Primary Site >> Pancreatic Cancer
Gene >> ABL1
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Ref: Effects of STI571 (gleevec) on pancreatic cancer cell growth. PMID: 14521721 |
Ref: Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. PMID: 16507911 Ref: N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. PMID: 17064066 |
Ref: Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer. PMID: 18797457 |
Ref: ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases. PMID: 19262174 Ref: Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts. PMID: 19509264 |
Ref: CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration. PMID: 19631450 Ref: Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. PMID: 20457609 |
Ref: RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation. PMID: 21470770 |
Ref: Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. PMID: 22935731 |
Ref: DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. PMID: 24096005 Ref: Oligomerization and phosphorylation dependent regulation of ArgBP2 adaptive capabilities and associated functions. PMID: 24475245 Ref: Development of detection method for novel fusion gene using GeneChip exon array. PMID: 24533689 Ref: Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. PMID: 24955955 Ref: Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. PMID: 25111230 |