: Assessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa. PMID: 15684335 Ref: Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. PMID: 15918186 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. PMID: 15946692 Ref: AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells. PMID: 16001080 Ref: Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line. PMID: 16151650 |
Ref: Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. PMID: 16618741 Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 Ref: Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. PMID: 17102938 Ref: Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas. PMID: 17207087 |
Ref: A highly polar xanthophyll of 9'-cis-neoxanthin induces apoptosis in HCT116 human colon cancer cells through mitochondrial dysfunction. PMID: 17186379 Ref: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. PMID: 17222494 Ref: Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. PMID: 17597109 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. PMID: 17711848 |
Ref: The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis. PMID: 18437576 Ref: Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. PMID: 18494941 Ref: Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. PMID: 18607570 Ref: Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. PMID: 18955103 |
Ref: Apoptosis-inducing factor and colon cancer. PMID: 18061616 Ref: In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF. PMID: 19105980 Ref: Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells. PMID: 19446247 Ref: Anti-proliferative effects of Lethariella zahlbruckneri extracts in human HT-29 human colon cancer cells. PMID: 19501127 Ref: [Expression of AIF and caspase-3 in colorectal carcinoma, adenoma, and normal mucosa and its correlation]. PMID: 19598027 |
Ref: Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. PMID: 20056314 Ref: Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway. PMID: 20596632 |
Ref: Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells. PMID: 21737934 Ref: Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: correlation with advanced stages. PMID: 21805040 |
Ref: Implications of cleaved caspase 3 and AIF expression in colorectal cancer based on patient age. PMID: 22447208 Ref: Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PMID: 22574158 Ref: Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells. PMID: 22634395 Ref: Diallyl trisulfide induces apoptosis in human primary colorectal cancer cells. PMID: 22736270 Ref: Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. PMID: 23100468 |
Ref: Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells. PMID: 23583412 Ref: FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PMID: 23700428 Ref: Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. PMID: 23729362 Ref: Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts. PMID: 23889944 |
Ref: Crude extract of Rheum palmatum L induced cell death in LS1034 human colon cancer cells acts through the caspase-dependent and -independent pathways. PMID: 23315830 Ref: Curcumin-enhanced chemosensitivity of FDA-approved platinum (II)-based anti-cancer drugs involves downregulation of nuclear endonuclease G and NF-kappaB as well as induction of apoptosis and G2/M arrest. PMID: 24438326 Ref: Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway. PMID: 24519064 Ref: DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia. PMID: 24562547 Ref: Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. PMID: 24581231 Ref: Transport and killing mechanism of a novel camptothecin-deoxycholic acid derivate on hepatocellular carcinoma cells. PMID: 24725118 Ref: GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. PMID: 24984063 Ref: Evaluation of the efficacy & biochemical mechanism of cell death induction by Piper longum extract selectively in in-vitro and in-vivo models of human cancer cells. PMID: 25401766 |
Ref: The Tomato Glycoalkaloid alpha-Tomatine Induces Caspase-Independent Cell Death in Mouse Colon Cancer CT-26 Cells and Transplanted Tumors in Mice. PMID: 25614934 Ref: Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PMID: 25870767 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. PMID: 26547530 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 |
Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. PMID: 26969764 Ref: Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer. PMID: 27543779 Ref: Apoptotic pathways and stemness in the colorectal epithelium and lamina propria mucosae during the human embryogenesis and carcinogenesis. PMID: 27612611 |
Ref: The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target. PMID: 28223542 Ref: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells. PMID: 29137335 |
Ref: Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-alpha-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells. PMID: 29115534 Ref: Annonaceous acetogenin mimic AA005 suppresses human colon cancer cell growth in vivo through downregulation of Mcl-1. PMID: 29921883 Ref: Antitumor activity of RT2 peptide derived from crocodile leukocyte peptide on human colon cancer xenografts in nude mice. PMID: 30019842 Ref: Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway. PMID: 30195873 |