Primary Site >> Colorectal Cancer
Gene >> AHR
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Ref: Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. PMID: 9783729 |
Ref: Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines. PMID: 12655030 Ref: Critical enhancer region to which AhR/ARNT and Sp1 bind in the human CYP1B1 gene. PMID: 12801909 |
Ref: Using a combination of cytochrome P450 1B1 and beta-catenin for early diagnosis and prevention of colorectal cancer. PMID: 16289386 |
Ref: Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. PMID: 16581943 |
Ref: Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. PMID: 18990750 |
Ref: CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers. PMID: 19287966 Ref: Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells. PMID: 19340314 |
Ref: UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. PMID: 19831498 Ref: Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2). PMID: 20460431 Ref: Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity. PMID: 20716622 Ref: Bi-functional induction of the quinone reductase and cytochrome P450 1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways. PMID: 20930371 |
Ref: Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. PMID: 21081473 Ref: Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. PMID: 21256954 Ref: A role of the aryl hydrocarbon receptor in attenuation of colitis. PMID: 21374063 Ref: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. PMID: 21458546 |
Ref: Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation. PMID: 22361730 Ref: Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. PMID: 22552404 |
Ref: The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. PMID: 23135549 Ref: Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. PMID: 23696052 |
Ref: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. PMID: 24714741 Ref: Integrated exon level expression analysis of driver genes explain their role in colorectal cancer. PMID: 25335079 |
Ref: Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer. PMID: 25447411 Ref: Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. PMID: 25873348 Ref: HIF1alpha deficiency reduces inflammation in a mouse model of proximal colon cancer. PMID: 26183215 Ref: Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia. PMID: 26264025 |
Ref: Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells. PMID: 26514676 Ref: Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells. PMID: 26515162 Ref: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins. PMID: 26861731 Ref: Tissue distribution of aryl hydrocarbon receptor in the intestine: Implication of putative roles in tumor suppression. PMID: 26973338 Ref: Regulation of CD40 signaling in colon cancer cells and its implications in clinical tissues. PMID: 27262846 Ref: The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse. PMID: 27433903 Ref: Indole-3-carbinol induces tumor cell death: function follows form. PMID: 27451867 Ref: Anorectal melanoma and seborrheic dermatitis - A case report. PMID: 29648758 |
Ref: The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation. PMID: 26856715 Ref: Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. PMID: 27837168 Ref: Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells. PMID: 28860561 Ref: Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women's health initiative. PMID: 29237415 |
Ref: Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals. PMID: 29436668 Ref: Obesity and Cancer: Existing and New Hypotheses for a Causal Connection. PMID: 29526577 Ref: Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. PMID: 29584932 |