Primary Site >> Colorectal Cancer
Gene >> ABCB1
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Ref: Detection of the 170 kDa P-glycoprotein in neoplastic and normal tissues. PMID: 2575816 |
Ref: Chemosensitivity patterns and expression of human multidrug resistance-associated MDR1 gene by human gastric and colorectal carcinoma cell lines. PMID: 1967320 Ref: Expression of the MDR1 gene in human gastric and colorectal carcinomas. PMID: 1977924 Ref: Expression of the multidrug resistance gene in human tumors. PMID: 1980915 Ref: Multidrug resistance: a transport system of antitumor agents and xenobiotics. PMID: 1983721 |
Ref: Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines. PMID: 1671208 Ref: Establishment of multidrug resistant human colorectal carcinoma HCT-15 cell lines and their properties. PMID: 1679619 Ref: Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody. PMID: 1681110 Ref: Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. PMID: 1682041 Ref: Co-amplification and over-expression of two mdr genes in a multidrug-resistant human colon carcinoma cell line. PMID: 1682162 Ref: Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines. PMID: 1717144 |
Ref: Factors contributing to adriamycin sensitivity in human xenograft tumors: the relationship between expression of the MDR1, GST-pi and topoisomerase II genes and tumor sensitivity to adriamycin. PMID: 1314532 Ref: Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line. PMID: 1346333 Ref: Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines. PMID: 1349044 Ref: Mechanism of multidrug resistance in human tumour cell lines and complete reversion of cellular resistance. PMID: 1352696 Ref: P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines. PMID: 1359686 Ref: Liposome-mediated modulation of multidrug resistance in human HL-60 leukemia cells. PMID: 1361008 Ref: Expression of the mdr1 gene in human colorectal carcinomas: relationship with multidrug resistance inferred from analysis of human colorectal carcinoma cell lines. PMID: 1537074 Ref: Effect of a dihydropyridine analogue, 2-[benzyl(phenyl)amino]ethyl 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo- 1,3,2-dioxaphosphorinan-2-yl)-1-(2-morpholinoethyl)-4-(3-nitrophenyl)-3 -pyridinecarboxylate on reversing in vivo resistance of tumor cells PMID: 1617639 Ref: Expression of MDR1 and glutathione S transferase-pi genes and chemosensitivities in human gastrointestinal cancer. PMID: 1735085 |
Ref: The development and characterization of Vinca alkaloid-resistant Caco-2 human colorectal cell lines expressing mdr-1. PMID: 8094716 Ref: Constitutive expression of multidrug resistance in human colorectal tumours and cell lines. PMID: 8098614 Ref: Variable effects of sodium butyrate on the expression and function of the MDR1 (P-glycoprotein) gene in colon carcinoma cell lines. PMID: 8103760 Ref: [Analysis of MDR1 (multidrug resistance) gene expression by RT-PCR]. PMID: 8387754 Ref: Increased chemosensitivity to doxorubicin of intrinsically multidrug-resistant human colon carcinoma cells by prolonged exposure to verapamil. PMID: 8398309 Ref: MDR1 gene expression in primary colorectal carcinomas. PMID: 8398695 Ref: Neuroblastoma: the result of multistep transformation? PMID: 8401251 |
Ref: P-glycoprotein mediates profound resistance to bisantrene. PMID: 7865904 Ref: Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells. PMID: 7908296 Ref: Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil. PMID: 7908691 Ref: In vivo expression of P-glycoprotein in a human colon carcinoma xenograft is modulated by therapy with free and monoclonal antibody-conjugated vinca alkaloids. PMID: 7915508 Ref: Relationship of P-glycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion, DNA ploidy, and disease relapse. PMID: 7954255 Ref: Influence of cytokines on mdr1 expression in human colon carcinoma cell lines: increased cytotoxicity of MDR relevant drugs. PMID: 8207045 Ref: Design of topoisomerase inhibitors to overcome MDR1-mediated drug resistance. PMID: 8996611 Ref: Phorbol 12-myristate 13-acetate (pma) induces neuroendocrine-like differentiation and reverses Doxorubicin-resistance of human colon-carcinoma cells in-vitro. PMID: 21566941 |
