Primary Site >> Liver Cancer
Gene >> TSC2
| 1. | |||||||||||
| Journal: | Mol Cancer Ther. 2009 Jul;8(7):1799-807. | ||||||||||
| Title: | Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. | ||||||||||
| Author: | Finlay, Geraldine A|Malhowski, Amy J|Polizzi, Kristen|Malinowska-Kolodziej, Izabela|Kwiatkowski, David J | ||||||||||
| PMID: | 19584242 | ||||||||||
| 2. | |||||||||||
| Journal: | Biochem Pharmacol. 2010 Jan 15;79(2):162-71. | ||||||||||
| Title: | Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. | ||||||||||
| Author: | Chiang, Po-Cheng|Lin, Ssu-Chia|Pan, Shiow-Lin|Kuo, Ching-Hua|Tsai, I-Lin|Kuo, Mao-Tien|Wen, Wu-Che|Chen, Peini|Guh, Jih-Hwa | ||||||||||
| PMID: | 19723512 | ||||||||||
| 3. | |||||||||||
| Journal: | Mol Cell Biochem. 2010 May;338(1-2):233-9. | ||||||||||
| Title: | Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats. | ||||||||||
| Author: | Sajankila, Shyama Prasad|Manthena, Praveen V|Adhikari, Sanjay|Choudhury, Sujata|Izumi, Keisuke|Roy, Rabindra | ||||||||||
| PMID: | 20033472 | ||||||||||
| 4. | |||||||||||
| Journal: | J Agric Food Chem. 2012 Aug 29;60(34):8363-71. | ||||||||||
| Title: | Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. | ||||||||||
| Author: | Chu, Yung-Lin|Ho, Chi-Tang|Chung, Jing-Gung|Rajasekaran, Raghu|Sheen, Lee-Yan | ||||||||||
| PMID: | 22860996 | ||||||||||
| 5. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78. | ||||||||||
| Title: | Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. | ||||||||||
| Author: | Hernandez-Breijo, Borja|Monserrat, Jorge|Roman, Irene D|Gonzalez-Rodriguez, Agueda|Fernandez-Moreno, Ma Dolores|Lobo, M Val T|Valverde, Angela M|Gisbert, Javier P|Guijarro, Luis G | ||||||||||
| PMID: | 23958494 | ||||||||||
| 6. | |||||||||||
| Journal: | Hepatol Res. 2014 Oct;44(11):1142-50. | ||||||||||
| Title: | Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy. | ||||||||||
| Author: | Huang, Ka-Te|Huang, Yue-Han|Li, Peng|He, Bin|Chen, Zhen-Kun|Yu, Xia|Chen, Jian-Ou|Zhang, Qi-Yu|Shi, Hong-Qi|Shan, Yun-Feng | ||||||||||
| PMID: | 24119083 | ||||||||||
| 7. | |||||||||||
| Journal: | Apoptosis. 2014 Apr;19(4):615-28. | ||||||||||
| Title: | Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma. | ||||||||||
| Author: | Park, In-Ja|Yang, Woo Kyeom|Nam, Sang-Hee|Hong, Jongki|Yang, Ki Ryeol|Kim, Joungmok|Kim, Sung Soo|Choe, Wonchae|Kang, Insug|Ha, Joohun | ||||||||||
| PMID: | 24173372 | ||||||||||
| 8. | |||||||||||
| Journal: | Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):979-90. | ||||||||||
| Title: | A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway. | ||||||||||
| Author: | Hsu, Jui-Ling|Liu, Shih-Ping|Lee, Chia-Chung|Hsu, Lih-Ching|Ho, Yunn-Fang|Huang, Hsu-Shan|Guh, Jih-Hwa | ||||||||||
| PMID: | 25005758 | ||||||||||
| 9. | |||||||||||
| Journal: | Gastroenterology. 2015 Oct;149(5):1226-1239.e4. | ||||||||||
| Title: | Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. | ||||||||||
