Literatures

Primary Site >> Colorectal Cancer

Gene >> ZHX2

1.
Journal:	Nucleic Acids Res. 1987 Jun 25;15(12):4809-20.
Title:	Activation of human c-raf-1 by replacing the N-terminal region with different sequences.
Author:	Tahira, T\|Ochiai, M\|Hayashi, K\|Nagao, M\|Sugimura, T
PMID:	2955285

2.
Journal:	Am J Med Sci. 1991 Apr;301(4):238-45.
Title:	Enhanced expression of oncogene-encoded mRNA in a rat model of colon cancer.
Author:	Alexander, R J\|Buxbaum, J N\|Raicht, R F
PMID:	2012108

3.
Journal:	Cancer Lett. 1992 Jan 10;61(2):119-28.
Title:	Detection of transforming oncogenes in rat colon tumors induced by direct perfusion with N-methyl-N-nitrosourea.
Author:	Alexander, R J\|Garte, S J\|Raicht, R F\|Buxbaum, J N
PMID:	1730134

4.
Journal:	Cancer. 1993 Feb 1;71(3):672-6.
Title:	Multiple polyps of esophagus, stomach, colon, and rectum accompanying rectal cancer in a patient with constitutional chromosomal inversion.
Author:	Sasajima, K\|Yamanaka, Y\|Inokuchi, K\|Takizawa, T\|Ujihara, Y\|Ide, Y\|Onda, M\|Takubo, K
PMID:	8431846

5.
Journal:	J Clin Invest. 1995 Jun;95(6):2822-30.
Title:	The neurotensin gene is a downstream target for Ras activation.
Author:	Evers, B M\|Zhou, Z\|Celano, P\|Li, J
PMID:	7769122

6.
Journal:	J R Army Med Corps. 1995 Oct;141(3):142-50.
Title:	Options for screening for colorectal cancer in the Royal Air Force: a cost-effectiveness evaluation.
Author:	Daniels, K\|McKee, M
PMID:	8568748

7.
Journal:	Cancer Res. 1996 Jun 15;56(12):2872-6.
Title:	Suppression of a human colon cancer cell line by introduction of an exogenous NF1 gene.
Author:	Li, Y\|White, R
PMID:	8665528

8.
Journal:	Surgery. 1997 Aug;122(2):180-5; discussion 185-6.
Title:	Src-mediated activation of the human neurotensin/neuromedin N promoter.
Author:	Banker, N A\|Hellmich, M R\|Kim, H J\|Townsend, C M Jr\|Evers, B M
PMID:	9288121

9.
Journal:	Jpn J Hum Genet. 1997 Sep;42(3):409-16.
Title:	Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells.
Author:	Furuse, M\|Shirasawa, S\|Okumura, K\|Ohmori, M\|Sasazuki, T
PMID:	12503187

10.
Journal:	Oncogene. 1998 Apr 9;16(14):1899-902.
Title:	Abrogation of c-Raf expression induces apoptosis in tumor cells.
Author:	Lau, Q C\|Brusselbach, S\|Muller, R
PMID:	9583688

11.
Journal:	Gastroenterology. 1998 Nov;115(5):1144-53.
Title:	Oncogenic ras induces gastrin gene expression in colon cancer.
Author:	Nakata, H\|Wang, S L\|Chung, D C\|Westwick, J K\|Tillotson, L G
PMID:	9797369

12.
Journal:	Oncogene. 1999 Mar 11;18(10):1807-17.
Title:	Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Author:	Plattner, R\|Gupta, S\|Khosravi-Far, R\|Sato, K Y\|Perucho, M\|Der, C J\|Stanbridge, E J
PMID:	10086335

13.
Journal:	Eur J Cancer. 1999 Jun;35(6):1014-9.
Title:	XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase.
Author:	Donaldson, M J\|Skoumas, V\|Watson, M\|Ashworth, P A\|Ryder, H\|Moore, M\|Coombes, R C
PMID:	10533487

14.
Journal:	Zentralbl Chir. 2000;125 Suppl 1:12-5.
Title:	[Deregulation of intracellular signal pathways in colorectal carcinoma].
Author:	Troppmair, J\|Rapp, U R
PMID:	10929640

15.
Journal:	Oncol Rep. 2001 Nov-Dec;8(6):1409-13.
Title:	Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Author:	Feng, J\|Hua, F\|Shuo, R\|Chongfeng, G\|Huimian, X\|Nakajima, T\|Subao, W\|Tsuchida, N
PMID:	11605075

16.
Journal:	J Biol Chem. 2002 Mar 22;277(12):9790-9.
Title:	Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.
Author:	Shields, Janiel M\|Rogers-Graham, Kelley\|Der, Channing J
PMID:	11773051

17.
Journal:	J Biol Chem. 2002 Sep 6;277(36):32624-31. Epub 2002 Jun 20.
Title:	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
Author:	Lee, Hae-Wan\|Ahn, Dae-Ho\|Crawley, Suzanne C\|Li, Jian-Dong\|Gum, James R Jr\|Basbaum, Carol B\|Fan, Nancy Q\|Szymkowski, David E\|Han, Sang-Young\|Lee, Bong H\|Sleisenger, Marvin H\|Kim, Young S
PMID:	12077118

18.
Journal:	Nature. 2002 Aug 29;418(6901):934.
Title:	Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.
Author:	Rajagopalan, Harith\|Bardelli, Alberto\|Lengauer, Christoph\|Kinzler, Kenneth W\|Vogelstein, Bert\|Velculescu, Victor E
PMID:	12198537

19.
Journal:	Cancer Res. 2002 Oct 1;62(19):5393-8.
Title:	Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis.
Author:	Khatib, Abdel-Majid\|Fallavollita, Lucia\|Wancewicz, Edward V\|Monia, Brett P\|Brodt, Pnina
PMID:	12359742

20.
Journal:	Cancer Res. 2002 Nov 15;62(22):6451-5.
Title:	Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.
Author:	Yuen, Siu T\|Davies, Helen\|Chan, Tsun L\|Ho, Judy W\|Bignell, Graham R\|Cox, Charles\|Stephens, Philip\|Edkins, Sarah\|Tsui, Wendy W\|Chan, Annie S\|Futreal, P Andrew\|Stratton, Michael R\|Wooster, Richard\|Leung, Suet Y
PMID:	12438234

21.
Journal:	Expert Rev Mol Med. 2002 Apr 25;4(8):1-18.
Title:	The role of Raf kinases in malignant transformation.
Author:	Kolch, Walter\|Kotwaliwale, Ashwin\|Vass, Keith\|Janosch, Petra
PMID:	14987392

22.
Journal:	Biochim Biophys Acta. 2003 Jun 5;1653(1):25-40.
Title:	Raf proteins and cancer: B-Raf is identified as a mutational target.
Author:	Mercer, Kathryn E\|Pritchard, Catrin A
PMID:	12781369

23.
Journal:	Cancer Res. 2003 Aug 15;63(16):4878-81.
Title:	BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.
Author:	Chan, Tsun L\|Zhao, Wei\|Leung, Suet Y\|Yuen, Siu T
PMID:	12941809

24.
Journal:	Oncogene. 2003 Dec 11;22(57):9192-6.
Title:	BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Author:	Oliveira, Carla\|Pinto, Mafalda\|Duval, Alex\|Brennetot, Caroline\|Domingo, Enric\|Espin, Eloi\|Armengol, Manel\|Yamamoto, Hiroyuki\|Hamelin, Richard\|Seruca, Raquel\|Schwartz, Simo Jr
PMID:	14668801

25.
Journal:	Cancer Res. 2003 Dec 1;63(23):8132-7.
Title:	Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.
Author:	Ikenoue, Tsuneo\|Hikiba, Yohko\|Kanai, Fumihiko\|Tanaka, Yasuo\|Imamura, Jun\|Imamura, Takaaki\|Ohta, Miki\|Ijichi, Hideaki\|Tateishi, Keisuke\|Kawakami, Takayuki\|Aragaki, Jun\|Matsumura, Masayuki\|Kawabe, Takao\|Omata, Masao
PMID:	14678966

26.
Journal:	Oncol Rep. 2004 Jan;11(1):137-41.
Title:	No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract.
Author:	Stoehr, Robert\|Brinkmann, Anke\|Filbeck, Thomas\|Gamper, Christoph\|Wild, Peter\|Blaszyk, Hagen\|Hofstaedter, Ferdinand\|Knuechel, Ruth\|Hartmann, Arndt
PMID:	14654916

27.
Journal:	Genes Chromosomes Cancer. 2004 Feb;39(2):138-42.
Title:	Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.
Author:	Domingo, Enric\|Espin, Eloi\|Armengol, Manel\|Oliveira, Carla\|Pinto, Mafalda\|Duval, Alex\|Brennetot, Caroline\|Seruca, Raquel\|Hamelin, Richard\|Yamamoto, Hiroyuki\|Schwartz, Simo Jr
PMID:	14695993

28.
Journal:	J Biol Chem. 2004 Apr 2;279(14):14287-93. Epub 2004 Jan 23.
Title:	Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells.
Author:	Shao, Jinyi\|Evers, B Mark\|Sheng, Hongmiao
PMID:	14742435

29.
Journal:	Oncogene. 2004 Mar 11;23(10):1885-95.
Title:	Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.
Author:	Wang, Xiaofu\|Wang, Qingding\|Hu, Wanqin\|Evers, B Mark
PMID:	14981539

30.
Journal:	J Pathol. 2004 Mar;202(3):336-40.
Title:	In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours.
Author:	Sieben, Nathalie L G\|Macropoulos, Patricia\|Roemen, Guido M J M\|Kolkman-Uljee, Sandra M\|Jan Fleuren, Gert\|Houmadi, Rifat\|Diss, Tim\|Warren, Bretta\|Al Adnani, Mudher\|De Goeij, Anton P M\|Krausz, Thomas\|Flanagan, Adrienne M
PMID:	14991899

31.
Journal:	Am J Obstet Gynecol. 2004 Apr;190(4):935-42.
Title:	RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers.
Author:	Mutch, David G\|Powell, Matthew A\|Mallon, Mary Ann\|Goodfellow, Paul J
PMID:	15118616

32.
Journal:	Cancer Res. 2004 May 15;64(10):3428-35.
Title:	Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular tra
Author:	Ikenoue, Tsuneo\|Hikiba, Yohko\|Kanai, Fumihiko\|Aragaki, Jun\|Tanaka, Yasuo\|Imamura, Jun\|Imamura, Takaaki\|Ohta, Miki\|Ijichi, Hideaki\|Tateishi, Keisuke\|Kawakami, Takayuki\|Matsumura, Masayuki\|Kawabe, Takao\|Omata, Masao
PMID:	15150094

33.
Journal:	Cancer Lett. 2004 Jul 28;211(1):105-9.
Title:	Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer.
Author:	Miyaki, Michiko\|Iijima, Takeru\|Yamaguchi, Tatsuro\|Kadofuku, Tsuyoki\|Funata, Nobuaki\|Mori, Takeo
PMID:	15194222

34.
Journal:	Mol Cancer Ther. 2004 Jun;3(6):755-62.
Title:	Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
Author:	Mallon, Robert\|Feldberg, Larry\|Kim, Steven\|Collins, Karen\|Wojciechowicz, Donald\|Kohler, Constance\|Kovacs, Diana\|Discafani, Carolyn\|Zhang, Nan\|Wu, Biqi\|Floyd, Brawner\|Powell, Dennis\|Berger, Dan
PMID:	15210862

35.
Journal:	Hum Mol Genet. 2004 Oct 1;13(19):2303-11. Epub 2004 Aug 4.
Title:	Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.
Author:	Oliveira, Carla\|Westra, Jantine L\|Arango, Diego\|Ollikainen, Miina\|Domingo, Enric\|Ferreira, Ana\|Velho, Sergia\|Niessen, Renee\|Lagerstedt, Kristina\|Alhopuro, Pia\|Laiho, Paivi\|Veiga, Isabel\|Teixeira, Manuel R\|Ligtenberg, Marjolijn\|Kleibeuker, Jan H\|Sijmons, R
PMID:	15294875

36.
Journal:	J Med Genet. 2004 Sep;41(9):664-8.
Title:	BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Author:	Domingo, E\|Laiho, P\|Ollikainen, M\|Pinto, M\|Wang, L\|French, A J\|Westra, J\|Frebourg, T\|Espin, E\|Armengol, M\|Hamelin, R\|Yamamoto, H\|Hofstra, R M W\|Seruca, R\|Lindblom, A\|Peltomaki, P\|Thibodeau, S N\|Aaltonen, L A\|Schwartz, S Jr
PMID:	15342696

37.
Journal:	Scand J Gastroenterol. 2004 Aug;39(8):748-53.
Title:	Mutational activation of the RAS-RAF-MAPK and the Wnt pathway in small intestinal adenocarcinomas.
Author:	Blaker, H\|Helmchen, B\|Bonisch, A\|Aulmann, S\|Penzel, R\|Otto, H F\|Rieker, R J
PMID:	15513360

38.
Journal:	J Clin Oncol. 2004 Nov 15;22(22):4584-94.
Title:	Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.
Author:	Nagasaka, Takeshi\|Sasamoto, Hiromi\|Notohara, Kenji\|Cullings, Harry M\|Takeda, Masanori\|Kimura, Keigo\|Kambara, Takeshi\|MacPhee, Donald G\|Young, Joanne\|Leggett, Barbara A\|Jass, Jeremy R\|Tanaka, Noriaki\|Matsubara, Nagahide
PMID:	15542810

39.
Journal:	J Pathol. 2005 Jan;205(1):74-81.
Title:	Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival.
Author:	Dundas, Sinclair R\|Lawrie, Laura C\|Rooney, Patrick H\|Murray, Graeme I
PMID:	15532096

40.
Journal:	J Biol Chem. 2005 Mar 4;280(9):7962-75. Epub 2004 Nov 24.
Title:	DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.
Author:	Bommer, Guido T\|Jager, Claudia\|Durr, Eva-Maria\|Baehs, Sebastian\|Eichhorst, Soren T\|Brabletz, Thomas\|Hu, Gang\|Frohlich, Thomas\|Arnold, Georg\|Kress, Dagmar C\|Goke, Burkhard\|Fearon, Eric R\|Kolligs, Frank T
PMID:	15563452

41.
Journal:	Anticancer Drugs. 2005 Feb;16(2):129-36.
Title:	The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
Author:	Heim, Martina\|Scharifi, Mariam\|Zisowsky, Jochen\|Jaehde, Ulrich\|Voliotis, Dimitris\|Seeber, Siegfried\|Strumberg, Dirk
PMID:	15655409

42.
Journal:	APMIS. 2005 Jan;113(1):54-7.
Title:	Mutational analysis of the ARAF gene in human cancers.
Author:	Lee, Jong Woo\|Soung, Young Hwa\|Kim, Su Young\|Park, Won Sang\|Nam, Suk Woo\|Min, Woo Sung\|Kim, Sang Ho\|Lee, Jung Young\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	15676015

43.
Journal:	Int J Cancer. 2005 Jul 10;115(5):673-7.
Title:	Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma.
Author:	Aust, Daniela E\|Haase, Michael\|Dobryden, Lyudmyla\|Markwarth, Annett\|Lohrs, Udo\|Wittekind, Christian\|Baretton, Gustavo B\|Tannapfel, Andrea
PMID:	15704157

44.
Journal:	Int J Cancer. 2005 Jul 20;115(6):943-50.
Title:	BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.
Author:	Ikehara, Nobunao\|Semba, Shuho\|Sakashita, Masanori\|Aoyama, Nobuo\|Kasuga, Masato\|Yokozaki, Hiroshi
PMID:	15729718

45.
Journal:	Carcinogenesis. 2005 Jul;26(7):1207-14.
Title:	Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade.
Author:	Zhu, Yongliang\|Zhong, Xian\|Zheng, Shu\|Ge, Zhen\|Du, Qin\|Zhang, Suzhang
PMID:	15774489

46.
Journal:	J Endocrinol. 2005 Jun;185(3):577-92.
Title:	Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.
Author:	Gilad, Liat Abovich\|Bresler, Tali\|Gnainsky, Julia\|Smirnoff, Patricia\|Schwartz, Betty
PMID:	15930183

47.
Journal:	Clin Colorectal Cancer. 2005 Sep;5(3):188-96.
Title:	Results of a phase I trial of sorafenib (BAY 43-9006) in combination with oxaliplatin in patients with refractory solid tumors, including colorectal cancer.
Author:	Kupsch, Petra\|Henning, Bernhard F\|Passarge, Katrin\|Richly, Heike\|Wiesemann, Katrin\|Hilger, Ralf A\|Scheulen, Max E\|Christensen, Olaf\|Brendel, Erich\|Schwartz, Brian\|Hofstra, Elke\|Voigtmann, Rudolf\|Seeber, Siegfried\|Strumberg, Dirk
PMID:	16197622

48.
Journal:	Cancer Biol Ther. 2005 Oct;4(10):1159-67. Epub 2005 Oct 23.
Title:	Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation.
Author:	Caraglia, Michele\|Marra, Monica\|Budillon, Alfredo\|Meo, Giuseppina\|Ricciardiello, Filippo\|Bismuto, Ettore\|Brachelente, Giovanni\|Francini, Guido\|Giordano, Antonio\|Correale, Pierpaolo\|Abbruzzese, Alberto
PMID:	16294035

49.
Journal:	Carcinogenesis. 2006 Mar;27(3):392-404. Epub 2005 Oct 11.
Title:	Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations.
Author:	Kim, Il-Jin\|Kang, Hio Chung\|Jang, Sang-Geun\|Kim, Kun\|Ahn, Sun-A\|Yoon, Hyun-Ju\|Yoon, Sang Nam\|Park, Jae-Gahb
PMID:	16219636

50.
Journal:	Oncogene. 2006 Jan 5;25(1):43-50.
Title:	Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Author:	Wang, Q\|Zhou, Y\|Wang, X\|Evers, B M
PMID:	16278684

51.
Journal:	Mol Cancer. 2006 Jan 10;5:2.
Title:	BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status.
Author:	Li, Wei Qi\|Kawakami, Kazuyuki\|Ruszkiewicz, Andrew\|Bennett, Graeme\|Moore, James\|Iacopetta, Barry
PMID:	16403224

52.
Journal:	Eur Urol. 2006 Nov;50(5):1102-9; discussion 1109-10.
Title:	Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.
Author:	Burger, Maximilian\|Denzinger, Stefan\|Hammerschmied, Christine\|Tannapfel, Andrea\|Maderstorfer, Armin\|Wieland, Wolf Ferdinand\|Hartmann, Arndt\|Stoehr, Robert
PMID:	16413100

