Primary Site >> Colorectal Cancer
Gene >> ABL1
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Ref: Biological characterization and oncogene expression in human colorectal carcinoma cell lines. PMID: 3338874 |
Ref: Enhanced expression of oncogene-encoded mRNA in a rat model of colon cancer. PMID: 2012108 |
Ref: T-cell immunity to oncogenic proteins including mutated ras and chimeric bcr-abl. PMID: 8103658 |
Ref: Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. PMID: 8674385 |
Ref: Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. PMID: 9988731 Ref: Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells. PMID: 10205210 Ref: Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. PMID: 10521789 |
Ref: Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. PMID: 12023887 Ref: The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy. PMID: 12208734 |
Ref: Induction of colonic epithelial cell apoptosis by p47-dependent oxidants. PMID: 12681507 |
Ref: Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571. PMID: 14726674 Ref: Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis. PMID: 15023347 Ref: Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors. PMID: 15613459 |
Ref: Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor. PMID: 15727903 Ref: Bcr is a negative regulator of the Wnt signalling pathway. PMID: 16211085 Ref: Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia. PMID: 16471312 |
Ref: Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition. PMID: 16391854 Ref: c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. PMID: 16505115 |
Ref: aCGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions including BCR and ABL. PMID: 17196995 Ref: Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. PMID: 17702597 Ref: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. PMID: 18220746 |
Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 Ref: DxS Ltd. PMID: 18384259 Ref: Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. PMID: 18480061 |
Ref: HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53. PMID: 19150257 Ref: The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma. PMID: 19232240 Ref: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells. PMID: 19382747 Ref: MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine. PMID: 19766113 Ref: Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. PMID: 19914164 |
Ref: A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes. PMID: 20233444 Ref: Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane. PMID: 20671195 Ref: Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PMID: 21152443 |
Ref: Dasatinib: an anti-tumour agent via Src inhibition. PMID: 21226671 Ref: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. PMID: 21670084 Ref: Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. PMID: 21949247 |
Ref: STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death. PMID: 22462553 Ref: Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing. PMID: 22845480 |
Ref: Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PMID: 23637631 Ref: The prevalence and prognostic significance of KRAS mutation in bladder cancer, chronic myeloid leukemia and colorectal cancer. PMID: 23640097 Ref: Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines. PMID: 23696836 Ref: Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase. PMID: 23811235 Ref: Chronic myeloid leukemia following colon cancer treatment: A case report and literature review. PMID: 24009972 Ref: Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer. PMID: 24135855 |
Ref: Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells. PMID: 24913355 Ref: [Genome sequencing and personalized medicine: perspectives and limitations]. PMID: 26259290 |
Ref: Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. PMID: 25432929 Ref: Optimizing and predicting the in vivo activity of AT9283 as a monotherapy and in combination with paclitaxel. PMID: 26346504 Ref: Overcoming Resistance to Targeted Therapies in Cancer. PMID: 26615134 |
Ref: GADD45alpha modulates curcumin sensitivity through c-Abl- and JNK-dependent signaling pathways in a mismatch repair-dependent manner. PMID: 26833194 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity. PMID: 27405013 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 |
Ref: In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione. PMID: 27889234 Ref: Biological evaluation of 2-pyrazolinyl-1-carbothioamide derivatives against HCT116 human colorectal cancer cell lines and elucidation on QSAR and molecular binding modes. PMID: 28811071 Ref: Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model. PMID: 29091939 |
Ref: 'MCC' protein interacts with E-cadherin and beta-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells. PMID: 29035389 Ref: Comparison of the effect of chemical composition of anthocyanin-rich plant extracts on colon cancer cell proliferation and their potential mechanism of action using in vitro, in silico, and biochemical assays. PMID: 29037704 Ref: Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis. PMID: 29430186 Ref: Structural-based design, synthesis, and antitumor activity of novel alloxazine analogues with potential selective kinase inhibition. PMID: 29684708 |