Primary Site >> Colorectal Cancer

Gene >> UGT1A9

Journal: Adv Enzyme Regul. 1998;38:207-22.
Title: AH receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms.
Author: Bock, K W|Gschaidmeier, H|Heel, H|Lehmkoster, T|Munzel, P A|Raschko, F|Bock-Hennig, B
PMID: 9762354
Journal: Drug Metab Dispos. 1999 May;27(5):569-73.
Title: Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells.
Author: Munzel, P A|Schmohl, S|Heel, H|Kalberer, K|Bock-Hennig, B S|Bock, K W
PMID: 10220484
Journal: Ther Drug Monit. 2000 Feb;22(1):10-3.
Title: Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid.
Author: Mackenzie, P I
PMID: 10688250
Journal: Cancer Res. 2003 Dec 1;63(23):8443-50.
Title: Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
Author: Cummings, Jeffrey|Ethell, Brian T|Jardine, Lesley|Boyd, Gary|Macpherson, Janet S|Burchell, Brian|Smyth, John F|Jodrell, Duncan I
PMID: 14679008
Journal: Int J Oncol. 2004 Oct;25(4):1049-56.
Title: Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR.
Author: Solmi, Rossella|De Sanctis, Paola|Zucchini, Cinzia|Ugolini, Giampaolo|Rosati, Giancarlo|Del Governatore, Marco|Coppola, Domenico|Yeatman, Thymothy J|Lenzi, Luca|Caira, Antonello|Zanotti, Simone|Taffurelli, Mario|Carinci, Paolo|Valvassori, Luisa|Strippoli,
PMID: 15375555
Journal: Clin Cancer Res. 2005 Feb 1;11(3):1226-36.
Title: UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.
Author: Carlini, Leslie E|Meropol, Neal J|Bever, John|Andria, Michael L|Hill, Todd|Gold, Philip|Rogatko, Andre|Wang, Hao|Blanchard, Rebecca L
PMID: 15709193
Journal: Mutat Res. 2008 Sep 26;644(1-2):56-63.
Title: UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans.
Author: Girard, Hugo|Butler, Lesley M|Villeneuve, Lyne|Millikan, Robert C|Sinha, Rashmi|Sandler, Robert S|Guillemette, Chantal
PMID: 18675828
Journal: J Clin Oncol. 2009 May 20;27(15):2457-65.
Title: Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.
Author: Cecchin, Erika|Innocenti, Federico|D'Andrea, Mario|Corona, Giuseppe|De Mattia, Elena|Biason, Paola|Buonadonna, Angela|Toffoli, Giuseppe
PMID: 19364970
Journal: Br J Cancer. 2010 Aug 10;103(4):581-9.
Title: UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.
Author: Martinez-Balibrea, E|Abad, A|Martinez-Cardus, A|Gines, A|Valladares, M|Navarro, M|Aranda, E|Marcuello, E|Benavides, M|Massuti, B|Carrato, A|Layos, L|Manzano, J L|Moreno, V
PMID: 20628391
Journal: Mol Cancer. 2010 Mar 2;9:46.
Title: Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.
Author: Raynal, Caroline|Pascussi, Jean-Marc|Leguelinel, Geraldine|Breuker, Cyril|Kantar, Jovana|Lallemant, Benjamin|Poujol, Sylvain|Bonnans, Caroline|Joubert, Dominique|Hollande, Frederic|Lumbroso, Serge|Brouillet, Jean-Paul|Evrard, Alexandre
PMID: 20196838
Journal: Tumori. 2011 Mar-Apr;97(2):243-7.
Title: Concurrence of UGT1A polymorphism and end-stage renal disease leads to severe toxicities of irinotecan in a patient with metastatic colon cancer.
Author: Huang, Sung-Hao|Chao, Yee|Wu, Ying-Ying|Luo, Jiing-Chyuan|Kao, Chien-Hui|Yen, Sang-Hue|Li, Chung-Pin
PMID: 21617725
Journal: Int J Mol Epidemiol Genet. 2012;3(2):96-106. Epub 2012 May 15.
Title: Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.
Author: Eichholzer, Monika|Rohrmann, Sabine|Barbir, Aline|Hermann, Silke|Teucher, Birgit|Kaaks, Rudolf|Linseisen, Jakob
PMID: 22724046
Journal: Tohoku J Exp Med. 2013;229(2):107-14.
Title: Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy.
Author: Inoue, Kazuyuki|Sonobe, Momoyo|Kawamura, Yukinori|Etoh, Takashi|Takagi, Masakazu|Matsumura, Takashi|Kikuyama, Masataka|Kimura, Midori|Minami, Sato|Utsuki, Hiroaki|Yamazaki, Tomoaki|Suzuki, Takayo|Tsuji, Daiki|Hayashi, Hideki|Itoh, Kunihiko
PMID: 23303296
Journal: PLoS One. 2013 Nov 14;8(11):e79172.
Title: UDP-glucuronosyltransferase 1A compromises intracellular accumulation and anti-cancer effect of tanshinone IIA in human colon cancer cells.
Author: Liu, Miao|Wang, Qiong|Liu, Fang|Cheng, Xuefang|Wu, Xiaolan|Wang, Hong|Wu, Mengqiu|Ma, Ying|Wang, Guangji|Hao, Haiping
PMID: 24244442
Journal: PLoS One. 2015 Feb 18;10(2):e0117051.
Title: UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of beta-lapachone in human colon cancer cells.
Author: Liu, Huiying|Li, Qingran|Cheng, Xuefang|Wang, Hong|Wang, Guangji|Hao, Haiping
PMID: 25692465
Journal: Endocr J. 2015;62(12):1133-7.
Title: Effect of dapagliflozin on colon cancer cell [Rapid Communication].
Author: Saito, Tsugumichi|Okada, Shuichi|Yamada, Eijiro|Shimoda, Yoko|Osaki, Aya|Tagaya, Yuko|Shibusawa, Ryo|Okada, Junichi|Yamada, Masanobu
PMID: 26522271
Journal: Mol Pharmacol. 2018 May;93(5):541-552.
Title: Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4alpha Is Mediated by a Novel Composite Regulatory Element.
Author: Mubarokah, Nurul|Hulin, Julie-Ann|Mackenzie, Peter I|McKinnon, Ross A|Haines, Alex Z|Hu, Dong Gui|Meech, Robyn
PMID: 29519853
Journal: Pharmacol Rep. 2018 Oct;70(5):972-980.
Title: Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7.
Author: Mroz, Anna|Ryska, Izabela|Sominko, Hanna|Bejrowska, Anna|Mazerska, Zofia
PMID: 30107347