53.
Journal:	Cell Death Differ. 2006 Nov;13(11):1982-93.
Title:	Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Author:	Lin, L\|Su, Z\|Lebedeva, I V\|Gupta, P\|Boukerche, H\|Rai, T\|Barber, G N\|Dent, P\|Sarkar, D\|Fisher, P B
PMID:	16575407

54.
Journal:	Anticancer Res. 2006 Mar-Apr;26(2A):1029-37.
Title:	EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitro.
Author:	Rishi, Arun K\|Parikh, Rakesh\|Wali, Anil\|Durko, Lukasz\|Zhang, Liyue\|Yu, Yingjie\|Majumdar, Adhip P N
PMID:	16619503

55.
Journal:	Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7.
Title:	Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Author:	Sansom, Owen J\|Meniel, Valerie\|Wilkins, Julie A\|Cole, Alicia M\|Oien, Karin A\|Marsh, Victoria\|Jamieson, Thomas J\|Guerra, Carmen\|Ashton, Gabrielle H\|Barbacid, Mariano\|Clarke, Alan R
PMID:	16959882

56.
Journal:	J Mol Diagn. 2006 Nov;8(5):540-3.
Title:	Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology.
Author:	Benlloch, Susana\|Paya, Artemio\|Alenda, Cristina\|Bessa, Xavier\|Andreu, Montserrat\|Jover, Rodrigo\|Castells, Antoni\|Llor, Xavier\|Aranda, F Ignacio\|Massuti, Bartomeu
PMID:	17065421

57.
Journal:	J Clin Oncol. 2006 Dec 20;24(36):5672-9.
Title:	Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients.
Author:	Al-Mulla, Fahd\|Hagan, Suzanne\|Behbehani, Abdulla I\|Bitar, Milad S\|George, Shirley S\|Going, James J\|Garcia, Jorge J Curto\|Scott, Lucy\|Fyfe, Nicky\|Murray, Graeme I\|Kolch, Walter
PMID:	17179102

58.
Journal:	Endocr Regul. 2006 Dec;40(4):129-38.
Title:	BRAF mutations in papillary thyroid carcinoma.
Author:	Wojciechowska, Katarzyna\|Lewinski, Andrzej
PMID:	17201587

59.
Journal:	Mol Cancer Ther. 2007 Mar;6(3):898-906.
Title:	In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.
Author:	Skobeleva, Natalia\|Menon, Sanjay\|Weber, Lutz\|Golemis, Erica A\|Khazak, Vladimir
PMID:	17363484

60.
Journal:	Cancer Res. 2007 Mar 15;67(6):2643-8.
Title:	Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.
Author:	Benvenuti, Silvia\|Sartore-Bianchi, Andrea\|Di Nicolantonio, Federica\|Zanon, Carlo\|Moroni, Mauro\|Veronese, Silvio\|Siena, Salvatore\|Bardelli, Alberto
PMID:	17363584

61.
Journal:	Int J Biol Markers. 2007 Jan-Mar;22(1):12-8.
Title:	Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer.
Author:	Symvoulakis, E K\|Zaravinos, A\|Panutsopulos, D\|Zoras, O\|Papalambros, E\|Sigala, F\|Spandidos, D A
PMID:	17393356

62.
Journal:	Anticancer Res. 2007 Mar-Apr;27(2):741-8.
Title:	Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase.
Author:	Lea, Michael A\|Ibeh, Chinwe\|Shah, Neel\|Moyer, Mary P
PMID:	17465197

63.
Journal:	Bioorg Med Chem. 2007 Jul 15;15(14):4923-32.
Title:	Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf.
Author:	Jayaprakasha, G K\|Mandadi, K K\|Poulose, Shibu M\|Jadegoud, Y\|Nagana Gowda, G A\|Patil, Bhimanagouda S
PMID:	17512744

64.
Journal:	Gastroenterology. 2007 Jul;133(1):219-31. Epub 2007 Apr 25.
Title:	Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
Author:	Zhu, Feng\|Zykova, Tatyana A\|Kang, Bong Seok\|Wang, Zhe\|Ebeling, Mara C\|Abe, Yasuhito\|Ma, Wei-Ya\|Bode, Ann M\|Dong, Zigang
PMID:	17631144

65.
Journal:	Zhonghua Yi Xue Za Zhi. 2007 Apr 10;87(14):982-6.
Title:	[Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells].
Author:	Wang, Xia\|Lu, Rong\|Fang, Jing-yuan
PMID:	17650425

66.
Journal:	Mol Cancer Ther. 2007 Aug;6(8):2220-9.
Title:	Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Author:	Hao, Honglin\|Muniz-Medina, Vanessa M\|Mehta, Heena\|Thomas, Nancy E\|Khazak, Vladimir\|Der, Channing J\|Shields, Janiel M
PMID:	17699719

67.
Journal:	Clin Cancer Res. 2007 Oct 1;13(19):5729-35.
Title:	Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways.
Author:	Sanchez-de-Abajo, Ana\|de la Hoya, Miguel\|van Puijenbroek, Marjo\|Tosar, Alicia\|Lopez-Asenjo, J A\|Diaz-Rubio, Eduardo\|Morreau, Hans\|Caldes, Trinidad
PMID:	17908962

68.
Journal:	Rev Recent Clin Trials. 2007 May;2(2):121-34.
Title:	Therapeutic strategies for targeting BRAF in human cancer.
Author:	Pratilas, Christine A\|Solit, David B
PMID:	18473997

69.
Journal:	J Biol Chem. 2008 Feb 15;283(7):4094-104. Epub 2007 Dec 15.
Title:	Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells.
Author:	Kang, Dong Woo\|Park, Mi Hee\|Lee, Young Jun\|Kim, Hyung Sik\|Kwon, Taeg Kyu\|Park, Won-Sang\|Min, Do Sik
PMID:	18084005

70.
Journal:	Nat Genet. 2008 May;40(5):600-8.
Title:	Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Author:	Haigis, Kevin M\|Kendall, Krystle R\|Wang, Yufang\|Cheung, Ann\|Haigis, Marcia C\|Glickman, Jonathan N\|Niwa-Kawakita, Michiko\|Sweet-Cordero, Alejandro\|Sebolt-Leopold, Judith\|Shannon, Kevin M\|Settleman, Jeffrey\|Giovannini, Marco\|Jacks, Tyler
PMID:	18372904

71.
Journal:	Pharmacogenomics. 2008 Apr;9(4):463-7.
Title:	DxS Ltd.
Author:	Cross, Joanne
PMID:	18384259

72.
Journal:	Mol Cancer Ther. 2008 Apr;7(4):915-22.
Title:	Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.
Author:	Serova, Maria\|Ghoul, Aida\|Benhadji, Karim A\|Faivre, Sandrine\|Le Tourneau, Christophe\|Cvitkovic, Esteban\|Lokiec, Francois\|Lord, Janet\|Ogbourne, Steven M\|Calvo, Fabien\|Raymond, Eric
PMID:	18413805

73.
Journal:	Cancer Sci. 2008 Jul;99(7):1348-54.
Title:	Individual tumorigenesis pathways of sporadic colorectal adenocarcinomas are associated with the biological behavior of tumors.
Author:	Kim, Jin C\|Cho, Young K\|Roh, Seon A\|Yu, Chang S\|Gong, Gyungyub\|Jang, Se J\|Kim, Seon Y\|Kim, Yong S
PMID:	18422752

74.
Journal:	Clin Cancer Res. 2008 May 1;14(9):2560-9.
Title:	Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
Author:	Suehiro, Yutaka\|Wong, Chi Wai\|Chirieac, Lucian R\|Kondo, Yutaka\|Shen, Lanlan\|Webb, C Renee\|Chan, Yee Wai\|Chan, Annie S Y\|Chan, Tsun Leung\|Wu, Tsung-Teh\|Rashid, Asif\|Hamanaka, Yuichiro\|Hinoda, Yuji\|Shannon, Rhonda L\|Wang, Xuemei\|Morris, Jeffrey\|Issa, Jean-P
PMID:	18451217

75.
Journal:	Oncogene. 2008 Aug 21;27(36):4921-32.
Title:	Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6.
Author:	Adachi, Y\|Shibai, Y\|Mitsushita, J\|Shang, W H\|Hirose, K\|Kamata, T
PMID:	18454176

76.
Journal:	Oncol Rep. 2008 Jul;20(1):3-11.
Title:	Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Author:	Georgieva, Milka\|Krasteva, Maria\|Angelova, Elka\|Ralchev, Krassimir\|Dimitrov, Valentin\|Bozhimirov, Stanislav\|Georgieva, Elena\|Berger, Martin R
PMID:	18575712

77.
Journal:	Neoplasia. 2008 Jul;10(7):680-6, 2 p following 686.
Title:	RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A.
Author:	Ahlquist, Terje\|Bottillo, Irene\|Danielsen, Stine A\|Meling, Gunn I\|Rognum, Torleiv O\|Lind, Guro E\|Dallapiccola, Bruno\|Lothe, Ragnhild A
PMID:	18592002

78.
Journal:	Gastroenterology. 2008 Sep;135(3):899-906.
Title:	B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival.
Author:	Matos, Paulo\|Oliveira, Carla\|Velho, Sergia\|Goncalves, Vania\|da Costa, Luis Teixiera\|Moyer, Mary Pat\|Seruca, Raquel\|Jordan, Peter
PMID:	18602919

79.
Journal:	Magy Onkol. 2008 Jun;52(2):185-91.
Title:	[The RAS paradox of the EGFR-targeted therapy in colorectal cancer].
Author:	Timar, Jozsef\|Lang, Istvan
PMID:	18640895

80.
Journal:	Oncologist. 2008 Aug;13(8):845-58.
Title:	Selected combination therapy with sorafenib: a review of clinical data and perspectives in advanced solid tumors.
Author:	Dal Lago, Lissandra\|D'Hondt, Veronique\|Awada, Ahmad
PMID:	18695262

81.
Journal:	Toxicol Appl Pharmacol. 2008 Nov 1;232(3):408-17.
Title:	Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.
Author:	Zeliadt, Nicholette A\|Mauro, Laura J\|Wattenberg, Elizabeth V
PMID:	18771677

82.
Journal:	Oncogene. 2008 Dec 4;27(57):7150-61.
Title:	Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.
Author:	Wickenden, J A\|Jin, H\|Johnson, M\|Gillings, A S\|Newson, C\|Austin, M\|Chell, S D\|Balmanno, K\|Pritchard, C A\|Cook, S J
PMID:	18806830

83.
Journal:	Mol Cancer Ther. 2008 Oct;7(10):3129-40.
Title:	Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.
Author:	Wilhelm, Scott M\|Adnane, Lila\|Newell, Philippa\|Villanueva, Augusto\|Llovet, Josep M\|Lynch, Mark
PMID:	18852116

84.
Journal:	Cell Death Differ. 2009 Mar;16(3):368-77.
Title:	Tumour cell survival signalling by the ERK1/2 pathway.
Author:	Balmanno, K\|Cook, S J
PMID:	18846109

85.
Journal:	Gastroenterology. 2009 May;136(5):1680-8.e7.
Title:	TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
Author:	Trobridge, Patty\|Knoblaugh, Sue\|Washington, M Kay\|Munoz, Nina M\|Tsuchiya, Karen D\|Rojas, Andres\|Song, Xiaoling\|Ulrich, Cornelia M\|Sasazuki, Takehiko\|Shirasawa, Senji\|Grady, William M
PMID:	19208363

86.
Journal:	Bioorg Med Chem Lett. 2009 May 15;19(10):2735-8.
Title:	Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.
Author:	Gopalsamy, Ariamala\|Ciszewski, Greg\|Hu, Yongbo\|Lee, Frederick\|Feldberg, Larry\|Frommer, Eileen\|Kim, Steven\|Collins, Karen\|Wojciechowicz, Donald\|Mallon, Robert
PMID:	19362830

87.
Journal:	Expert Opin Biol Ther. 2009 May;9(5):565-77.
Title:	KRAS mutations and sensitivity to anti-EGFR monoclonal antibodies in metastatic colorectal carcinoma: an open issue.
Author:	Silvestris, Nicola\|Tommasi, Stefania\|Santini, Daniele\|Russo, Antonio\|Simone, Gianni\|Petriella, Daniela\|Maiello, Evaristo\|Tonini, Giuseppe\|Colucci, Giuseppe
PMID:	19368524

88.
Journal:	Mol Cancer Ther. 2009 Apr;8(4):834-43.
Title:	KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Author:	Yeh, Jen Jen\|Routh, Elizabeth D\|Rubinas, Tara\|Peacock, Janie\|Martin, Timothy D\|Shen, Xiang Jun\|Sandler, Robert S\|Kim, Hong Jin\|Keku, Temitope O\|Der, Channing J
PMID:	19372556

89.
Journal:	Int J Cancer. 2009 Jul 15;125(2):297-307.
Title:	Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Author:	Zhang, Hui-Hua\|Walker, Francesca\|Kiflemariam, Sara\|Whitehead, Robert H\|Williams, David\|Phillips, Wayne A\|Mikeska, Thomas\|Dobrovic, Alexander\|Burgess, Antony W
PMID:	19378335

90.
Journal:	IUBMB Life. 2009 Jun;61(6):685-92.
Title:	Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author:	Song, Chunjiao\|Wang, Weimin\|Li, Meng\|Liu, Yanxin\|Zheng, Dexian
PMID:	19472191

91.
Journal:	Gut. 2009 Sep;58(9):1234-41.
Title:	Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer.
Author:	Seth, R\|Crook, S\|Ibrahem, S\|Fadhil, W\|Jackson, D\|Ilyas, M
PMID:	19474002

92.
Journal:	PLoS One. 2009 May 27;4(5):e5717.
Title:	Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors.
Author:	Jaiswal, Bijay S\|Janakiraman, Vasantharajan\|Kljavin, Noelyn M\|Eastham-Anderson, Jeffrey\|Cupp, James E\|Liang, Yuxin\|Davis, David P\|Hoeflich, Klaus P\|Seshagiri, Somasekar
PMID:	19492075

93.
Journal:	Clin Cancer Res. 2009 Jun 15;15(12):4046-57.
Title:	CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy.
Author:	Bao, Rudi\|Lai, Cheng-Jung\|Qu, Hui\|Wang, Dagong\|Yin, Ling\|Zifcak, Brian\|Atoyan, Ruzanna\|Wang, Jing\|Samson, Maria\|Forrester, Jeffrey\|DellaRocca, Steven\|Xu, Guang-Xin\|Tao, Xu\|Zhai, Hai-Xiao\|Cai, Xiong\|Qian, Changgeng
PMID:	19509149

94.
Journal:	Anticancer Res. 2009 Aug;29(8):3115-23.
Title:	Chemoresponsiveness associated with canonical molecular changes in colorectal adenocarcinomas.
Author:	Kim, Jin C\|Roh, Seon A\|Cho, Dong H\|Kim, Tae W\|Yoon, Sang N\|Kim, Chan W\|Yu, Chang S\|Kim, Seon Y\|Kim, Yong S
PMID:	19661324

95.
Journal:	Mol Cancer Res. 2009 Aug;7(8):1390-8.
Title:	Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.
Author:	Mori, Akira\|Moser, Christian\|Lang, Sven A\|Hackl, Christina\|Gottfried, Eva\|Kreutz, Marina\|Schlitt, Hans J\|Geissler, Edward K\|Stoeltzing, Oliver
PMID:	19671674

96.
Journal:	Cancer Epidemiol. 2009 Aug;33(2):123-9.
Title:	A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans.
Author:	Scholtka, Bettina\|Schneider, Mandy\|Melcher, Ralph\|Katzenberger, Tiemo\|Friedrich, Daniela\|Berghof-Jager, Kornelia\|Scheppach, Wolfgang\|Steinberg, Pablo
PMID:	19679059

97.
Journal:	Cell Signal. 2009 Dec;21(12):1846-56.
Title:	Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Author:	Krueger, Felix\|Madeja, Zofia\|Hemberger, Myriam\|McMahon, Martin\|Cook, Simon J\|Gaunt, Stephen J
PMID:	19686845

98.
Journal:	Carcinogenesis. 2009 Oct;30(10):1670-7.
Title:	Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells.
Author:	Calleros, Laura\|Sanchez-Hernandez, Irene\|Baquero, Pablo\|Toro, Maria Jose\|Chiloeches, Antonio
PMID:	19700418

99.
Journal:	World J Gastroenterol. 2009 Sep 28;15(36):4547-55.
Title:	Effects of lysophosphatidic acid on human colon cancer cells and its mechanisms of action.
Author:	Sun, Hong\|Ren, Juan\|Zhu, Qing\|Kong, Fan-Zhong\|Wu, Lei\|Pan, Bo-Rong
PMID:	19777613

100.
Journal:	Clin Transl Oncol. 2009 Nov;11(11):737-47.
Title:	Biomarkers and anti-EGFR therapies for KRAS wild-type metastatic colorectal cancer.
Author:	Garcia-Saenz, Jose A\|Sastre, Javier\|Diaz-Rubio Garcia, Eduardo
PMID:	19917537

101.
Journal:	Clin Cancer Res. 2009 Dec 1;15(23):7322-9.
Title:	KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803.
Author:	Ogino, Shuji\|Meyerhardt, Jeffrey A\|Irahara, Natsumi\|Niedzwiecki, Donna\|Hollis, Donna\|Saltz, Leonard B\|Mayer, Robert J\|Schaefer, Paul\|Whittom, Renaud\|Hantel, Alexander\|Benson, Al B 3rd\|Goldberg, Richard M\|Bertagnolli, Monica M\|Fuchs, Charles S
PMID:	19934290

102.
Journal:	Mol Cancer. 2009 Dec 16;8:124.
Title:	The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.
Author:	Menigatti, Mirco\|Cattaneo, Elisa\|Sabates-Bellver, Jacob\|Ilinsky, Valery V\|Went, Philip\|Buffoli, Federico\|Marquez, Victor E\|Jiricny, Josef\|Marra, Giancarlo
PMID:	20015382

103.
Journal:	Oncology. 2009;77 Suppl 1:57-68.
Title:	The long and winding road to useful predictive factors for anti-EGFR therapy in metastatic colorectal carcinoma: the KRAS/BRAF pathway.
Author:	Russo, Antonio\|Rizzo, Sergio\|Bronte, Giuseppe\|Silvestris, Nicola\|Colucci, Giuseppe\|Gebbia, Nicola\|Bazan, Viviana\|Fulfaro, Fabio
PMID:	20130433

