Primary Site >> Liver Cancer

Gene >> WNT3A

Journal: PLoS One. 2008 Apr 2;3(4):e1878.
Title: A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling.
Author: Quelard, Delphine|Lavergne, Elise|Hendaoui, Ismail|Elamaa, Harri|Tiirola, Ulla|Heljasvaara, Ritva|Pihlajaniemi, Taina|Clement, Bruno|Musso, Orlando
PMID: 18382662
Journal: Toxicology. 2009 Jun 16;260(1-3):104-11.
Title: 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.
Author: Simeckova, P|Vondracek, J|Prochazkova, J|Kozubik, A|Krcmar, P|Machala, M
PMID: 19464575
Journal: Clin Cancer Res. 2009 Dec 15;15(24):7529-7537.
Title: Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer.
Author: Naik, Snehal|Dothager, Robin S|Marasa, Jayne|Lewis, Cory L|Piwnica-Worms, David
PMID: 20008853
Journal: Hepatology. 2010 Nov;52(5):1680-9.
Title: The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation.
Author: Lai, Jin-Ping|Oseini, Abdul M|Moser, Catherine D|Yu, Chunrong|Elsawa, Sherine F|Hu, Chunling|Nakamura, Ikuo|Han, Tao|Aderca, Ileana|Isomoto, Hajime|Garrity-Park, Megan M|Shire, Abdirashid M|Li, Jia|Sanderson, Schuyler O|Adjei, Alex A|Fernandez-Zapico, Mar
PMID: 20725905
Journal: Arch Virol. 2011 Jun;156(6):1013-23.
Title: Hepatitis C virus core protein activates Wnt/beta-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line.
Author: Liu, Jiao|Wang, Zengchan|Tang, Jia|Tang, Renkuan|Shan, Xiaoliang|Zhang, Wenlu|Chen, Qingmei|Zhou, Fan|Chen, Ke|Huang, Ailong|Tang, Ni
PMID: 21340743
Journal: Biochem Pharmacol. 2011 Dec 1;82(11):1682-91.
Title: Interferon-alpha2b and transforming growth factor-beta1 treatments on HCC cell lines: Are Wnt/beta-catenin pathway and Smads signaling connected in hepatocellular carcinoma?
Author: Ceballos, Maria Paula|Parody, Juan Pablo|Alvarez, Maria de Lujan|Ingaramo, Paola Ines|Carnovale, Cristina Ester|Carrillo, Maria Cristina
PMID: 21843516
Journal: PLoS One. 2011;6(11):e27496.
Title: Enhancement of canonical Wnt/beta-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells.
Author: Liu, Jiao|Ding, Xiong|Tang, Jia|Cao, Youde|Hu, Peng|Zhou, Fan|Shan, Xiaoliang|Cai, Xuefei|Chen, Qingmei|Ling, Ning|Zhang, Bingqiang|Bi, Yang|Chen, Ke|Ren, Hong|Huang, Ailong|He, Tong-Chuan|Tang, Ni
PMID: 22110662
Journal: PLoS One. 2012;7(6):e39668.
Title: Kruppel-like factor 8 is a new Wnt/beta-catenin signaling target gene and regulator in hepatocellular carcinoma.
Author: Yang, Tian|Cai, Sheng-Yun|Zhang, Jin|Lu, Jun-Hua|Lin, Chuan|Zhai, Jian|Wu, Meng-Chao|Shen, Feng
PMID: 22761862
Journal: World J Gastroenterol. 2013;19(43):7680-95.
Title: 8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of beta-catenin.
Author: Quan, Mei-Fang|Xiao, Li-Hong|Liu, Zhi-Hong|Guo, Hui|Ren, Kai-Qun|Liu, Fei|Cao, Jian-Guo|Deng, Xi-Yun
PMID: 24431896
Journal: Mol Cell Biochem. 2013 Sep;381(1-2):139-44.
Title: Sorafenib sensitizes hepatocellular carcinoma cell to cisplatin via suppression of Wnt/beta-catenin signaling.
Author: Wei, Yongpeng|Shen, Ningjia|Wang, Zhouchong|Yang, Guangshun|Yi, Bin|Yang, Ning|Qiu, Yinghe|Lu, Junhua
PMID: 23756716
Journal: Carcinogenesis. 2013 May;34(5):962-73.
Title: Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling.
Author: Zhang, Qi|Bai, Xueli|Chen, Wei|Ma, Tao|Hu, Qida|Liang, Chao|Xie, Shangzhi|Chen, Conglin|Hu, Liqiang|Xu, Shiguo|Liang, Tingbo
PMID: 23358852
Journal: Hepatology. 2014 Aug;60(2):576-87.
Title: Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy.
Author: Gao, Wei|Kim, Heungnam|Feng, Mingqian|Phung, Yen|Xavier, Charles P|Rubin, Jeffrey S|Ho, Mitchell
PMID: 24492943
Journal: Mol Med Rep. 2014 Nov;10(5):2643-8.