Ref: A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line. PMID: 7476894 Ref: Structure-activity relationship of verapamil analogs and reversal of multidrug resistance. PMID: 7488241 Ref: Immunomagnetic purification of human breast carcinoma cells allows tumor-specific detection of multidrug resistance gene 1-mRNA by reverse transcriptase polymerase chain reaction in fine-needle aspirates. PMID: 7540237 Ref: Cell-specific effects of RAS oncogene and protein kinase C agonist TPA on P-glycoprotein function. PMID: 7628641 Ref: The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. PMID: 7671223 Ref: Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil. PMID: 7707383 Ref: Enhancement by recombinant human interferon alfa of the reversal of multidrug resistance by MRK-16 monoclonal antibody. PMID: 7707396 Ref: Acute induction of adriamycin-resistance in human colon carcinoma HT-29 cells exposed to a sublethal dose of adriamycin. PMID: 7730148 Ref: Circumvention of confluence-dependent resistance in a human multi-drug-resistant colon-cancer cell line. PMID: 7790124 |
Ref: Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent. PMID: 8609150 Ref: P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. PMID: 8633005 Ref: Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease. PMID: 8637029 Ref: Expression of the low-density lipoprotein receptor, HMG-CoA reductase, and multidrug resistance (Mdr1) genes in colorectal carcinomas. PMID: 8678896 Ref: Biology of colorectal and gastric cancer cell lines. PMID: 8806095 Ref: Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells. PMID: 8827016 Ref: MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases. PMID: 8898977 Ref: Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance. PMID: 8912533 Ref: The amplification and expression of MDR1 gene in adriamycine resistant cell line of colon cancer cell HR8348. PMID: 9206112 Ref: Anti-tumor ribonuclease, combined with or conjugated to monoclonal antibody MRK16, overcomes multidrug resistance to vincristine in vitro and in vivo. PMID: 21544469 |
Ref: Bromocriptine transcriptionally activates the multidrug resistance gene (pgp2/mdr1b) by a novel pathway. PMID: 9111066 Ref: Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. PMID: 9145912 Ref: Suramin is synergistic with vinblastine in human colonic tumor cell lines: effect of cell density and timing of drug delivery. PMID: 9216665 Ref: Employment of the mdr1 promoter for the chemotherapy-inducible expression of therapeutic genes in cancer gene therapy. PMID: 9231070 Ref: Treatment of advanced colorectal cancer with doxorubicin combined with two potential multidrug-resistance-reversing agents: high-dose oral tamoxifen and dexverapamil. PMID: 9292709 Ref: MDR1 RNA transcripts do not indicate long-term prognosis in colorectal carcinomas. PMID: 9337699 Ref: p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. PMID: 9380755 Ref: Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cells. PMID: 9398612 Ref: Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism. PMID: 9547673 |
Ref: Characterization of 2-chloro-N10-substituted phenoxazines for reversing multidrug resistance in cancer cells. PMID: 9613455 Ref: Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. PMID: 9632821 Ref: Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression. PMID: 9655887 Ref: Cellular resistance to adriamycin conferred by enhanced Rb expression is associated with increased MDR1 expression. PMID: 9705821 Ref: Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL. PMID: 9713996 Ref: Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HMAF) against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft. PMID: 9797706 |
Ref: Hyperthermia for treatment of rectal cancer: evaluation for induction of multidrug resistance gene (mdr1) expression. PMID: 9935221 Ref: Multidrug-resistant phenotype influences the differentiation of a human colon carcinoma cell line. PMID: 10334913 Ref: Follicle-like structures formed by intestinal cell lines derived from the HT29-D4 adenocarcinoma cell line: morphological and functional characterization. PMID: 10399829 Ref: Tumor-specific expression of anti-mdr1 ribozyme selectively restores chemosensitivity in multidrug-resistant colon-adenocarcinoma cells. PMID: 10399951 |
Ref: Methionine depletion enhances the antitumoral efficacy of cytotoxic agents in drug-resistant human tumor xenografts. PMID: 10690550 Ref: Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas. PMID: 10873092 Ref: Molecular genetics of cancer susceptibility. PMID: 10971208 Ref: Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. PMID: 10987283 |