104.
Journal:	An R Acad Nac Med (Madr). 2009;126(2):243-57; discussion 258-62.
Title:	[Biomarkers and anti-EGFR therapies for KRAS wild-type tumors in metastatic colorectal cancer patients].
Author:	Diaz-Rubio Garcia, Eduardo
PMID:	20432670

105.
Journal:	Oncologist. 2010;15(1):73-84.
Title:	The evolving role of monoclonal antibodies in colorectal cancer: early presumptions and impact on clinical trial development.
Author:	Eng, Cathy
PMID:	20067946

106.
Journal:	Curr Cancer Drug Targets. 2010 Feb;10(1):68-79.
Title:	Molecular predictors of efficacy to anti-EGFR agents in colorectal cancer patients.
Author:	Ruzzo, Annamaria\|Graziano, Francesco\|Canestrari, Emanuele\|Magnani, Mauro
PMID:	20088793

107.
Journal:	J Transl Med. 2010 Feb 10;8:15.
Title:	TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status.
Author:	Herreros-Villanueva, Marta\|Muniz, Pilar\|Garcia-Giron, Carlos\|Cavia-Saiz, Monica\|del Corral, Maria J Coma
PMID:	20146801

108.
Journal:	J Korean Med Sci. 2010 Mar;25(3):353-60.
Title:	Growth and invasion of sporadic colorectal adenocarcinomas in terms of genetic change.
Author:	Roh, Seon Ae\|Choi, Eun Young\|Cho, Dong Hyung\|Jang, Se Jin\|Kim, Seon Young\|Kim, Yong Sung\|Kim, Jin Cheon
PMID:	20191032

109.
Journal:	Int J Oncol. 2010 Apr;36(4):941-53.
Title:	Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Author:	Lee, Hwa Young\|Crawley, Suzanne\|Hokari, Ryota\|Kwon, Sungwon\|Kim, Young S
PMID:	20198339

110.
Journal:	Oncogene. 2010 Jun 10;29(23):3398-410.
Title:	The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells.
Author:	Greenhough, A\|Wallam, C A\|Hicks, D J\|Moorghen, M\|Williams, A C\|Paraskeva, C
PMID:	20348947

111.
Journal:	Mol Cancer Ther. 2010 May;9(5):1308-17.
Title:	Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells.
Author:	Serova, Maria\|Astorgues-Xerri, Lucile\|Bieche, Ivan\|Albert, Sebastien\|Vidaud, Michel\|Benhadji, Karim A\|Emami, Shahin\|Vidaud, Dominique\|Hammel, Pascal\|Theou-Anton, Nathalie\|Gespach, Christian\|Faivre, Sandrine\|Raymond, Eric
PMID:	20406951

112.
Journal:	Curr Opin Investig Drugs. 2010 Jun;11(6):699-706.
Title:	PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
Author:	Smalley, Keiran S M
PMID:	20496265

113.
Journal:	Cancer Cell. 2010 Aug 9;18(2):135-46.
Title:	Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Author:	Bennecke, Moritz\|Kriegl, Lydia\|Bajbouj, Monther\|Retzlaff, Kristin\|Robine, Sylvie\|Jung, Andreas\|Arkan, Melek C\|Kirchner, Thomas\|Greten, Florian R
PMID:	20708155

114.
Journal:	Cancer Lett. 2010 Dec 28;299(2):137-49.
Title:	Raf kinase inhibitor protein suppresses nuclear factor-kappaB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression.
Author:	Beshir, Anwar B\|Ren, Gang\|Magpusao, Anniefer N\|Barone, Lauren M\|Yeung, Kam C\|Fenteany, Gabriel
PMID:	20855151

115.
Journal:	Biomed Pharmacother. 2010 Nov;64(9):583-8.
Title:	GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells.
Author:	Miao, Yufeng\|Zhang, Youwei\|Wan, Haijun\|Chen, Longbang\|Wang, Fangyu
PMID:	20888181

116.
Journal:	Mol Cancer Ther. 2010 Dec;9(12):3351-62.
Title:	Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Author:	Tentler, John J\|Nallapareddy, Sujatha\|Tan, Aik Choon\|Spreafico, Anna\|Pitts, Todd M\|Morelli, M Pia\|Selby, Heather M\|Kachaeva, Maria I\|Flanigan, Sara A\|Kulikowski, Gillian N\|Leong, Stephen\|Arcaroli, John J\|Messersmith, Wells A\|Eckhardt, S Gail
PMID:	20923857

117.
Journal:	Cancer Treat Rev. 2010 Nov;36 Suppl 3:S56-61.
Title:	Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
Author:	Rizzo, Sergio\|Bronte, Giuseppe\|Fanale, Daniele\|Corsini, Lidia\|Silvestris, Nicola\|Santini, Daniele\|Gulotta, Gaspare\|Bazan, Viviana\|Gebbia, Nicola\|Fulfaro, Fabio\|Russo, Antonio
PMID:	21129611

118.
Journal:	Int J Biol Markers. 2010 Oct-Dec;25(4):179-84.
Title:	Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer.
Author:	Bennani, Bahia\|Gilles, Sophie\|Fina, Frederic\|Nanni, Isabelle\|Ibrahimi, Sidi Adil\|Riffi, Afaf Amarti\|Nejjari, Chakib\|Benajeh, Dafr-Allah\|El Abkari, Mohammed\|Martin, Pierre-Marie\|Ouafik, L'Houcine
PMID:	21161938

119.
Journal:	Cancers (Basel). 2010 Dec 29;3(1):91-105.
Title:	Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1.
Author:	Schneider, Mandy\|Scholtka, Bettina\|Gottschalk, Uwe\|Faiss, Siegbert\|Schatz, Daniela\|Berghof-Jager, Kornelia\|Steinberg, Pablo
PMID:	24212608

120.
Journal:	Int J Cancer. 2011 Feb 1;128(3):691-701.
Title:	Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: a new drug combination for cancer therapy.
Author:	Biran, Anat\|Brownstein, Michael\|Haklai, Ronit\|Kloog, Yoel
PMID:	20473860

121.
Journal:	Lancet Oncol. 2011 Jun;12(6):594-603.
Title:	KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
Author:	De Roock, Wendy\|De Vriendt, Veerle\|Normanno, Nicola\|Ciardiello, Fortunato\|Tejpar, Sabine
PMID:	21163703

122.
Journal:	J Natl Compr Canc Netw. 2011 Jan;9(1):13-25.
Title:	Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer.
Author:	Kelley, Robin K\|Van Bebber, Stephanie L\|Phillips, Kathryn A\|Venook, Alan P
PMID:	21233242

123.
Journal:	Pathol Oncol Res. 2011 Sep;17(3):633-7.
Title:	B-Raf mutations, microsatellite instability and p53 protein expression in sporadic basal cell carcinomas.
Author:	Stamatelli, Angeliki\|Saetta, Angelica A\|Bei, Thaleia\|Kavantzas, Nicolaos\|Michalopoulos, Nicolaos V\|Patsouris, Efstratios\|Aroni, Kiriaki
PMID:	21274671

124.
Journal:	Cancer Res. 2011 May 15;71(10):3635-48.
Title:	The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models.
Author:	LaBonte, Melissa J\|Wilson, Peter M\|Fazzone, Will\|Russell, Jared\|Louie, Stan G\|El-Khoueiry, Anthony\|Lenz, Heinz-Josef\|Ladner, Robert D
PMID:	21464044

125.
Journal:	Cancer Chemother Pharmacol. 2011 Aug;68(2):547-52.
Title:	Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer.
Author:	Boasberg, Peter D\|Redfern, Charles H\|Daniels, Gregory A\|Bodkin, David\|Garrett, Chris R\|Ricart, Alejandro D
PMID:	21516509

126.
Journal:	Clin Chim Acta. 2011 Aug 17;412(17-18):1578-81.
Title:	KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing.
Author:	French, Deborah\|Smith, Andrew\|Powers, Martin P\|Wu, Alan H B
PMID:	21575616

127.
Journal:	J Dig Dis. 2011 Jun;12(3):193-8.
Title:	Clinical features and molecular alterations of traditional serrated adenoma in sporadic colorectal carcinogenesis.
Author:	Han, Ying\|Zhou, Zhi Yong
PMID:	21615873

128.
Journal:	Curr Colorectal Cancer Rep. 2011 Jun 1;7(2):113-120.
Title:	An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer.
Author:	Nandan, Mandayam O\|Yang, Vincent W
PMID:	21625338

129.
Journal:	Cancer Res. 2011 Aug 15;71(16):5535-45.
Title:	Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.
Author:	Wang, Huisheng\|Daouti, Sherif\|Li, Wen-Hui\|Wen, Yang\|Rizzo, Christine\|Higgins, Brian\|Packman, Kathryn\|Rosen, Neal\|Boylan, John F\|Heimbrook, David\|Niu, Huifeng
PMID:	21705440

130.
Journal:	Br J Cancer. 2011 Jul 12;105(2):246-54.
Title:	Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.
Author:	Weidlich, S\|Walsh, K\|Crowther, D\|Burczynski, M E\|Feuerstein, G\|Carey, F A\|Steele, R J C\|Wolf, C R\|Miele, G\|Smith, G
PMID:	21712828

131.
Journal:	Gan To Kagaku Ryoho. 2011 Jul;38(7):1079-83.
Title:	[Predictive biomarkers of anti-EGFR monoclonal anti-body in colorectal cancer].
Author:	Soeda, Hiroshi\|Shimodaira, Hideki\|Ishioka, Chikashi
PMID:	21772090

132.
Journal:	PLoS One. 2011;6(7):e22769.
Title:	PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.
Author:	Janku, Filip\|Lee, J Jack\|Tsimberidou, Apostolia M\|Hong, David S\|Naing, Aung\|Falchook, Gerald S\|Fu, Siqing\|Luthra, Rajyalakshmi\|Garrido-Laguna, Ignacio\|Kurzrock, Razelle
PMID:	21829508

133.
Journal:	Oncotarget. 2011 Aug;2(8):638-45.
Title:	The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
Author:	Mazumdar, Tapati\|DeVecchio, Jennifer\|Agyeman, Akwasi\|Shi, Ting\|Houghton, Janet A
PMID:	21860067

134.
Journal:	Rinsho Byori. 2011 Aug;59(8):757-62.
Title:	[Tm analysis method using a quenching probe is a simple and rapid way to simultaneously detect KRAS and BRAF mutations].
Author:	Akagi, Kiwamu\|Arai, Yoshiko
PMID:	21942085

135.
Journal:	PLoS One. 2011;6(10):e25806.
Title:	BRAF mutations in advanced cancers: clinical characteristics and outcomes.
Author:	El-Osta, Hazem\|Falchook, Gerald\|Tsimberidou, Apostolia\|Hong, David\|Naing, Aung\|Kim, Kevin\|Wen, Sijin\|Janku, Filip\|Kurzrock, Razelle
PMID:	22039425

136.
Journal:	PLoS One. 2011;6(12):e28841.
Title:	Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors.
Author:	Morgillo, Floriana\|Martinelli, Erika\|Troiani, Teresa\|Orditura, Michele\|De Vita, Ferdinando\|Ciardiello, Fortunato
PMID:	22174910

137.
Journal:	Oncogene. 2012 Mar 29;31(13):1623-35.
Title:	MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression.
Author:	Oneyama, C\|Morii, E\|Okuzaki, D\|Takahashi, Y\|Ikeda, J\|Wakabayashi, N\|Akamatsu, H\|Tsujimoto, M\|Nishida, T\|Aozasa, K\|Okada, M
PMID:	21860426

138.
Journal:	Anticancer Agents Med Chem. 2012 Feb;12(2):163-71.
Title:	Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers?
Author:	Yokota, Tomoya
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139.
Journal:	Clin Cancer Res. 2012 Feb 1;18(3):890-900.
Title:	Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803.
Author:	Ogino, Shuji\|Shima, Kaori\|Meyerhardt, Jeffrey A\|McCleary, Nadine J\|Ng, Kimmie\|Hollis, Donna\|Saltz, Leonard B\|Mayer, Robert J\|Schaefer, Paul\|Whittom, Renaud\|Hantel, Alexander\|Benson, Al B 3rd\|Spiegelman, Donna\|Goldberg, Richard M\|Bertagnolli, Monica M\|Fuch
PMID:	22147942

140.
Journal:	Mol Cancer Ther. 2012 Mar;11(3):720-9.
Title:	Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.
Author:	Jing, Junping\|Greshock, Joel\|Holbrook, Joanna Dawn\|Gilmartin, Aidan\|Zhang, Xiping\|McNeil, Elizabeth\|Conway, Theresa\|Moy, Christopher\|Laquerre, Sylvie\|Bachman, Kurt\|Wooster, Richard\|Degenhardt, Yan
PMID:	22169769

141.
Journal:	Cancer Res. 2012 Feb 1;72(3):779-89.
Title:	Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
Author:	Yang, Hong\|Higgins, Brian\|Kolinsky, Kenneth\|Packman, Kathryn\|Bradley, William D\|Lee, Richard J\|Schostack, Kathleen\|Simcox, Mary Ellen\|Kopetz, Scott\|Heimbrook, David\|Lestini, Brian\|Bollag, Gideon\|Su, Fei
PMID:	22180495

142.
Journal:	Hematol Oncol. 2012 Dec;30(4):190-3.
Title:	Real-time PCR-based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia.
Author:	Ewalt, Mark\|Nandula, Subhadra\|Phillips, Adrienne\|Alobeid, Bachir\|Murty, Vundavalli V\|Mansukhani, Mahesh M\|Bhagat, Govind
PMID:	22246856

143.
Journal:	Biochem Soc Trans. 2012 Feb;40(1):73-8.
Title:	Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.
Author:	Little, Annette S\|Balmanno, Kathryn\|Sale, Matthew J\|Smith, Paul D\|Cook, Simon J
PMID:	22260668

144.
Journal:	Clin Cancer Res. 2012 Apr 15;18(8):2316-25.
Title:	The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.
Author:	Shimizu, Toshio\|Tolcher, Anthony W\|Papadopoulos, Kyriakos P\|Beeram, Muralidhar\|Rasco, Drew W\|Smith, Lon S\|Gunn, Shelly\|Smetzer, Leslie\|Mays, Theresa A\|Kaiser, Brianne\|Wick, Michael J\|Alvarez, Cathy\|Cavazos, Aracely\|Mangold, Gina L\|Patnaik, Amita
PMID:	22261800

145.
Journal:	PLoS One. 2012;7(1):e29532.
Title:	A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Author:	Al-Mulla, Fahd\|Bitar, Milad S\|Feng, Jingwei\|Park, Sungdae\|Yeung, Kam C
PMID:	22279539

146.
Journal:	Mol Cancer Ther. 2012 Apr;11(4):930-41.
Title:	CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity.
Author:	James, Joyce\|Ruggeri, Bruce\|Armstrong, Robert C\|Rowbottom, Martin W\|Jones-Bolin, Susan\|Gunawardane, Ruwanthi N\|Dobrzanski, Pawel\|Gardner, Michael F\|Zhao, Hugh\|Cramer, Merryl D\|Hunter, Kathryn\|Nepomuceno, Ronald R\|Cheng, Mangeng\|Gitnick, Dana\|Yazdanian, Me
PMID:	22319199

147.
Journal:	Int J Mol Med. 2012 May;29(5):920-6.
Title:	MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.
Author:	Feng, Yin-Hsun\|Wu, Chao-Liang\|Shiau, Ai-Li\|Lee, Jenq-Chang\|Chang, Jan-Gowth\|Lu, Pei-Jung\|Tung, Chao-Ling\|Feng, Li-Yia\|Huang, Wen-Tsung\|Tsao, Chao-Jung
PMID:	22322462

148.
Journal:	World J Surg Oncol. 2012 Feb 29;10:47.
Title:	ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.
Author:	Levidou, Georgia\|Saetta, Angelica A\|Gigelou, Fanie\|Karlou, Maria\|Papanastasiou, Polyanthi\|Stamatelli, Angeliki\|Kavantzas, Nikolaos\|Michalopoulos, Nikolaos V\|Agrogiannis, George\|Patsouris, Efstratios\|Korkolopoulou, Penelope
PMID:	22376079

149.
Journal:	Clin Cancer Res. 2012 May 1;18(9):2515-25.
Title:	Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
Author:	Migliardi, Giorgia\|Sassi, Francesco\|Torti, Davide\|Galimi, Francesco\|Zanella, Eugenia R\|Buscarino, Michela\|Ribero, Dario\|Muratore, Andrea\|Massucco, Paolo\|Pisacane, Alberto\|Risio, Mauro\|Capussotti, Lorenzo\|Marsoni, Silvia\|Di Nicolantonio, Federica\|Bardelli,
PMID:	22392911

150.
Journal:	Clin Cancer Res. 2012 May 1;18(9):2658-67.
Title:	A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors.
Author:	Mross, Klaus\|Frost, Annette\|Steinbild, Simone\|Hedbom, Susanne\|Buchert, Martin\|Fasol, Ulrike\|Unger, Clemens\|Kratzschmar, Jorn\|Heinig, Roland\|Boix, Oliver\|Christensen, Olaf
PMID:	22421192

151.
Journal:	Cancer Discov. 2012 Mar;2(3):227-35.
Title:	EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
Author:	Corcoran, Ryan B\|Ebi, Hiromichi\|Turke, Alexa B\|Coffee, Erin M\|Nishino, Michiya\|Cogdill, Alexandria P\|Brown, Ronald D\|Della Pelle, Patricia\|Dias-Santagata, Dora\|Hung, Kenneth E\|Flaherty, Keith T\|Piris, Adriano\|Wargo, Jennifer A\|Settleman, Jeffrey\|Mino-Kenu
PMID:	22448344

152.
Journal:	Crit Rev Oncog. 2012;17(1):97-121.
Title:	Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.
Author:	Roring, Michael\|Brummer, Tilman
PMID:	22471666

153.
Journal:	J Transl Med. 2012 Apr 10;10:71.
Title:	Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab.
Author:	Scartozzi, Mario\|Giampieri, Riccardo\|Maccaroni, Elena\|Mandolesi, Alessandra\|Biagetti, Simona\|Alfonsi, Simona\|Giustini, Lucio\|Loretelli, Cristian\|Faloppi, Luca\|Bittoni, Alessandro\|Bianconi, Maristella\|Del Prete, Michela\|Bearzi, Italo\|Cascinu, Stefano
PMID:	22490361

154.
Journal:	Clin Cancer Res. 2012 Jun 1;18(11):3132-41.
Title:	Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer.
Author:	Kemper, Kristel\|Versloot, Miranda\|Cameron, Katherine\|Colak, Selcuk\|de Sousa e Melo, Felipe\|de Jong, Joan H\|Bleackley, Joanne\|Vermeulen, Louis\|Versteeg, Rogier\|Koster, Jan\|Medema, Jan Paul
PMID:	22496204