Title: MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells.
Author: Yang, Yang|Li, Menghe|Chang, Su'e|Wang, Lumin|Song, Tusheng|Gao, Ling|Hu, Lili|Li, Zongfang|Liu, Liying|Yao, Jiayi|Huang, Chen
PMID: 25174704
Journal: Oncotarget. 2015 Oct 6;6(30):29357-74.
Title: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer.
Author: Lian, Jiayan|Tang, Jianming|Shi, Huijuan|Li, Hui|Zhen, Tiantian|Xie, Wenlin|Zhang, Fenfen|Yang, Yang|Han, Anjia
PMID: 26296979
Journal: PLoS One. 2015 Sep 2;10(9):e0137664.
Title: Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells.
Author: Gao, Wei|Kim, Heungnam|Ho, Mitchell
PMID: 26332121
Journal: Cell Mol Gastroenterol Hepatol. 2015 Sep 1;1(5):535-549.e14.
Title: Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/beta-catenin Signaling in the Liver.
Author: Protiva, Petr|Gong, Jingjing|Sreekumar, Bharath|Torres, Richard|Zhang, Xuchen|Belinsky, Glenn S|Cornwell, Mona|Crawford, Susan E|Iwakiri, Yasuko|Chung, Chuhan
PMID: 26473164
Journal: Gut. 2016 Sep;65(9):1522-34.
Title: The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/beta-catenin signalling pathway.
Author: Chen, Jianxiang|Rajasekaran, Muthukumar|Xia, Hongping|Zhang, Xiaoqian|Kong, Shik Nie|Sekar, Karthik|Seshachalam, Veerabrahma Pratap|Deivasigamani, Amudha|Goh, Brian Kim Poh|Ooi, London Lucien|Hong, Wanjin|Hui, Kam M
PMID: 26941395
Journal: Zhonghua Yi Xue Za Zhi. 2016 Nov 29;96(44):3554-3558.
Title: [Clinical values of Wnt3a as a novel biomarker in diagnosis and prognosis of hepatocellular carcinoma].
Author: Wang, L|Pan, L H|Yao, M|Zheng, W J|Fang, M|Qiu, L W|Dong, Z Z|Yao, D F
PMID: 27916074
Journal: PLoS Genet. 2016 May 20;12(5):e1006051.
Title: Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma.
Author: Lin, Yung-Feng|Li, Ling-Hui|Lin, Chih-Hung|Tsou, Mei-Hua|Chuang, Ming-Tai Kiffer|Wu, Keh-Ming|Liao, Tsai-Lien|Li, Jian-Chiuan|Wang, Wei-Jie|Tomita, Angela|Tomita, Beverly|Huang, Shiu-Feng|Tsai, Shih-Feng
PMID: 27203079
Journal: Oncotarget. 2016 Jun 28;7(26):39026-39043.
Title: De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas.
Author: Mebarki, Sihem|Desert, Romain|Sulpice, Laurent|Sicard, Marie|Desille, Mireille|Canal, Frederic|Dubois-Pot Schneider, Helene|Bergeat, Damien|Turlin, Bruno|Bellaud, Pascale|Lavergne, Elise|Le Guevel, Remy|Corlu, Anne|Perret, Christine|Coulouarn, Cedric|Clem
PMID: 27191501
Journal: World J Gastroenterol. 2016 Apr 14;22(14):3829-36.
Title: Oncogenic Wnt3a expression as an estimable prognostic marker for hepatocellular carcinoma.
Author: Pan, Liu-Hong|Yao, Min|Cai, Yin|Gu, Juan-Juan|Yang, Xu-Li|Wang, Li|Yao, Deng-Fu
PMID: 27076768
Journal: Tumour Biol. 2016 May;37(5):6045-51.
Title: Wnt/beta-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma.
Author: Wu, Wen-Jie|Shi, Jia|Hu, Gang|Yu, Xin|Lu, Han|Yang, Ming-Liang|Liu, Bin|Wu, Zhi-Xiang
PMID: 26602384
Journal: Tumour Biol. 2016 Apr;37(4):5561-8.
Title: Abnormality of Wnt3a expression as novel specific biomarker for diagnosis and differentiation of hepatocellular carcinoma.
Author: Pan, Liuhong|Yao, Min|Zheng, Wenjie|Gu, Juanjuan|Yang, Xuli|Qiu, Liwei|Cai, Yin|Wu, Wei|Yao, Dengfu
PMID: 26577850
Journal: Exp Biol Med (Maywood). 2017 Jun;242(11):1142-1149.
Title: Atypical regulators of Wnt/beta-catenin signaling as potential therapeutic targets in Hepatocellular Carcinoma.