Ref: Modulation of protein kinase C in antitumor treatment. PMID: 11190577 Ref: Identification of an organic anion transport system in the human colon carcinoma cell line HT29 clone 19A. PMID: 11212217 Ref: Drug resistance induced by ouabain via the stimulation of MDR1 gene expression in human carcinomatous pulmonary cells. PMID: 11245485 Ref: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. PMID: 11297522 Ref: Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. PMID: 11323103 Ref: In vitro and in vivo tracer characteristics of an established multidrug-resistant human colon cancer cell line. PMID: 11337555 Ref: Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. PMID: 11369762 Ref: Effects of MDR1/P-glycoprotein expression on prognosis in advanced colorectal cancer after surgery. PMID: 11410790 Ref: Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression. PMID: 11500053 Ref: Establishment and characterization of adriamycin-resistant human colorectal adenocarcinoma HCT-15 cell lines with multidrug resistance. PMID: 11593059 Ref: The role of P-glycoprotein (MDR1) polymorphisms and mutations in colorectal cancer. PMID: 11678332 |
Ref: Use of the human MDR1 promoter for heat-inducible expression of therapeutic genes. PMID: 11857422 Ref: Digoxin up-regulates MDR1 in human colon carcinoma Caco-2 cells. PMID: 11890691 Ref: Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine. PMID: 11901227 Ref: Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability. PMID: 11980438 Ref: Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-MDR1 ribozymes. PMID: 12297834 Ref: Reversal of drug resistance using hammerhead ribozymes against multidrug resistance-associated protein and multidrug resistance 1 gene. PMID: 12370750 Ref: Effect of protein kinase C on multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cells. PMID: 12376294 Ref: Overcoming multidrug drug resistance in P-glycoprotein/MDR1-overexpressing cell lines by ecteinascidin 743. PMID: 12516966 |
Ref: NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. PMID: 12527911 Ref: Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. PMID: 12605985 Ref: Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors. PMID: 12606785 Ref: Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. PMID: 12625868 Ref: Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines. PMID: 12636175 Ref: Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model. PMID: 12680473 Ref: Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA. PMID: 12788075 Ref: Molecular modes of action of artesunate in tumor cell lines. PMID: 12869643 Ref: Effect of MDR1 phosphorothioate antisense oligodeoxynucleotides in multidrug-resistant human tumor cell lines and xenografts. PMID: 12894558 Ref: MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry. PMID: 12894567 |
Ref: Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resistant human colon carcinoma LoVo/5-FU cells. PMID: 15222051 Ref: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. PMID: 15290871 Ref: Effect of rabeprazole on MDR1-mediated transport of Rhodamine 123 in Caco-2 and Hvr100-6 cells. PMID: 15467223 Ref: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. PMID: 15504753 |
Ref: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. PMID: 15655543 Ref: Tamoxifen can reverse multidrug resistance of colorectal carcinoma in vivo. PMID: 15742416 Ref: Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP. PMID: 15796208 Ref: Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients. PMID: 15912392 Ref: Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. PMID: 15920164 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: Cancer cell adaptation to chemotherapy. PMID: 16026610 Ref: Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136. PMID: 16046116 Ref: Gene expression profiling in chemoresistant variants of three cell lines of different origin. PMID: 16080509 |
Ref: Role of pharmacogenetics in irinotecan therapy. PMID: 16343744 Ref: ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach. PMID: 16434479 Ref: [Is C3435T polymorphism of MDR1 related to inflammatory bowel disease or colorectal cancer in Korean?]. PMID: 16434865 Ref: Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes. PMID: 16505951 Ref: Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction. PMID: 16508161 Ref: Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. PMID: 16651436 Ref: Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. PMID: 16678547 Ref: MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. PMID: 16702732 Ref: Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. PMID: 16753005 Ref: Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression? PMID: 16755466 Ref: Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans. PMID: 16800822 Ref: [The lethal effect of combined MDR1 antisense RNA with oxaliplatin and 5-FU on drug-resistant rectal carcinoma cells]. PMID: 16836929 Ref: Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines. PMID: 17091771 Ref: Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells. PMID: 17091772 |