155.
Journal:	Nutr Cancer. 2012;64(4):559-68.
Title:	Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis.
Author:	Kansal, S\|Negi, A K\|Bhatnagar, A\|Agnihotri, N
PMID:	22519408

156.
Journal:	Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2127-33.
Title:	Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Author:	Ohashi, Kadoaki\|Sequist, Lecia V\|Arcila, Maria E\|Moran, Teresa\|Chmielecki, Juliann\|Lin, Ya-Lun\|Pan, Yumei\|Wang, Lu\|de Stanchina, Elisa\|Shien, Kazuhiko\|Aoe, Keisuke\|Toyooka, Shinichi\|Kiura, Katsuyuki\|Fernandez-Cuesta, Lynnette\|Fidias, Panos\|Yang, James Chi
PMID:	22773810

157.
Journal:	Small GTPases. 2012 Apr-Jun;3(2):126-30.
Title:	Differential involvement of RalA and RalB in colorectal cancer.
Author:	Martin, Timothy D\|Der, Channing J
PMID:	22790202

158.
Journal:	PLoS One. 2012;7(7):e41343.
Title:	BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.
Author:	Lau, Ken S\|Zhang, Tinghu\|Kendall, Krystle R\|Lauffenburger, Douglas\|Gray, Nathanael S\|Haigis, Kevin M
PMID:	22815993

159.
Journal:	Carcinogenesis. 2012 Nov;33(11):2228-35.
Title:	PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.
Author:	Wang, Xiao\|Li, Xuebing\|Fan, Fengjuan\|Jiao, Shi\|Wang, Lingdi\|Zhu, Lu\|Pan, Yi\|Wu, Guohao\|Ling, Zhi-Qiang\|Fang, Jing\|Chen, Yan
PMID:	22828136

160.
Journal:	Cancer Biol Ther. 2012 Nov;13(13):1235-43.
Title:	K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
Author:	Stec, Rafal\|Bodnar, Lubomir\|Charkiewicz, Radoslaw\|Korniluk, Jan\|Rokita, Marta\|Smoter, Marta\|Ciechowicz, Marzena\|Chyczewski, Lech\|Niklinski, Jacek\|Kozlowski, Wojciech\|Szczylik, Cezary
PMID:	22909976

161.
Journal:	Int J Oncol. 2012 Nov;41(5):1855-62.
Title:	Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells.
Author:	Subramanian, Romesh R\|Yamakawa, Akio
PMID:	22922669

162.
Journal:	Arch Pathol Lab Med. 2012 Sep;136(9):983-92.
Title:	High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed, paraffin-embedded tissues.
Author:	Ney, Jasmin Teresa\|Froehner, Stefanie\|Roesler, Angelika\|Buettner, Reinhard\|Merkelbach-Bruse, Sabine
PMID:	22938585

163.
Journal:	Curr Med Chem. 2012;19(33):5735-44.
Title:	Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules.
Author:	Efferth, T
PMID:	23033949

164.
Journal:	Cancer Biol Ther. 2012 Dec;13(14):1390-5.
Title:	A LIN28B polymorphism predicts for colon cancer survival.
Author:	Ye, Yuanqing\|Madison, Blair\|Wu, Xifeng\|Rustgi, Anil K
PMID:	23052130

165.
Journal:	World J Gastroenterol. 2012 Oct 21;18(39):5551-9.
Title:	MUC5AC/beta-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.
Author:	Nakae, Kosaburo\|Mitomi, Hiroyuki\|Saito, Tsuyoshi\|Takahashi, Michiko\|Morimoto, Takashi\|Hidaka, Yasuhiro\|Sakamoto, Naoto\|Yao, Takashi\|Watanabe, Sumio
PMID:	23112547

166.
Journal:	Gan To Kagaku Ryoho. 2012 Nov;39(11):1618-25.
Title:	[Predictive biomarkers for anti-EGFR antibodies].
Author:	Bando, Hideaki\|Yoshino, Takayuki
PMID:	23152013

167.
Journal:	Zhonghua Bing Li Xue Za Zhi. 2012 Sep;41(9):584-9.
Title:	[KRAS and BRAF gene mutations in correlation with clinicopathologic features of colorectal carcinoma in Chinese].
Author:	Zhu, Xiao-li\|Cai, Xu\|Zhang, Ling\|Yang, Fei\|Sheng, Wei-qi\|Lu, Yong-ming\|Du, Xiang\|Zhou, Xiao-yan
PMID:	23157824

168.
Journal:	Nihon Rinsho. 2012 Dec;70(12):2152-8.
Title:	[Anti-EGFR antibody therapy for colorectal cancer].
Author:	Ishikawa, Toshiaki\|Uetake, Hiroyuki\|Sugihara, Kenichi
PMID:	23259389

169.
Journal:	BMC Cancer. 2012 Dec 21;12:612.
Title:	Alternative dosing of dual PI3K and MEK inhibition in cancer therapy.
Author:	Jokinen, Elina\|Laurila, Niina\|Koivunen, Jussi P
PMID:	23259591

170.
Journal:	Asian Pac J Cancer Prev. 2012;13(11):5599-603.
Title:	Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients.
Author:	Tong, Lin\|Yang, Xue-Xi\|Liu, Min-Feng\|Yao, Guang-Yu\|Dong, Jian-Yu\|Ye, Chang-Sheng\|Li, Ming
PMID:	23317280

171.
Journal:	World J Nucl Med. 2012 May;11(2):65-9.
Title:	(18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors.
Author:	Desar, Ingrid M E\|Gilles, Rozemarie\|van Herpen, Carla M L\|Timmer-Bonte, Anja J N H\|Cantarini, Mireille V\|van der Graaf, Winette T A\|Oyen, Wim J G
PMID:	23372439

172.
Journal:	Int J Colorectal Dis. 2013 Mar;28(3):385-98.
Title:	Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft--no benefit of combination therapy.
Author:	Wehler, Thomas C\|Hamdi, Swaantje\|Maderer, Annett\|Graf, Claudine\|Gockel, Ines\|Schmidtmann, Irene\|Hainz, Michael\|Berger, Martin R\|Theobald, Matthias\|Galle, Peter R\|Moehler, Markus\|Schimanski, Carl C
PMID:	22983756

173.
Journal:	J Gastroenterol. 2013 Mar;48(3):350-9.
Title:	Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway.
Author:	Wu, Keng-Liang\|Huang, Eng-Yen\|Jhu, En-Wei\|Huang, Ya-Hui\|Su, Wen-Hong\|Chuang, Pei-Chin\|Yang, Kuender D
PMID:	23015305

174.
Journal:	Hum Pathol. 2013 May;44(5):829-36.
Title:	Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: loss of PTEN is associated with worse clinical outcome.
Author:	Bettstetter, Marcus\|Berezowska, Sabina\|Keller, Gisela\|Walch, Axel\|Feuchtinger, Annette\|Slotta-Huspenina, Julia\|Feith, Marcus\|Drecoll, Enken\|Hofler, Heinz\|Langer, Rupert
PMID:	23158210

175.
Journal:	Phytother Res. 2013 Oct;27(10):1481-8.
Title:	Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin.
Author:	Kim, Ho Young\|Jung, Sung Keun\|Byun, Sanguine\|Son, Joe Eun\|Oh, Mi Hyun\|Lee, Jihoon\|Kang, Min Jeong\|Heo, Yong-Seok\|Lee, Ki Won\|Lee, Hyong Joo
PMID:	23172826

176.
Journal:	Mol Cancer Res. 2013 Feb;11(2):109-21.
Title:	Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Author:	Tabusa, Hana\|Brooks, Teresa\|Massey, Andrew J
PMID:	23233484

177.
Journal:	Int J Cancer. 2013 Aug 1;133(3):590-6.
Title:	Alternative splicing of BRAF transcripts and characterization of C-terminally truncated B-Raf isoforms in colorectal cancer.
Author:	Hirschi, Benjamin\|Kolligs, Frank T
PMID:	23354951

178.
Journal:	Cancer Discov. 2013 May;3(5):520-33.
Title:	Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Author:	Montero-Conde, Cristina\|Ruiz-Llorente, Sergio\|Dominguez, Jose M\|Knauf, Jeffrey A\|Viale, Agnes\|Sherman, Eric J\|Ryder, Mabel\|Ghossein, Ronald A\|Rosen, Neal\|Fagin, James A
PMID:	23365119

179.
Journal:	BMC Cancer. 2013 Feb 2;13:49.
Title:	Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes.
Author:	Pentheroudakis, George\|Kotoula, Vassiliki\|De Roock, Wendy\|Kouvatseas, George\|Papakostas, Pavlos\|Makatsoris, Thomas\|Papamichael, Demetris\|Xanthakis, Ioannis\|Sgouros, Joseph\|Televantou, Despina\|Kafiri, Georgia\|Tsamandas, Athanassios C\|Razis, Evangelia\|Galan
PMID:	23374602

180.
Journal:	BMC Cancer. 2013 Apr 1;13:169.
Title:	High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.
Author:	Guedes, Joana G\|Veiga, Isabel\|Rocha, Patricia\|Pinto, Pedro\|Pinto, Carla\|Pinheiro, Manuela\|Peixoto, Ana\|Fragoso, Maria\|Raimundo, Ana\|Ferreira, Paula\|Machado, Manuela\|Sousa, Nuno\|Lopes, Paula\|Araujo, Antonio\|Macedo, Joana\|Alves, Fernando\|Coutinho, Camila\|He
PMID:	23548132

181.
Journal:	Dev Biol. 2013 Jun 15;378(2):122-40.
Title:	APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
Author:	Wang, Chenhui\|Zhao, Rui\|Huang, Pin\|Yang, Fu\|Quan, Zhenghui\|Xu, Na\|Xi, Rongwen
PMID:	23570874

182.
Journal:	Magy Onkol. 2013 Mar;57(1):56-62.
Title:	[Biomarkers in solid tumors].
Author:	Nagy, Zsuzsanna
PMID:	23573523

183.
Journal:	Cancer Manag Res. 2013 Apr 12;5:49-55.
Title:	Critical appraisal of the use of regorafenib in the management of colorectal cancer.
Author:	Festino, Lucia\|Fabozzi, Alessio\|Manzo, Anna\|Gambardella, Valentina\|Martinelli, Erika\|Troiani, Teresa\|De Vita, Ferdinando\|Orditura, Michele\|Ciardiello, Fortunato\|Morgillo, Floriana
PMID:	23610528

184.
Journal:	Int J Cancer. 2013 Nov;133(9):2089-101.
Title:	Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.
Author:	Martinelli, Erika\|Troiani, Teresa\|D'Aiuto, Elena\|Morgillo, Floriana\|Vitagliano, Donata\|Capasso, Anna\|Costantino, Sarah\|Ciuffreda, Loreta Pia\|Merolla, Francesco\|Vecchione, Loredana\|De Vriendt, Veerle\|Tejpar, Sabine\|Nappi, Anna\|Sforza, Vincenzo\|Martini, Giu
PMID:	23629727

185.
Journal:	Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.
Title:	In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Author:	Shima, Fumi\|Yoshikawa, Yoko\|Ye, Min\|Araki, Mitsugu\|Matsumoto, Shigeyuki\|Liao, Jingling\|Hu, Lizhi\|Sugimoto, Takeshi\|Ijiri, Yuichi\|Takeda, Azusa\|Nishiyama, Yuko\|Sato, Chie\|Muraoka, Shin\|Tamura, Atsuo\|Osoda, Tsutomu\|Tsuda, Ken-ichiro\|Miyakawa, Tomoya\|Fukunis
PMID:	23630290

186.
Journal:	Expert Opin Investig Drugs. 2013 Jun;22(6):739-49.
Title:	Phase I/II RAF kinase inhibitors in cancer therapy.
Author:	Turajlic, Samra\|Ali, Zohra\|Yousaf, Nadia\|Larkin, James
PMID:	23642225

187.
Journal:	JAMA. 2013 Jun 26;309(24):2563-71.
Title:	Aspirin use and risk of colorectal cancer according to BRAF mutation status.
Author:	Nishihara, Reiko\|Lochhead, Paul\|Kuchiba, Aya\|Jung, Seungyoun\|Yamauchi, Mai\|Liao, Xiaoyun\|Imamura, Yu\|Qian, Zhi Rong\|Morikawa, Teppei\|Wang, Molin\|Spiegelman, Donna\|Cho, Eunyoung\|Giovannucci, Edward\|Fuchs, Charles S\|Chan, Andrew T\|Ogino, Shuji
PMID:	23800934

188.
Journal:	Virchows Arch. 2013 Oct;463(4):509-23.
Title:	Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis.
Author:	Neumann, Jens\|Wehweck, Laura\|Maatz, Susanne\|Engel, Jutta\|Kirchner, Thomas\|Jung, Andreas
PMID:	23934607

189.
Journal:	Clin Chem. 2013 Dec;59(12):1722-31.
Title:	Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients.
Author:	Taly, Valerie\|Pekin, Deniz\|Benhaim, Leonor\|Kotsopoulos, Steve K\|Le Corre, Delphine\|Li, Xinyu\|Atochin, Ivan\|Link, Darren R\|Griffiths, Andrew D\|Pallier, Karine\|Blons, Helene\|Bouche, Olivier\|Landi, Bruno\|Hutchison, J Brian\|Laurent-Puig, Pierre
PMID:	23938455

190.
Journal:	Med Oncol. 2013;30(3):686.
Title:	Pattern of clinically relevant mutations in consecutive series of Russian colorectal cancer patients.
Author:	Yanus, Grigoriy A\|Belyaeva, Anna V\|Ivantsov, Alexandr O\|Kuligina, Ekatherina Sh\|Suspitsin, Evgeny N\|Mitiushkina, Natalia V\|Aleksakhina, Svetlana N\|Iyevleva, Aglaya G\|Zaitseva, Olga A\|Yatsuk, Olga S\|Gorodnova, Tatiana V\|Strelkova, Tatiana N\|Efremova, Sofia
PMID:	23943423

191.
Journal:	APMIS. 2013 Oct;121(10):954-66.
Title:	Molecular alterations of Ras-Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt signaling pathways in colorectal cancers from a tertiary hospital at Kuala Lumpur, Malaysia.
Author:	Yip, Wai Kien\|Choo, Chee Wei\|Leong, Vincent Ching-Shian\|Leong, Pooi Pooi\|Jabar, Mohd Faisal\|Seow, Heng Fong
PMID:	23992303

192.
Journal:	Cancer Biol Ther. 2013 Oct 1;14(10):877-8.
Title:	Multi-kinase modulation for colon cancer therapy.
Author:	Dent, Paul
PMID:	24025253

193.
Journal:	Hum Pathol. 2013 Nov;44(11):2563-70.
Title:	Comparison of 2 monoclonal antibodies for immunohistochemical detection of BRAF V600E mutation in malignant melanoma, pulmonary carcinoma, gastrointestinal carcinoma, thyroid carcinoma, and gliomas.
Author:	Routhier, Caitlin Ann\|Mochel, Mark C\|Lynch, Kerry\|Dias-Santagata, Dora\|Louis, David N\|Hoang, Mai P
PMID:	24071017

194.
Journal:	Exp Mol Pathol. 2013 Dec;95(3):336-42.
Title:	B-Raf mutation: a key player in molecular biology of cancer.
Author:	Rahman, M A\|Salajegheh, A\|Smith, R A\|Lam, A K-Y
PMID:	24161954

195.
Journal:	Ann Pharmacother. 2013 Dec;47(12):1685-96.
Title:	Regorafenib: a novel multitargeted tyrosine kinase inhibitor for colorectal cancer and gastrointestinal stromal tumors.
Author:	Crona, Daniel J\|Keisler, Meredith D\|Walko, Christine M
PMID:	24259629

196.
Journal:	Front Oncol. 2013 Nov 15;3:281.
Title:	Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF.
Author:	Thiel, Alexandra\|Ristimaki, Ari
PMID:	24298448

197.
Journal:	Cancer Biol Ther. 2013 Dec;14(12):1075-6.
Title:	Not all antibodies are equal.
Author:	Booth, Laurence
PMID:	24317328

198.
Journal:	BMC Cancer. 2013 Dec 13;13:599.
Title:	The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer.
Author:	Huang, Ching-Wen\|Tsai, Hsiang-Lin\|Chen, Yi-Ting\|Huang, Chun-Ming\|Ma, Cheng-Jen\|Lu, Chien-Yu\|Kuo, Chao-Hung\|Wu, Deng-Chyang\|Chai, Chee-Yin\|Wang, Jaw-Yuan
PMID:	24330663

199.
Journal:	Mol Clin Oncol. 2013 Mar;1(2):291-296.
Title:	Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.
Author:	Tanaka, Toshio\|Ichikawa, Kazuhito\|Maruoka, Takashi\|Tomita, Shigeki\|Ueda, Hirofumi\|Yamaguchi, Takeshi\|Shida, Yosuke\|Kato, Hiroyuki\|Nagata, Hitoshi\|Kubota, Keiichi\|Akimoto, Naohiko\|Sakamoto, Chouitsu\|Imura, Johji\|Arita, Munefumi\|Tanaka, Hiroyuki\|Okamoto, Yo
PMID:	24649163

200.
Journal:	Gastroenterol Hepatol Bed Bench. 2013 Winter;6(1):6-13.
Title:	Clinical implications of BRAF mutation test in colorectal cancer.
Author:	Nazemalhosseini Mojarad, Ehsan\|Farahani, Roya Kishani\|Haghighi, Mahdi Montazer\|Aghdaei, Hamid Asadzadeh\|Kuppen, Peter Jk\|Zali, Mohammad Reza
PMID:	24834238

201.
Journal:	Enzymes. 2013;33 Pt A:213-48.
Title:	A two-hybrid approach to identify inhibitors of the RAS-RAF interaction.
Author:	Khazak, Vladimir\|Eyrisch, Susanne\|Kato, Juran\|Tamanoi, Fuyuhiko\|Golemis, Erica A
PMID:	25033807

202.
Journal:	Enzymes. 2013;34 Pt. B:1-23.
Title:	Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras.GTP-effector interaction.
Author:	Shima, Fumi\|Yoshikawa, Yoko\|Matsumoto, Shigeyuki\|Kataoka, Tohru
PMID:	25034098

203.
Journal:	Clin Gastroenterol Hepatol. 2014 Jan;12(1):139-44.
Title:	Personalizing therapy for colorectal cancer.
Author:	Wong, Ashley\|Ma, Brigette B Y
PMID:	24025538