Author: Chen, Jianxiang|Rajasekaran, Muthukumar|Hui, Kam M
PMID: 28429652
Journal: Exp Ther Med. 2017 May;13(5):2501-2506.
Title: Propofol inhibits hepatocellular carcinoma growth and invasion through the HMGA2-mediated Wnt/beta-catenin pathway.
Author: Ou, Wei|Lv, Jie|Zou, Xiaohua|Yao, Yin|Wu, Jinli|Yang, Jian|Wang, Zhumei|Ma, Yan
PMID: 28565871
Journal: Sci Rep. 2017 Jul 14;7(1):5387.
Title: Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Author: Sakurai, Yoshitaka|Kubota, Naoto|Takamoto, Iseki|Obata, Atsushi|Iwamoto, Masahiko|Hayashi, Takanori|Aihara, Masakazu|Kubota, Tetsuya|Nishihara, Hiroshi|Kadowaki, Takashi
PMID: 28710407
Journal: Life Sci. 2017 Sep 15;185:114-125.
Title: Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways.
Author: Zaghloul, Randa A|Elsherbiny, Nehal M|Kenawy, Hany I|El-Karef, Amr|Eissa, Laila A|El-Shishtawy, Mamdouh M
PMID: 28754618
Journal: Mol Med Rep. 2017 Nov;16(5):6920-6927.
Title: MicroRNA214 targets Wnt3a to suppress liver cancer cell proliferation.
Author: Yang, Yang|Zhao, Zhenghao|Hou, Ni|Li, Yulong|Wang, Xiaofei|Wu, Fei|Sun, Ruifang|Han, Jia|Sun, Hongfei|Song, Tusheng|Huang, Chen|Shao, Yuan
PMID: 28901526
Journal: Int J Oncol. 2017 Oct;51(4):1135-1145.
Title: Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis.
Author: Lu, Caijie|He, Yifeng|Duan, Juan|Yang, Yongguang|Zhong, Chunqiang|Zhang, Jian|Liao, Weiguo|Huang, Xiaojie|Zhu, Runzhi|Li, Mingyi
PMID: 28902357
Journal: Hepatobiliary Pancreat Dis Int. 2018 Jun;17(3):227-232.
Title: Expression of hepatic Wnt5a and its clinicopathological features in patients with hepatocellular carcinoma.
Author: Wang, Li|Yao, Min|Fang, Miao|Zheng, Wen-Jie|Dong, Zhi-Zhen|Pan, Liu-Hong|Zhang, Hai-Jian|Yao, Deng-Fu
PMID: 29709351
Journal: Cancer Manag Res. 2018 Jul 2;10:1817-1826.
Title: Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/beta-catenin signaling pathways.
Author: Chen, Wei|You, Jia|Zheng, Qi|Zhu, Yue-Yong
PMID: 29997441
Journal: Cancer Immunol Res. 2018 Aug;6(8):941-952.
Title: Wnt3a/beta-Catenin Signaling Conditions Differentiation of Partially Exhausted T-effector Cells in Human Cancers.
Author: Schinzari, Valeria|Timperi, Eleonora|Pecora, Giulia|Palmucci, Francesco|Gallerano, Daniela|Grimaldi, Alessio|Covino, Daniela Angela|Guglielmo, Nicola|Melandro, Fabio|Manzi, Emy|Sagnotta, Andrea|Lancellotti, Francesco|Sacco, Luca|Chirletti, Piero|Grazi, Gi
PMID: 30018041
Journal: Int Immunopharmacol. 2018 Oct;63:253-260.
Title: TMEM9 mediates IL-6 and IL-1beta secretion and is modulated by the Wnt pathway.
Author: Wei, Wei|Jiang, Fei|Liu, Xiao-Chang|Su, Qian
PMID: 30119033
Journal: Mol Cells. 2018 Aug 27. pii: molcells.2018.0181.
Title: MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma.
Author: You, Yu|Que, Keting|Zhou, Yun|Zhang, Zhen|Zhao, Xiaoping|Gong, Jianpin|Liu, Zuojin
PMID: 30145863
Journal: Cell Physiol Biochem. 2018 Sep 26;49(6):2099-2110.
Title: Propofol Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis Through Down-Regulating miR-374a in Hepatocarcinoma Cell Lines.
Author: Liu, Sheng-Qun|Zhang, Jing-Liang|Li, Zhan-Wen|Hu, Zhen-Hua|Liu, Zhe|Li, Yi
PMID: 30257238
Journal: J Biol Chem. 2018 Oct 25. pii: RA118.004434.
Title: Oligomerization of Frizzled and low-density lipoprotein receptor-related protein 5/6 initiates intracellular signaling for the canonical WNT/beta-catenin pathway.
Author: Hua, Yue|Yang, Yilin|Li, Qian|He, Xinyu|Zhu, Wei|Wang, Jiyong|Gan, Xiaoqing
PMID: 30361437