Ref: Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers. PMID: 17146660 Ref: Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180. PMID: 17163579 Ref: Venlafaxine induces P-glycoprotein in human Caco-2 cells. PMID: 17191263 Ref: Heat-inducible in vivo gene therapy of colon carcinoma by human mdr1 promoter-regulated tumor necrosis factor-alpha expression. PMID: 17237282 Ref: Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. PMID: 17262809 Ref: Identification of NR1I2 genetic variation using resequencing. PMID: 17404718 Ref: Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. PMID: 17541169 Ref: Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines. PMID: 17579122 Ref: Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein. PMID: 17620438 Ref: The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells. PMID: 17671692 Ref: Functional evaluation of multidrug resistance transporter activity in surgical samples of solid tumors. PMID: 17767422 Ref: Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells. PMID: 18025283 |
Ref: ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136. PMID: 17563765 Ref: No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients. PMID: 17674045 Ref: ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. PMID: 18267032 Ref: Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability. PMID: 18305404 Ref: Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. PMID: 18385293 Ref: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. PMID: 18509181 Ref: Mucronulatol from Caribbean propolis exerts cytotoxic effects on human tumor cell lines. PMID: 18538108 Ref: MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese. PMID: 18644389 Ref: Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. PMID: 18673531 Ref: Combination therapy and noninvasive imaging with a dual therapeutic vector expressing MDR1 short hairpin RNA and a sodium iodide symporter. PMID: 18703598 Ref: Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells. PMID: 19020725 Ref: ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer. PMID: 19192650 |
Ref: The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study. PMID: 19250544 Ref: Identification of proteins associated to multi-drug resistance in LoVo human colon cancer cells. PMID: 19360340 Ref: Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells. PMID: 19380024 Ref: ABCB1 gene polymorphisms and haplotype analysis in colorectal cancer. PMID: 19415305 Ref: Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513. PMID: 19491037 Ref: Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. PMID: 19699770 Ref: [Correlation of chemosensitivity tested using histoculture drug response assay to expression of multidrug resistance genes and proteins in colorectal cancer tissues]. PMID: 19728910 Ref: Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. PMID: 19930591 Ref: Stable reversal of multidrug resistance in colon cancer cells by RNA interference targeting the MDR1 gene. PMID: 21475869 |
Ref: MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer. PMID: 19862647 Ref: Evaluation of biodistribution and safety of adenovirus vector containing MDR1 in mice. PMID: 20044941 Ref: Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells. PMID: 20118549 Ref: Reduced drug accumulation is more important in acquired resistance against oxaliplatin than against cisplatin in isogenic colon cancer cells. PMID: 20168208 Ref: Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. PMID: 20176655 Ref: Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model. PMID: 20186172 Ref: Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. PMID: 20217131 Ref: Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy. PMID: 20298675 Ref: Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells. PMID: 20406951 Ref: ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer. PMID: 20533057 Ref: Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. PMID: 20540746 Ref: Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. PMID: 20651349 Ref: CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium. PMID: 20699370 Ref: [Effects of changwelqing on nuclear translocation of Y-box binding protein-1 and expression of P-glycoprotein in human colon cancer cell line with drug-resistance induced by vincristine]. PMID: 20929136 Ref: Evaluation of the reversal of multidrug resistance by MDR1 ribonucleic acid interference in a human colon cancer model using a Renilla luciferase reporter gene and coelenterazine. PMID: 21084030 Ref: ABCB1 gene polymorphisms are associated with adverse reactions in fluoropyrimidine-treated colorectal cancer patients. PMID: 21142915 |