204.
Journal:	Biochim Biophys Acta. 2014 Feb;1843(2):372-86.
Title:	CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.
Author:	Ellis, Blake C\|Graham, Lloyd D\|Molloy, Peter L
PMID:	24184209

205.
Journal:	Pharmacol Res. 2014 Jan;79:34-74.
Title:	The ErbB/HER family of protein-tyrosine kinases and cancer.
Author:	Roskoski, Robert Jr
PMID:	24269963

206.
Journal:	Tumour Biol. 2014 May;35(5):4377-80.
Title:	Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Author:	Wang, Qin\|Wu, Xiaodong\|Wu, Ting\|Li, Gui-mei\|Shi, Yi
PMID:	24420151

207.
Journal:	Cancer Biol Ther. 2014;15(2):147-8.
Title:	When to screen and not to screen.
Author:	Cruickshanks, Nichola
PMID:	24424112

208.
Journal:	Int J Clin Oncol. 2014 Apr;19(2):211-9.
Title:	Is biomarker research advancing in the era of personalized medicine for head and neck cancer?
Author:	Yokota, Tomoya
PMID:	24442754

209.
Journal:	Digestion. 2014;89(1):18-23.
Title:	Biomarkers for predicting the efficacy of anti-epidermal growth factor receptor antibody in the treatment of colorectal cancer.
Author:	Okada, Yasuyuki\|Miyamoto, Hiroshi\|Goji, Takahiro\|Takayama, Tetsuji
PMID:	24458108

210.
Journal:	Biochem Pharmacol. 2014 Mar 15;88(2):150-7.
Title:	Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway.
Author:	Li, Yuhua\|Sun, Yang\|Fan, Lei\|Zhang, Feng\|Meng, Jin\|Han, Jin\|Guo, Xin\|Zhang, Dian\|Zhang, Rong\|Yue, Zhenggang\|Mei, Qibing
PMID:	24462916

211.
Journal:	Mol Cancer. 2014 Feb 4;13:21.
Title:	Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status.
Author:	Gaur, Shikha\|Chen, Linling\|Ann, Vincent\|Lin, Wei-Chen\|Wang, Yafan\|Chang, Vincent H S\|Hsu, Nan Yong\|Shia, Her-Shuyong\|Yen, Yun
PMID:	24495750

212.
Journal:	Cancer. 2014 May 15;120(10):1482-90.
Title:	Mutational analysis and clinical correlation of metastatic colorectal cancer.
Author:	Russo, Andrea L\|Borger, Darrell R\|Szymonifka, Jackie\|Ryan, David P\|Wo, Jennifer Y\|Blaszkowsky, Lawrence S\|Kwak, Eunice L\|Allen, Jill N\|Wadlow, Raymond C\|Zhu, Andrew X\|Murphy, Janet E\|Faris, Jason E\|Dias-Santagata, Dora\|Haigis, Kevin M\|Ellisen, Leif W\|Iafr
PMID:	24500602

213.
Journal:	Gastroenterology. 2014 May;146(5):1301-12.e1-10.
Title:	PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Author:	Li, Xin\|Stevens, Payton D\|Liu, Jianyu\|Yang, Haihua\|Wang, Wei\|Wang, Chi\|Zeng, Zheng\|Schmidt, Micheal D\|Yang, Mike\|Lee, Eun Y\|Gao, Tianyan
PMID:	24530606

214.
Journal:	Gastrointest Cancer Res. 2014 Jan;7(1):23-6.
Title:	KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.
Author:	Kumar, Shalini Sree\|Price, Timothy J\|Mohyieldin, Omar\|Borg, Matthew\|Townsend, Amanda\|Hardingham, Jennifer E
PMID:	24558511

215.
Journal:	J Med Chem. 2014 Mar 27;57(6):2692-703.
Title:	Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib.
Author:	Cheng, Huimin\|Chang, Yu\|Zhang, Lianwen\|Luo, Jinfeng\|Tu, Zhengchao\|Lu, Xiaoyun\|Zhang, Qingwen\|Lu, Jibu\|Ren, Xiaomei\|Ding, Ke
PMID:	24588073

216.
Journal:	Nihon Rinsho. 2014 Jan;72(1):29-34.
Title:	[Perspective of personalized (precise) cancer therapy based on predictive biomarkers].
Author:	Osera, Shozo\|Yoshino, Takayuki
PMID:	24597345

217.
Journal:	J Clin Endocrinol Metab. 2014 Jul;99(7):E1163-72.
Title:	ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
Author:	Qiang, Wei\|Zhao, Yuan\|Yang, Qi\|Liu, Wei\|Guan, Haixia\|Lv, Siqing\|Ji, Meiju\|Shi, Bingyin\|Hou, Peng
PMID:	24684457

218.
Journal:	PLoS One. 2014 Apr 1;9(4):e92147.
Title:	Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status.
Author:	Pietrantonio, Filippo\|Maggi, Claudia\|Di Bartolomeo, Maria\|Facciorusso, Maria Grazia\|Perrone, Federica\|Testi, Adele\|Iacovelli, Roberto\|Miceli, Rosalba\|Bossi, Ilaria\|Leone, Giorgia\|Milione, Massimo\|Pelosi, Giuseppe\|de Braud, Filippo
PMID:	24691006

219.
Journal:	Recent Results Cancer Res. 2014;201:215-25.
Title:	Vemurafenib.
Author:	Garbe, Claus\|Abusaif, Sail\|Eigentler, Thomas K
PMID:	24756795

220.
Journal:	Rev Recent Clin Trials. 2014;9(1):8-12.
Title:	The Emerging Role of NRAS Mutations in Colorectal Cancer Patients Selected for Anti-EGFR Therapies.
Author:	Meriggi, Fausto\|Vermi, William\|Bertocchi, Paola\|Zaniboni, Alberto
PMID:	24758538

221.
Journal:	Clin Cancer Res. 2014 Jul 1;20(13):3472-84.
Title:	Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.
Author:	Chen, Dongshi\|Wei, Liang\|Yu, Jian\|Zhang, Lin
PMID:	24763611

222.
Journal:	Anticancer Res. 2014 May;34(5):2061-8.
Title:	Molecular biomarkers and classification models in the evaluation of the prognosis of colorectal cancer.
Author:	Sideris, Michail\|Papagrigoriadis, Savvas
PMID:	24778007

223.
Journal:	Clin Cancer Res. 2014 Jul 15;20(14):3775-86.
Title:	Primary and acquired resistance of colorectal cancer cells to anti-EGFR antibodies converge on MEK/ERK pathway activation and can be overcome by combined MEK/EGFR inhibition.
Author:	Troiani, Teresa\|Napolitano, Stefania\|Vitagliano, Donata\|Morgillo, Floriana\|Capasso, Anna\|Sforza, Vincenzo\|Nappi, Anna\|Ciardiello, Davide\|Ciardiello, Fortunato\|Martinelli, Erika
PMID:	24812410

224.
Journal:	Curr Opin Oncol. 2014 Jul;26(4):454-61.
Title:	Ras in digestive oncology: from molecular biology to clinical implications.
Author:	Charette, Nicolas\|Vandeputte, Caroline\|Starkel, Peter
PMID:	24849046

225.
Journal:	Mol Cancer. 2014 May 24;13:122.
Title:	Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells.
Author:	Hirschi, Benjamin\|Gallmeier, Eike\|Ziesch, Andreas\|Marschall, Maximilian\|Kolligs, Frank T
PMID:	24885690

226.
Journal:	Mol Oncol. 2014 Sep 12;8(6):1084-94.
Title:	Acquired resistance to EGFR-targeted therapies in colorectal cancer.
Author:	Van Emburgh, Beth O\|Sartore-Bianchi, Andrea\|Di Nicolantonio, Federica\|Siena, Salvatore\|Bardelli, Alberto
PMID:	24913799

227.
Journal:	J Cancer Res Clin Oncol. 2014 Nov;140(11):1863-71.
Title:	The BRAF mutation is associated with the prognosis in colorectal cancer.
Author:	Ahn, Tae Sung\|Jeong, Dongjun\|Son, Myoung Won\|Jung, Haeil\|Park, Soyoung\|Kim, Hyungjoo\|Bae, Sang Byung\|Kim, Han Jo\|Jeon, Young-Woo\|Lee, Moon Soo\|Baek, Moo-Jun
PMID:	24942334

228.
Journal:	Clin Cancer Res. 2014 Aug 15;20(16):4251-61.
Title:	Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.
Author:	Zimmer, Lisa\|Barlesi, Fabrice\|Martinez-Garcia, Maria\|Dieras, Veronique\|Schellens, Jan H M\|Spano, Jean-Philippe\|Middleton, Mark R\|Calvo, Emiliano\|Paz-Ares, Luiz\|Larkin, James\|Pacey, Simon\|Venturi, Miro\|Kraeber-Bodere, Francoise\|Tessier, Jean J L\|Eberhardt,
PMID:	24947927

229.
Journal:	Int J Oncol. 2014 Sep;45(3):1036-42.
Title:	Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.
Author:	Kang, Mi-Hye\|Kim, In-Hye\|Nam, Taek-Jeong
PMID:	24970012

230.
Journal:	PLoS One. 2014 Jul 8;9(7):e101889.
Title:	The study of a novel sorafenib derivative HLC-080 as an antitumor agent.
Author:	Tang, Ke\|Luo, Can\|Li, Yan\|Lu, Chenshu\|Zhou, Wanqi\|Huang, Haihong\|Chen, Xiaoguang
PMID:	25004130

231.
Journal:	Ann Oncol. 2014 Oct;25(10):1995-2001.
Title:	Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.
Author:	Missiaglia, E\|Jacobs, B\|D'Ario, G\|Di Narzo, A F\|Soneson, C\|Budinska, E\|Popovici, V\|Vecchione, L\|Gerster, S\|Yan, P\|Roth, A D\|Klingbiel, D\|Bosman, F T\|Delorenzi, M\|Tejpar, S
PMID:	25057166

232.
Journal:	Cancer Discov. 2014 Oct;4(10):1182-1197.
Title:	Development of siRNA payloads to target KRAS-mutant cancer.
Author:	Yuan, Tina L\|Fellmann, Christof\|Lee, Chih-Shia\|Ritchie, Cayde D\|Thapar, Vishal\|Lee, Liam C\|Hsu, Dennis J\|Grace, Danielle\|Carver, Joseph O\|Zuber, Johannes\|Luo, Ji\|McCormick, Frank\|Lowe, Scott W
PMID:	25100204

233.
Journal:	Cancer Biomark. 2014;14(5):389-400.
Title:	Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: a meta-analysis.
Author:	Yu, Min\|Wang, Qian\|Ding, Jiang-Wu\|Yang, Zhen\|Xie, Chuan\|Lu, Nong-Hua
PMID:	25171481

234.
Journal:	Mol Cancer. 2014 Aug 29;13:201.
Title:	Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.
Author:	El-Baba, Chirine\|Mahadevan, Vijayalakshmi\|Fahlbusch, Fabian B\|Mohan S, Suma\|Rau, Tilman T\|Gali-Muhtasib, Hala\|Schneider-Stock, Regine
PMID:	25174975

235.
Journal:	BMC Cancer. 2014 Nov 3;14:802.
Title:	BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients.
Author:	Chen, Jing\|Guo, Fang\|Shi, Xin\|Zhang, Lihua\|Zhang, Aifeng\|Jin, Hui\|He, Youji
PMID:	25367198

236.
Journal:	Oncol Res Treat. 2014;37(11):646-52.
Title:	Efficacy of triplet combination chemotherapy with oxaliplatin, irinotecan and capecitabine (OCX) in metastatic colorectal cancer in relation to RAS/RAF mutation status: results of a retrospective analysis.
Author:	Brunner, Stefan\|von Moos, Roger\|Mey, Ulrich\|Camenisch Gross, Ulrike\|Freyholdt, Tobias\|Cathomas, Richard
PMID:	25427581

237.
Journal:	Clin Colorectal Cancer. 2014 Dec;13(4):207-12.
Title:	Ganetespib, a novel Hsp90 inhibitor in patients with KRAS mutated and wild type, refractory metastatic colorectal cancer.
Author:	Cercek, Andrea\|Shia, Jinru\|Gollub, Marc\|Chou, Joanne F\|Capanu, Marinela\|Raasch, Pamela\|Reidy-Lagunes, Diane\|Proia, David A\|Vakiani, Efsevia\|Solit, David B\|Saltz, Leonard B
PMID:	25444464

238.
Journal:	Pak J Biol Sci. 2014 Apr;17(4):565-9.
Title:	High frequency of BRAF proto-oncogene hot spot mutation V600E in cohort of colorectal cancer patients from Ahvaz City, southwest Iran.
Author:	Asl, Javad Mohammadi\|Almasi, Shekoufeh\|Tabatabaiefar, Mohammad Amin
PMID:	25911848

239.
Journal:	Oncogene. 2015 Jan 22;34(4):531-6.
Title:	A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Author:	Bajpe, P K\|Prahallad, A\|Horlings, H\|Nagtegaal, I\|Beijersbergen, R\|Bernards, R
PMID:	24469059

240.
Journal:	Histopathology. 2015 Jan;66(1):49-65.
Title:	Colorectal serrated pathway cancers and precursors.
Author:	O'Brien, Michael J\|Zhao, Qing\|Yang, Shi
PMID:	25263173

241.
Journal:	Br J Cancer. 2015 Jan 20;112(2):403-12.
Title:	B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P.
Author:	Inoue, A\|Okamoto, K\|Fujino, Y\|Nakagawa, T\|Muguruma, N\|Sannomiya, K\|Mitsui, Y\|Takaoka, T\|Kitamura, S\|Miyamoto, H\|Okahisa, T\|Fujimori, T\|Imoto, I\|Takayama, T
PMID:	25314065

242.
Journal:	Cancer Chemother Pharmacol. 2015 Jan;75(1):17-23.
Title:	Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer.
Author:	Hochster, H S\|Uboha, N\|Messersmith, W\|Gold, P J\|ONeil, B H\|Cohen, D\|Denlinger, C\|Cohen, S\|Leichman, C G\|Leichman, L\|Lenz, H-J
PMID:	25322874

243.
Journal:	Tumour Biol. 2015 Feb;36(2):1313-21.
Title:	MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase.
Author:	Chai, Jie\|Wang, Shan\|Han, Dali\|Dong, Wei\|Xie, Chao\|Guo, Hongliang
PMID:	25355599

244.
Journal:	Cancer Res. 2015 Jan 1;75(1):216-29.
Title:	B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells.
Author:	Herr, Ricarda\|Kohler, Martin\|Andrlova, Hana\|Weinberg, Florian\|Moller, Yvonne\|Halbach, Sebastian\|Lutz, Lisa\|Mastroianni, Justin\|Klose, Martin\|Bittermann, Nicola\|Kowar, Silke\|Zeiser, Robert\|Olayioye, Monilola A\|Lassmann, Silke\|Busch, Hauke\|Boerries, Melanie
PMID:	25381152

245.
Journal:	Clin Cancer Res. 2015 Mar 15;21(6):1313-20.
Title:	Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients.
Author:	Yaeger, Rona\|Cercek, Andrea\|O'Reilly, Eileen M\|Reidy, Diane L\|Kemeny, Nancy\|Wolinsky, Tamar\|Capanu, Marinela\|Gollub, Marc J\|Rosen, Neal\|Berger, Michael F\|Lacouture, Mario E\|Vakiani, Efsevia\|Saltz, Leonard B
PMID:	25589621

246.
Journal:	Invest New Drugs. 2015 Jun;33(3):720-8.
Title:	Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer.
Author:	Do, Khanh\|Speranza, Giovanna\|Bishop, Rachel\|Khin, Sonny\|Rubinstein, Larry\|Kinders, Robert J\|Datiles, Manuel\|Eugeni, Michelle\|Lam, Michael H\|Doyle, L Austin\|Doroshow, James H\|Kummar, Shivaani
PMID:	25637165

247.
Journal:	Cancer Discov. 2015 Apr;5(4):358-67.
Title:	Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.
Author:	Ahronian, Leanne G\|Sennott, Erin M\|Van Allen, Eliezer M\|Wagle, Nikhil\|Kwak, Eunice L\|Faris, Jason E\|Godfrey, Jason T\|Nishimura, Koki\|Lynch, Kerry D\|Mermel, Craig H\|Lockerman, Elizabeth L\|Kalsy, Anuj\|Gurski, Joseph M Jr\|Bahl, Samira\|Anderka, Kristin\|Green,
PMID:	25673644

248.
Journal:	Mol Cancer Res. 2015 Jun;13(6):1003-8.
Title:	AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.
Author:	Hechtman, Jaclyn F\|Sadowska, Justyna\|Huse, Jason T\|Borsu, Laetitia\|Yaeger, Rona\|Shia, Jinru\|Vakiani, Efsevia\|Ladanyi, Marc\|Arcila, Maria E
PMID:	25714871

249.
Journal:	Front Oncol. 2015 Mar 3;5:54.
Title:	Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas.
Author:	Penman, Catherine Louise\|Faulkner, Claire\|Lowis, Stephen P\|Kurian, Kathreena M
PMID:	25785246

250.
Journal:	Am J Pathol. 2015 Apr;185(4):1135-44.
Title:	Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author:	Peng, Hui\|Li, Tony W H\|Yang, Heping\|Moyer, Mary P\|Mato, Jose M\|Lu, Shelly C
PMID:	25794709

251.
Journal:	Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1724-33.
Title:	Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.
Author:	Yu, Bing\|Swatkoski, Stephen\|Holly, Alesia\|Lee, Liam C\|Giroux, Valentin\|Lee, Chih-Shia\|Hsu, Dennis\|Smith, Jordan L\|Yuen, Garmen\|Yue, Junqiu\|Ann, David K\|Simpson, R Mark\|Creighton, Chad J\|Figg, William D\|Gucek, Marjan\|Luo, Ji
PMID:	25805818

252.
Journal:	Clin Cancer Res. 2015 Jul 1;21(13):2975-83.
Title:	Primary and Acquired Resistance of Colorectal Cancer to Anti-EGFR Monoclonal Antibody Can Be Overcome by Combined Treatment of Regorafenib with Cetuximab.
Author:	Napolitano, Stefania\|Martini, Giulia\|Rinaldi, Barbara\|Martinelli, Erika\|Donniacuo, Maria\|Berrino, Liberato\|Vitagliano, Donata\|Morgillo, Floriana\|Barra, Giusy\|De Palma, Raffaele\|Merolla, Francesco\|Ciardiello, Fortunato\|Troiani, Teresa
PMID:	25838391