| Author: | Zucman-Rossi, Jessica|Villanueva, Augusto|Nault, Jean-Charles|Llovet, Josep M | ||||||||||
| PMID: | 26099527 | ||||||||||
| 10. | |||||||||||
| Journal: | Cell Death Discov. 2015 Nov 30;1:15051. | ||||||||||
| Title: | Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling. | ||||||||||
| Author: | Tsai, M-C|Chen, K-D|Wang, C-C|Huang, K-T|Wu, C-H|Kuo, I-Y|Chen, L-Y|Hu, T-H|Goto, S|Nakano, T|Dorling, A|McVey, J H|Chen, C-L|Lin, C-C | ||||||||||
| PMID: | 27551480 | ||||||||||
| 11. | |||||||||||
| Journal: | Hepatology. 2015 Dec;62(6):1791-803. | ||||||||||
| Title: | Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. | ||||||||||
| Author: | Guan, Dong-Xian|Shi, Jie|Zhang, Yang|Zhao, Jiang-Sha|Long, Ling-Yun|Chen, Tian-Wei|Zhang, Er-Bin|Feng, Yuan-Yuan|Bao, Wen-Dai|Deng, Yue-Zhen|Qiu, Lin|Zhang, Xue-Li|Koeffler, H Phillip|Cheng, Shu-qun|Li, Jing-Jing|Xie, Dong | ||||||||||
| PMID: | 26257239 | ||||||||||
| 12. | |||||||||||
| Journal: | Fitoterapia. 2015 Jul;104:31-40. | ||||||||||
| Title: | SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. | ||||||||||
| Author: | Zhao, Peng|Dou, Yannong|Chen, Li|Li, Linhu|Wei, Zhifeng|Yu, Juntao|Wu, Xin|Dai, Yue|Xia, Yufeng | ||||||||||
| PMID: | 25964188 | ||||||||||
| 13. | |||||||||||
| Journal: | Int J Oncol. 2015 May;46(5):2216-22. | ||||||||||
| Title: | Effects of fucoidan on proliferation, AMP-activated protein kinase, and downstream metabolism- and cell cycle-associated molecules in poorly differentiated human hepatoma HLF cells. | ||||||||||
| Author: | Kawaguchi, Takumi|Hayakawa, Masako|Koga, Hironori|Torimura, Takuji | ||||||||||
| PMID: | 25776104 | ||||||||||
| 14. | |||||||||||
| Journal: | Mol Cancer Ther. 2015 May;14(5):1224-35. | ||||||||||
| Title: | Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus. | ||||||||||
| Author: | Huynh, Hung|Hao, Huai-Xiang|Chan, Stephen L|Chen, David|Ong, Richard|Soo, Khee Chee|Pochanard, Panisa|Yang, David|Ruddy, David|Liu, Manway|Derti, Adnan|Balak, Marissa N|Palmer, Michael R|Wang, Yan|Lee, Benjamin H|Sellami, Dalila|Zhu, Andrew X|Schlegel, Ro | ||||||||||
| PMID: | 25724664 | ||||||||||
| 15. | |||||||||||
| Journal: | Mod Pathol. 2015 Jan;28(1):103-10. | ||||||||||
| Title: | mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma. | ||||||||||
| Author: | Riehle, Kimberly J|Yeh, Matthew M|Yu, Jeannette J|Kenerson, Heidi L|Harris, William P|Park, James O|Yeung, Raymond S | ||||||||||
| PMID: | 24925055 | ||||||||||
| 16. | |||||||||||
| Journal: | Sci Rep. 2016 Feb 16;6:21260. | ||||||||||
| Title: | Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling. | ||||||||||
| Author: | Liu, Feng|Zhang, Wen|Yang, Fusheng|Feng, Tingting|Zhou, Meng|Yu, Yuan|Yu, Xiuping|Zhao, Weiming|Yi, Fan|Tang, Wei|Lu, Yi | ||||||||||
| PMID: | 26879559 | ||||||||||
| 17. | |||||||||||
| Journal: | J Hepatol. 2016 Aug;65(2):296-304. | ||||||||||