Ref: Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population. PMID: 20127181 Ref: Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. PMID: 20177420 Ref: Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. PMID: 20368715 Ref: COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. PMID: 21296766 Ref: Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. PMID: 21317201 Ref: Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. PMID: 21459094 Ref: Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. PMID: 21490239 Ref: Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. PMID: 21566063 Ref: Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. PMID: 21636699 Ref: Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells. PMID: 21733184 Ref: The role of paclitaxel in the development and treatment of multidrug resistant cancer cell lines. PMID: 21775090 Ref: The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein. PMID: 21775706 Ref: Prognostic impact of DeltaTAp73 isoform levels and their target genes in colon cancer patients. PMID: 21807636 Ref: Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. PMID: 21917707 Ref: MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. PMID: 21925160 Ref: A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PMID: 21931543 Ref: MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells. PMID: 21948564 Ref: Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis. PMID: 21965738 Ref: MDR1 gene polymorphisms: possible association with its expression and clinicopathology characteristics in colorectal cancer patients. PMID: 22394004 |
Ref: TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. PMID: 22188812 Ref: MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case-control studies. PMID: 22358302 Ref: A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer. PMID: 22396794 Ref: Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo. PMID: 22397993 Ref: GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells. PMID: 22424291 Ref: Impact of mutant beta-catenin on ABCB1 expression and therapy response in colon cancer cells. PMID: 22460269 Ref: ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese. PMID: 22567180 Ref: Can immunohistochemistry of multidrug-resistant proteins replace the histoculture drug response assay in colorectal adenocarcinomas? PMID: 22580657 Ref: Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines. PMID: 22846052 Ref: Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer. PMID: 22870247 Ref: Quantitative analysis of cancer-associated gene methylation connected to risk factors in Korean colorectal cancer patients. PMID: 22880157 Ref: Pharmacogenetic markers of toxicity for chemotherapy in colorectal cancer patients. PMID: 22909207 Ref: Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues. PMID: 23133566 |
Ref: Associations between the functional polymorphisms in the ABCB1 transporter gene and colorectal cancer risk: a case-control study in Turkish population. PMID: 23193993 Ref: Systematic review: diet-gene interactions and the risk of colorectal cancer. PMID: 23216531 Ref: ABCB1/MDR1 gene polymorphism and colorectal cancer risk: a meta-analysis of case-control studies. PMID: 23279665 Ref: Role of conventional chemosensitivity test and tissue biomarker expression in predicting response to treatment of peritoneal carcinomatosis from colon cancer. PMID: 23332421 Ref: The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. PMID: 23471840 Ref: Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer susceptibility : a meta-analysis based on 11,339 subjects. PMID: 23504525 Ref: Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer. PMID: 23543295 Ref: Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis. PMID: 23597015 Ref: Effect of ionizing radiation on transcription of colorectal cancer MDR1 gene of HCT-8 cells. PMID: 23608383 Ref: Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis. PMID: 23746184 Ref: [Correlation of MDR1 and ABCG2 genetic polymorphisms with the efficacy and adverse events of irinotecan chemotherapy in patients with colorectal cancer]. PMID: 23801203 Ref: Associations of ABCB1 and XPC genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis in a Chinese population. PMID: 23803084 Ref: JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells. PMID: 23911788 Ref: Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. PMID: 23934261 Ref: A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO). PMID: 23953030 Ref: Low ABCB1 gene expression is an early event in colorectal carcinogenesis. PMID: 23977225 Ref: Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. PMID: 23999162 Ref: Lgr5 promotes cancer stemness and confers chemoresistance through ABCB1 in colorectal cancer. PMID: 24138824 Ref: Characterization of human colorectal cancer MDR1/P-gp Fab antibody. PMID: 24348182 Ref: Meta-Analysis of ABCB1 3435C>T Polymorphism and Colorectal Cancer. PMID: 24353734 |
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