253.
Journal:	Eur J Med Chem. 2015 May 5;95:453-63.
Title:	Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives.
Author:	Abdel-Maksoud, Mohammed S\|Kim, Mi-Ryeong\|El-Gamal, Mohammed I\|Gamal El-Din, Mahmoud M\|Tae, Jinsung\|Choi, Hong Seok\|Lee, Kyung-Tae\|Yoo, Kyung Ho\|Oh, Chang-Hyun
PMID:	25841200

254.
Journal:	Cancer Discov. 2015 Apr;5(4):348-50.
Title:	Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling.
Author:	Meador, Catherine B\|Pao, William
PMID:	25847954

255.
Journal:	Clin Colorectal Cancer. 2015 Sep;14(3):154-61.
Title:	A Phase II Study of Sorafenib Combined With Cetuximab in EGFR-Expressing, KRAS-Mutated Metastatic Colorectal Cancer.
Author:	Do, Khanh\|Cao, Liang\|Kang, Zhigang\|Turkbey, Baris\|Lindenberg, Maria L\|Larkins, Erin\|Holkova, Beata\|Steinberg, Seth M\|Raffeld, Mark\|Peer, Cody J\|Figg, William D\|Eugeni, Michelle\|Jacobs, Paula\|Choyke, Peter\|Wright, John J\|Doroshow, James H\|Kummar, Shivaani
PMID:	25861837

256.
Journal:	Mol Cancer. 2015 Apr 11;14:80.
Title:	Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma.
Author:	Chow, Ariel K M\|Cheng, Nathan S M\|Lam, Colin S C\|Ng, Lui\|Wong, Sunny K M\|Wan, Timothy M H\|Man, Johnny H W\|Cheung, Alvin H K\|Yau, Thomas C C\|Poon, Jensen T C\|Law, Wai-Lun\|Pang, Roberta W C
PMID:	25884645

257.
Journal:	BMC Cancer. 2015 Apr 8;15:240.
Title:	HGUE-C-1 is an atypical and novel colon carcinoma cell line.
Author:	Grasso, Silvina\|Martinez-Lacaci, Isabel\|Barbera, Victor Manuel\|Castillejo, Adela\|Soto, Jose Luis\|Gallego-Plazas, Javier\|Lopez-Riquelme, Natividad\|Garcia-Morales, Pilar\|Mata-Balaguer, Trinidad\|Ferragut, Jose Antonio\|Saceda, Miguel
PMID:	25885658

258.
Journal:	J Surg Oncol. 2015 Jun;111(7):905-10.
Title:	Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers.
Author:	Lan, Yuan-Tzu\|Jen-Kou, Lin\|Lin, Chien-Hsing\|Yang, Shung-Haur\|Lin, Chun-Chi\|Wang, Huann-Sheng\|Chen, Wei-Shone\|Lin, Tzu-Chen\|Jiang, Jeng-Kai\|Chang, Shih-Ching
PMID:	25920435

259.
Journal:	Mol Oncol. 2015 Aug;9(7):1434-46.
Title:	KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.
Author:	Leiser, Dominic\|Medova, Michaela\|Mikami, Kei\|Nisa, Lluis\|Stroka, Deborah\|Blaukat, Andree\|Bladt, Friedhelm\|Aebersold, Daniel M\|Zimmer, Yitzhak
PMID:	25933688

260.
Journal:	ACS Med Chem Lett. 2015 Mar 18;6(5):543-7.
Title:	N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors.
Author:	Li, Yingjun\|Cheng, Huimin\|Zhang, Zhang\|Zhuang, Xiaoxi\|Luo, Jinfeng\|Long, Huoyou\|Zhou, Yang\|Xu, Yong\|Taghipouran, Rana\|Li, Dan\|Patterson, Adam\|Smaill, Jeff\|Tu, Zhengchao\|Wu, Donghai\|Ren, Xiaomei\|Ding, Ke
PMID:	26005530

261.
Journal:	Drug Resist Updat. 2015 May;20:39-70.
Title:	Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy.
Author:	De Mattia, Elena\|Cecchin, Erika\|Toffoli, Giuseppe
PMID:	26027741

262.
Journal:	Oncotarget. 2015 May 30;6(15):13334-46.
Title:	Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.
Author:	Gyorffy, Balazs\|Stelniec-Klotz, Iwona\|Sigler, Christian\|Kasack, Katharina\|Redmer, Torben\|Qian, Yu\|Schafer, Reinhold
PMID:	26033452

263.
Journal:	Mar Drugs. 2015 Jun 5;13(6):3625-39.
Title:	Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation.
Author:	Josse, Rozenn\|Zhang, Yong-Wei\|Giroux, Valentin\|Ghosh, Arun K\|Luo, Ji\|Pommier, Yves
PMID:	26058013

264.
Journal:	Cancer Treat Rev. 2015 Sep;41(8):671-9.
Title:	Rectal and colon cancer: Not just a different anatomic site.
Author:	Tamas, K\|Walenkamp, A M E\|de Vries, E G E\|van Vugt, M A T M\|Beets-Tan, R G\|van Etten, B\|de Groot, D J A\|Hospers, G A P
PMID:	26145760

265.
Journal:	Mol Cancer Ther. 2015 Oct;14(10):2187-97.
Title:	BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Author:	Tang, Zhiyu\|Yuan, Xi\|Du, Rong\|Cheung, Shing-Hu\|Zhang, Guoliang\|Wei, Jing\|Zhao, Yuan\|Feng, Yingcai\|Peng, Hao\|Zhang, Yi\|Du, Yunguang\|Hu, Xiaoxia\|Gong, Wenfeng\|Liu, Yong\|Gao, Yajuan\|Liu, Ye\|Hao, Rui\|Li, Shengjian\|Wang, Shaohui\|Ji, Jiafu\|Zhang, Lianhai\|Li, Sh
PMID:	26208524

266.
Journal:	Oncotarget. 2015 Aug 28;6(25):20785-800.
Title:	Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance.
Author:	Morkel, Markus\|Riemer, Pamela\|Blaker, Hendrik\|Sers, Christine
PMID:	26299805

267.
Journal:	Nat Commun. 2015 Aug 24;6:8022.
Title:	Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.
Author:	Song, Wei\|Liu, Wenjie\|Zhao, Hong\|Li, Shangze\|Guan, Xin\|Ying, Jianming\|Zhang, Yefan\|Miao, Fei\|Zhang, Mengmeng\|Ren, Xiaoxia\|Li, Xiaolu\|Wu, Fan\|Zhao, Yuechao\|Tian, Yuanyuan\|Wu, Wenming\|Fu, Jun\|Liang, Junbo\|Wu, Wei\|Liu, Changzheng\|Yu, Jia\|Zong, Shudong\|Miao,
PMID:	26300397

268.
Journal:	Bioorg Med Chem Lett. 2015 Oct 1;25(19):4287-92.
Title:	Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway.
Author:	Diez-Cecilia, Elena\|Carson, Robert\|Kelly, Brendan\|van Schaeybroeck, Sandra\|Murray, James T\|Rozas, Isabel
PMID:	26318998

269.
Journal:	Cancer Lett. 2015 Dec 28;369(2):368-75.
Title:	Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells.
Author:	Henriques, Andreia F A\|Barros, Patricia\|Moyer, Mary Pat\|Matos, Paulo\|Jordan, Peter
PMID:	26341689

270.
Journal:	Mol Cancer Ther. 2015 Dec;14(12):2700-11.
Title:	Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.
Author:	Whittaker, Steven R\|Cowley, Glenn S\|Wagner, Steve\|Luo, Flora\|Root, David E\|Garraway, Levi A
PMID:	26351322

271.
Journal:	J Exp Clin Cancer Res. 2015 Oct 1;34:108.
Title:	Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.
Author:	Giordano, Guido\|Febbraro, Antonio\|Tomaselli, Eugenio\|Sarnicola, Maria Lucia\|Parcesepe, Pietro\|Parente, Domenico\|Forte, Nicola\|Fabozzi, Alessio\|Remo, Andrea\|Bonetti, Andrea\|Manfrin, Erminia\|Ghasemi, Somayehsadat\|Ceccarelli, Michele\|Cerulo, Luigi\|Bazzoni, F
PMID:	26427914

272.
Journal:	Genom Data. 2015 Apr 28;4:158-61.
Title:	Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines.
Author:	Boerries, Melanie\|Herr, Ricarda\|Brummer, Tilman\|Busch, Hauke
PMID:	26484206

273.
Journal:	Gan To Kagaku Ryoho. 2015 Nov;42(12):2215-7.
Title:	[A Case of Serrated Polyposis Syndrome with Early Colon Cancer].
Author:	Suzuki, Okihide\|Chika, Noriyasu\|Tachikawa, Tetsuhiko\|Aoyagi, Nobuhiko\|Eguchi, Hidetaka\|Kumamoto, Kensuke\|Mochiki, Erito\|Miura, Ichiro\|Yao, Takashi\|Ishida, Hideyuki
PMID:	26805315

274.
Journal:	J Pathol Clin Res. 2014 Nov 5;1(1):3-17.
Title:	The molecular background of mucinous carcinoma beyond MUC2.
Author:	Hugen, Niek\|Simons, Michiel\|Halilovic, Altuna\|van der Post, Rachel S\|Bogers, Anna J\|Marijnissen-van Zanten, Monica Aj\|de Wilt, Johannes Hw\|Nagtegaal, Iris D
PMID:	27499889

275.
Journal:	Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):27-38.
Title:	RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Author:	Fang, Bingliang
PMID:	26350096

276.
Journal:	J Cell Physiol. 2016 May;231(5):1097-105.
Title:	Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells.
Author:	Mirone, Giovanna\|Perna, Stefania\|Shukla, Arvind\|Marfe, Gabriella
PMID:	26419617

277.
Journal:	Mini Rev Med Chem. 2016;16(5):345-57.
Title:	Past, Present, and Future of Targeting Ras for Cancer Therapies.
Author:	Tan, Zhi\|Zhang, Shuxing
PMID:	26423695

278.
Journal:	Future Oncol. 2016 Jan;12(1):25-30.
Title:	Targeting BRAF aberrations in advanced colorectal carcinoma: from bench to bedside.
Author:	Abdel-Rahman, Omar
PMID:	26616508

279.
Journal:	Mol Cancer Res. 2016 Mar;14(3):296-301.
Title:	Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.
Author:	Hechtman, Jaclyn F\|Zehir, Ahmet\|Yaeger, Rona\|Wang, Lu\|Middha, Sumit\|Zheng, Tao\|Hyman, David M\|Solit, David\|Arcila, Maria E\|Borsu, Laetitia\|Shia, Jinru\|Vakiani, Efsevia\|Saltz, Leonard\|Ladanyi, Marc
PMID:	26660078

280.
Journal:	Invest New Drugs. 2016 Apr;34(2):168-75.
Title:	A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.
Author:	Deming, Dustin A\|Cavalcante, Ludmila L\|Lubner, Sam J\|Mulkerin, Daniel L\|LoConte, Noelle K\|Eickhoff, Jens C\|Kolesar, Jill M\|Fioravanti, Suzanne\|Greten, Tim F\|Compton, Kathryn\|Doyle, Austin G\|Wilding, George\|Duffy, Austin\|Liu, Glenn
PMID:	26666244

281.
Journal:	Neoplasma. 2016;63(2):193-200.
Title:	Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice.
Author:	Liu, L\|Qiu, S\|Liu, Y\|Liu, Z\|Zheng, Y\|Su, X\|Chen, B\|Chen, H
PMID:	26774139

282.
Journal:	J Clin Pathol. 2016 Sep;69(9):767-71.
Title:	Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases.
Author:	Malapelle, Umberto\|Pisapia, Pasquale\|Sgariglia, Roberta\|Vigliar, Elena\|Biglietto, Maria\|Carlomagno, Chiara\|Giuffre, Giuseppe\|Bellevicine, Claudio\|Troncone, Giancarlo
PMID:	26797410

283.
Journal:	Oncotarget. 2016 Feb 23;7(8):9188-221.
Title:	BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.
Author:	Goulielmaki, Maria\|Koustas, Evangelos\|Moysidou, Eirini\|Vlassi, Margarita\|Sasazuki, Takehiko\|Shirasawa, Senji\|Zografos, George\|Oikonomou, Eftychia\|Pintzas, Alexander
PMID:	26802026

284.
Journal:	Radiother Oncol. 2016 Feb;118(2):382-6.
Title:	Phase I study of pre-operative continuous 5-FU and sorafenib with external radiation therapy in locally advanced rectal adenocarcinoma.
Author:	Kim, Richard\|Prithviraj, Gopi Kesaria\|Shridhar, Ravi\|Hoffe, Sarah E\|Jiang, Kun\|Zhao, Xiuhua\|Chen, Dung-Tsa\|Almhanna, Khaldoun\|Strosberg, Jonathan\|Campos, Tiffany\|Shibata, David
PMID:	26861740

285.
Journal:	Cancer Genomics Proteomics. 2016 Mar-Apr;13(2):141-50.
Title:	GeneGazer: A Toolkit Integrating Two Pipelines for Personalized Profiling and Biosignature Identification.
Author:	Luo, Ji-Dung\|Chang, Yu-Jia\|Chang, Chung-Ming\|You, Jeng-Fu\|Wei, Po-Li\|Chiou, Chiuan-Chian
PMID:	26912804

286.
Journal:	Mol Cancer Ther. 2016 Mar;15(3):354-65.
Title:	A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.
Author:	Waizenegger, Irene C\|Baum, Anke\|Steurer, Steffen\|Stadtmuller, Heinz\|Bader, Gerd\|Schaaf, Otmar\|Garin-Chesa, Pilar\|Schlattl, Andreas\|Schweifer, Norbert\|Haslinger, Christian\|Colbatzky, Florian\|Mousa, Sien\|Kalkuhl, Arno\|Kraut, Norbert\|Adolf, Gunther R
PMID:	26916115

287.
Journal:	Asian Pac J Cancer Prev. 2016;17(2):743-8.
Title:	Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Author:	Yousef, Amany I\|El-Masry, Omar S\|Abdel Mohsen, Mohamed A
PMID:	26925673

288.
Journal:	Clin Cancer Res. 2016 Mar 1;22(5):1173-1184.
Title:	PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor.
Author:	Shi, Liangrong\|Chen, Lujun\|Wu, Changping\|Zhu, Yibei\|Xu, Bin\|Zheng, Xiao\|Sun, Mingfen\|Wen, Wen\|Dai, Xichao\|Yang, Min\|Lv, Quansheng\|Lu, Binfeng\|Jiang, Jingting
PMID:	26933175

289.
Journal:	Mol Cancer. 2016 Mar 8;15:22.
Title:	ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells.
Author:	Thamkachy, Reshma\|Kumar, Rohith\|Rajasekharan, K N\|Sengupta, Suparna
PMID:	26956619

290.
Journal:	Cell Cycle. 2016;15(4):506-18.
Title:	Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author:	Lochhead, Pamela A\|Clark, Jonathan\|Wang, Lan-Zhen\|Gilmour, Lesley\|Squires, Matthew\|Gilley, Rebecca\|Foxton, Caroline\|Newell, David R\|Wedge, Stephen R\|Cook, Simon J
PMID:	26959608

291.
Journal:	Proteomics. 2016 May;16(10):1557-69.
Title:	Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.
Author:	Tai, William Chi-Shing\|Wong, Wing-Yan\|Lee, Magnolia Muk-Lan\|Chan, Brandon Dow\|Lu, Cheng\|Hsiao, Wen-Luan Wendy
PMID:	26970558

292.
Journal:	J Cancer Res Ther. 2016 Jan-Mar;12(1):96-102.
Title:	The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status.
Author:	Akman, Tulay\|Oztop, Ilhan\|Baskin, Yasemin\|Unek, Ilkay Tugba\|Demir, Necla\|Ellidokuz, Hulya\|Yilmaz, Ahmet Ugur
PMID:	27072218

293.
Journal:	Medicine (Baltimore). 2016 Apr;95(15):e3321.
Title:	MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers.
Author:	Choi, Yong Won\|Song, Young Soo\|Lee, Hyunwoo\|Yi, Kijong\|Kim, Young-Bae\|Suh, Kwang Wook\|Lee, Dakeun
PMID:	27082577

294.
Journal:	Sci Rep. 2016 Apr 20;6:24720.
Title:	miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling.
Author:	El-Daly, Sherien M\|Abba, Mohammed L\|Patil, Nitin\|Allgayer, Heike
PMID:	27095166

295.
Journal:	Am J Transl Res. 2016 Feb 15;8(2):742-8. eCollection 2016.
Title:	BRD7: a novel tumor suppressor gene in different cancers.
Author:	Yu, Xin\|Li, Zheng\|Shen, Jianxiong
PMID:	27158366

296.
Journal:	Dev Reprod. 2016 Mar;20(1):1-10.
Title:	Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells.
Author:	Oh, Iljoong\|Cho, Hyunchul\|Lee, Yonghoon\|Cheon, Minseok\|Park, Deokbae\|Lee, Youngki
PMID:	27294206

297.
Journal:	Mol Cell Oncol. 2015 May 21;3(1):e1048405.
Title:	Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations.
Author:	Ahronian, Leanne G\|Corcoran, Ryan B
PMID:	27308562

298.
Journal:	Oncotarget. 2016 Jul 26;7(30):47699-47710.
Title:	BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells.
Author:	He, Kan\|Chen, Dongshi\|Ruan, Hang\|Li, Xiangyun\|Tong, Jingshan\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	27351224

299.
Journal:	Virchows Arch. 2016 Oct;469(4):459-64.
Title:	Challenging a dogma: co-mutations exist in MAPK pathway genes in colorectal cancer.
Author:	Grellety, Thomas\|Gros, Audrey\|Pedeutour, Florence\|Merlio, Jean-Philippe\|Duranton-Tanneur, Valerie\|Italiano, Antoine\|Soubeyran, Isabelle
PMID:	27401719

300.
Journal:	J Pharm Biomed Anal. 2016 Sep 10;129:142-147.
Title:	Determination of a novel B-Raf(V600E) and EGFR dual inhibitor in rat plasma by HPLC-MS/MS and its application in a pharmacokinetic study.
Author:	Zhou, Zhi-Ling\|Deng, Ji-Feng\|Li, Ying-Jun\|Chang, Yu\|Cheng, Hui-Min
PMID:	27423011

301.
Journal:	Exp Mol Med. 2016 Jul 29;48(7):e249.
Title:	Sur8 mediates tumorigenesis and metastasis in colorectal cancer.
Author:	Lee, Young-Mi\|Kaduwal, Saluja\|Lee, Kug Hwa\|Park, Jong-Chan\|Jeong, Woo-Jeong\|Choi, Kang-Yell
PMID:	27469030

