Primary Site >> Colorectal Cancer

Gene >> UGT1A8

Journal: Ther Drug Monit. 2000 Feb;22(1):10-3.
Title: Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid.
Author: Mackenzie, P I
PMID: 10688250
Journal: Drug Metab Dispos. 2003 Apr;31(4):452-61.
Title: Glucuronides of tea catechins: enzymology of biosynthesis and biological activities.
Author: Lu, Hong|Meng, Xiaofeng|Li, Chuan|Sang, Shengmin|Patten, Christopher|Sheng, Shuqun|Hong, Jungil|Bai, Naisheng|Winnik, Bozena|Ho, Chi-Tang|Yang, Chung S
PMID: 12642472
Journal: Carcinogenesis. 2004 Dec;25(12):2407-15. Epub 2004 Aug 19.
Title: Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk.
Author: van der Logt, E M J|Bergevoet, S M|Roelofs, H M J|van Hooijdonk, Z|te Morsche, R H M|Wobbes, T|de Kok, J B|Nagengast, F M|Peters, W H M
PMID: 15319294
Journal: Zhonghua Yi Xue Za Zhi. 2005 Mar 30;85(12):819-24.
Title: [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells].
Author: Wang, Min|Li, Yan-Qing|Zhong, Ning|Chen, Jian|Xu, Xiao-Qun|Yuan, Meng-Biao
PMID: 15949398
Journal: Zhonghua Yi Xue Za Zhi. 2006 Jan 10;86(2):82-7.
Title: [The role of NF-E2-related factor 2 in the induction of uridine 5'-diphosphate-glucuronosyltransferase 1A and its isoforms by epigallocatechin gallate in colon cancer cells].
Author: Yang, Xiao-yun|Zhao, Wei-ping|Li, Yan-qing|Sun, Zi-yuan|Zhang, Yan|Guo, Yu-ting|Yuan, Jun-hua|Zhu, Qiang|Wang, Min
PMID: 16620709
Journal: Anticancer Res. 2006 May-Jun;26(3B):2189-96.
Title: Glucuronidation of SN-38 and NU/ICRF 505 in human colon cancer and adjacent normal colon.
Author: Cummings, Jeffrey|Ethell, Brian T|Jardine, Lesley|Burchell, Brian
PMID: 16821585
Journal: Pharmacology. 2007;80(4):269-78. Epub 2007 Jul 26.
Title: Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice.
Author: Yuan, Jun-Hua|Li, Yan-Qing|Yang, Xiao-Yun
PMID: 17657175
Journal: Chin J Physiol. 2012 Apr 30;55(2):134-44.
Title: Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.
Author: Wang, Min|Chen, Shuo|Wang, Shuai|Sun, Defeng|Chen, Jian|Li, Yanqing|Han, Wei|Yang, Xiaoyun|Gao, Hai-Qing
PMID: 22559738
Journal: Oncol Lett. 2014 Dec;8(6):2407-2416.
Title: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.
Author: Wang, Min|Zhu, Jing-Yu|Chen, Shuo|Qing, Ying|Wu, Dong|Lin, Ying-Min|Luo, Ji-Zhuang|Han, Wei|Li, Yan-Qing
PMID: 25364403
Journal: J Clin Pharmacol. 2016 Aug;56(8):966-73.
Title: Phase 1 Study of ABT-751 in Combination With CAPIRI (Capecitabine and Irinotecan) and Bevacizumab in Patients With Advanced Colorectal Cancer.
Author: Rudek, Michelle A|Dasari, Arvind|Laheru, Daniel|He, Ping|Jin, Runyan|Walker, Rosalind|Taylor, Gretchen E|Jimeno, Antonio|Donehower, Ross C|Hidalgo, Manuel|Messersmith, Wells A|Purcell, W Thomas
PMID: 26632033
Journal: Mol Pharmacol. 2018 May;93(5):541-552.
Title: Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4alpha Is Mediated by a Novel Composite Regulatory Element.
Author: Mubarokah, Nurul|Hulin, Julie-Ann|Mackenzie, Peter I|McKinnon, Ross A|Haines, Alex Z|Hu, Dong Gui|Meech, Robyn
PMID: 29519853