| Title: | Integrative biomarker analyses indicate etiological variations in hepatocellular carcinoma. | ||||||||||
| Author: | Zhu, Andrew X|Chen, David|He, Wei|Kanai, Masayuki|Voi, Maurizio|Chen, Li-Tzong|Daniele, Bruno|Furuse, Junji|Kang, Yoon-Koo|Poon, Ronnie T P|Vogel, Arndt|Chiang, Derek Y | ||||||||||
| PMID: | 27130844 | ||||||||||
| 18. | |||||||||||
| Journal: | Transl Oncol. 2016 Oct;9(5):466-471. | ||||||||||
| Title: | Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma. | ||||||||||
| Author: | Cho, Jinhyun|Lee, Jeeyun|Kim, Jusun|Kim, Seung Tae|Lee, Sujin|Kim, Sun Young|Ha, Sang Yun|Park, Cheol-Keun|Lim, Ho Yeong | ||||||||||
| PMID: | 27751352 | ||||||||||
| 19. | |||||||||||
| Journal: | Gut. 2017 Aug;66(8):1496-1506. | ||||||||||
| Title: | TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication. | ||||||||||
| Author: | Ho, Daniel W H|Chan, Lo K|Chiu, Yung T|Xu, Iris M J|Poon, Ronnie T P|Cheung, Tan T|Tang, Chung N|Tang, Victor W L|Lo, Irene L O|Lam, Polly W Y|Yau, Derek T W|Li, Miao X|Wong, Chun M|Ng, Irene O L | ||||||||||
| PMID: | 27974549 | ||||||||||
| 20. | |||||||||||
| Journal: | J Hepatol. 2017 Oct;67(4):727-738. | ||||||||||
| Title: | Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. | ||||||||||
| Author: | Calderaro, Julien|Couchy, Gabrielle|Imbeaud, Sandrine|Amaddeo, Giuliana|Letouze, Eric|Blanc, Jean-Frederic|Laurent, Christophe|Hajji, Yacine|Azoulay, Daniel|Bioulac-Sage, Paulette|Nault, Jean-Charles|Zucman-Rossi, Jessica | ||||||||||
| PMID: | 28532995 | ||||||||||
| 21. | |||||||||||
| Journal: | Transl Oncol. 2017 Oct;10(5):793-799. | ||||||||||
| Title: | Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1(+/-) Mice. | ||||||||||
| Author: | Shen, Ming Hong|Samsel, Paulina|Shen, Louise L|Narov, Kalin|Yang, Jian|Sampson, Julian R | ||||||||||
| PMID: | 28844017 | ||||||||||
| 22. | |||||||||||
| Journal: | Oncogene. 2018 Jan 25;37(4):478-488. | ||||||||||
| Title: | TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex. | ||||||||||
| Author: | Guo, P|Ma, X|Zhao, W|Huai, W|Li, T|Qiu, Y|Zhang, Y|Han, L | ||||||||||
| PMID: | 28967907 | ||||||||||
| 23. | |||||||||||
| Journal: | Med Sci Monit. 2018 May 3;24:2735-2743. | ||||||||||
| Title: | Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC). | ||||||||||
| Author: | Zhang, Yu|Jia, Qing-An|Kadel, Dhruba|Zhang, Xiao-Fei|Zhang, Quan-Bao | ||||||||||
| PMID: | 29720580 | ||||||||||
| 24. | |||||||||||
| Journal: | Clin Cancer Res. 2018 Oct 16. pii: 1078-0432.CCR-18-1833. | ||||||||||
| Title: | PTEN Expression, Not Mutation Status for TSC1, TSC2 or mTOR, Correlates With Outcome on Everolimus in Patients With Renal Cell Carcinoma Treated on RECORD-3. | ||||||||||
| Author: | Voss, Martin H|Chen, David|Reising, Albert|Marker, Mahtab|Shi, Jiayuan|Xu, Jianing|Ostrovnaya, Irina|Seshan, Venkatraman|Redzematovic, Almedina|Chen, Ying-Bei|Patel, Parul|Han, Xia|Hsieh, James J|Hakimi, A Ari|Motzer, Robert J | ||||||||||
| PMID: | 30327302 | ||||||||||