302.
Journal:	Oncotarget. 2016 Oct 18;7(42):68546-68558.
Title:	Specific inhibition of p110alpha subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers.
Author:	Fernandes, Maria Sofia\|Melo, Soraia\|Velho, Sergia\|Carneiro, Patricia\|Carneiro, Fatima\|Seruca, Raquel
PMID:	27602501

303.
Journal:	World J Gastroenterol. 2016 Aug 21;22(31):7099-110.
Title:	Current understanding concerning intestinal stem cells.
Author:	Cui, Shuang\|Chang, Peng-Yu
PMID:	27610020

304.
Journal:	Mol Cancer Res. 2016 Dec;14(12):1204-1216.
Title:	MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling.
Author:	McNew, Kelsey L\|Whipple, William J\|Mehta, Anita K\|Grant, Trevor J\|Ray, Leah\|Kenny, Connor\|Singh, Anurag
PMID:	27655129

305.
Journal:	Oncologist. 2016 Nov;21(11):1306-1314.
Title:	Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer.
Author:	Rankin, Andrew\|Klempner, Samuel J\|Erlich, Rachel\|Sun, James X\|Grothey, Axel\|Fakih, Marwan\|George, Thomas J Jr\|Lee, Jeeyun\|Ross, Jeffrey S\|Stephens, Philip J\|Miller, Vincent A\|Ali, Siraj M\|Schrock, Alexa B
PMID:	27682134

306.
Journal:	Eur J Cancer. 2016 Nov;68:38-50.
Title:	6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells.
Author:	Zhao, Yueliang\|Fan, Daming\|Ru, Beibei\|Cheng, Ka-Wing\|Hu, Shuting\|Zhang, Jiangwen\|Li, Edmund T S\|Wang, Mingfu
PMID:	27710830

307.
Journal:	Sci Signal. 2016 Oct 11;9(449):rs11.
Title:	Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.
Author:	Simmons, Alan J\|Scurrah, Cherie R\|McKinley, Eliot T\|Herring, Charles A\|Irish, Jonathan M\|Washington, M Kay\|Coffey, Robert J\|Lau, Ken S
PMID:	27729552

308.
Journal:	Zhonghua Wei Chang Wai Ke Za Zhi. 2016 Oct 25;19(10):1197-1200.
Title:	[Research progress of serrated polyposis syndrome].
Author:	Dong, Shihao\|Chen, Jingsong
PMID:	27781259

309.
Journal:	Curr Oncol. 2016 Dec;23(6):e571-e575.
Title:	Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study.
Author:	Sheffield, B S\|Tessier-Cloutier, B\|Li-Chang, H\|Shen, Y\|Pleasance, E\|Kasaian, K\|Li, Y\|Jones, S J M\|Lim, H J\|Renouf, D J\|Huntsman, D G\|Yip, S\|Laskin, J\|Marra, M\|Schaeffer, D F
PMID:	28050146

310.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(12):2280-2282.
Title:	[A Systematic Analysis of Oncogene and Tumor Suppressor Genes for Panitumumab-Resistant Rectal Cancer with Wild RAS Gene - A Case Report].
Author:	Tajima, Yosuke\|Shimada, Yoshifumi\|Yagi, Ryoma\|Okamura, Takuma\|Nakano, Masato\|Kameyama, Hitoshi\|Nogami, Hitoshi\|Maruyama, Satoshi\|Takii, Yasumasa\|Miura, Kohei\|Ichikawa, Hiroshi\|Nagahashi, Masayuki\|Sakata, Jun\|Kobayashi, Takashi\|Wakai, Toshifumi
PMID:	28133295

311.
Journal:	Gan To Kagaku Ryoho. 2016 Nov;43(12):2307-2309.
Title:	[A Case of Metastatic Colorectal Cancer with HER2 Overexpression/Amplification].
Author:	Matsumoto, Akio\|Shimada, Yoshifumi\|Yagi, Ryoma\|Miura, Kohei\|Tajima, Yosuke\|Okamura, Takuma\|Nakano, Masato\|Kameyama, Hitoshi\|Nogami, Hitoshi\|Maruyama, Satoshi\|Takii, Yasumasa\|Ichikawa, Hiroshi\|Sakata, Jun\|Kobayashi, Takashi\|Wakai, Toshifumi
PMID:	28133304

312.
Journal:	Oncogene. 2017 Feb 9;36(6):787-796.
Title:	FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
Author:	Tong, J\|Tan, S\|Zou, F\|Yu, J\|Zhang, L
PMID:	27399335

313.
Journal:	Clin Cancer Res. 2017 Apr 15;23(8):2027-2037.
Title:	The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer.
Author:	Ma, Yufang\|Wang, Lihong\|Neitzel, Leif R\|Loganathan, Sudan N\|Tang, Nan\|Qin, Lili\|Crispi, Emily E\|Guo, Yan\|Knapp, Stefan\|Beauchamp, R Daniel\|Lee, Ethan\|Wang, Jialiang
PMID:	27678457

314.
Journal:	Int J Cancer. 2017 Feb 15;140(4):922-929.
Title:	EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer.
Author:	Algars, Annika\|Sundstrom, Jari\|Lintunen, Minnamaija\|Jokilehto, Terhi\|Kytola, Soili\|Kaare, Milja\|Vainionpaa, Reetta\|Orpana, Arto\|Osterlund, Pia\|Ristimaki, Ari\|Carpen, Olli\|Ristamaki, Raija
PMID:	27879995

315.
Journal:	Oncotarget. 2017 Jan 17;8(3):5048-5056.
Title:	FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway.
Author:	Li, Kun\|Guo, Qunfeng\|Yang, Jun\|Chen, Hui\|Hu, Kewen\|Zhao, Juan\|Zheng, Shunxin\|Pang, Xiufeng\|Zhou, Sufang\|Dang, Yongyan\|Li, Lei
PMID:	27926503

316.
Journal:	Oncotarget. 2017 Feb 7;8(6):9251-9266.
Title:	LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.
Author:	Vakana, Eliza\|Pratt, Susan\|Blosser, Wayne\|Dowless, Michele\|Simpson, Nicholas\|Yuan, Xiu-Juan\|Jaken, Susan\|Manro, Jason\|Stephens, Jennifer\|Zhang, Youyan\|Huber, Lysiane\|Peng, Sheng-Bin\|Stancato, Louis F
PMID:	27999210

317.
Journal:	Anticancer Res. 2017 Jan;37(1):239-247.
Title:	Metastatic Pattern of Stage IV Colorectal Cancer with High-Frequency Microsatellite Instability as a Prognostic Factor.
Author:	Fujiyoshi, Kenji\|Yamamoto, Gou\|Takenoya, Takashi\|Takahashi, Akemi\|Arai, Yoshiko\|Yamada, Mina\|Kakuta, Miho\|Yamaguchi, Kensei\|Akagi, Yoshito\|Nishimura, Yoji\|Sakamoto, Hirohiko\|Akagi, Kiwamu
PMID:	28011498

318.
Journal:	Oncotarget. 2017 Feb 7;8(6):9280-9292.
Title:	Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.
Author:	Li, Xiangyun\|Li, Mei\|Ruan, Hang\|Qiu, Wei\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	28030835

319.
Journal:	Cancer Sci. 2017 Mar;108(3):296-307.
Title:	Hepatocyte growth factor/MET in cancer progression and biomarker discovery.
Author:	Matsumoto, Kunio\|Umitsu, Masataka\|De Silva, Dinuka M\|Roy, Arpita\|Bottaro, Donald P
PMID:	28064454

320.
Journal:	Cancer Treat Rev. 2017 Feb;53:61-69.
Title:	Cancer resistance to therapies against the EGFR-RAS-RAF pathway: The role of MEK.
Author:	Martinelli, Erika\|Morgillo, Floriana\|Troiani, Teresa\|Ciardiello, Fortunato
PMID:	28073102

321.
Journal:	Br J Cancer. 2017 Feb 28;116(5):575-583.
Title:	A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor.
Author:	Bendell, Johanna C\|Javle, Milind\|Bekaii-Saab, Tanios S\|Finn, Richard S\|Wainberg, Zev A\|Laheru, Daniel A\|Weekes, Colin D\|Tan, Benjamin R\|Khan, Gazala N\|Zalupski, Mark M\|Infante, Jeffrey R\|Jones, Suzanne\|Papadopoulos, Kyriakos P\|Tolcher, Anthony W\|Chavira,
PMID:	28152546

322.
Journal:	Anticancer Res. 2017 Feb;37(2):651-657.
Title:	Comparative Study of Mutations in Single Nucleotide Polymorphism Loci of KRAS and BRAF Genes in Patients Who Underwent Screening Colonoscopy, With and Without Premalignant Intestinal Polyps.
Author:	Galanopoulos, Michail\|Papanikolaou, Ioannis S\|Zografos, Eleni\|Viazis, Nikos\|Papatheodoridis, George\|Karamanolis, Dimitrios\|Marinos, Evangelos\|Mantzaris, Gerassimos J\|Gazouli, Maria
PMID:	28179313

323.
Journal:	Mol Cancer Res. 2017 Jun;15(6):708-713.
Title:	Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.
Author:	Ptashkin, Ryan N\|Pagan, Carlos\|Yaeger, Rona\|Middha, Sumit\|Shia, Jinru\|O'Rourke, Kevin P\|Berger, Michael F\|Wang, Lu\|Cimera, Robert\|Wang, Jiajing\|Klimstra, David S\|Saltz, Leonard\|Ladanyi, Marc\|Zehir, Ahmet\|Hechtman, Jaclyn F
PMID:	28184012

324.
Journal:	Nat Commun. 2017 Feb 10;8:14262.
Title:	Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Author:	Schutte, Moritz\|Risch, Thomas\|Abdavi-Azar, Nilofar\|Boehnke, Karsten\|Schumacher, Dirk\|Keil, Marlen\|Yildiriman, Reha\|Jandrasits, Christine\|Borodina, Tatiana\|Amstislavskiy, Vyacheslav\|Worth, Catherine L\|Schweiger, Caroline\|Liebs, Sandra\|Lange, Martin\|Warnatz
PMID:	28186126

325.
Journal:	Eur J Cardiothorac Surg. 2017 Feb 1;51(2):255-262.
Title:	Perioperative bevacizumab improves survival following lung metastasectomy for colorectal cancer in patients harbouring v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue exon 2 codon 12 mutationsdagger.
Author:	Renaud, Stephane\|Schaeffer, Mickael\|Falcoz, Pierre-Emmanuel\|Seitlinger, Joseph\|Romain, Benoit\|Voegeli, Anne-Claire\|Legrain, Michele\|Reeb, Jeremie\|Santelmo, Nicola\|Rohr, Serge\|Brigand, Cecile\|Olland, Anne\|Guenot, Dominique\|Massard, Gilbert
PMID:	28186237

326.
Journal:	Mol Cell Proteomics. 2017 Apr;16(4):663-679.
Title:	Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.
Author:	Kubiniok, Peter\|Lavoie, Hugo\|Therrien, Marc\|Thibault, Pierre
PMID:	28188228

327.
Journal:	Cancer Lett. 2017 Jun 28;396:145-154.
Title:	Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.
Author:	Wang, Yi-Jun\|Zhang, Yun-Kai\|Zhang, Guan-Nan\|Al Rihani, Sweilem B\|Wei, Meng-Ning\|Gupta, Pranav\|Zhang, Xiao-Yu\|Shukla, Suneet\|Ambudkar, Suresh V\|Kaddoumi, Amal\|Shi, Zhi\|Chen, Zhe-Sheng
PMID:	28302530

328.
Journal:	Cancer Lett. 2017 Jun 28;396:94-102.
Title:	Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer.
Author:	Koustas, Evangelos\|Karamouzis, Michalis V\|Mihailidou, Chrysovalantou\|Schizas, Dimitrios\|Papavassiliou, Athanasios G
PMID:	28323034

329.
Journal:	Org Biomol Chem. 2017 Apr 18;15(16):3455-3465.
Title:	Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.
Author:	Wang, Lu\|Zhu, Gaoyuan\|Zhang, Qing\|Duan, Chunqi\|Zhang, Yanmin\|Zhang, Zhimin\|Zhou, Yujun\|Lu, Tao\|Tang, Weifang
PMID:	28368067

330.
Journal:	Cancer Med. 2017 May;6(5):928-936.
Title:	The prognostic value of simultaneous tumor and serum RAS/RAF mutations in localized colon cancer.
Author:	Thomsen, Caroline Emilie B\|Appelt, Ane Lindegaard\|Andersen, Rikke Fredslund\|Lindebjerg, Jan\|Jensen, Lars Henrik\|Jakobsen, Anders
PMID:	28378527

331.
Journal:	Cancer Immunol Immunother. 2017 Jul;66(7):927-939.
Title:	Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer.
Author:	Lee, Kyu Sang\|Kwak, Yoonjin\|Ahn, Soyeon\|Shin, Eun\|Oh, Heung-Kwon\|Kim, Duck-Woo\|Kang, Sung-Bum\|Choe, Gheeyoung\|Kim, Woo Ho\|Lee, Hye Seung
PMID:	28405764

332.
Journal:	Oncology (Williston Park). 2017 Apr 15;31(4):301-12.
Title:	Molecular Testing to Optimize and Personalize Decision Making in the Management of Colorectal Cancer.
Author:	Al-Hajeili, Marwan\|Shields, Anthony F\|Hwang, Jimmy J\|Wadlow, Raymond C\|Marshall, John L
PMID:	28412781

333.
Journal:	Oncol Lett. 2017 Mar;13(3):1379-1385.
Title:	Downregulation of RASAL2 promotes the proliferation, epithelial-mesenchymal transition and metastasis of colorectal cancer cells.
Author:	Jia, Zeming\|Liu, Weidong\|Gong, Liansheng\|Xiao, Zhongfu
PMID:	28454265

334.
Journal:	Pharmacol Res. 2017 Jul;121:202-212.
Title:	ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers.
Author:	Roskoski, Robert Jr
PMID:	28465216

335.
Journal:	Biochem Biophys Res Commun. 2017 Jul 15;489(1):14-20.
Title:	AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes.
Author:	Wang, Hongbin\|Quan, Haitian\|Lou, Liguang
PMID:	28536078

336.
Journal:	Oncol Lett. 2017 Jun;13(6):4720-4726.
Title:	Colorectal cancer in cases of multiple primary cancers: Clinical features of 59 cases and point mutation analyses.
Author:	Wu, Anshan\|He, Siqi\|Li, Jingjing\|Liu, Ling\|Liu, Chunlan\|Wang, Qi\|Peng, Xiaowei\|Zhou, Jianda\|Cao, Pei-Guo\|Cao, Ke
PMID:	28599473

337.
Journal:	Clin Cancer Res. 2017 Sep 15;23(18):5547-5560.
Title:	Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations.
Author:	Yao, Yung-Mae M\|Donoho, Gregory P\|Iversen, Philip W\|Zhang, Youyan\|Van Horn, Robert D\|Forest, Amelie\|Novosiadly, Ruslan D\|Webster, Yue Wang\|Ebert, Philip\|Bray, Steven\|Ting, Jason C\|Aggarwal, Amit\|Henry, James R\|Tiu, Ramon V\|Plowman, Gregory D\|Peng, Sheng-B
PMID:	28611205

338.
Journal:	Cancer Biother Radiopharm. 2017 Jun;32(5):149-160.
Title:	Molecular Targeted Drugs and Treatment of Colorectal Cancer: Recent Progress and Future Perspectives.
Author:	Geng, Fang\|Wang, Zheng\|Yin, Hang\|Yu, Junxian\|Cao, Bangwei
PMID:	28622036

339.
Journal:	Life Sci. 2017 Aug 15;183:37-44.
Title:	Discovery of a novel pan-RAF inhibitor with potent anti-tumor activity in preclinical models of BRAF(V600E) mutant cancer.
Author:	Hong, Sung Pyo\|Ahn, Soon Kil
PMID:	28645859

340.
Journal:	Mol Cancer Res. 2017 Oct;15(10):1431-1444.
Title:	BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Author:	Emery, Caroline M\|Monaco, Kelli-Ann\|Wang, Ping\|Balak, Marissa\|Freeman, Alyson\|Meltzer, Jodi\|Delach, Scott M\|Rakiec, Daniel\|Ruddy, David A\|Korn, Joshua M\|Haling, Jacob\|Acker, Michael G\|Caponigro, Giordano
PMID:	28655712

341.
Journal:	Int J Mol Sci. 2017 Jul 14;18(7). pii: ijms18071522.
Title:	Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment.
Author:	Bignucolo, Alessia\|De Mattia, Elena\|Cecchin, Erika\|Roncato, Rossana\|Toffoli, Giuseppe
PMID:	28708103

342.
Journal:	Ann Surg. 2017 Oct;266(4):610-616.
Title:	Understanding and Resetting Radiation Sensitivity in Rectal Cancer.
Author:	Kelley, Katherine A\|Ruhl, Rebecca A\|Rana, Shushan R\|Dewey, Elizabeth\|Espinosa, Cristina\|Thomas, Charles R Jr\|Martindale, Robert G\|Anand, Sudarshan\|Tsikitis, Vassiliki L
PMID:	28742699

343.
Journal:	Int J Mol Sci. 2017 Aug 29;18(9). pii: ijms18091871.
Title:	Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis.
Author:	Balc'h, Eric Le\|Grandin, Nathalie\|Demattei, Marie-Veronique\|Guyetant, Serge\|Tallet, Anne\|Pages, Jean-Christophe\|Ouaissi, Mehdi\|Lecomte, Thierry\|Charbonneau, Michel
PMID:	28850092

344.
Journal:	J Antibiot (Tokyo). 2017 Sep 6. pii: ja2017100.
Title:	A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.
Author:	Iijima, Masatomi\|Kubota, Yuji\|Sawa, Ryuichi\|Kubota, Yumiko\|Hatano, Masaki\|Igarashi, Masayuki\|Kawada, Manabu\|Momose, Isao\|Takekawa, Mutsuhiro\|Shibasaki, Masakatsu
PMID:	28874847

345.
Journal:	Cancer Res. 2017 Dec 1;77(23):6513-6523.
Title:	Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition.
Author:	Yaeger, Rona\|Yao, Zhan\|Hyman, David M\|Hechtman, Jaclyn F\|Vakiani, Efsevia\|Zhao, HuiYong\|Su, Wenjing\|Wang, Lu\|Joelson, Andrew\|Cercek, Andrea\|Baselga, Jose\|de Stanchina, Elisa\|Saltz, Leonard\|Berger, Michael F\|Solit, David B\|Rosen, Neal
PMID:	28951457

346.
Journal:	PLoS One. 2017 Oct 17;12(10):e0186271.
Title:	Colorectal carcinoma tumour budding and podia formation in the xenograft microenvironment.
Author:	Prall, Friedrich\|Maletzki, Claudia\|Huhns, Maja\|Krohn, Mathias\|Linnebacher, Michael
PMID:	29040282

347.
Journal:	Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Dec;161(4):360-368.
Title:	Derivation and basic characterization of colorectal carcinoma primary cell lines.
Author:	Krbal, Lukas\|Soukup, Jiri\|Stanislav, John\|Hanusova, Veronika
PMID:	29042709

348.
Journal:	Oncotarget. 2017 Aug 29;8(44):76574-76586.
Title:	Functional consequence of the p53 codon 72 polymorphism in colorectal cancer.
Author:	Katkoori, Venkat R\|Manne, Upender\|Chaturvedi, Lakshmi S\|Basson, Marc D\|Haan, Pam\|Coffey, Daniel\|Bumpers, Harvey L
PMID:	29100333

349.
Journal:	Oncol Lett. 2017 Nov;14(5):5221-5228.
Title:	Lack of microsatellite instability in gastrointestinal stromal tumors.
Author:	Campanella, Nathalia C\|Scapulatempo-Neto, Cristovam\|Abrahao-Machado, Lucas Faria\|Torres De Oliveira, Antonio Talvane\|Berardinelli, Gustavo N\|Guimaraes, Denise Peixoto\|Reis, Rui M
PMID:	29113157

350.
Journal:	Ann Gastroenterol. 2017;30(6):613-621.
Title:	Current and future biomarkers in colorectal cancer.
Author:	Zarkavelis, George\|Boussios, Stergios\|Papadaki, Alexandra\|Katsanos, Konstantinos H\|Christodoulou, Dimitrios K\|Pentheroudakis, George
PMID:	29118555

351.
Journal:	Cancer Cell Int. 2017 Oct 28;17:91.
Title:	miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1.
Author:	Wei, Wen-Ting\|Nian, Xin-Xin\|Wang, Shu-Yang\|Jiao, Hong-Li\|Wang, Yong-Xia\|Xiao, Zhi-Yuan\|Yang, Run-Wei\|Ding, Yan-Qing\|Ye, Ya-Ping\|Liao, Wen-Ting
PMID:	29118671

352.
Journal:	Oncotarget. 2017 Sep 27;8(62):105072-105080.
Title:	Targeted next generation sequencing in Chinese colorectal cancer patients guided anti-EGFR treatment and facilitated precision cancer medicine.
Author:	Hou, Helei\|Liu, Dong\|Zhang, Chuantao\|Jiang, Yanxia\|Lu, Guifang\|Zhou, Na\|Yang, Xiaonan\|Zhang, Xiaoping\|Li, Zhuokun\|Zhu, Hongmei\|Qian, Zhaoyang\|Zhang, Xiaochun
PMID:	29285234

353.
Journal:	Oncotarget. 2017 Dec 9;8(70):114663-114676.
Title:	EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function.
Author:	Huang, Ching-Wen\|Chen, Yi-Ting\|Tsai, Hsiang-Lin\|Yeh, Yung-Sung\|Su, Wei-Chih\|Ma, Cheng-Jen\|Tsai, Tsen-Ni\|Wang, Jaw-Yuan
PMID:	29383110

354.
Journal:	J Cell Physiol. 2018 Mar;233(3):2058-2066.
Title:	Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer.
Author:	Bahrami, Afsane\|Hassanian, Seyed Mahdi\|ShahidSales, Soodabeh\|Farjami, Zahra\|Hasanzadeh, Malihe\|Anvari, Kazem\|Aledavood, Amir\|Maftouh, Mina\|Ferns, Gordon A\|Khazaei, Majid\|Avan, Amir
PMID:	28262927

355.
Journal:	J Cell Physiol. 2018 Mar;233(3):2162-2169.
Title:	The therapeutic potential of targeting the BRAF mutation in patients with colorectal cancer.
Author:	Bahrami, Afsane\|Hesari, AmirReza\|Khazaei, Majid\|Hassanian, Seyed Mahdi\|Ferns, Gordon A\|Avan, Amir
PMID:	28407239

356.
Journal:	J Pharmacol Exp Ther. 2018 Jan;364(1):46-54.
Title:	Synergistic Antiproliferative Activity of the RAD51 Inhibitor IBR2 with Inhibitors of Receptor Tyrosine Kinases and Microtubule Protein.
Author:	Ferguson, Peter J\|Vincent, Mark D\|Koropatnick, James
PMID:	29061656

357.
Journal:	J Cell Biochem. 2018 Mar;119(3):2864-2874.
Title:	HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway.
Author:	Zhang, Xianxiang\|Liu, Guangwei\|Ding, Lei\|Jiang, Tao\|Shao, Shihong\|Gao, Yuan\|Lu, Yun
PMID:	29073728

358.
Journal:	Oncogene. 2018 Feb 22;37(8):1031-1040.
Title:	MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.
Author:	Schroyer, A L\|Stimes, N W\|Abi Saab, W F\|Chadee, D N
PMID:	29084209

359.
Journal:	Clin Colorectal Cancer. 2018 Mar;17(1):e69-e76.
Title:	Treatment and Survival Outcome of BRAF-Mutated Metastatic Colorectal Cancer: A Retrospective Matched Case-Control Study.
Author:	Kayhanian, Hamzeh\|Goode, Emily\|Sclafani, Francesco\|Ang, Joo Ern\|Gerlinger, Marco\|Gonzalez de Castro, David\|Shepherd, Scott\|Peckitt, Clare\|Rao, Sheela\|Watkins, David\|Chau, Ian\|Cunningham, David\|Starling, Naureen
PMID:	29129559

360.
Journal:	Biomed Pharmacother. 2018 Jan;97:1138-1146.
Title:	Identification and validation of cetuximab resistance associated long noncoding RNA biomarkers in metastatic colorectal cancer.
Author:	Peng, Ke\|Liu, Ruiqi\|Yu, Yiyi\|Liang, Li\|Yu, Shan\|Xu, Xiaojing\|Liu, Tianshu
PMID:	29136952

361.
Journal:	Mol Cancer Ther. 2018 Apr;17(4):806-813.
Title:	Wnt/beta-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer.
Author:	Chen, Guangming\|Gao, Chenxi\|Gao, Xuan\|Zhang, Dennis Han\|Kuan, Shih-Fan\|Burns, Timothy F\|Hu, Jing
PMID:	29167314

362.
Journal:	Pharmacol Rev. 2018 Jan;70(1):1-11.
Title:	RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.
Author:	Yan, Chao\|Theodorescu, Dan
PMID:	29196555

363.
Journal:	Oncol Rep. 2018 Mar;39(3):1516-1522.
Title:	Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author:	Kim, In-Hye\|Nam, Taek-Jeong
PMID:	29328495

364.
Journal:	Exp Mol Pathol. 2018 Feb;104(1):98-107.
Title:	MiR-142-5p act as an oncogenic microRNA in colorectal cancer: Clinicopathological and functional insights.
Author:	Islam, Farhadul\|Gopalan, Vinod\|Vider, Jelena\|Lu, Cu-Tai\|Lam, Alfred K-Y
PMID:	29337244

365.
Journal:	Med Sci Monit. 2018 Jan 17;24:332-341.
Title:	Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor.
Author:	Yang, Juanli\|Zhu, Tienian\|Zhao, Ruijing\|Gao, Dongmei\|Cui, Yujie\|Wang, Kun\|Guo, Yanli
PMID:	29339715

366.
Journal:	Cell Death Dis. 2018 Feb 13;9(2):217.
Title:	Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling.
Author:	Wang, Zhou\|Ma, Lingman\|Su, Mengqi\|Zhou, Yiran\|Mao, Ke\|Li, Chengqin\|Peng, Guangyong\|Zhou, Changlin\|Shen, Baiyong\|Dou, Jie
PMID:	29440765

367.
Journal:	Oncotarget. 2018 Jan 22;9(6):7271.
Title:	Correction: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.
Author:	Li, Xiangyun\|Li, Mei\|Ruan, Hang\|Qiu, Wei\|Xu, Xiang\|Lin, Zhang\|Yu, Jian
PMID:	29467964

368.
Journal:	Clin Colorectal Cancer. 2018 Jun;17(2):e331-e352.
Title:	Phosphorylation of p70 Ribosomal Protein S6 Kinase beta-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer.
Author:	Wiesweg, Marcel\|Reis, Henning\|Koster, Tobias\|Goetz, Moritz\|Worm, Karl\|Herold, Thomas\|Paul, Andreas\|Dechene, Alexander\|Schumacher, Brigitte\|Markus, Peter\|Virchow, Isabel\|Kostbade, Karina\|Wolf, Nathalie\|Zaun, Gregor\|Metzenmacher, Martin\|Schmid, Kurt W\|Schul
PMID:	29526493

369.
Journal:	Oncogene. 2018 Jun;37(24):3183-3199.
Title:	Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations.
Author:	Dankner, Matthew\|Rose, April A N\|Rajkumar, Shivshankari\|Siegel, Peter M\|Watson, Ian R
PMID:	29540830

370.
Journal:	Expert Rev Mol Diagn. 2018 Jun;18(6):499-512.
Title:	BRAF-mutant colorectal cancer, a different breed evolving.
Author:	Lai, Eleonora\|Pretta, Andrea\|Impera, Valentino\|Mariani, Stefano\|Giampieri, Riccardo\|Casula, Laura\|Pusceddu, Valeria\|Coni, Pierpaolo\|Fanni, Daniela\|Puzzoni, Marco\|Demurtas, Laura\|Ziranu, Pina\|Faa, Gavino\|Scartozzi, Mario
PMID:	29708446

371.
Journal:	Cancer. 2018 Aug 1;124(15):3145-3153.
Title:	Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome.
Author:	Adar, Tomer\|Rodgers, Linda H\|Shannon, Kristen M\|Yoshida, Makoto\|Ma, Tianle\|Mattia, Anthony\|Lauwers, Gregory Y\|Iafrate, Anthony J\|Hartford, Nicole M\|Oliva, Esther\|Chung, Daniel C
PMID:	29750335

372.
Journal:	Curr Treat Options Oncol. 2018 May 11;19(6):29.
Title:	Promising New Agents for Colorectal Cancer.
Author:	Das, Satya\|Ciombor, Kristen K\|Haraldsdottir, Sigurdis\|Goldberg, Richard M
PMID:	29752549

373.
Journal:	Oncotarget. 2018 Apr 24;9(31):21950-21964.
Title:	An improved method for culturing patient-derived colorectal cancer spheroids.
Author:	Miyoshi, Hiroyuki\|Maekawa, Hisatsugu\|Kakizaki, Fumihiko\|Yamaura, Tadayoshi\|Kawada, Kenji\|Sakai, Yoshiharu\|Taketo, M Mark
PMID:	29774115

374.
Journal:	Apoptosis. 2018 Jun;23(5-6):356-374.
Title:	Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer.
Author:	Li, Sanhong\|Tian, Jilai\|Zhang, Hongming\|Zhou, Shoubing\|Wang, Xiyong\|Zhang, Lei\|Yang, Jiapeng\|Zhang, Zhigang\|Ji, Zhenling
PMID:	29777330

375.
Journal:	Cell Physiol Biochem. 2018;47(2):680-693.
Title:	Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
Author:	Gong, Shu\|Xu, Dongsheng\|Zhu, Jialin\|Zou, Fangdong\|Peng, Rui
PMID:	29794421

376.
Journal:	Nat Med. 2018 Jul;24(7):961-967.
Title:	SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.
Author:	Mainardi, Sara\|Mulero-Sanchez, Antonio\|Prahallad, Anirudh\|Germano, Giovanni\|Bosma, Astrid\|Krimpenfort, Paul\|Lieftink, Cor\|Steinberg, Jeffrey D\|de Wit, Niels\|Goncalves-Ribeiro, Samuel\|Nadal, Ernest\|Bardelli, Alberto\|Villanueva, Alberto\|Bernards, Rene
PMID:	29808006

377.
Journal:	Mol Carcinog. 2018 Oct;57(10):1300-1310.
Title:	AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.
Author:	Huang, Chenfei\|Cao, Zhe\|Ma, Jun\|Shen, Yi\|Bu, Yiwen\|Khoshaba, Ramina\|Shi, Guiyuan\|Huang, Dan\|Liao, Duan-Fang\|Ji, Haitao\|Jin, Junfei\|Cao, Deliang
PMID:	29846015

378.
Journal:	Cancer Res. 2018 Sep 1;78(17):4839-4852.
Title:	Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
Author:	Stevens, Payton D\|Wen, Yang-An\|Xiong, Xiaopeng\|Zaytseva, Yekaterina Y\|Li, Austin T\|Wang, Chi\|Stevens, Ashley T\|Farmer, Trevor N\|Gan, Tong\|Weiss, Heidi L\|Inagaki, Masaki\|Marchetto, Sylvie\|Borg, Jean-Paul\|Gao, Tianyan
PMID:	29980571

379.
Journal:	Dev Reprod. 2018 Jun;22(2):133-142.
Title:	Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells.
Author:	Kim, Taewan\|Kim, Taehyung\|Choi, Soonyoung\|Ko, Hyeran\|Park, Deokbae\|Lee, Youngki
PMID:	30023463

380.
Journal:	Clin Colorectal Cancer. 2018 Jun 8. pii: S1533-0028(18)30141-5.
Title:	Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer.
Author:	Sundar, Raghav\|Miranda, Susana\|Rodrigues, Daniel Nava\|Chenard-Poirier, Maxime\|Dolling, David\|Clarke, Matthew\|Figueiredo, Ines\|Bertan, Claudia\|Yuan, Wei\|Ferreira, Ana\|Chistova, Rossitza\|Boysen, Gunther\|Perez, Desamparados Roda\|Tunariu, Nina\|Mateo, Joaquin\|
PMID:	30042009

381.
Journal:	Recent Results Cancer Res. 2018;211:77-89.
Title:	Vemurafenib.
Author:	Garbe, Claus\|Eigentler, Thomas K
PMID:	30069761

382.
Journal:	Cancer Manag Res. 2018 Aug 1;10:2289-2301.
Title:	Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer.
Author:	Pan, Jing-Hua\|Zhou, Hong\|Zhu, Sheng-Bin\|Huang, Jin-Lian\|Zhao, Xiao-Xu\|Ding, Hui\|Pan, Yun-Long
PMID:	30122982

383.
Journal:	J Natl Compr Canc Netw. 2018 Sep;16(9):1035-1040.
Title:	Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon.
Author:	Burkart, Jarred\|Owen, Dwight\|Shah, Manisha H\|Abdel-Misih, Sherif R Z\|Roychowdhury, Sameek\|Wesolowski, Robert\|Haraldsdottir, Sigurdis\|Reeser, Julie W\|Samorodnitsky, Eric\|Smith, Amy\|Konda, Bhavana
PMID:	30181415

384.
Journal:	Mol Carcinog. 2018 Sep 4.
Title:	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.
Author:	Yuan, Gang\|Chen, Tingjia\|Zhang, Haiqing\|Cao, Qinghua\|Qiu, Yun\|Que, Biao\|Peng, Sui\|Chen, Minhu\|Ji, Weidong
PMID:	30182433

385.
Journal:	Am J Transl Res. 2018 Aug 15;10(8):2402-2412. eCollection 2018.
Title:	Extracellular galectin-3 facilitates colon cancer cell migration and is related to the epidermal growth factor receptor.
Author:	Wu, Keng-Liang\|Kuo, Chung-Mou\|Huang, Eng-Yen\|Pan, Hui-Mei\|Huang, Chao-Cheng\|Chen, Yi-Fan\|Hsiao, Chang-Chun\|Yang, Kuender D
PMID:	30210679

386.
Journal:	Eur Biophys J. 2018 Sep 14. pii: 10.1007/s00249-018-1334-y.
Title:	Electrostatic mechanism of V600E mutation-induced B-Raf constitutive activation in colorectal cancer: molecular implications for the selectivity difference between type-I and type-II inhibitors.
Author:	Liu, Tie\|Wang, Zhaoshun\|Guo, Peng\|Ding, Na
PMID:	30218115

387.
Journal:	Mol Cancer Res. 2018 Oct 1. pii: 1541-7786.MCR-17-0554.
Title:	Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance.
Author:	Aronchik, Ida\|Dai, Yumin\|Labenski, Matt\|Barnes, Carmen\|Jones, Terri\|QIao, Lixin\|Beebe, Lisa\|Malek, Mehnaz\|Elis, Winfried\|Shi, Tao\|Mavrommatis, Konstantinos\|Bray, Gordon L\|Filvaroff, Ellen H
PMID:	30275173

388.
Journal:	Ann Oncol. 2018 Oct 18. pii: 5136414.
Title:	Biomarker analysis beyond angiogenesis: RAS/RAF mutation status, tumour sidedness, and second-line ramucirumab efficacy in patients with metastatic colorectal carcinoma from RAISE, a global phase 3 study.
Author:	Yoshino, T\|Portnoy, D C\|Obermannova, R\|Bodoky, G\|Prausova, J\|Garcia-Carbonero, R\|Ciuleanu, T\|Garcia-Alfonso, P\|Cohn, A L\|Van Cutsem, E\|Yamazaki, K\|Lonardi, S\|Muro, K\|Kim, T W\|Yamaguchi, K\|Grothey, A\|O'Connor, J\|Taieb, J\|Wijayawardana, S R\|Hozak, R R\|Nasro
PMID:	30339194

389.
Journal:	Cell Physiol Biochem. 2018 Oct 25;50(4):1496-1509.
Title:	Comprehensive Analysis of the Relationship Between RAS and RAF Mutations and MSI Status of Colorectal Cancer in Northeastern China.
Author:	Li, Wenqi\|Li, Huining\|Liu, Ruiqi\|Yang, Xinxin\|Gao, Yuhui\|Niu, Yangyang\|Geng, Jiashi\|Xue, Yingwei\|Jin, Xiaoming\|You, Qi\|Geng, Jingshu\|Meng, Hongxue
PMID:	30359964

390.
Journal:	Br J Cancer. 2018 Nov 2. pii: 10.1038/s41416-018-0230-7.
Title:	Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data.
Author:	Trinh, Anne\|Ladrach, Claudia\|Dawson, Heather E\|Ten Hoorn, Sanne\|Kuppen, Peter J K\|Reimers, Marlies S\|Koopman, Miriam\|Punt, Cornelis J A\|Lugli, Alessandro\|Vermeulen, Louis\|Zlobec, Inti
PMID:	30385823